SG11201808207RA - Phenyl [a]indole[2,3-g]quinolizine compounds, preparation method therefor, pharmaceutical composition, and applications thereof - Google Patents
Phenyl [a]indole[2,3-g]quinolizine compounds, preparation method therefor, pharmaceutical composition, and applications thereofInfo
- Publication number
- SG11201808207RA SG11201808207RA SG11201808207RA SG11201808207RA SG11201808207RA SG 11201808207R A SG11201808207R A SG 11201808207RA SG 11201808207R A SG11201808207R A SG 11201808207RA SG 11201808207R A SG11201808207R A SG 11201808207RA SG 11201808207R A SG11201808207R A SG 11201808207RA
- Authority
- SG
- Singapore
- Prior art keywords
- indole
- phenyl
- applications
- preparation
- pharmaceutical composition
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D459/00—Heterocyclic compounds containing benz [g] indolo [2, 3-a] quinolizine ring systems, e.g. yohimbine; 16, 18-lactones thereof, e.g. reserpic acid lactone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/472—Non-condensed isoquinolines, e.g. papaverine
- A61K31/4725—Non-condensed isoquinolines, e.g. papaverine containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/4738—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems
- A61K31/4745—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems condensed with ring systems having nitrogen as a ring hetero atom, e.g. phenantrolines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains three hetero rings
- C07D471/14—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/22—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains four or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
- C07D495/22—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains four or more hetero rings
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Epidemiology (AREA)
- Gastroenterology & Hepatology (AREA)
- Urology & Nephrology (AREA)
- Vascular Medicine (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Child & Adolescent Psychology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201610192571.9A CN107286158A (en) | 2016-03-30 | 2016-03-30 | Phenyl [a] indoles [2,3-g] and quinolizine class compound, its preparation method, pharmaceutical composition and its application |
| PCT/CN2017/078616 WO2017167202A1 (en) | 2016-03-30 | 2017-03-29 | Phenyl [a]indole[2,3-g]quinolizine compounds, preparation method therefor, pharmaceutical composition, and applications thereof |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| SG11201808207RA true SG11201808207RA (en) | 2018-11-29 |
Family
ID=59962595
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SG11201808207RA SG11201808207RA (en) | 2016-03-30 | 2017-03-29 | Phenyl [a]indole[2,3-g]quinolizine compounds, preparation method therefor, pharmaceutical composition, and applications thereof |
Country Status (9)
| Country | Link |
|---|---|
| US (1) | US10927107B2 (en) |
| EP (1) | EP3438108B1 (en) |
| JP (1) | JP6837076B2 (en) |
| KR (1) | KR102205109B1 (en) |
| CN (2) | CN107286158A (en) |
| CA (1) | CA3023171C (en) |
| RU (1) | RU2756197C9 (en) |
| SG (1) | SG11201808207RA (en) |
| WO (1) | WO2017167202A1 (en) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN112679469B (en) * | 2020-12-29 | 2021-11-16 | 山东研峰新材料科技有限公司 | Tetrahydroisoquinoline derivatives, preparation method and application |
| CN115594679A (en) * | 2021-06-28 | 2023-01-13 | 广州嘉越医药科技有限公司（Cn） | Crystal forms of phenyl [ a ] indole [2,3-g ] quinolizine compounds, salts thereof and crystal forms of salts, preparation methods and applications |
| WO2023104051A1 (en) * | 2021-12-07 | 2023-06-15 | 广州嘉越医药科技有限公司 | Combined use of indole substituted tetrahydroisoquinoline compound and statin compound |
| CN117510512A (en) * | 2022-07-29 | 2024-02-06 | 中国科学院上海药物研究所 | Polysubstituted tetrahydroisoquinoline compound, preparation method, pharmaceutical composition and application |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3772306A (en) * | 1971-11-26 | 1973-11-13 | Warner Lambert Co | 1,2,4a,5,6,8,9,14,14a,14b-decahydrobenz(a)indolo(2,3-g)quinolizin-3(4h)-ones |
| ATE335742T1 (en) * | 2001-06-21 | 2006-09-15 | Lilly Icos Llc | CARBOLINE DERIVATIVES AS PDEV INHIBITORS |
| PL372657A1 (en) * | 2002-04-03 | 2005-07-25 | Orion Corporation | Polycyclic compounds as potent alpha2-adrenoceptor antagonists |
| PT1537078E (en) * | 2002-08-29 | 2010-06-18 | Merck Sharp & Dohme | Indoles having anti-diabetic activity |
| CN1759834B (en) * | 2004-09-17 | 2010-06-23 | 中国医学科学院医药生物技术研究所 | Application of berberine or associated with Simvastatin in preparing product for preventing or curing disease or symptom related to blood fat |
| EP2370434B8 (en) * | 2008-12-23 | 2014-10-15 | CVI Pharmaceuticals Limited | Isoquinolinyl-containing alkaloid compounds and compositions useful for reducing lipid levels |
| CN103664974B (en) * | 2012-09-17 | 2016-12-21 | 中国科学院上海药物研究所 | Aryl [a] indole [2,3-g] quinolizine compounds, its preparation method, pharmaceutical composition and application thereof |
-
2016
- 2016-03-30 CN CN201610192571.9A patent/CN107286158A/en active Pending
-
2017
- 2017-03-29 CN CN201780019415.5A patent/CN109071541B/en active Active
- 2017-03-29 US US16/089,713 patent/US10927107B2/en active Active
- 2017-03-29 CA CA3023171A patent/CA3023171C/en active Active
- 2017-03-29 JP JP2018551115A patent/JP6837076B2/en active Active
- 2017-03-29 KR KR1020187031486A patent/KR102205109B1/en active IP Right Grant
- 2017-03-29 RU RU2018138216A patent/RU2756197C9/en active
- 2017-03-29 EP EP17773232.8A patent/EP3438108B1/en active Active
- 2017-03-29 WO PCT/CN2017/078616 patent/WO2017167202A1/en active Application Filing
- 2017-03-29 SG SG11201808207RA patent/SG11201808207RA/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| CN109071541A (en) | 2018-12-21 |
| WO2017167202A1 (en) | 2017-10-05 |
| JP2019510049A (en) | 2019-04-11 |
| KR20190003533A (en) | 2019-01-09 |
| RU2018138216A3 (en) | 2020-04-30 |
| CN109071541B (en) | 2021-06-18 |
| EP3438108A1 (en) | 2019-02-06 |
| CA3023171C (en) | 2022-01-18 |
| CA3023171A1 (en) | 2017-10-05 |
| EP3438108A4 (en) | 2019-09-04 |
| RU2756197C9 (en) | 2022-03-14 |
| JP6837076B2 (en) | 2021-03-03 |
| RU2018138216A (en) | 2020-04-30 |
| US20190194185A1 (en) | 2019-06-27 |
| US10927107B2 (en) | 2021-02-23 |
| RU2756197C2 (en) | 2021-09-28 |
| CN107286158A (en) | 2017-10-24 |
| KR102205109B1 (en) | 2021-01-20 |
| EP3438108B1 (en) | 2022-08-10 |
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