SG11201704285XA - Tim protein-bound carrier, methods for obtaining, removing and detecting extracellular membrane vesicles and viruses using said carrier, and kit including said carrier - Google Patents

Tim protein-bound carrier, methods for obtaining, removing and detecting extracellular membrane vesicles and viruses using said carrier, and kit including said carrier

Info

Publication number
SG11201704285XA
SG11201704285XA SG11201704285XA SG11201704285XA SG11201704285XA SG 11201704285X A SG11201704285X A SG 11201704285XA SG 11201704285X A SG11201704285X A SG 11201704285XA SG 11201704285X A SG11201704285X A SG 11201704285XA SG 11201704285X A SG11201704285X A SG 11201704285XA
Authority
SG
Singapore
Prior art keywords
carrier
viruses
obtaining
methods
membrane vesicles
Prior art date
Application number
SG11201704285XA
Inventor
Takahiro Nishibu
Naoko IMAWAKA
Ken NARUSE
Rikinari HANAYAMA
Original Assignee
Wako Pure Chem Ind Ltd
Univ Osaka
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Wako Pure Chem Ind Ltd, Univ Osaka filed Critical Wako Pure Chem Ind Ltd
Publication of SG11201704285XA publication Critical patent/SG11201704285XA/en

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/70503—Immunoglobulin superfamily
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
    • G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
    • G01N33/5076—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics involving cell organelles, e.g. Golgi complex, endoplasmic reticulum
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/14—Extraction; Separation; Purification
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K17/00—Carrier-bound or immobilised peptides; Preparation thereof
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K17/00—Carrier-bound or immobilised peptides; Preparation thereof
    • C07K17/02—Peptides being immobilised on, or in, an organic carrier
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N7/00—Viruses; Bacteriophages; Compositions thereof; Preparation or purification thereof
    • C12N7/02—Recovery or purification
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
    • G01N33/54313—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals the carrier being characterised by its particulate form
    • G01N33/5432—Liposomes or microcapsules
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6803—General methods of protein analysis not limited to specific proteins or families of proteins
    • G01N33/6842—Proteomic analysis of subsets of protein mixtures with reduced complexity, e.g. membrane proteins, phosphoproteins, organelle proteins
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/40—Fusion polypeptide containing a tag for immunodetection, or an epitope for immunisation
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2760/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses negative-sense
    • C12N2760/00011—Details
    • C12N2760/16011—Orthomyxoviridae
    • C12N2760/16111—Influenzavirus A, i.e. influenza A virus
    • C12N2760/16151—Methods of production or purification of viral material
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2760/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses negative-sense
    • C12N2760/00011—Details
    • C12N2760/18011—Paramyxoviridae
    • C12N2760/18511—Pneumovirus, e.g. human respiratory syncytial virus
    • C12N2760/18551—Methods of production or purification of viral material
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
    • G01N15/10—Investigating individual particles
    • G01N15/14—Optical investigation techniques, e.g. flow cytometry
    • G01N15/149—Optical investigation techniques, e.g. flow cytometry specially adapted for sorting particles, e.g. by their size or optical properties
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
    • G01N15/01—Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials specially adapted for biological cells, e.g. blood cells
    • G01N2015/016—White blood cells
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
    • G01N15/10—Investigating individual particles
    • G01N2015/1006—Investigating individual particles for cytology
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
    • G01N2333/705—Assays involving receptors, cell surface antigens or cell surface determinants
    • G01N2333/70503—Immunoglobulin superfamily, e.g. VCAMs, PECAM, LFA-3
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Molecular Biology (AREA)
  • Immunology (AREA)
  • Genetics & Genomics (AREA)
  • Biomedical Technology (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Biophysics (AREA)
  • Biotechnology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • Physics & Mathematics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Zoology (AREA)
  • Microbiology (AREA)
  • Analytical Chemistry (AREA)
  • Cell Biology (AREA)
  • Wood Science & Technology (AREA)
  • General Engineering & Computer Science (AREA)
  • Pathology (AREA)
  • Food Science & Technology (AREA)
  • General Physics & Mathematics (AREA)
  • Toxicology (AREA)
  • Bioinformatics & Computational Biology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Plant Pathology (AREA)
  • Virology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Peptides Or Proteins (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
  • Apparatus For Radiation Diagnosis (AREA)
  • Gyroscopes (AREA)
SG11201704285XA 2014-12-05 2015-11-27 Tim protein-bound carrier, methods for obtaining, removing and detecting extracellular membrane vesicles and viruses using said carrier, and kit including said carrier SG11201704285XA (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP2014246876 2014-12-05
PCT/JP2015/083505 WO2016088689A1 (en) 2014-12-05 2015-11-27 Tim protein-bound carrier, methods for obtaining, removing and detecting extracellular membrane vesicles and viruses using said carrier, and kit including said carrier

Publications (1)

Publication Number Publication Date
SG11201704285XA true SG11201704285XA (en) 2017-06-29

Family

ID=56091632

Family Applications (1)

Application Number Title Priority Date Filing Date
SG11201704285XA SG11201704285XA (en) 2014-12-05 2015-11-27 Tim protein-bound carrier, methods for obtaining, removing and detecting extracellular membrane vesicles and viruses using said carrier, and kit including said carrier

Country Status (8)

Country Link
US (2) US10794899B2 (en)
EP (2) EP3690041B1 (en)
JP (2) JP6824742B2 (en)
KR (2) KR102582192B1 (en)
CN (2) CN113980089A (en)
AU (2) AU2015356180B2 (en)
SG (1) SG11201704285XA (en)
WO (1) WO2016088689A1 (en)

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KR101875594B1 (en) * 2017-01-13 2018-07-06 ㈜로제타엑소좀 Method of isolating extracellular vesicles using metal
EP3623384A4 (en) 2017-05-08 2021-01-27 Osaka University Anti-cldn-5 antibody, and drug containing said antibody
US11904259B2 (en) * 2017-07-26 2024-02-20 Rosetta Exosome Method for isolating extracellular vesicles using cations
EP3731947B1 (en) 2017-12-29 2023-03-01 The United States of America, as represented by the Secretary, Department of Health and Human Services Purification and labeling of extracellular vesicles using a mixed mode resin composition
CN108245685B (en) * 2018-01-11 2019-04-19 广西壮族自治区人民医院 The drug and preparation method thereof of the prevention and treatment allergic disease of fusion protein based on TIM albumen and IgG albumen
US20210396633A1 (en) * 2018-10-17 2021-12-23 H.U. Group Research Institute G.K. Method for recovering extracellular vesicles
WO2020130038A1 (en) * 2018-12-20 2020-06-25 株式会社ジェネシス Composition for regenerative therapy and method of producing composition for regenerative therapy
CN109580960A (en) * 2019-01-14 2019-04-05 周明 The separation method of extracellular vesica and the method and kit of the extracellular vesicle surface marker of detection
WO2020194968A1 (en) * 2019-03-26 2020-10-01 株式会社カネカ Method for producing extracellular membrane vesicle-binding carrier
WO2020218121A1 (en) 2019-04-24 2020-10-29 公益財団法人がん研究会 Cancer detection method and detection reagent
US20200362307A1 (en) * 2019-05-15 2020-11-19 George Mason University Membrane coverage and orientation and methods, compositions, and kits related thereto
EP4007333A4 (en) * 2019-07-29 2022-09-07 KDDI Corporation Control device, control method, and program
EP4067906A4 (en) * 2019-11-29 2023-04-26 FUJIFILM Wako Pure Chemical Corporation Method for assisting with diagnosis of alzheimer's disease or mild cognitive impairment, biomarker, reagent kit, and device
JP7348604B2 (en) * 2019-11-29 2023-09-21 富士フイルム和光純薬株式会社 Methods, biomarkers, reagent kits and devices to aid in the diagnosis of Parkinson's disease
CN115004031A (en) 2019-12-27 2022-09-02 富士胶片株式会社 Method for aiding diagnosis of metastatic androgen-blockade therapy resistant prostate cancer
WO2021145394A1 (en) 2020-01-15 2021-07-22 富士フイルム和光純薬株式会社 Anti-inflammatory agent and method for producing extracellular vesicles having anti-inflammatory action
JP7425092B2 (en) * 2020-01-15 2024-01-30 富士フイルム株式会社 Antifibrotic agent and method for producing extracellular vesicles having antifibrotic effect
JP7538150B2 (en) * 2020-01-15 2024-08-21 富士フイルム株式会社 Angiogenic agent and method for producing extracellular vesicles having angiogenic activity
WO2021200299A1 (en) * 2020-03-31 2021-10-07 富士フイルム和光純薬株式会社 Cellular aging inhibitor, biological tissue repair promoter, gene expression regulator, and manufacturing method
CN111849903A (en) * 2020-05-26 2020-10-30 武汉生之源生物科技股份有限公司 Kit for separating exosome from cell supernatant and using method thereof
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CN113008652A (en) * 2021-02-25 2021-06-22 重庆医科大学附属第三医院(捷尔医院） Method for separating exosome by using TIM-4 functionalized fishbone-shaped microfluidic chip
JP7569253B2 (en) 2021-03-30 2024-10-17 公益財団法人がん研究会 Enhancer for Western Blotting
GB2616452A (en) 2022-03-09 2023-09-13 Oxford Nanoimaging Ltd Assay
CN114917325B (en) * 2022-06-29 2024-08-13 山东大学 Application of human soluble TIM-4 protein in preparation of antitumor drugs
WO2024071374A1 (en) * 2022-09-30 2024-04-04 富士フイルム株式会社 Screening method for cell that produces objective substance, nucleic acid production method, and objective substance production method
CN115598355A (en) * 2022-12-09 2023-01-13 北京艾瑞克阳医疗科技有限公司（Cn） Detection method for determining exosome content and application
WO2024143439A1 (en) * 2022-12-28 2024-07-04 富士フイルム株式会社 Method for producing recycled carrier, cleaning liquid, kit, and method for producing extracellular vesicle
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Also Published As

Publication number Publication date
JP2021012200A (en) 2021-02-04
EP3228709B1 (en) 2020-05-20
WO2016088689A1 (en) 2016-06-09
KR20170085493A (en) 2017-07-24
EP3690041A1 (en) 2020-08-05
US20200393449A1 (en) 2020-12-17
JPWO2016088689A1 (en) 2017-11-16
CN113980089A (en) 2022-01-28
EP3690041B1 (en) 2024-09-25
EP3228709A1 (en) 2017-10-11
AU2021229127A1 (en) 2021-09-30
AU2015356180B2 (en) 2021-08-05
CN107002072A (en) 2017-08-01
AU2015356180A1 (en) 2017-06-15
KR102632022B1 (en) 2024-01-31
US11639924B2 (en) 2023-05-02
KR102582192B1 (en) 2023-09-25
JP6824742B2 (en) 2021-02-03
JP6952842B2 (en) 2021-10-27
KR20230004955A (en) 2023-01-06
US10794899B2 (en) 2020-10-06
US20180120299A1 (en) 2018-05-03
EP3228709A4 (en) 2018-06-20
AU2021229127B2 (en) 2023-09-14

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