SG11201703931QA - Non-human animals having a humanized cluster of differentiation 274 gene - Google Patents
Non-human animals having a humanized cluster of differentiation 274 geneInfo
- Publication number
- SG11201703931QA SG11201703931QA SG11201703931QA SG11201703931QA SG11201703931QA SG 11201703931Q A SG11201703931Q A SG 11201703931QA SG 11201703931Q A SG11201703931Q A SG 11201703931QA SG 11201703931Q A SG11201703931Q A SG 11201703931QA SG 11201703931Q A SG11201703931Q A SG 11201703931QA
- Authority
- SG
- Singapore
- Prior art keywords
- differentiation
- gene
- human animals
- humanized
- cluster
- Prior art date
Links
Classifications
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- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; CARE OF BIRDS, FISHES, INSECTS; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K67/00—Rearing or breeding animals, not otherwise provided for; New breeds of animals
- A01K67/027—New breeds of vertebrates
- A01K67/0275—Genetically modified vertebrates, e.g. transgenic
- A01K67/0278—Humanized animals, e.g. knockin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K49/00—Preparations for testing in vivo
- A61K49/0004—Screening or testing of compounds for diagnosis of disorders, assessment of conditions, e.g. renal clearance, gastric emptying, testing for diabetes, allergy, rheuma, pancreas functions
- A61K49/0008—Screening agents using (non-human) animal models or transgenic animal models or chimeric hosts, e.g. Alzheimer disease animal model, transgenic model for heart failure
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
- C07K14/70596—Molecules with a "CD"-designation not provided for elsewhere
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/30—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; CARE OF BIRDS, FISHES, INSECTS; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2207/00—Modified animals
- A01K2207/15—Humanized animals
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; CARE OF BIRDS, FISHES, INSECTS; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2217/00—Genetically modified animals
- A01K2217/07—Animals genetically altered by homologous recombination
- A01K2217/072—Animals genetically altered by homologous recombination maintaining or altering function, i.e. knock in
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; CARE OF BIRDS, FISHES, INSECTS; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2217/00—Genetically modified animals
- A01K2217/15—Animals comprising multiple alterations of the genome, by transgenesis or homologous recombination, e.g. obtained by cross-breeding
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; CARE OF BIRDS, FISHES, INSECTS; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2227/00—Animals characterised by species
- A01K2227/10—Mammal
- A01K2227/105—Murine
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; CARE OF BIRDS, FISHES, INSECTS; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2267/00—Animals characterised by purpose
- A01K2267/02—Animal zootechnically ameliorated
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; CARE OF BIRDS, FISHES, INSECTS; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2267/00—Animals characterised by purpose
- A01K2267/03—Animal model, e.g. for test or diseases
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; CARE OF BIRDS, FISHES, INSECTS; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2267/00—Animals characterised by purpose
- A01K2267/03—Animal model, e.g. for test or diseases
- A01K2267/0331—Animal model for proliferative diseases
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201462089549P | 2014-12-09 | 2014-12-09 | |
US201562106525P | 2015-01-22 | 2015-01-22 | |
PCT/US2015/064626 WO2016094481A1 (en) | 2014-12-09 | 2015-12-09 | Non-human animals having a humanized cluster of differentiation 274 gene |
Publications (1)
Publication Number | Publication Date |
---|---|
SG11201703931QA true SG11201703931QA (en) | 2017-06-29 |
Family
ID=55024286
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
SG11201703931QA SG11201703931QA (en) | 2014-12-09 | 2015-12-09 | Non-human animals having a humanized cluster of differentiation 274 gene |
SG10202100792XA SG10202100792XA (en) | 2014-12-09 | 2015-12-09 | Non-human animals having a humanized cluster of differentiation 274 gene |
Family Applications After (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
SG10202100792XA SG10202100792XA (en) | 2014-12-09 | 2015-12-09 | Non-human animals having a humanized cluster of differentiation 274 gene |
Country Status (23)
Country | Link |
---|---|
US (3) | US9913461B2 (en) |
EP (2) | EP3808775B1 (en) |
JP (3) | JP2018500896A (en) |
KR (2) | KR102457921B1 (en) |
CN (2) | CN107257624B (en) |
AU (2) | AU2015360667B2 (en) |
BR (1) | BR112017011982A2 (en) |
CA (1) | CA2968675C (en) |
CY (1) | CY1123723T1 (en) |
DK (1) | DK3230320T3 (en) |
ES (1) | ES2841353T3 (en) |
HR (1) | HRP20202034T1 (en) |
HU (1) | HUE052606T2 (en) |
IL (3) | IL282649B (en) |
LT (1) | LT3230320T (en) |
MX (1) | MX2017007636A (en) |
PT (1) | PT3230320T (en) |
RS (1) | RS61218B1 (en) |
RU (1) | RU2711729C2 (en) |
SG (2) | SG11201703931QA (en) |
SI (1) | SI3230320T1 (en) |
WO (1) | WO2016094481A1 (en) |
ZA (1) | ZA201703263B (en) |
Families Citing this family (21)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2016094481A1 (en) * | 2014-12-09 | 2016-06-16 | Regeneron Pharmaceuticals, Inc. | Non-human animals having a humanized cluster of differentiation 274 gene |
AU2016358101B2 (en) | 2015-11-20 | 2022-12-01 | Regeneron Pharmaceuticals, Inc. | Non-human animals having a humanized Lymphocyte-activation gene 3 |
KR102487839B1 (en) | 2016-02-04 | 2023-01-12 | 리제너론 파마슈티칼스 인코포레이티드 | Non-human animals with an engineered ANGPTL8 gene |
PT3422845T (en) | 2016-02-29 | 2021-08-26 | Regeneron Pharma | Rodents having a humanized tmprss gene |
DK3476865T3 (en) | 2016-06-28 | 2023-12-18 | Biocytogen Pharmaceuticals Beijing Co Ltd | PROCEDURE FOR CONSTRUCTION OF PD-1 GENE-MODIFIED HUMANIZED ANIMAL MODEL AND USE THEREOF |
CN107815466B (en) | 2016-08-31 | 2020-03-13 | 百奥赛图江苏基因生物技术有限公司 | Preparation method and application of humanized gene modified animal model |
WO2018041120A1 (en) | 2016-08-31 | 2018-03-08 | Beijing Biocytogen Co., Ltd | Genetically modified non-human animal with human or chimeric tigit |
CN107815467B (en) | 2016-08-31 | 2021-03-16 | 百奥赛图(北京)医药科技股份有限公司 | Preparation method and application of humanized gene modified animal model |
DK3507373T3 (en) | 2016-08-31 | 2023-10-30 | Biocytogen Pharmaceuticals Beijing Co Ltd | GENETICALLY MODIFIED NON-HUMAN ANIMAL WITH HUMAN OR CHIMERIC PD-L1 |
MX2019006448A (en) | 2016-12-01 | 2020-02-05 | Regeneron Pharma | Radiolabeled anti-pd-l1 antibodies for immuno-pet imaging. |
CN109666701B (en) * | 2017-10-13 | 2021-08-24 | 百奥赛图(北京)医药科技股份有限公司 | Construction method and application of PD-1 gene modified humanized animal model |
WO2019072241A1 (en) | 2017-10-13 | 2019-04-18 | Beijing Biocytogen Co., Ltd | Genetically modified non-human animal with human or chimeric pd-1 |
AU2018375796A1 (en) | 2017-11-30 | 2020-04-23 | Regeneron Pharmaceuticals, Inc. | Non-human animals comprising a humanized TRKB locus |
AU2019242586A1 (en) | 2018-03-26 | 2020-10-01 | Regeneron Pharmaceuticals, Inc. | Humanized rodents for testing therapeutic agents |
WO2020018511A1 (en) | 2018-07-16 | 2020-01-23 | Regeneron Pharmaceuticals, Inc. | Non-human animal models of ditra disease and uses thereof |
CN110846321B (en) * | 2018-08-21 | 2021-11-19 | 中国科学院动物研究所 | Mutant gene and application thereof in constructing speckled ichthyosis miniature pig model |
WO2020081585A1 (en) * | 2018-10-15 | 2020-04-23 | The Brigham And Women's Hospital, Inc. | The long non-coding rna inca1 and homo sapiens heterogeneous nuclear ribonucleoprotein h1 (hnrnph1) as therapeutic targets for immunotherapy |
CN109452229B (en) * | 2018-11-19 | 2021-10-22 | 百奥赛图(北京)医药科技股份有限公司 | Preparation method and application of caninized PD-1 gene modified animal model |
CN109979539B (en) * | 2019-04-10 | 2020-10-02 | 电子科技大学 | Gene sequence optimization method and device and data processing terminal |
EP4294180A1 (en) * | 2021-02-19 | 2023-12-27 | Biocytogen Pharmaceuticals (Beijing) Co., Ltd. | Genetically modified non-human animal with human or chimeric cd3 genes |
CN112999368A (en) * | 2021-04-09 | 2021-06-22 | 广东药康生物科技有限公司 | Establishment of method for evaluating drug effect by using humanized model |
Family Cites Families (49)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5670356A (en) | 1994-12-12 | 1997-09-23 | Promega Corporation | Modified luciferase |
US6485964B1 (en) * | 1995-03-20 | 2002-11-26 | Arris Pharmaceutical Corporation | Transgenic mammals lacking expression of erythropoietin or of erythropoietin receptor, transgenic mammals expressing chimeric erythropoietin receptors, constructs for producing the transgenic mammals and uses therefor |
GB9517779D0 (en) | 1995-08-31 | 1995-11-01 | Roslin Inst Edinburgh | Biological manipulation |
GB9517780D0 (en) | 1995-08-31 | 1995-11-01 | Roslin Inst Edinburgh | Biological manipulation |
US5874304A (en) | 1996-01-18 | 1999-02-23 | University Of Florida Research Foundation, Inc. | Humanized green fluorescent protein genes and methods |
WO2002000692A2 (en) | 2000-06-28 | 2002-01-03 | Genetics Institute, Llc. | Pd-l2 molecules: pd-1 ligands and uses therefor |
US6586251B2 (en) | 2000-10-31 | 2003-07-01 | Regeneron Pharmaceuticals, Inc. | Methods of modifying eukaryotic cells |
AU2002258941A1 (en) | 2001-04-20 | 2002-11-05 | Mayo Foundation For Medical Education And Research | Methods of enhancing cell responsiveness |
DE10211088A1 (en) * | 2002-03-13 | 2003-09-25 | Ugur Sahin | Gene products differentially expressed in tumors and their use |
DE10161767T1 (en) | 2002-07-03 | 2018-06-07 | Honjo Tasuku | Immunopotentiating compositions containing an anti-PD-L1 antibody |
KR20050084317A (en) * | 2002-12-16 | 2005-08-26 | 제넨테크, 인크. | Transgenic mice expressing human cd20 and/or cd16 |
US7521051B2 (en) | 2002-12-23 | 2009-04-21 | Medimmune Limited | Methods of upmodulating adaptive immune response using anti-PD-1 antibodies |
ATE510020T1 (en) | 2003-12-24 | 2011-06-15 | G2 Inflammation Pty Ltd | TRANSGENIC NON-HUMAN MAMMAL WITH A POLYNUCLEOTIDE CODING FOR HUMAN-C5AR OR HUMANIZED C5AR |
AU2004304665B2 (en) | 2003-12-24 | 2009-03-12 | Novo Nordisk A/S | Transgenic non-human mammal comprising a polynucleotide encoding human or humanized C5aR |
CA2943949C (en) | 2004-10-06 | 2020-03-31 | Mayo Foundation For Medical Education And Research | B7-h1 and methods of diagnosis, prognosis, and treatment of cancer |
CA2827654C (en) | 2004-10-19 | 2019-04-02 | Regeneron Pharmaceuticals, Inc. | Method for generating an animal homozygous for a genetic modification |
HUE026039T2 (en) | 2005-07-01 | 2016-05-30 | Squibb & Sons Llc | Human monoclonal antibodies to programmed death ligand 1 (pd-l1) |
US8216996B2 (en) | 2006-03-03 | 2012-07-10 | Ono Pharmaceutical Co., Ltd. | Multimer of extracellular domain of cell surface functional molecule |
KR102097887B1 (en) | 2008-09-26 | 2020-04-06 | 다나-파버 캔서 인스티튜트 인크. | Human anti-pd-1, pd-l1, and pd-l2 antibodies and uses therefor |
RU2573912C2 (en) | 2008-10-08 | 2016-01-27 | Интрексон Корпорейшн | Constructed cells, expressing multiple immunomodulators, and thereof application |
CN112680475A (en) * | 2008-12-18 | 2021-04-20 | 伊拉兹马斯大学鹿特丹医学中心 | Non-human transgenic animals expressing humanized antibodies and uses thereof |
EP3192811A1 (en) | 2009-02-09 | 2017-07-19 | Université d'Aix-Marseille | Pd-1 antibodies and pd-l1 antibodies and uses thereof |
RU2425880C2 (en) * | 2009-07-30 | 2011-08-10 | Учреждение Российской академии наук Институт общей генетики им. Н.И. Вавилова РАН | Method of producing transgene mice |
US8354389B2 (en) | 2009-08-14 | 2013-01-15 | Regeneron Pharmaceuticals, Inc. | miRNA-regulated differentiation-dependent self-deleting cassette |
KR101778813B1 (en) * | 2009-08-28 | 2017-09-14 | 리제너론 파마슈티칼스 인코포레이티드 | Antikine antibodies that bind to multiple cc chemokines |
JP5874881B2 (en) | 2009-10-06 | 2016-03-02 | リジェネロン・ファーマシューティカルズ・インコーポレイテッド | Genetically modified mice and transplantation methods |
US20120263692A1 (en) | 2009-11-16 | 2012-10-18 | Bertone Alicia L | Engineered Xenogeneic Cells for Repair of Biological Tissue |
HUE037159T2 (en) * | 2009-11-24 | 2018-08-28 | Medimmune Ltd | Targeted binding agents against b7-h1 |
TR201808011T4 (en) * | 2009-12-21 | 2018-06-21 | Regeneron Pharma | Humanized fc gamma rats. |
AU2011237630B2 (en) * | 2010-04-06 | 2016-01-21 | Alnylam Pharmaceuticals, Inc. | Compositions and methods for inhibiting expression of CD274/PD-L1 gene |
MY162984A (en) | 2011-02-15 | 2017-07-31 | Regeneron Pharma | Humanized m-csf mice |
CA3074400A1 (en) * | 2011-10-28 | 2013-05-02 | Regeneron Pharmaceuticals, Inc. | Genetically modified major histocompatibility complex mice |
EP3696262A1 (en) | 2011-11-23 | 2020-08-19 | The Trustees Of The University Of Pennsylvania | Use of pdl1 expressing cells to convert t cells into regulatory t cells |
AU2012344260B2 (en) | 2011-11-28 | 2017-09-07 | Merck Patent Gmbh | Anti-PD-L1 antibodies and uses thereof |
CN111499755A (en) | 2012-08-03 | 2020-08-07 | 丹娜法伯癌症研究院 | anti-PD-L1 and PD-L2 double-binding antibody single reagents and methods of use thereof |
US20140047572A1 (en) * | 2012-08-13 | 2014-02-13 | University Of Rochester | Thrombopoietin mimetics for the treatment of radiation or chemical induced bone marrow injury |
EP4011915B8 (en) * | 2012-08-21 | 2023-11-15 | Sanofi Biotechnology | Methods for treating or preventing asthma by administering an il-4r antagonist |
JP6283031B2 (en) | 2012-09-07 | 2018-02-21 | イエール ユニバーシティ | Genetically modified non-human animals and uses thereof |
US20140242077A1 (en) | 2013-01-23 | 2014-08-28 | Abbvie, Inc. | Methods and compositions for modulating an immune response |
EP2958990B1 (en) | 2013-02-20 | 2019-10-16 | Regeneron Pharmaceuticals, Inc. | Genetic modification of rats |
DK2958938T3 (en) * | 2013-02-20 | 2019-07-15 | Regeneron Pharma | Mice expressing humanized T cell co-receptors |
US10154658B2 (en) * | 2013-02-22 | 2018-12-18 | Regeneron Pharmaceuticals, Inc. | Genetically modified major histocompatibility complex mice |
PT3456831T (en) | 2013-04-16 | 2021-09-10 | Regeneron Pharma | Targeted modification of rat genome |
CN103242448B (en) * | 2013-05-27 | 2015-01-14 | 郑州大学 | Full-humanized anti-PD-1 monoclonal antibody and preparation method and application thereof |
AU2014275166B2 (en) | 2013-06-06 | 2020-09-10 | Dana-Farber Cancer Institute, Inc. | Compositions and methods for identification, assessment prevention, and treatment of cancer using PD-L1 isoforms |
TWI680138B (en) | 2014-01-23 | 2019-12-21 | 美商再生元醫藥公司 | Human antibodies to pd-l1 |
SG10201811116UA (en) * | 2014-06-19 | 2019-01-30 | Regeneron Pharma | Non-human animals having a humanized programmed cell death 1 gene |
WO2016094481A1 (en) * | 2014-12-09 | 2016-06-16 | Regeneron Pharmaceuticals, Inc. | Non-human animals having a humanized cluster of differentiation 274 gene |
DK3507373T3 (en) | 2016-08-31 | 2023-10-30 | Biocytogen Pharmaceuticals Beijing Co Ltd | GENETICALLY MODIFIED NON-HUMAN ANIMAL WITH HUMAN OR CHIMERIC PD-L1 |
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2015
- 2015-12-09 WO PCT/US2015/064626 patent/WO2016094481A1/en active Application Filing
- 2015-12-09 RU RU2017123754A patent/RU2711729C2/en active
- 2015-12-09 LT LTEP15816631.4T patent/LT3230320T/en unknown
- 2015-12-09 KR KR1020217033684A patent/KR102457921B1/en active IP Right Grant
- 2015-12-09 SG SG11201703931QA patent/SG11201703931QA/en unknown
- 2015-12-09 CA CA2968675A patent/CA2968675C/en active Active
- 2015-12-09 EP EP20194168.9A patent/EP3808775B1/en active Active
- 2015-12-09 HU HUE15816631A patent/HUE052606T2/en unknown
- 2015-12-09 MX MX2017007636A patent/MX2017007636A/en unknown
- 2015-12-09 JP JP2017530591A patent/JP2018500896A/en not_active Withdrawn
- 2015-12-09 CN CN201580067025.6A patent/CN107257624B/en active Active
- 2015-12-09 SI SI201531463T patent/SI3230320T1/en unknown
- 2015-12-09 SG SG10202100792XA patent/SG10202100792XA/en unknown
- 2015-12-09 BR BR112017011982A patent/BR112017011982A2/en not_active Application Discontinuation
- 2015-12-09 KR KR1020177016266A patent/KR102316842B1/en active IP Right Grant
- 2015-12-09 RS RS20201547A patent/RS61218B1/en unknown
- 2015-12-09 US US14/963,402 patent/US9913461B2/en active Active
- 2015-12-09 AU AU2015360667A patent/AU2015360667B2/en active Active
- 2015-12-09 IL IL282649A patent/IL282649B/en unknown
- 2015-12-09 EP EP15816631.4A patent/EP3230320B1/en active Active
- 2015-12-09 ES ES15816631T patent/ES2841353T3/en active Active
- 2015-12-09 PT PT158166314T patent/PT3230320T/en unknown
- 2015-12-09 DK DK15816631.4T patent/DK3230320T3/en active
- 2015-12-09 CN CN202110688677.9A patent/CN113412818B/en active Active
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2017
- 2017-05-11 ZA ZA2017/03263A patent/ZA201703263B/en unknown
- 2017-06-06 IL IL252695A patent/IL252695B/en active IP Right Grant
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2018
- 2018-01-30 US US15/883,477 patent/US10881086B2/en active Active
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2020
- 2020-07-06 IL IL275864A patent/IL275864B/en active IP Right Grant
- 2020-10-05 JP JP2020168478A patent/JP7145920B2/en active Active
- 2020-12-03 US US17/110,868 patent/US20210105983A1/en active Pending
- 2020-12-18 HR HRP20202034TT patent/HRP20202034T1/en unknown
- 2020-12-23 CY CY20201101215T patent/CY1123723T1/en unknown
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2021
- 2021-12-16 AU AU2021286369A patent/AU2021286369A1/en active Pending
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2022
- 2022-09-20 JP JP2022148949A patent/JP2022184973A/en active Pending
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