SG11201701039PA - Combination therapy of antibodies activating human cd40 and antibodies against human pd-l1 - Google Patents
Combination therapy of antibodies activating human cd40 and antibodies against human pd-l1Info
- Publication number
- SG11201701039PA SG11201701039PA SG11201701039PA SG11201701039PA SG11201701039PA SG 11201701039P A SG11201701039P A SG 11201701039PA SG 11201701039P A SG11201701039P A SG 11201701039PA SG 11201701039P A SG11201701039P A SG 11201701039PA SG 11201701039P A SG11201701039P A SG 11201701039PA
- Authority
- SG
- Singapore
- Prior art keywords
- antibodies
- human
- combination therapy
- activating
- antibodies against
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/24—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against cytokines, lymphokines or interferons
- C07K16/241—Tumor Necrosis Factors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/24—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against cytokines, lymphokines or interferons
- C07K16/244—Interleukins [IL]
- C07K16/248—IL-6
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
- C07K16/2827—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against B7 molecules, e.g. CD80, CD86
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2878—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the NGF-receptor/TNF-receptor superfamily, e.g. CD27, CD30, CD40, CD95
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
- A61K2039/507—Comprising a combination of two or more separate antibodies
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/75—Agonist effect on antigen
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Immunology (AREA)
- Medicinal Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Peptides Or Proteins (AREA)
- Mycology (AREA)
- Microbiology (AREA)
- Epidemiology (AREA)
- Oncology (AREA)
- Biomedical Technology (AREA)
- Endocrinology (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP14181067 | 2014-08-14 | ||
| EP15159611.1A EP3070102A1 (en) | 2015-03-18 | 2015-03-18 | Combination therapy of antibodies human cd40 activating antibodies and anti human pld-1 antibodies |
| PCT/EP2015/068404 WO2016023875A1 (en) | 2014-08-14 | 2015-08-11 | Combination therapy of antibodies activating human cd40 and antibodies against human pd-l1 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| SG11201701039PA true SG11201701039PA (en) | 2017-03-30 |
Family
ID=53800992
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SG11201701039PA SG11201701039PA (en) | 2014-08-14 | 2015-08-11 | Combination therapy of antibodies activating human cd40 and antibodies against human pd-l1 |
Country Status (14)
| Country | Link |
|---|---|
| US (3) | US20160045597A1 (en) |
| EP (2) | EP3180357B1 (en) |
| JP (1) | JP6586454B2 (en) |
| KR (1) | KR20170035945A (en) |
| CN (1) | CN106659780A (en) |
| AU (1) | AU2015303239A1 (en) |
| BR (1) | BR112016029334A2 (en) |
| CA (1) | CA2949739A1 (en) |
| IL (1) | IL249189A0 (en) |
| MX (1) | MX2017001976A (en) |
| RU (1) | RU2017108173A (en) |
| SG (1) | SG11201701039PA (en) |
| TW (1) | TW201609141A (en) |
| WO (1) | WO2016023875A1 (en) |
Families Citing this family (25)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP4169951A1 (en) | 2008-12-09 | 2023-04-26 | F. Hoffmann-La Roche AG | Anti-pd-l1 antibodies and their use to enhance t-cell function |
| MY194225A (en) | 2015-03-13 | 2022-11-22 | Cytomx Therapeutics Inc | Anti-pdl1 antibodies, activatable anti-pdl1 antibodies, and methods of use thereof |
| WO2016197367A1 (en) | 2015-06-11 | 2016-12-15 | Wuxi Biologics (Shanghai) Co. Ltd. | Novel anti-pd-l1 antibodies |
| WO2017020291A1 (en) | 2015-08-06 | 2017-02-09 | Wuxi Biologics (Shanghai) Co. Ltd. | Novel anti-pd-l1 antibodies |
| ES2837428T3 (en) | 2016-01-08 | 2021-06-30 | Hoffmann La Roche | CEA-Positive Cancer Treatment Procedures Using PD-1 Axis Binding Antagonists and Anti-CEA / Anti-CD3 Bispecific Antibodies |
| WO2017129790A1 (en) | 2016-01-28 | 2017-08-03 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Methods and pharmaceutical composition for the treatment of cancer |
| BR112018076281A2 (en) | 2016-06-20 | 2019-03-26 | Kymab Limited | immunocytocin, use of an immunocytocin, method, pharmaceutical composition, method for treating a proliferative disease in an animal, nucleic acid, vector, host and antibody or fragment thereof |
| EP3606956B1 (en) * | 2017-04-04 | 2024-07-31 | F. Hoffmann-La Roche AG | Novel bispecific antigen binding molecules capable of specific binding to cd40 and to fap |
| BR112019021411A2 (en) * | 2017-04-13 | 2020-05-05 | Hoffmann La Roche | methods to treat or slow the progression of cancer and to improve function, uses of an immunoconjugate, an agonist, an antagonist, compositions, kit and invention |
| HRP20230812T1 (en) * | 2017-06-01 | 2023-11-24 | Akamis Bio Limited | Oncolytic virus and method |
| CN110914302A (en) | 2017-06-01 | 2020-03-24 | 赛托姆克斯治疗学股份有限公司 | Activatable anti-PDL 1 antibodies and methods of use thereof |
| CA3094500A1 (en) * | 2018-03-23 | 2019-09-26 | The University Of Western Australia | Method for immunotherapy drug treatment |
| US20210147547A1 (en) * | 2018-04-13 | 2021-05-20 | Novartis Ag | Dosage Regimens For Anti-Pd-L1 Antibodies And Uses Thereof |
| JP2021528393A (en) | 2018-06-15 | 2021-10-21 | フラグシップ パイオニアリング イノベーションズ ブイ，インコーポレーテッド | Increased immune activity by regulation of posterior cell signaling factors |
| AU2019379576A1 (en) | 2018-11-13 | 2021-06-03 | Compass Therapeutics Llc | Multispecific binding constructs against checkpoint molecules and uses thereof |
| AR117091A1 (en) * | 2018-11-19 | 2021-07-07 | Bristol Myers Squibb Co | MONOCLONAL ANTIBODIES ANTAGONISTS AGAINST CD40 AND THEIR USES |
| CN113677365A (en) * | 2019-01-22 | 2021-11-19 | 瑞伟生物科技公司(美国) | Novel anti-CD 40 antibodies |
| EP3962493A2 (en) | 2019-05-03 | 2022-03-09 | Flagship Pioneering Innovations V, Inc. | Methods of modulating immune activity/level of irf or sting or of treating cancer, comprising the administration of a sting modulator and/or purinergic receptor modulator or postcellular signaling factor |
| US20230114107A1 (en) | 2019-12-17 | 2023-04-13 | Flagship Pioneering Innovations V, Inc. | Combination anti-cancer therapies with inducers of iron-dependent cellular disassembly |
| CA3184366A1 (en) | 2020-06-29 | 2022-01-06 | Darby Rye Schmidt | Viruses engineered to promote thanotransmission and their use in treating cancer |
| WO2022152701A1 (en) | 2021-01-13 | 2022-07-21 | F. Hoffmann-La Roche Ag | Combination therapy |
| KR20230165276A (en) | 2021-03-31 | 2023-12-05 | 플래그쉽 파이어니어링 이노베이션스 브이, 인크. | Thanotransmission polypeptides and their use in the treatment of cancer |
| EP4363059A1 (en) | 2021-06-29 | 2024-05-08 | Flagship Pioneering Innovations V, Inc. | Immune cells engineered to promote thanotransmission and uses thereof |
| US20240174732A1 (en) | 2022-10-05 | 2024-05-30 | Flagship Pioneering Innovations V, Inc. | Nucleic acid molecules encoding trif and additional polypeptides and their use in treating cancer |
| US20240269251A1 (en) | 2023-01-09 | 2024-08-15 | Flagship Pioneering Innovations V, Inc. | Genetic switches and their use in treating cancer |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1988007089A1 (en) | 1987-03-18 | 1988-09-22 | Medical Research Council | Altered antibodies |
| AR039067A1 (en) * | 2001-11-09 | 2005-02-09 | Pfizer Prod Inc | ANTIBODIES FOR CD40 |
| MY150740A (en) * | 2002-10-24 | 2014-02-28 | Abbvie Biotechnology Ltd | Low dose methods for treating disorders in which tnf? activity is detrimental |
| CA2691357C (en) * | 2007-06-18 | 2014-09-23 | N.V. Organon | Antibodies to human programmed death receptor pd-1 |
| EP4169951A1 (en) * | 2008-12-09 | 2023-04-26 | F. Hoffmann-La Roche AG | Anti-pd-l1 antibodies and their use to enhance t-cell function |
| TW201840336A (en) * | 2011-08-01 | 2018-11-16 | 美商建南德克公司 | Methods of treating cancer using pd-1 axis binding antagonists and mek inhibitors |
| US20130071403A1 (en) * | 2011-09-20 | 2013-03-21 | Vical Incorporated | Synergistic anti-tumor efficacy using alloantigen combination immunotherapy |
| US9682143B2 (en) * | 2012-08-14 | 2017-06-20 | Ibc Pharmaceuticals, Inc. | Combination therapy for inducing immune response to disease |
-
2015
- 2015-08-11 KR KR1020177003938A patent/KR20170035945A/en not_active Application Discontinuation
- 2015-08-11 EP EP15748249.8A patent/EP3180357B1/en not_active Not-in-force
- 2015-08-11 EP EP19177793.7A patent/EP3626740A1/en not_active Withdrawn
- 2015-08-11 RU RU2017108173A patent/RU2017108173A/en not_active Application Discontinuation
- 2015-08-11 SG SG11201701039PA patent/SG11201701039PA/en unknown
- 2015-08-11 CN CN201580036567.7A patent/CN106659780A/en active Pending
- 2015-08-11 BR BR112016029334A patent/BR112016029334A2/en not_active Application Discontinuation
- 2015-08-11 JP JP2017507983A patent/JP6586454B2/en not_active Expired - Fee Related
- 2015-08-11 WO PCT/EP2015/068404 patent/WO2016023875A1/en active Application Filing
- 2015-08-11 CA CA2949739A patent/CA2949739A1/en not_active Abandoned
- 2015-08-11 AU AU2015303239A patent/AU2015303239A1/en not_active Abandoned
- 2015-08-11 MX MX2017001976A patent/MX2017001976A/en unknown
- 2015-08-13 TW TW104126436A patent/TW201609141A/en unknown
- 2015-08-14 US US14/827,044 patent/US20160045597A1/en not_active Abandoned
-
2016
- 2016-11-24 IL IL249189A patent/IL249189A0/en unknown
-
2017
- 2017-10-02 US US15/722,585 patent/US20180051077A1/en not_active Abandoned
-
2019
- 2019-12-11 US US16/710,188 patent/US20200095313A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| CA2949739A1 (en) | 2016-02-18 |
| EP3626740A1 (en) | 2020-03-25 |
| BR112016029334A2 (en) | 2018-01-09 |
| TW201609141A (en) | 2016-03-16 |
| JP2017529327A (en) | 2017-10-05 |
| JP6586454B2 (en) | 2019-10-02 |
| WO2016023875A1 (en) | 2016-02-18 |
| EP3180357B1 (en) | 2019-07-03 |
| CN106659780A (en) | 2017-05-10 |
| US20200095313A1 (en) | 2020-03-26 |
| IL249189A0 (en) | 2017-01-31 |
| EP3180357A1 (en) | 2017-06-21 |
| US20160045597A1 (en) | 2016-02-18 |
| KR20170035945A (en) | 2017-03-31 |
| US20180051077A1 (en) | 2018-02-22 |
| AU2015303239A1 (en) | 2016-12-15 |
| RU2017108173A (en) | 2018-09-17 |
| MX2017001976A (en) | 2017-08-02 |
| RU2017108173A3 (en) | 2019-03-11 |
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