SG11201802658VA - Quencher containing water-soluble polymer-conjugated nanomaterial and use thereof - Google Patents

Quencher containing water-soluble polymer-conjugated nanomaterial and use thereof

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Publication number
SG11201802658VA
SG11201802658VA SG11201802658VA SG11201802658VA SG11201802658VA SG 11201802658V A SG11201802658V A SG 11201802658VA SG 11201802658V A SG11201802658V A SG 11201802658VA SG 11201802658V A SG11201802658V A SG 11201802658VA SG 11201802658V A SG11201802658V A SG 11201802658VA
Authority
SG
Singapore
Prior art keywords
soluble polymer
containing water
quencher containing
nanomaterial
conjugated
Prior art date
Application number
SG11201802658VA
Inventor
Cheolhee Won
Dal-Hee Min
Original Assignee
Lemonex Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Lemonex Inc filed Critical Lemonex Inc
Publication of SG11201802658VA publication Critical patent/SG11201802658VA/en

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    • G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
    • G01N21/64—Fluorescence; Phosphorescence
    • G01N21/6428—Measuring fluorescence of fluorescent products of reactions or of fluorochrome labelled reactive substances, e.g. measuring quenching effects, using measuring "optrodes"
    • G01N2021/6432—Quenching
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
    • G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
    • G01N21/64—Fluorescence; Phosphorescence
    • G01N21/6428—Measuring fluorescence of fluorescent products of reactions or of fluorochrome labelled reactive substances, e.g. measuring quenching effects, using measuring "optrodes"
    • G01N2021/6439—Measuring fluorescence of fluorescent products of reactions or of fluorochrome labelled reactive substances, e.g. measuring quenching effects, using measuring "optrodes" with indicators, stains, dyes, tags, labels, marks
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
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Families Citing this family (15)

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KR102119010B1 (en) 2017-06-15 2020-06-04 건국대학교 산학협력단 Composition for downregulating expression of target gene comprising peptide nucleic acid and polyethylene glycol-engrafted graphene oxide
CN107796938B (en) * 2017-10-17 2020-03-27 中国农业科学院农业质量标准与检测技术研究所 Nucleic acid aptamer fluorescent test strip and preparation method and application thereof
CN110237252A (en) * 2018-03-08 2019-09-17 中国科学院苏州纳米技术与纳米仿生研究所 A kind of core-shell type multifunctional composite nano materials and the preparation method and application thereof
CN109400887B (en) * 2018-10-17 2021-03-16 江西中洪博元生物技术有限公司 Preparation method of double-fluorescence labeling nano material
JP2020076673A (en) * 2018-11-08 2020-05-21 国立大学法人埼玉大学 Fluorescent probe and rapid fluorescence measuring method using probe
CN109913504B (en) * 2019-04-23 2021-05-28 集美大学 Method for preparing bioethanol from modified agar
CN110501494B (en) * 2019-07-16 2020-10-09 中国农业大学 Microorganism detection method based on manganese dioxide nanoflowers and fluorescent materials
KR102533992B1 (en) * 2019-09-10 2023-05-19 서울대학교산학협력단 Method for confirming introduction of foreign gene into cells and method for manufacturing introduction foreign gene into cells
KR102239459B1 (en) * 2019-09-16 2021-04-12 한국화학연구원 Composition for temperature sensors including graphene oxide, DNAzyme and PNA and temperature sensing method using the same
KR102376443B1 (en) * 2020-02-26 2022-03-17 포항공과대학교 산학협력단 A nanostructure, a biosensor including the nanostructure, and a screening method
JP2024509494A (en) * 2020-12-30 2024-03-04 ホークアイ バイオ，リミテッド Pure graphene-based biosensors and associated core particles, materials, compositions, methods and systems for biomarker detection
WO2022217079A1 (en) * 2021-04-08 2022-10-13 Georgia State University Research Foundation, Inc. Graphene oxide nanoparticles and methods of use for stimulating immune responses
US20230071672A1 (en) * 2021-09-08 2023-03-09 Lions VisionGift Preserving fluorophore function
WO2023089506A1 (en) * 2021-11-17 2023-05-25 Biorchestra Co., Ltd. Amplification-free methods for measuring mirna
WO2024010609A1 (en) * 2022-07-06 2024-01-11 Hawkeye Bio, Limited Pristine graphene based biosensor for biomarker detection and related core particles, materials compositions methods and systems

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR101554173B1 (en) 2010-06-25 2015-09-18 한국과학기술원 A fluorescence-based method for assay of enzyme activity
KR101818177B1 (en) 2011-08-10 2018-01-12 한국과학기술원 A kit for assaying Endonuclease or Methyltrasnferase activities based on graphene oxide
CN102603896B (en) 2012-02-13 2015-03-04 中国科学院苏州纳米技术与纳米仿生研究所 Nano graphene oxide protein complex, preparation method and applications thereof
KR101496671B1 (en) 2012-04-24 2015-03-02 서울대학교산학협력단 Composition for detecting nucleic acid, and detecting method of nucleic acid using the same
KR20140014443A (en) * 2012-07-24 2014-02-06 국립암센터 Graphene oxide-photosensitizers complex containing disulfide linker and composition for diagonosis and therapy of canncer using the same
US20140100124A1 (en) * 2012-10-04 2014-04-10 Asuragen, Inc. Diagnostic mirnas for differential diagnosis of incidental pancreatic cystic lesions
KR101419254B1 (en) 2012-10-15 2014-07-17 국립암센터 Enzyme-responsive graphene oxide/biopolymer-photosensitizer nanocomplex and composition for fluorescence image and photodynamic/photothermal treatment comprising thereof
KR101552943B1 (en) * 2013-03-29 2015-09-14 한양대학교 산학협력단 Imaging Immune Reactions Using Fluorescence Resonance Energy Transfer
KR102250362B1 (en) 2014-07-08 2021-05-12 세메스 주식회사 Predischarging unit, Apparatus and Method for treating substrate with the unit
CN104634963A (en) * 2015-01-29 2015-05-20 江苏大学 Sensor based on polyethylene-glycol modification and method for detecting thrombin

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KR102109084B1 (en) 2020-05-11
EP3358348A4 (en) 2019-03-27
WO2017057823A1 (en) 2017-04-06
KR20190014566A (en) 2019-02-12
BR112018006680A2 (en) 2018-10-09
CA3000631A1 (en) 2017-04-06
MY183402A (en) 2021-02-18
EP3358348A1 (en) 2018-08-08
CA3000631C (en) 2023-07-04
AU2016329919B2 (en) 2023-05-18
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MX2018004067A (en) 2018-08-01
AU2016329919A1 (en) 2018-05-10
HK1253746A1 (en) 2019-06-28
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