SG11201803190SA - Detection of foetal chromosomal aneuploidies using dna regions that are differentially methylated between the foetus and the pregnant female - Google Patents

Detection of foetal chromosomal aneuploidies using dna regions that are differentially methylated between the foetus and the pregnant female

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Publication number
SG11201803190SA
SG11201803190SA SG11201803190SA SG11201803190SA SG11201803190SA SG 11201803190S A SG11201803190S A SG 11201803190SA SG 11201803190S A SG11201803190S A SG 11201803190SA SG 11201803190S A SG11201803190S A SG 11201803190SA SG 11201803190S A SG11201803190S A SG 11201803190SA
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SG
Singapore
Prior art keywords
foetus
detection
pregnant female
dna regions
differentially methylated
Prior art date
Application number
SG11201803190SA
Inventor
Steffi Werler
Wera Hofmann
Matthias Sachse
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Lifecodexx Ag
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Publication date
Application filed by Lifecodexx Ag filed Critical Lifecodexx Ag
Publication of SG11201803190SA publication Critical patent/SG11201803190SA/en

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    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6806—Preparing nucleic acids for analysis, e.g. for polymerase chain reaction [PCR] assay
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    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6844—Nucleic acid amplification reactions
    • C12Q1/6851—Quantitative amplification
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6844—Nucleic acid amplification reactions
    • C12Q1/686—Polymerase chain reaction [PCR]
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2523/00—Reactions characterised by treatment of reaction samples
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    • C12Q2537/00—Reactions characterised by the reaction format or use of a specific feature
    • C12Q2537/10—Reactions characterised by the reaction format or use of a specific feature the purpose or use of
    • C12Q2537/143—Multiplexing, i.e. use of multiple primers or probes in a single reaction, usually for simultaneously analyse of multiple analysis
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    • C12Q2545/00—Reactions characterised by their quantitative nature
    • C12Q2545/10—Reactions characterised by their quantitative nature the purpose being quantitative analysis
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    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/112—Disease subtyping, staging or classification
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    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/154—Methylation markers
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    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/16—Primer sets for multiplex assays

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  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Engineering & Computer Science (AREA)
  • Analytical Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Microbiology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biotechnology (AREA)
  • Molecular Biology (AREA)
  • Immunology (AREA)
  • General Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biochemistry (AREA)
  • Physics & Mathematics (AREA)
  • Biophysics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pathology (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • General Chemical & Material Sciences (AREA)
SG11201803190SA 2015-11-10 2016-11-09 Detection of foetal chromosomal aneuploidies using dna regions that are differentially methylated between the foetus and the pregnant female SG11201803190SA (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP15193966.7A EP3168309B8 (en) 2015-11-10 2015-11-10 Detection of foetal chromosomal aneuploidies using dna regions that are differentially methylated between the foetus and the pregnant female
PCT/EP2016/077065 WO2017081047A1 (en) 2015-11-10 2016-11-09 Detection of foetal chromosomal aneuploidies using dna regions that are differentially methylated between the foetus and the pregnant female

Publications (1)

Publication Number Publication Date
SG11201803190SA true SG11201803190SA (en) 2018-05-30

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SG11201803190SA SG11201803190SA (en) 2015-11-10 2016-11-09 Detection of foetal chromosomal aneuploidies using dna regions that are differentially methylated between the foetus and the pregnant female

Country Status (15)

Country Link
US (1) US11753684B2 (en)
EP (2) EP3168309B8 (en)
JP (1) JP2018533953A (en)
KR (1) KR20180093902A (en)
CN (1) CN109689896A (en)
AU (1) AU2016351889A1 (en)
BR (1) BR112018008532A2 (en)
CA (1) CA3042946A1 (en)
DK (1) DK3168309T3 (en)
ES (1) ES2965036T3 (en)
HU (2) HUE050491T2 (en)
IL (1) IL258796A (en)
MA (1) MA43214A (en)
SG (1) SG11201803190SA (en)
WO (1) WO2017081047A1 (en)

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CN113249458B (en) * 2020-02-10 2023-07-07 北京优乐复生科技有限责任公司 Method and kit for predicting evaluation and prediction of placenta-derived diseases
CN112662763A (en) * 2020-03-10 2021-04-16 博尔诚（北京）科技有限公司 Probe composition for detecting common amphoteric cancers
CN112662764A (en) * 2020-03-17 2021-04-16 博尔诚（北京）科技有限公司 Probe composition for detecting 11 cancers
KR102332540B1 (en) * 2020-07-02 2021-11-29 의료법인 성광의료재단 Down syndrome diagnosis method using epigenetic marker specific for Down syndrome
CN112143790B (en) * 2020-09-29 2021-08-24 时伟丽 Method for assessing risk of Down syndrome based on m6A methylation modification of NRIP1 mRNA and application thereof
RU2760701C1 (en) * 2021-04-13 2021-11-29 Государственное автономное учреждение здравоохранения "Республиканская клиническая больница Министерства здравоохранения Республики Татарстан" Method for detecting chromosomal abnormalities in low-risk pregnant women based on the results of combined prenatal screening in the second and third trimester of pregnancy
CN113046435B (en) * 2021-05-14 2023-10-03 吉林大学第一医院 Specific primer for preparing PCR reaction system for detecting prenatal fetal 21-trisomy syndrome
CN113643755B (en) * 2021-08-11 2023-10-13 上海小海龟科技有限公司 NIPT kit positive rate correction method, NIPT kit positive rate correction device, computer equipment and medium

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Publication number Publication date
CN109689896A (en) 2019-04-26
AU2016351889A1 (en) 2018-06-28
MA43214A (en) 2018-09-19
KR20180093902A (en) 2018-08-22
BR112018008532A2 (en) 2018-10-30
ES2965036T3 (en) 2024-04-10
US11753684B2 (en) 2023-09-12
EP3374519A1 (en) 2018-09-19
US20190249249A1 (en) 2019-08-15
IL258796A (en) 2018-06-28
EP3374519B1 (en) 2023-10-04
EP3168309B8 (en) 2020-06-03
DK3168309T3 (en) 2020-06-22
EP3168309A1 (en) 2017-05-17
HUE050491T2 (en) 2020-12-28
CA3042946A1 (en) 2017-05-18
EP3168309B1 (en) 2020-04-08
EP3374519C0 (en) 2023-10-04
HUE064507T2 (en) 2024-03-28
WO2017081047A1 (en) 2017-05-18
JP2018533953A (en) 2018-11-22

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