SG11201907571WA - Therapeutic compositions and related methods for photoimmunotherapy - Google Patents
Therapeutic compositions and related methods for photoimmunotherapyInfo
- Publication number
- SG11201907571WA SG11201907571WA SG11201907571WA SG11201907571WA SG11201907571WA SG 11201907571W A SG11201907571W A SG 11201907571WA SG 11201907571W A SG11201907571W A SG 11201907571WA SG 11201907571W A SG11201907571W A SG 11201907571WA SG 11201907571W A SG11201907571W A SG 11201907571WA
- Authority
- SG
- Singapore
- Prior art keywords
- conjugates
- international
- dual
- california
- photoimmunotherapy
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K41/00—Medicinal preparations obtained by treating materials with wave energy or particle radiation ; Therapies using these preparations
- A61K41/0057—Photodynamic therapy with a photosensitizer, i.e. agent able to produce reactive oxygen species upon exposure to light or radiation, e.g. UV or visible light; photocleavage of nucleic acids with an agent
- A61K41/0071—PDT with porphyrins having exactly 20 ring atoms, i.e. based on the non-expanded tetrapyrrolic ring system, e.g. bacteriochlorin, chlorin-e6, or phthalocyanines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
- A61K47/6835—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment the modifying agent being an antibody or an immunoglobulin bearing at least one antigen-binding site
- A61K47/6845—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment the modifying agent being an antibody or an immunoglobulin bearing at least one antigen-binding site the antibody targeting a cytokine, e.g. growth factors, VEGF, TNF, a lymphokine or an interferon
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
- A61K47/6889—Conjugates wherein the antibody being the modifying agent and wherein the linker, binder or spacer confers particular properties to the conjugates, e.g. peptidic enzyme-labile linkers or acid-labile linkers, providing for an acid-labile immuno conjugate wherein the drug may be released from its antibody conjugated part in an acidic, e.g. tumoural or environment
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
Abstract
International Patent Classification: (72) Inventors: GARCIA-GUZMAN, Miguel; 11080 Roselle A61K 41/00 (2006.01) A61K 47/62 (2017.01) Street, San Diego, California 92121 (US). MAKINGS, A61K 47/42 (2017.01) A61K 47/68 (2017.01) Lewis R.; 11080 Roselle Street, San Diego, California A61K 47/50 (2017.01) A61P 35/00 (2006.01) 92121 (US). CHIN, Eileen Sun; 11080 Roselle Street, San (21) International Application Number: Diego, California 92121 (US). PCT/US2018/019294 (22) International Filing Date: 22 February 2018 (22.02.2018) (25) Filing Language: English (26) Publication Language: English (30) Priority Data: 62/462,898 23 February 2017 (23.02.2017) US (71) Applicant: ASPYRIAN THERAPEUTICS, INC. [US/US]; 11080 Roselle Street, San Diego, California 92121 (US). (74) Agent: AHN, Sejin; Morrison & Foerster LLP, 12531 High Bluff Drive, Suite 100, San Diego, California 92130 (US). (81) Designated States (unless otherwise indicated, for every kind of national protection available): AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, (12) INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) (19) World Intellectual Property Organization International Bureau (43) International Publication Date 30 August 2018 (30.08.2018) WIPO I PCT (54) Title: THERAPEUTIC COMPOSITIONS AND RELATED METHODS FOR PHOTOIMMUNOTHERAPY FIG. 1A 0111111010 0111 °nolo monim H OH oimIE (10) International Publication Number WO 2018/156815 Al 25 O I • 20 72 • , -- c 15 0, ° co • -q. 0 10 • -a • ez • 5 u_ 0 ENo light 0 Light 00 00 O C A431+CetuximabIR700 FaDu+Cetuximab I R700 Treatment (57) : Provided are conjugates, e.g., dual conjugates, compositions and methods for use in photoimmunotherapy, such as photoimmunotherapy induced by activation of a phthalocyanine dye in the dual conjugate. In some embodiments, the dual conjugate contains a targeting molecule and a therapeutic agent. In some embodiments, the phthalocyanine-dye in the conjugate, e.g., dual con- jugate, can be activated by irradiation with near-infrared light. Also provided are therapeutic methods using the conjugates, e.g., dual conjugates, and compositions for treatment of a lesion associated with diseases and conditions, including tumors or cancers. Features of the conjugates, e.g., dual conjugates, compositions, combinations and methods, including the dose of the conjugate, provide various advantages, such as efficient delivery and targeting of the therapeutic agent to the site of the lesion. [Continued on next page] WO 2018/156815 Al MIDEDIMOMOIDEIREEMOMOMHOHOMMIS SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW. (84) Designated States (unless otherwise indicated, for every kind of regional protection available): ARIPO (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW), Eurasian (AM, AZ, BY, KG, KZ, RU, TJ, TM), European (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR), OAPI (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG). Declarations under Rule 4.17: as to the applicant's entitlement to claim the priority of the earlier application (Rule 4.17(iii)) Published: — with international search report (Art. 21(3)) — with sequence listing part of description (Rule 5.2(a))
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201762462898P | 2017-02-23 | 2017-02-23 | |
PCT/US2018/019294 WO2018156815A1 (en) | 2017-02-23 | 2018-02-22 | Therapeutic compositions and related methods for photoimmunotherapy |
Publications (1)
Publication Number | Publication Date |
---|---|
SG11201907571WA true SG11201907571WA (en) | 2019-09-27 |
Family
ID=63253005
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
SG11201907571WA SG11201907571WA (en) | 2017-02-23 | 2018-02-22 | Therapeutic compositions and related methods for photoimmunotherapy |
Country Status (8)
Country | Link |
---|---|
US (1) | US20190365897A1 (en) |
EP (1) | EP3585433A4 (en) |
JP (1) | JP2020508323A (en) |
CN (1) | CN110545846A (en) |
AU (1) | AU2018225177A1 (en) |
CA (1) | CA3053573A1 (en) |
SG (1) | SG11201907571WA (en) |
WO (1) | WO2018156815A1 (en) |
Families Citing this family (18)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US8524239B2 (en) | 2010-07-09 | 2013-09-03 | The United States of America as represented by the Secrectary, Department of Health and Human Services | Photosensitizing antibody-fluorophore conjugates |
CN111388672A (en) | 2014-08-08 | 2020-07-10 | 美国政府(由卫生和人类服务部的部长所代表) | Photocontrolled removal of targets in vivo and in vitro |
CA2994822C (en) | 2015-08-07 | 2023-01-03 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | Near infrared photoimmunotherapy (nir-pit) of suppressor cells to treat cancer |
DK3337568T3 (en) | 2015-08-18 | 2021-09-27 | Rakuten Medical Inc | Phthalocyanine dye conjugates and their storage |
CN108136039A (en) | 2015-08-18 | 2018-06-08 | 阿斯皮利安治疗学股份有限公司 | For the composition of photoimmunotherapy, combination and correlation technique |
US10682602B2 (en) * | 2017-01-19 | 2020-06-16 | National University Of Singapore | Nanofibrous filter |
TW201837051A (en) | 2017-02-08 | 2018-10-16 | 美商必治妥美雅史谷比公司 | Modified relaxin polypeptides comprising a pharmacokinetic enhancer and uses thereof |
AU2019350466A1 (en) * | 2018-09-28 | 2021-04-29 | Pierre Fabre Medicament | New immunocytokines for the treatment of cancer |
EP3948274A1 (en) * | 2019-03-29 | 2022-02-09 | Rakuten Medical, Inc. | Methods for photoimmunotherapy and related biomarkers |
US11826430B2 (en) | 2019-05-14 | 2023-11-28 | Nuvation Bio Inc. | Anti-cancer nuclear hormone receptor-targeting compounds |
WO2020247598A1 (en) * | 2019-06-05 | 2020-12-10 | Emory University | Photolysis to unlock caged protein therapeutics |
EP4058464A1 (en) | 2019-11-13 | 2022-09-21 | Nuvation Bio Inc. | Anti-cancer nuclear hormone receptor-targeting compounds |
JP2023505222A (en) * | 2019-12-06 | 2023-02-08 | ラクテン・メディカル,インコーポレイテッド | Methods for immune enhancement and tumor treatment |
EP4073102A2 (en) | 2019-12-12 | 2022-10-19 | Ting Therapeutics LLC | Compositions and methods for the prevention and treatment of hearing loss |
CN111057063B (en) * | 2019-12-19 | 2022-06-14 | 福州大学 | Phthalocyanine derivative for targeted photodynamic therapy of acute lymphocytic leukemia and preparation method thereof |
CN111423497B (en) * | 2020-03-16 | 2021-12-24 | 山东大学 | Antagonistic peptide, copolymer and nano assembly thereof, and preparation method and application thereof |
US20240101685A1 (en) * | 2021-01-29 | 2024-03-28 | The United States Of America, As Represented By The Secretary, Department Of Health And Human | Near infrared photoimmunotherapy (nir-pit) combination therapy to treat cancer |
US11834458B2 (en) | 2021-03-23 | 2023-12-05 | Nuvation Bio Inc. | Anti-cancer nuclear hormone receptor-targeting compounds |
Family Cites Families (10)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US8153111B2 (en) * | 2004-06-18 | 2012-04-10 | Ceramoptec Industries, Inc. | Photo-triggered release of active substances from dendrimer-photosensitizer complexes |
US20060134064A1 (en) * | 2004-12-20 | 2006-06-22 | David Goldstein | Combined treatment with interferon-alpha and an epidermal growth factor receptor kinase inhibitor |
WO2009038776A1 (en) * | 2007-09-18 | 2009-03-26 | Victor Manneh | Therapeutic nanoconjugates |
US9682143B2 (en) * | 2012-08-14 | 2017-06-20 | Ibc Pharmaceuticals, Inc. | Combination therapy for inducing immune response to disease |
US20150231241A1 (en) * | 2012-08-14 | 2015-08-20 | Ibc Pharmaceuticals, Inc. | Combination therapy for inducing immune response to disease |
CN107252485A (en) * | 2013-04-03 | 2017-10-17 | Ibc药品公司 | For inducing the combination treatment to the immune response of disease |
US10011587B2 (en) * | 2014-05-15 | 2018-07-03 | The Methodist Hospital System | Multivalent ligands targeting VEGFR |
CN111388672A (en) * | 2014-08-08 | 2020-07-10 | 美国政府(由卫生和人类服务部的部长所代表) | Photocontrolled removal of targets in vivo and in vitro |
DK3337568T3 (en) * | 2015-08-18 | 2021-09-27 | Rakuten Medical Inc | Phthalocyanine dye conjugates and their storage |
CN108136039A (en) * | 2015-08-18 | 2018-06-08 | 阿斯皮利安治疗学股份有限公司 | For the composition of photoimmunotherapy, combination and correlation technique |
-
2018
- 2018-02-22 WO PCT/US2018/019294 patent/WO2018156815A1/en unknown
- 2018-02-22 US US16/487,419 patent/US20190365897A1/en not_active Abandoned
- 2018-02-22 JP JP2019545958A patent/JP2020508323A/en active Pending
- 2018-02-22 AU AU2018225177A patent/AU2018225177A1/en not_active Abandoned
- 2018-02-22 CN CN201880026696.1A patent/CN110545846A/en active Pending
- 2018-02-22 SG SG11201907571WA patent/SG11201907571WA/en unknown
- 2018-02-22 EP EP18757204.5A patent/EP3585433A4/en active Pending
- 2018-02-22 CA CA3053573A patent/CA3053573A1/en active Pending
Also Published As
Publication number | Publication date |
---|---|
EP3585433A4 (en) | 2020-12-30 |
JP2020508323A (en) | 2020-03-19 |
CN110545846A (en) | 2019-12-06 |
EP3585433A1 (en) | 2020-01-01 |
US20190365897A1 (en) | 2019-12-05 |
WO2018156815A1 (en) | 2018-08-30 |
AU2018225177A1 (en) | 2019-09-05 |
CA3053573A1 (en) | 2018-08-30 |
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