SG11201809197XA - Compositions for use in treating tendon degeneration - Google Patents

Compositions for use in treating tendon degeneration

Info

Publication number
SG11201809197XA
SG11201809197XA SG11201809197XA SG11201809197XA SG11201809197XA SG 11201809197X A SG11201809197X A SG 11201809197XA SG 11201809197X A SG11201809197X A SG 11201809197XA SG 11201809197X A SG11201809197X A SG 11201809197XA SG 11201809197X A SG11201809197X A SG 11201809197XA
Authority
SG
Singapore
Prior art keywords
international
pct
street
compositions
treating
Prior art date
Application number
SG11201809197XA
Inventor
Colin White
Edward Ahn
Sekoni Noel
Original Assignee
Anika Therapeutics Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Anika Therapeutics Inc filed Critical Anika Therapeutics Inc
Publication of SG11201809197XA publication Critical patent/SG11201809197XA/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/14—Macromolecular materials
    • A61L27/20—Polysaccharides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/39—Connective tissue peptides, e.g. collagen, elastin, laminin, fibronectin, vitronectin, cold insoluble globulin [CIG]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/06—Ointments; Bases therefor; Other semi-solid forms, e.g. creams, sticks, gels
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/36—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix
    • A61L27/38—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix containing added animal cells
    • A61L27/3839—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix containing added animal cells characterised by the site of application in the body
    • A61L27/3843—Connective tissue
    • A61L27/386—Ligaments, tendons
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/04—Drugs for skeletal disorders for non-specific disorders of the connective tissue
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2400/00—Materials characterised by their function or physical properties
    • A61L2400/06—Flowable or injectable implant compositions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2430/00—Materials or treatment for tissue regeneration
    • A61L2430/10—Materials or treatment for tissue regeneration for reconstruction of tendons or ligaments

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Dermatology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Oral & Maxillofacial Surgery (AREA)
  • Transplantation (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Zoology (AREA)
  • Molecular Biology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Botany (AREA)
  • Cell Biology (AREA)
  • Vascular Medicine (AREA)
  • Rheumatology (AREA)
  • Rehabilitation Therapy (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Immunology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Materials For Medical Uses (AREA)
  • Infusion, Injection, And Reservoir Apparatuses (AREA)
  • Peptides Or Proteins (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Details Of Rigid Or Semi-Rigid Containers (AREA)

Abstract

INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) (19) World Intellectual Property 11111111111111111111111111111111111111111111111111111111111111111111111111111111 Organization International Bureau (10) International Publication Number (43) International Publication Date .....0\"\" WO 2017/189723 Al 02 November 2017 (02.11.2017) W I PO I PCT (51) International Patent Classification: (74) Agent: SCOZZAFAVA, Mary, Rose et al.; Wilmer Cutler A61K 31/715 (2006.01) A61P 19/00 (2006.01) Pickering Hale And Don LLP, 60 State Street, Boston, MA (21) International Application Number: 02109 (US). PCT/US2017/029635 (81) Designated States (unless otherwise indicated, for every (22) International Filing Date: kind of national protection available): AE, AG, AL, AM, 26 April 2017 (26.04.2017) AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, (25) Filing Language: English DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, (26) Publication Language: English HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, (30) Priority Data: MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, 62/328,396 27 April 2016 (27.04.2016) US PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, 62/367,377 27 July 2016 (27.07.2016) US SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW. (71) Applicant: ANIKA THERAPEUTICS, INC. [US/US]; 32 Wiggins Avenue, Bedford, MA 01730 (US). (84) Designated States (unless otherwise indicated, for every kind of regional protection available): ARIPO (BW, GH, (72) Inventors; and GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, (71) Applicants: WHITE, Colin, D. [GB/US]; 74 Oak Ridge UG, ZM, ZW), Eurasian (AM, AZ, BY, KG, KZ, RU, TJ, Terrace, Lynnfield, MA 01940 (US). AHN, Edward, S. TM), European (AL, AT, BE, BG, CH, CY, CZ, DE, DK, [US/US]; 175 Dedham Street, Dover, MA 02030 (US). EE, ES, FL FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, NOEL, Sekoni, Daouda [US/US]; 529 Boylston Street, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, Newton Centre, MA 02459 (US). — = Title: COMPOSITIONS FOR USE IN TREATING TENDON DEGENERATION (54) = = = ifl = ' icra 103 = _ lio t e ek. 4 4vr, = 105- X*: • = V *iti . o f 106 itto .' 4 41 1:(1 4 4 — = - • 4 •$ Jo _ = 107 104 .. • :-.;_:.“.-:_...,.:::; z 102 _ 1 1 M ei IN c:r cc ,-1 CM/ FIG. I IN (57) : Injectable compositions and methods for treating an injured tendon in an animal or human are disclosed herein. The 1-1 © injectable compositions include an effective amount of a carbohydrate to increase osteotendinous hydration and lubrication. ei C [Continued on next page] WO 2017/189723 Al MIDEDIMOMMIONMEMOMMOHEIHMIDOMEHOIS TR), OAPI (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG). Published: — with international search report (Art. 21(3)) — before the expiration of the time limit for amending the claims and to be republished in the event of receipt of amendments (Rule 48.2(h))
SG11201809197XA 2016-04-27 2017-04-26 Compositions for use in treating tendon degeneration SG11201809197XA (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201662328396P 2016-04-27 2016-04-27
US201662367377P 2016-07-27 2016-07-27
PCT/US2017/029635 WO2017189723A1 (en) 2016-04-27 2017-04-26 Compositions for use in treating tendon degeneration

Publications (1)

Publication Number Publication Date
SG11201809197XA true SG11201809197XA (en) 2018-11-29

Family

ID=58709560

Family Applications (2)

Application Number Title Priority Date Filing Date
SG10201913342UA SG10201913342UA (en) 2016-04-27 2017-04-26 Compositions for use in treating tendon degeneration
SG11201809197XA SG11201809197XA (en) 2016-04-27 2017-04-26 Compositions for use in treating tendon degeneration

Family Applications Before (1)

Application Number Title Priority Date Filing Date
SG10201913342UA SG10201913342UA (en) 2016-04-27 2017-04-26 Compositions for use in treating tendon degeneration

Country Status (15)

Country Link
US (1) US10441677B2 (en)
EP (1) EP3448394B1 (en)
JP (1) JP6826657B2 (en)
KR (1) KR20190009303A (en)
CN (1) CN109562124A (en)
AU (1) AU2017257956B2 (en)
CA (1) CA3021764C (en)
IL (1) IL262507B (en)
MX (1) MX2018012964A (en)
NZ (1) NZ747413A (en)
RU (1) RU2018141386A (en)
SG (2) SG10201913342UA (en)
TW (2) TWI755392B (en)
WO (1) WO2017189723A1 (en)
ZA (1) ZA201807136B (en)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP3735204B1 (en) 2018-01-02 2023-09-06 Cartiheal (2009) Ltd. Implantation tool for optimized solid substrates promoting cell and tissue growth

Family Cites Families (37)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2946819A (en) 1958-04-14 1960-07-26 Gen Aniline & Film Corp Process of producing carbodimides
DE1156401B (en) 1960-05-24 1963-10-31 Bayer Ag Process for the preparation of carbodiimides
DE1149712B (en) 1961-11-14 1963-06-06 Bayer Ag Process for the preparation of carbodiimides
US3644456A (en) 1964-08-12 1972-02-22 Upjohn Co Di((isocyanatobenzyl)-phenyl) carbodiimides and preparation of organic carbodiimides
US3972933A (en) 1974-05-28 1976-08-03 Monsanto Company Preparation of carbodiimides from ureas by dehydration
GB1476088A (en) 1975-04-03 1977-06-10 Ici Ltd Carbodiimides
DE2556760A1 (en) 1975-12-17 1977-06-30 Hoechst Ag METHOD FOR PRODUCING CARBODIIMIDES
GB1584153A (en) 1976-09-22 1981-02-04 Ici Ltd Carbodimides
US4066629A (en) 1976-10-28 1978-01-03 Celanese Corporation Process for preparing carbodiimides utilizing a phosphonium salt catalyst
US4098973A (en) 1977-01-31 1978-07-04 The Upjohn Company Compounds and process
US4851521A (en) 1985-07-08 1989-07-25 Fidia, S.P.A. Esters of hyaluronic acid
IT1219587B (en) 1988-05-13 1990-05-18 Fidia Farmaceutici SELF-CROSS-LINKED CARBOXYLY POLYSACCHARIDES
US5356883A (en) 1989-08-01 1994-10-18 Research Foundation Of State University Of N.Y. Water-insoluble derivatives of hyaluronic acid and their methods of preparation and use
ITPD940054A1 (en) 1994-03-23 1995-09-23 Fidia Advanced Biopolymers Srl SULPHATED POLYSACCHARIDES
ES2189166T3 (en) 1997-04-04 2003-07-01 Fidia Advanced Biopolymers Srl N-SULFATED HIALURONIC ACID COMPOUNDS, ITS DERIVATIVES AND PROCESS FOR PREPARATION.
ITPD980169A1 (en) 1998-07-06 2000-01-06 Fidia Advanced Biopolymers Srl AMIDES OF HYALURONIC ACID AND ITS DERIVATIVES AND PROCESS FOR THEIR PREPARATION.
EP1237585B1 (en) 1999-12-09 2003-06-18 Biosyntech Canada Inc. Mineral-polymer hybrid composition
WO2002009792A1 (en) 2000-07-28 2002-02-07 Anika Therapeutics, Inc. Bioabsorbable composites of derivatized hyaluronic acid
IT1317359B1 (en) 2000-08-31 2003-06-16 Fidia Advanced Biopolymers Srl PERCARBOXYLATE POLYSACCHARIDES, SUCH AS HYALURONIC ACID, PROCESS FOR THEIR PREPARATION AND USE IN THE PHARMACEUTICAL FIELD AND
IT1317358B1 (en) 2000-08-31 2003-06-16 Fidia Advanced Biopolymers Srl CROSS-LINKATED DERIVATIVES OF HYALURONIC ACID.
CA2437417C (en) 2001-02-22 2016-07-26 Anika Therapeutics, Inc. Thiol-modified hyaluronan
US20060272221A1 (en) 2001-11-29 2006-12-07 Treibacher Schleifmittel Gmbh Al2O3 and ZrO2 based abrasive grain, method for the production and use thereof
CA2476653C (en) 2002-02-21 2009-01-27 Encelle, Inc. Cross-linked bioactive hydrogel matrices
ITPD20020064A1 (en) 2002-03-12 2003-09-12 Fidia Advanced Biopolymers Srl FOREIGN DERIVATIVES OF HYALURONIC ACID FOR THE PREPARATION OF HYDROGELD FOR USE IN THE BIOMEDICAL, SANITARY AND SURGICAL FIELD AND AS A SYSTEM
US7393405B2 (en) 2002-06-19 2008-07-01 H.C. Robert Mathys Stiftung Hydraulic cement based on calcium phosphate for surgical use
US8455458B2 (en) * 2002-10-16 2013-06-04 Arthrodynamic Technologies, Animal Health Division, Inc. Composition and method for treating connective tissue damage
DE10257554B4 (en) 2002-12-10 2008-04-10 Treibacher Schleifmittel Gmbh Abrasive grains coated with an aqueous binder and a complex fine oxide compound, methods for treating such abrasive grains, and their use for resin bonded abrasives
WO2005032562A1 (en) 2003-10-09 2005-04-14 Robert John Petrella Methods for treating acute and overuse sprain and strain using hyaluronic acid
US8124120B2 (en) 2003-12-22 2012-02-28 Anika Therapeutics, Inc. Crosslinked hyaluronic acid compositions for tissue augmentation
EP1968614A2 (en) 2005-12-14 2008-09-17 Anika Therapeutics Inc. Treatment of arthritis and other musculoskeletal disorders with crosslinked hyaluronic acid
EP1891984A1 (en) 2006-08-24 2008-02-27 Graftys Macroporous and highly resorbable apatitic calcium-phosphate cement
IT1393419B1 (en) 2009-03-19 2012-04-20 Medivis S R L OPHTHALMIC COMPOSITIONS OF OMEGA-3 AND OMEGA-6 POLYSATURATED FATTY ACIDS.
AU2010298484B2 (en) * 2009-09-23 2014-09-25 Glenpharma Ab Compositions and methods for inducing or enhancing connective tissue repair
WO2012170805A2 (en) 2011-06-09 2012-12-13 Knee Creations, Llc Instruments and devices for subchondral joint repair
US9649190B2 (en) 2012-03-22 2017-05-16 Trb Chemedica International S.A. Method for repair of ligament or tendon
NO2900247T3 (en) * 2012-09-26 2018-06-16
AU2015221389B2 (en) * 2014-02-20 2018-12-13 Ortho Regenerative Technologies Inc. Freeze-dried polymer compositions for mixing with platelet rich plasma to form implants for tissue repair and/or compositions for therapeutic intra-articular injections

Also Published As

Publication number Publication date
AU2017257956B2 (en) 2019-11-07
CA3021764C (en) 2021-01-19
JP6826657B2 (en) 2021-02-03
IL262507B (en) 2020-10-29
IL262507A (en) 2018-12-31
TW202114712A (en) 2021-04-16
US10441677B2 (en) 2019-10-15
MX2018012964A (en) 2019-06-10
ZA201807136B (en) 2021-05-26
KR20190009303A (en) 2019-01-28
US20170326271A1 (en) 2017-11-16
CN109562124A (en) 2019-04-02
JP2019516784A (en) 2019-06-20
RU2018141386A (en) 2020-05-27
EP3448394A1 (en) 2019-03-06
WO2017189723A1 (en) 2017-11-02
EP3448394C0 (en) 2023-09-13
TWI755392B (en) 2022-02-21
NZ747413A (en) 2020-09-25
SG10201913342UA (en) 2020-03-30
AU2017257956A1 (en) 2018-11-15
RU2018141386A3 (en) 2020-05-27
EP3448394B1 (en) 2023-09-13
CA3021764A1 (en) 2017-11-02
WO2017189723A9 (en) 2018-06-28
TW201739457A (en) 2017-11-16

Similar Documents

Publication Publication Date Title
SG11201806302RA (en) Inhibitors of receptor-interacting protein kinase 1
SG11201804373VA (en) Compositions and methods for immunooncology
SG11201908330PA (en) Farnesoid x receptor agonists and uses thereof
SG11201811564QA (en) Methods of treating ovarian cancer
SG11201900163PA (en) Macrocycle kinase inhibitors
SG11201804132UA (en) Eif4-a-inhibiting compounds and methods related thereto
SG11201804901WA (en) Compounds for the treatment of cancer and inflammatory disease
SG11201809202XA (en) Methods and compositions for the treatment of degenerate bone
SG11201807913XA (en) Stabilized soluble pre-fusion rsv f proteins
SG11201907435PA (en) Combinations of a 4-pyrimidinesulfamide derivative with active ingredients for the treatment of endothelin related diseases
SG11201808222RA (en) Methods of treatment of cholestatic diseases
SG11201809908TA (en) Stabilized glycopeptide antibiotic formulations
SG11201808713YA (en) Ophthalmic compositions comprising levodopa, an antioxidant and an aqueous carrier
SG11201902531QA (en) Liquid pharmaceutical composition
SG11201907420VA (en) Inhibition of smarca2 for treatment of cancer
SG11201806544XA (en) Compounds and methods of treating rna-mediated diseases
SG11201809882XA (en) Pharmaceutical combinations for treating cancer
SG11201809875VA (en) Compositions and methods for treating spinal muscular atrophy
SG11201810078PA (en) Stabilized pre-fusion rsv f proteins
SG11201808221QA (en) 1,5-dihydro-4h-pyrazolo[3,4-d]pyrimidin-4-ones and 1,5-dihydro-4h-pyrazolo[4,3-c]pyridin-4-ones as pde1 inhibitors
SG11201805061YA (en) Crystalline form of gemcitabine
SG11201809531SA (en) BINDING MOLECULES SPECIFIC FOR FCγGAMMA RIIA AND USES THEREOF
SG11201804885TA (en) Monomaleimide-functionalized platinum compounds for cancer therapy
SG11201808829VA (en) Tdp-43 mitochondrial localization inhibitor for the treatment of neurodegenerative disease
SG11201811686UA (en) 18f-labeled triazole containing psma inhibitors