SG11201803781XA - Treatment of retinal degeneration using progenitor cells - Google Patents

Abstract

INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) (19) World Intellectual Property -' Organization International Bureau R.:54i (43) International Publication Date ..... ....r .„,,,i 8 June 2017 (08.06.2017) IN I PO I PCT ID Hit (10) WO International 2017/095991 111111111111111111111111111111111111111111111111111111111111111111111111111111 Publication Al Number (51) International Patent Classification: (81) Designated States (unless otherwise indicated, for every C12N 5/071 (2010.01) kind of national protection available): AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, (21) International Application Number: BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, PCT/US2016/064336 DO, DZ, EC, EE, EG, ES, FE GB, GD, GE, GH, GM, GT, (22) International Filing Date: HN, HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KN, KP, KR, 1 December 2016 (01.12.2016) KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, (25) Filing Language: English OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, (26) Publication Language: English SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, (30) Priority Data: ZW. 62/263,463 4 December 2015 (04.12.2015) US (84) Designated States (unless otherwise indicated, for every (71) Applicant: JANSSEN BIOTECH, INC. [US/US]; kind of regional protection available): ARIPO (BW, GH, 800/850 Ridgeview Drive, Horsham, Pennsylvania 19044 GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, (US). TZ, UG, ZM, ZW), Eurasian (AM, AZ, BY, KG, KZ, RU, (72) Inventors: HARRIS, Ian; 1400 McKean Road, Spring TJ, TM), European (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, House, Pennsylvania 19477 (US). CAO, Jing; 1400 McK- LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, can Road, Spring House, Pennsylvania 19477 (US). DE- SM, TR), OAPI (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, JNEKA, Nadine Sophia; 1400 McKean Road, Spring House, Pennsylvania 19477 (US). GW, KM, ML, MR, NE, SN, TD, TG). Declarations under Rule 4.17: (74) Agents: SHIRTZ, Joseph F. et al.; Johnson & Johnson, One Johnson & Johnson Plaza, New Brunswick, New Jer- — as to applicant's entitlement to apply for and be granted a sey 08933 (US). patent (Rule 4.170) [Continued on next page] (54) Title: TREATMENT OF RETINAL DEGENERATION USING PROGENITOR CELLS (57) : Methods and compositions for treating and re- ducing retinal degeneration using progenitor cells and condi- from tioned media progenitor cells, such as postpartum-de- **** rived cells are disclosed. Genetic factors and receptors ex - I I * * pressed by the progenitor cells that aid in protection of retinal 100 ' . cells and inhibition of apoptosis of retinal cells such as ****n.s. cells are also disclosed. photoreceptor 171) > 80- a) co to • 60- o , 0 40 0 11111 • 1111 E F 20- Nk . Vi kG 0 1\ e lk GO GS G. GO 54 S4 o_0 5 a 0S7 0 _0 k e 03S 4 Q\" \) \ ` - ‘Y` - \t - l‘ ikk 1\ 9- 0 9- \0\" \t\"(` ` vr ve \ ** 0 11 / 4 - .0 1 / 4 4 ‘.4 ‘.0 ‘ 1,4 0.9 ., cp , e s , o 1 / 4 2,S e\ 0 ,,,,, ,-, .4t • CO S3 : 3 •CA 13 •0 \ te t ee S %N. aG cy ci, .#0 . 0 0 0 __ %., 40 3e2P s y r car Cr .0 * s yew Il O\ O\ un FIG. 1 C\ C IN Il C ei O WO 2017/095991 Al MIDEDIMOMMIDIROMMIMINECIMMOVOIMIE — as to the applicant's entitlement to claim the priority of — with sequence listing part of description (Rule 5.2(a)) the earlier application (Rule 4.17(iii)) Published: — with international search report (Art. 21(3))