SG11201809007YA - Substituted fused pyrimidinone compounds - Google Patents

Abstract

INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) (19) World Intellectual Property 1111111111111111111111111111111111111111111111111111111111111111111111111 Organization International Bureau (10) International Publication Number (43) International Publication Date ......0\" WO 2017/187324 Al 02 November 2017 (02.11.2017) WIP0 I PCT (51) International Patent Classification: (74) Agent: MAJUMDAR, Subhatosh et al.; S. Majumdar C07D 405/14 (2006.01) A61K 31/517 (2006.01) & Co., 5 Harish Mukherjee Road, State of West Bengal, CO7D 403/14 (2006.01) A61P 11/00 (2006.01) Kolkata 700 025 (IN). (21) International Application Number: (81) Designated States (unless otherwise indicated, for every PCT/IB2017/052352 kind of national protection available): AE, AG, AL, AM, (22) International Filing Date: AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, 25 April 2017 (25.04.2017) CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, (25) Filing Language: English HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KH, KN, KP, KR, (26) Publication Language: English KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, (30) Priority Data: PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, 201621014526 26 April 2016 (26.04.2016) IN SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW. (71) Applicant: TORRENT PHARMACEUTICALS LIMITED [IN/IN]; Torrent House, Off Ashram Road, Gu- (84) Designated States (unless otherwise indicated, for every jarat, Ahmedabad 380 009 (IN). kind of regional protection available): ARIPO (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, (72) Inventors: DUTT, Chaitanya; Torrent Research Centre, UG, ZM, ZW), Eurasian (AM, AZ, BY, KG, KZ, RU, TJ, Tal & Dist. Gandhinagar, Gujarat, Bhat 382 428 (IN). TM), European (AL, AT, BE, BG, CH, CY, CZ, DE, DK, JOSHI, Deep a; ; Torrent Research Centre, Tal & Dist. Gand-EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, hinagar, Gujarat, Bhat 382 428 (IN). RODE, Milind; Tor- MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, rent Research Centre, Tal & Dist. Gandhinagar, Gujarat, TR), OAPI (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, Bhat 382 428 (IN). SRIVASTAVA, Sanjay; Torrent Re-KM, ML, MR, NE, SN, TD, TG). search Centre, Tal & Dist. Gandhinagar, Gujarat, Bhat 382 = 428 (IN). TULI, Davinder; Torrent Research Centre, Tal Declarations under Rule 4.17: _ — & Dist. Gandhinagar, Gujarat, Bhat 382 428 (IN). GUP- — as to applicant's entitlement to apply for and be granted a TA, Ramesh, Chandra; Torrent Research Centre, Tal & patent (Rule 4.17(ii)) Dist. Gandhinagar, Gujarat, Bhat 382 428 (IN). RAI, Deep- — as to the applicant's entitlement to claim the priority of the ak; Torrent Research Centre, Tal & Dist. Gandhinagar, Gu earlier application (Rule 4.17(iii)) jarat, Bhat 382 428 (IN). JAMADARKHANA, Prashant; = = - Torrent Research Centre, Tal & Dist. Gandhinagar, Gujarat, Published: Bhat 382 428 (IN). DESHPANDE, Shailesh; Torrent Re- — with international search report (Art. 21(3)) = search Centre, Tal & Dist. Gandhinagar, Gujarat, Bhat 382 428 (IN). MISHRA, Vivek; Torrent Research Centre, Tal = & Dist. Gandhinagar, Gujarat, Bhat 382 428 (IN). ABRA- = HAM, Jaya; Torrent Research Centre, Tal & Dist. Gandhi- nagar, Gujarat, Bhat 382 428 (IN). = = = = (54) Title: SUBSTITUTED FUSED PYRIMIDINONE COMPOUNDS (57) : Provided herein are novel fused pyrimidinone derivatives of For- = ER 2],i mula (I) and synthetic intermediates that are useful in preparing the compounds of formula (I). Further provided herein is a method for preparation of a compound of formula (I) or intermediates, a pharmaceutical composition comprising a compound — Il .4 ei (R ']q ,X of formula (I), and use of a compound of formula (I) . 41:11 R 8 M _N IN R 5 GC \ Il R 6 IN Il R 3 Z lip [R 4 ] q 0 N (I) O