SG11201806620TA - Compositions and methods for treating infections - Google Patents
Compositions and methods for treating infectionsInfo
- Publication number
- SG11201806620TA SG11201806620TA SG11201806620TA SG11201806620TA SG11201806620TA SG 11201806620T A SG11201806620T A SG 11201806620TA SG 11201806620T A SG11201806620T A SG 11201806620TA SG 11201806620T A SG11201806620T A SG 11201806620TA SG 11201806620T A SG11201806620T A SG 11201806620TA
- Authority
- SG
- Singapore
- Prior art keywords
- international
- co7d
- pct
- new york
- methods
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P33/00—Antiparasitic agents
- A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
- C07D239/50—Three nitrogen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Tropical Medicine & Parasitology (AREA)
- General Chemical & Material Sciences (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Pyridine Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Plural Heterocyclic Compounds (AREA)
Abstract
INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) (19) World Intellectual Property Organization International Bureau (43) International Publication Date 10 August 2017 (10.08.2017) WIPO I PCT (10) International Publication Number WO 2017/136556 Al 111111 11111111 0 111011111111111 010 11111 01110111 01111111H11111 111111111111111 0111111 (81) Designated States (unless otherwise indicated, for every kind of national protection available): AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW. (84) Designated States (unless otherwise indicated, for every kind of regional protection available): ARIPO (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW), Eurasian (AM, AZ, BY, KG, KZ, RU, TJ, TM), European (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR), OAPI (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG). Declarations under Rule 4.17: — of inventorship (Rule 4.17(iv)) Published: — with international search report (Art. 21(3)) (51) International Patent Classification: CO7D 401/04 (2006.01) A61K 31/506 (2006.01) CO7D 403/04 (2006.01) A61P 33/02 (2006.01) CO7D 403/14 (2006.01) (21) International Application Number: PCT/US2017/016224 (22) International Filing Date: 2 February 2017 (02.02.2017) (25) Filing Language: English (26) Publication Language: English (30) Priority Data: 62/291,900 5 February 2016 (05.02.2016) US 62/375,712 16 August 2016 (16.08.2016) US (71) Applicant: TURING PHARMACEUTICALS LLC [US/US]; 1177 Avenue of the Americas, 39th Floor, New York, NY 10013 (US). (72) Inventors; and (71) Applicants (for US only): THOMAS, Stephen [US/US]; 73 W71 St., Apt. B, New York, NY 10023 (US). HOP- PER, Allen, T. [US/US]; 14 Moseman Ave, Katonah, NY 10536 (US). WELSCH, Mathew [US/US]; 400 W 53rd St., Apt. 25, New York, NY 10019 (US). = (74) Agents: ABELLEIRA, Susan, M. et al.; Foley Hoag LLP, 155 Seaport Boulevard, Boston, MA 02210-2600 (US). W O 20 17 / 13655 6 Al (54) Title: COMPOSITIONS AND METHODS FOR TREATING INFECTIONS (57) : The invention relates to inhibitors of dihydrotolate reductase and pharmaceutical preparations thereof. The invention further relates to methods of treatment of parasitic infections, such as T. gondii, T. cruzi, P. falciparum, T. hrucei, or L. major infec- tions, using the novel inhibitors of the invention.
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201662291900P | 2016-02-05 | 2016-02-05 | |
| US201662375712P | 2016-08-16 | 2016-08-16 | |
| PCT/US2017/016224 WO2017136556A1 (en) | 2016-02-05 | 2017-02-02 | Compositions and methods for treating infections |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| SG11201806620TA true SG11201806620TA (en) | 2018-09-27 |
Family
ID=59500993
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SG11201806620TA SG11201806620TA (en) | 2016-02-05 | 2017-02-02 | Compositions and methods for treating infections |
| SG10202007239QA SG10202007239QA (en) | 2016-02-05 | 2017-02-02 | Compositions and methods for treating infections |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SG10202007239QA SG10202007239QA (en) | 2016-02-05 | 2017-02-02 | Compositions and methods for treating infections |
Country Status (17)
| Country | Link |
|---|---|
| US (2) | US10774073B2 (en) |
| EP (1) | EP3411367A4 (en) |
| JP (1) | JP6949055B2 (en) |
| KR (1) | KR20180119590A (en) |
| CN (1) | CN109071486A (en) |
| AU (2) | AU2017213824B9 (en) |
| BR (1) | BR112018015924A2 (en) |
| CA (1) | CA3013760A1 (en) |
| CL (1) | CL2018002074A1 (en) |
| CU (1) | CU20180083A7 (en) |
| EA (1) | EA201891766A1 (en) |
| IL (2) | IL260952B (en) |
| MX (1) | MX2018009504A (en) |
| PH (1) | PH12018501646A1 (en) |
| SG (2) | SG11201806620TA (en) |
| TW (1) | TW201731836A (en) |
| WO (1) | WO2017136556A1 (en) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| BR112018015924A2 (en) | 2016-02-05 | 2018-12-26 | Vyera Pharmaceuticals Llc | compositions and methods for treating infections |
| EP3665165A4 (en) * | 2017-08-07 | 2021-08-11 | Vyera Pharmaceuticals, LLC | Dhfr inhibitors, compositions, and methods related thereto |
| WO2019205058A1 (en) * | 2018-04-26 | 2019-10-31 | 广州中科蓝华生物科技有限公司 | Attenuation system and use thereof |
| WO2022040002A1 (en) | 2020-08-17 | 2022-02-24 | Aligos Therapeutics, Inc. | Methods and compositions for targeting pd-l1 |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4532240A (en) * | 1982-09-09 | 1985-07-30 | Warner-Lambert Company | Diaminopyrimidines |
| CA1244028A (en) | 1983-04-14 | 1988-11-01 | Hans Maag | Pyrimidine derivatives |
| US20040006042A1 (en) * | 1998-08-13 | 2004-01-08 | Berry David Allen | Diaminopyrimidines and combination therapies effective for treatment of P-glycoprotein positive cancers |
| AU4690999A (en) * | 1998-08-13 | 2000-03-06 | Warner-Lambert Company | Diaminopyrimidines and combination therapies effective for treatment of p-glycoprotein positive cancers |
| BR112018015924A2 (en) | 2016-02-05 | 2018-12-26 | Vyera Pharmaceuticals Llc | compositions and methods for treating infections |
| EP3665165A4 (en) | 2017-08-07 | 2021-08-11 | Vyera Pharmaceuticals, LLC | Dhfr inhibitors, compositions, and methods related thereto |
-
2017
- 2017-02-02 BR BR112018015924A patent/BR112018015924A2/en active Search and Examination
- 2017-02-02 WO PCT/US2017/016224 patent/WO2017136556A1/en active Application Filing
- 2017-02-02 EA EA201891766A patent/EA201891766A1/en unknown
- 2017-02-02 US US16/075,924 patent/US10774073B2/en active Active
- 2017-02-02 SG SG11201806620TA patent/SG11201806620TA/en unknown
- 2017-02-02 AU AU2017213824A patent/AU2017213824B9/en active Active
- 2017-02-02 MX MX2018009504A patent/MX2018009504A/en unknown
- 2017-02-02 JP JP2018560444A patent/JP6949055B2/en active Active
- 2017-02-02 SG SG10202007239QA patent/SG10202007239QA/en unknown
- 2017-02-02 CN CN201780021371.XA patent/CN109071486A/en active Pending
- 2017-02-02 CU CU2018000083A patent/CU20180083A7/en unknown
- 2017-02-02 EP EP17748159.5A patent/EP3411367A4/en active Pending
- 2017-02-02 KR KR1020187025469A patent/KR20180119590A/en not_active Application Discontinuation
- 2017-02-02 CA CA3013760A patent/CA3013760A1/en active Pending
- 2017-02-03 TW TW106103740A patent/TW201731836A/en unknown
-
2018
- 2018-08-02 PH PH12018501646A patent/PH12018501646A1/en unknown
- 2018-08-02 IL IL260952A patent/IL260952B/en unknown
- 2018-08-02 CL CL2018002074A patent/CL2018002074A1/en unknown
-
2020
- 2020-09-10 US US17/016,702 patent/US11530198B2/en active Active
-
2022
- 2022-02-14 AU AU2022200967A patent/AU2022200967A1/en not_active Abandoned
- 2022-03-10 IL IL291266A patent/IL291266A/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| AU2017213824B9 (en) | 2021-11-25 |
| IL291266A (en) | 2022-05-01 |
| WO2017136556A1 (en) | 2017-08-10 |
| KR20180119590A (en) | 2018-11-02 |
| CL2018002074A1 (en) | 2019-02-01 |
| IL260952B (en) | 2022-04-01 |
| AU2017213824A1 (en) | 2018-09-06 |
| SG10202007239QA (en) | 2020-09-29 |
| CN109071486A (en) | 2018-12-21 |
| US20200407345A1 (en) | 2020-12-31 |
| CA3013760A1 (en) | 2017-08-10 |
| JP2019504889A (en) | 2019-02-21 |
| CU20180083A7 (en) | 2019-03-04 |
| US20190077794A1 (en) | 2019-03-14 |
| BR112018015924A2 (en) | 2018-12-26 |
| AU2017213824B2 (en) | 2021-11-18 |
| EA201891766A1 (en) | 2019-02-28 |
| PH12018501646A1 (en) | 2019-05-27 |
| EP3411367A4 (en) | 2019-07-10 |
| EP3411367A1 (en) | 2018-12-12 |
| JP6949055B2 (en) | 2021-10-13 |
| US11530198B2 (en) | 2022-12-20 |
| US10774073B2 (en) | 2020-09-15 |
| AU2022200967A1 (en) | 2022-03-03 |
| TW201731836A (en) | 2017-09-16 |
| MX2018009504A (en) | 2019-05-06 |
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