SG11201901973RA - 7-substituted 1-aryl-naphthyridine-3-carboxylic acid amides and use thereof - Google Patents

7-substituted 1-aryl-naphthyridine-3-carboxylic acid amides and use thereof

Info

Publication number
SG11201901973RA
SG11201901973RA SG11201901973RA SG11201901973RA SG11201901973RA SG 11201901973R A SG11201901973R A SG 11201901973RA SG 11201901973R A SG11201901973R A SG 11201901973RA SG 11201901973R A SG11201901973R A SG 11201901973RA SG 11201901973R A SG11201901973R A SG 11201901973RA
Authority
SG
Singapore
Prior art keywords
substituted
naphthyridine
aryl
carboxylic acid
acid amides
Prior art date
Application number
SG11201901973RA
Inventor
Henrik Teller
Alexandros Vakalopoulos
Arapinis Melissa Boultadakis
Alexander Straub
Hanna Tinel
Markus Brechmann
Matthias Wittwer
Maximilian Kullmann
Till Freudenberger
Thomas Mondritzki
Tobias Marquardt
Original Assignee
Bayer Ag
Bayer Pharma AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from EP16188728.6A external-priority patent/EP3296298A1/en
Application filed by Bayer Ag, Bayer Pharma AG filed Critical Bayer Ag
Publication of SG11201901973RA publication Critical patent/SG11201901973RA/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/4375—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a six-membered ring having nitrogen as a ring heteroatom, e.g. quinolizines, naphthyridines, berberine, vincamine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
    • A61K31/551—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole having two nitrogen atoms, e.g. dilazep
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/06—Antiarrhythmics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/10—Spiro-condensed systems
    • C07D491/107—Spiro-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Urology & Nephrology (AREA)
  • Epidemiology (AREA)
  • Vascular Medicine (AREA)
  • Hospice & Palliative Care (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pyridine Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)

Abstract

7-SUBSTITUTED 1-ARYL-NAPHTHYRIDINE-3-CARBOXYLIC ACID AMIDES AND USE THEREOF The present application relates to novel 7-substituted 1-arylnaphthyridine-3-carboxamides, to processes for their preparation, to their use, alone or in combinations, for the treatment and/or prevention of diseases, and to their use for the production of medicaments for the treatment and/or prevention of diseases, in par- ticular for the treatment and/or prevention of cardiovascular disorders and/or renal disorders. No Figure
SG11201901973RA 2016-09-14 2017-09-06 7-substituted 1-aryl-naphthyridine-3-carboxylic acid amides and use thereof SG11201901973RA (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP16188728.6A EP3296298A1 (en) 2016-09-14 2016-09-14 7-substituted 1-aryl-naphthyridin-3-carboxamides and their use
EP16202509 2016-12-06
PCT/EP2017/072339 WO2018050510A1 (en) 2016-09-14 2017-09-06 7-substituted 1-aryl-naphthyridine-3-carboxylic acid amides and use thereof

Publications (1)

Publication Number Publication Date
SG11201901973RA true SG11201901973RA (en) 2019-04-29

Family

ID=59966701

Family Applications (1)

Application Number Title Priority Date Filing Date
SG11201901973RA SG11201901973RA (en) 2016-09-14 2017-09-06 7-substituted 1-aryl-naphthyridine-3-carboxylic acid amides and use thereof

Country Status (40)

Country Link
US (3) US10927109B2 (en)
EP (1) EP3512849B1 (en)
JP (1) JP7295019B2 (en)
KR (2) KR20230035437A (en)
CN (4) CN115554294A (en)
AU (1) AU2017326297B2 (en)
BR (1) BR112019004982A2 (en)
CA (1) CA3036497A1 (en)
CL (1) CL2019000670A1 (en)
CO (1) CO2019002361A2 (en)
CR (1) CR20190131A (en)
CU (1) CU24618B1 (en)
CY (1) CY1124492T1 (en)
DK (1) DK3512849T3 (en)
DO (1) DOP2019000060A (en)
EC (1) ECSP19018116A (en)
ES (1) ES2887674T3 (en)
GE (1) GEP20217332B (en)
HR (1) HRP20211396T1 (en)
HU (1) HUE056343T2 (en)
IL (1) IL265106B (en)
JO (1) JOP20190045A1 (en)
LT (1) LT3512849T (en)
MA (1) MA46235B1 (en)
MX (1) MX2019003007A (en)
MY (1) MY196473A (en)
NI (1) NI201900023A (en)
NZ (1) NZ751297A (en)
PE (1) PE20190803A1 (en)
PH (1) PH12019500535A1 (en)
PL (1) PL3512849T3 (en)
RS (1) RS62299B1 (en)
SG (1) SG11201901973RA (en)
SI (1) SI3512849T1 (en)
TN (1) TN2019000083A1 (en)
TW (1) TWI758325B (en)
UA (1) UA125627C2 (en)
UY (1) UY37403A (en)
WO (1) WO2018050510A1 (en)
ZA (1) ZA201902325B (en)

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JOP20190045A1 (en) 2016-09-14 2019-03-14 Bayer Ag 7-substituted 1-aryl-naphthyridine-3-carboxylic acid amides and use thereof
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Publication number Publication date
KR20190046851A (en) 2019-05-07
TN2019000083A1 (en) 2020-07-15
JP7295019B2 (en) 2023-06-20
TWI758325B (en) 2022-03-21
LT3512849T (en) 2021-08-25
MY196473A (en) 2023-04-12
US10927109B2 (en) 2021-02-23
CU20190020A7 (en) 2019-11-04
CU24618B1 (en) 2022-08-09
EP3512849A1 (en) 2019-07-24
PE20190803A1 (en) 2019-06-10
IL265106B (en) 2022-05-01
MA46235A (en) 2021-04-14
EP3512849B1 (en) 2021-06-23
RS62299B1 (en) 2021-09-30
CN115554294A (en) 2023-01-03
UA125627C2 (en) 2022-05-04
MA46235B1 (en) 2021-10-29
JP2019534320A (en) 2019-11-28
CO2019002361A2 (en) 2019-06-19
AU2017326297B2 (en) 2021-07-29
HUE056343T2 (en) 2022-02-28
MX2019003007A (en) 2019-07-18
DOP2019000060A (en) 2019-04-15
AU2017326297A1 (en) 2019-03-28
PL3512849T3 (en) 2021-11-29
DK3512849T3 (en) 2021-08-16
CL2019000670A1 (en) 2019-08-02
CN109689656A (en) 2019-04-26
JOP20190045A1 (en) 2019-03-14
CN115477649A (en) 2022-12-16
US20210261541A1 (en) 2021-08-26
CN115429798A (en) 2022-12-06
TW201811785A (en) 2018-04-01
ES2887674T3 (en) 2021-12-27
GEP20217332B (en) 2021-12-10
US11472803B2 (en) 2022-10-18
US20190263805A1 (en) 2019-08-29
ZA201902325B (en) 2022-03-30
UY37403A (en) 2018-04-30
CY1124492T1 (en) 2022-07-22
CA3036497A1 (en) 2018-03-22
ECSP19018116A (en) 2019-03-29
BR112019004982A2 (en) 2019-08-20
KR20230035437A (en) 2023-03-13
WO2018050510A1 (en) 2018-03-22
PH12019500535A1 (en) 2019-11-04
HRP20211396T1 (en) 2021-12-10
NI201900023A (en) 2019-05-23
CR20190131A (en) 2019-05-15
NZ751297A (en) 2022-12-23
CN109689656B (en) 2022-10-04
SI3512849T1 (en) 2021-10-29
US20220089591A1 (en) 2022-03-24

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