SG11201900460RA - Substituted diazahetero-bicyclic compounds and their use - Google Patents

Substituted diazahetero-bicyclic compounds and their use

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Publication number
SG11201900460RA
SG11201900460RA SG11201900460RA SG11201900460RA SG11201900460RA SG 11201900460R A SG11201900460R A SG 11201900460RA SG 11201900460R A SG11201900460R A SG 11201900460RA SG 11201900460R A SG11201900460R A SG 11201900460RA SG 11201900460R A SG11201900460R A SG 11201900460RA
Authority
SG
Singapore
Prior art keywords
substituted
diazahetero
prevention
treatment
bicyclic compounds
Prior art date
Application number
SG11201900460RA
Inventor
Martina Delbeck
Michael Hahn
Thomas Müller
Klemens Lustig
Johanna Anlahr
Udo Albus
Doris Gehring
Björn Rosenstein
Karl Collins
Niels Lindner
Janine Nicolai
Moritz Beck-Broichsitter
Original Assignee
Bayer Ag
Bayer Pharma AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bayer Ag, Bayer Pharma AG filed Critical Bayer Ag
Publication of SG11201900460RA publication Critical patent/SG11201900460RA/en

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/08—Bridged systems
    • G—PHYSICS
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    • G16C—COMPUTATIONAL CHEMISTRY; CHEMOINFORMATICS; COMPUTATIONAL MATERIALS SCIENCE
    • G16C20/00—Chemoinformatics, i.e. ICT specially adapted for the handling of physicochemical or structural data of chemical particles, elements, compounds or mixtures
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    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/439—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom the ring forming part of a bridged ring system, e.g. quinuclidine
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    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/444—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring heteroatom, e.g. amrinone
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Abstract

Substituted diazahetero-bicyclic compounds and their use The present application relates to novel (imidazo[1,2-a]pyridin-3-yl)methyl-substituted diazaheterobicyclic compounds, to processes for preparation thereof, to the use thereof 5 alone or in combinations for treatment and/or prevention of diseases, and to the use thereof for production of medicaments for treatment and/or prevention of diseases, especially for treatment and/or prevention of respiratory disorders including sleep-related respiratory disorders such as obstructive sleep apnoea and central sleep apnoea and snoring. The present application further relates to a method of discovering a compound having TASK-I - 10 and/or TASK-3-blocking properties.
SG11201900460RA 2016-07-20 2017-07-10 Substituted diazahetero-bicyclic compounds and their use SG11201900460RA (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP16180315 2016-07-20
EP16203964 2016-12-14
PCT/EP2017/067273 WO2018015196A1 (en) 2016-07-20 2017-07-10 Substituted diazahetero-bicyclic compounds and their use

Publications (1)

Publication Number Publication Date
SG11201900460RA true SG11201900460RA (en) 2019-02-27

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Family Applications (1)

Application Number Title Priority Date Filing Date
SG11201900460RA SG11201900460RA (en) 2016-07-20 2017-07-10 Substituted diazahetero-bicyclic compounds and their use

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US (2) US20210024545A1 (en)
EP (1) EP3487856A1 (en)
JP (3) JP6999639B2 (en)
KR (1) KR102444687B1 (en)
CN (2) CN109476665B (en)
AU (2) AU2017298421B2 (en)
BR (1) BR112019001141A2 (en)
CA (1) CA3031136A1 (en)
CL (1) CL2019000129A1 (en)
IL (1) IL264258B (en)
JO (1) JOP20190005A1 (en)
MA (1) MA45709A (en)
MX (1) MX2019000785A (en)
PH (1) PH12019500131A1 (en)
SG (1) SG11201900460RA (en)
SV (1) SV2019005812A (en)
TN (1) TN2020000021A1 (en)
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Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP3386979B1 (en) 2015-12-10 2020-07-29 Bayer Pharma Aktiengesellschaft 2-phenyl-3-(piperazinomethyl)imidazo[1,2-a]pyridine derivatives as blockers of the task-1 and task-2 channels for treating sleep-related breathing disorders
CA3007699A1 (en) 2015-12-10 2017-06-15 Bayer Pharma Aktiengesellschaft Substituted perhydropyrrolo[3,4-c]pyrrole derivatives and the use of same
JOP20190284A1 (en) * 2017-06-14 2019-12-11 Bayer Pharma AG Diazabicyclic substituted imidazopyrimidines and their use for the treatment of breathing disorders
WO2018227427A1 (en) * 2017-06-14 2018-12-20 Bayer Aktiengesellschaft Substituted bridged diazepane derivatives and use thereof
JOP20210121A1 (en) 2018-11-27 2023-01-30 Bayer Ag Process for producing pharmaceutical dosage forms containing task-1 and task-3 channel inhibitors, and the use of same in breathing disorder therapy
US20220218695A1 (en) 2019-05-09 2022-07-14 Bayer Aktiengesellschaft Combination of an alpha2-adrenoceptor subtype c (alpha-2c) antagonists with a task1/3 channel blocker for the treatment of sleep apnea
IL292656A (en) 2019-11-06 2022-07-01 Bayer Ag Inhibitors of adrenoreceptor adrac2
US20240000767A1 (en) 2020-07-06 2024-01-04 Bayer Aktiengesellschaft Combination of an alpha2-adrenoceptor subtype c (alpha-2c) antagonist with a task1/3 channel blocker for the treatment of sleep apnea
WO2023118102A1 (en) 2021-12-22 2023-06-29 Bayer Aktiengesellschaft Combination of a task1/3 channel blocker with a muscarinic receptor antagonist for the treatment of sleep apnea
TW202342052A (en) 2021-12-22 2023-11-01 德商拜耳廠股份有限公司 Combination of a task1/3 channel blocker with a norepinephrine reuptake inhibitor for the treatment of sleep apnea
TW202342045A (en) 2021-12-22 2023-11-01 德商拜耳廠股份有限公司 Combination of a task1/3 channel blocker with a p2x3 receptor antagonist for the treatment of sleep apnea
WO2023131640A1 (en) 2022-01-07 2023-07-13 Bayer Aktiengesellschaft α2-ADRENOCEPTOR SUBTYPE C ANTAGONISTS FOR THE TREATMENT OF SLEEP APNEA
WO2023131638A1 (en) 2022-01-07 2023-07-13 Bayer Aktiengesellschaft 2,3-dihydrobenzo [b][1, 4]dioxin-2-ylmethyl)piperazin-1-yl derivates for the treatment of sleep apnea

Family Cites Families (31)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE19834044A1 (en) 1998-07-29 2000-02-03 Bayer Ag New substituted pyrazole derivatives
DE19834047A1 (en) 1998-07-29 2000-02-03 Bayer Ag Substituted pyrazole derivatives
DE19943639A1 (en) 1999-09-13 2001-03-15 Bayer Ag Dicarboxylic acid derivatives with novel pharmaceutical properties
DE19943635A1 (en) 1999-09-13 2001-03-15 Bayer Ag Novel aminodicarboxylic acid derivatives with pharmaceutical properties
DE19943634A1 (en) 1999-09-13 2001-04-12 Bayer Ag Novel dicarboxylic acid derivatives with pharmaceutical properties
DE19943636A1 (en) 1999-09-13 2001-03-15 Bayer Ag Novel dicarboxylic acid derivatives with pharmaceutical properties
US6552037B2 (en) 2000-06-30 2003-04-22 Neurogen Corporation 2-Substituted imidazo[1,2-A]pyridine derivatives
GB0017256D0 (en) 2000-07-13 2000-08-30 Merck Sharp & Dohme Therapeutic agents
AR031176A1 (en) 2000-11-22 2003-09-10 Bayer Ag NEW DERIVATIVES OF PIRAZOLPIRIDINA SUBSTITUTED WITH PIRIDINE
SE0100568D0 (en) 2001-02-20 2001-02-20 Astrazeneca Ab Compounds
DE10110750A1 (en) 2001-03-07 2002-09-12 Bayer Ag Novel aminodicarboxylic acid derivatives with pharmaceutical properties
DE10110749A1 (en) 2001-03-07 2002-09-12 Bayer Ag Substituted aminodicarboxylic acid derivatives
DE10220570A1 (en) 2002-05-08 2003-11-20 Bayer Ag Carbamate-substituted pyrazolopyridines
DE10247269A1 (en) 2002-10-10 2004-04-22 Grünenthal GmbH New C-(imidazo-(1,2-a)-pyridin-3-yl)-methylamines, are nitrogen monoxide synthase inhibitors useful e.g. for treating migraine, septic shock, neurodegenerative diseases, inflammatory pain or cancer
EP2012758A2 (en) 2006-04-27 2009-01-14 Sanofi-Aventis Deutschland GmbH Inhibitors of the task-1 and task-3 ion channel
AU2009249186B2 (en) * 2008-05-19 2014-05-22 Sunovion Pharmaceuticals Inc. Imidazo [1, 2-a] pyridine compounds as GABA-A receptor modulators
AU2011229423B2 (en) 2010-03-18 2015-12-10 Institut National De La Sante Et De La Recherche Medicale (Inserm) Anti-infective compounds
DE102010021637A1 (en) 2010-05-26 2011-12-01 Bayer Schering Pharma Aktiengesellschaft Substituted 5-fluoro-1H-pyrazolopyridines and their use
CN106977530A (en) 2010-07-09 2017-07-25 拜耳知识产权有限责任公司 Ring fusion pyrimidine and triazine and its be used for treat and/or prevention of cardiovascular disease purposes
DE102010040233A1 (en) 2010-09-03 2012-03-08 Bayer Schering Pharma Aktiengesellschaft Bicyclic aza heterocycles and their use
DE102010043379A1 (en) 2010-11-04 2012-05-10 Bayer Schering Pharma Aktiengesellschaft Substituted 6-fluoro-1H-pyrazolo [4,3-b] pyridines and their use
JP5931752B2 (en) 2011-02-01 2016-06-08 協和発酵キリン株式会社 Fused heterocyclic derivatives
CA2831356A1 (en) 2011-03-31 2012-10-04 Emblem Technology Transfer Gmbh Imidazo [1,2-a]pyridine_compounds for use in therapy
KR20140093610A (en) 2011-04-21 2014-07-28 재단법인 한국파스퇴르연구소 Anti-inflammation compounds
CA2846366A1 (en) * 2011-09-16 2013-03-21 Sanofi Substituted 4,5,6,7-tetrahydro-1h-pyrazolo[4,3-c]pyridines, their use as medicament, and pharmaceutical preparations comprising them
US9284333B2 (en) * 2012-02-03 2016-03-15 Sanofi Fused pyrroledicarboxamides and their use as pharmaceuticals
JP2016519662A (en) * 2013-03-14 2016-07-07 ザ・リージエンツ・オブ・ザ・ユニバーシテイー・オブ・カリフオルニア Regulation of K2P channel
WO2014187922A1 (en) 2013-05-24 2014-11-27 Iomet Pharma Ltd. Slc2a transporter inhibitors
CN110204550B (en) 2014-03-26 2022-05-17 豪夫迈·罗氏有限公司 Bicyclic compounds as Autotaxin (ATX) and lysophosphatidic acid (LPA) production inhibitors
JP2018012645A (en) 2014-11-26 2018-01-25 持田製薬株式会社 Novel diazabicyclo derivative
JP2018016544A (en) 2014-12-03 2018-02-01 持田製薬株式会社 Novel diazabicyclo [2.2.2]octane derivative

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