SG11201700517PA - Dimethylphenylammonium long-chain compound, preparation, self-assembled structure and use thereof - Google Patents

Dimethylphenylammonium long-chain compound, preparation, self-assembled structure and use thereof

Info

Publication number
SG11201700517PA
SG11201700517PA SG11201700517PA SG11201700517PA SG11201700517PA SG 11201700517P A SG11201700517P A SG 11201700517PA SG 11201700517P A SG11201700517P A SG 11201700517PA SG 11201700517P A SG11201700517P A SG 11201700517PA SG 11201700517P A SG11201700517P A SG 11201700517PA
Authority
SG
Singapore
Prior art keywords
dimethylphenylammonium
self
preparation
long
assembled structure
Prior art date
Application number
SG11201700517PA
Inventor
Lei Tang
Jin Liu
Wensheng Zhang
Jun Yang
Bowen Ke
Qinqin Yin
Original Assignee
West China Hospital Sichuan Univ
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by West China Hospital Sichuan Univ filed Critical West China Hospital Sichuan Univ
Publication of SG11201700517PA publication Critical patent/SG11201700517PA/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C237/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups
    • C07C237/02—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton
    • C07C237/04—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being acyclic and saturated
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/16—Amides, e.g. hydroxamic acids
    • A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
    • A61K31/167—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide having the nitrogen of a carboxamide group directly attached to the aromatic ring, e.g. lidocaine, paracetamol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/107—Emulsions ; Emulsion preconcentrates; Micelles
    • A61K9/1075—Microemulsions or submicron emulsions; Preconcentrates or solids thereof; Micelles, e.g. made of phospholipids or block copolymers
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C219/00—Compounds containing amino and esterified hydroxy groups bound to the same carbon skeleton
    • C07C219/02—Compounds containing amino and esterified hydroxy groups bound to the same carbon skeleton having esterified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton
    • C07C219/04—Compounds containing amino and esterified hydroxy groups bound to the same carbon skeleton having esterified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C231/00—Preparation of carboxylic acid amides
    • C07C231/12—Preparation of carboxylic acid amides by reactions not involving the formation of carboxamide groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C237/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups
    • C07C237/02—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton
    • C07C237/16—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being acyclic and unsaturated
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C237/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups
    • C07C237/02—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton
    • C07C237/20—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton containing six-membered aromatic rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Pain & Pain Management (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Molecular Biology (AREA)
  • Dispersion Chemistry (AREA)
  • Biophysics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
SG11201700517PA 2014-08-01 2015-07-22 Dimethylphenylammonium long-chain compound, preparation, self-assembled structure and use thereof SG11201700517PA (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
CN201410373447 2014-08-01
PCT/CN2015/084760 WO2016015581A1 (en) 2014-08-01 2015-07-22 Dimethylphenylammonium long-chain compound, preparation, self-assembled structure and use thereof

Publications (1)

Publication Number Publication Date
SG11201700517PA true SG11201700517PA (en) 2017-02-27

Family

ID=55216757

Family Applications (1)

Application Number Title Priority Date Filing Date
SG11201700517PA SG11201700517PA (en) 2014-08-01 2015-07-22 Dimethylphenylammonium long-chain compound, preparation, self-assembled structure and use thereof

Country Status (11)

Country Link
US (1) US10011562B2 (en)
EP (1) EP3187485A4 (en)
JP (1) JP2017523175A (en)
KR (1) KR20170039258A (en)
CN (1) CN105315170B (en)
AU (1) AU2015296380A1 (en)
CA (1) CA2955719A1 (en)
PH (1) PH12017500136A1 (en)
RU (1) RU2017103962A (en)
SG (1) SG11201700517PA (en)
WO (1) WO2016015581A1 (en)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN110092731B (en) * 2018-01-31 2022-03-04 四川大学华西医院 Long-chain amine substituted dimethylanilinium compounds, preparation, self-assembly structure and application
WO2019154287A1 (en) * 2018-02-11 2019-08-15 四川大学华西医院 Quaternary ammonium salt compound, preparation method therefor and use thereof
CN108409614B (en) * 2018-04-02 2019-09-24 成都联创蓉成医药科技有限公司 A kind of amides compound, its pharmaceutical composition, Preparation method and use
CN110776481B (en) * 2018-07-24 2023-06-16 四川大学华西医院 Biscationic compound, preparation method and application thereof
CN108727248B (en) * 2018-07-25 2021-05-25 四川大学华西医院 Biquaternary ammonium compound and preparation method and application thereof
CN112390724B (en) * 2019-08-19 2023-07-21 鲁南制药集团股份有限公司 Preparation method of N-diethylaminoacetyl-2, 6-dimethylaniline quaternary ammonium salt
CN112574098B (en) * 2019-09-30 2022-06-07 四川大学华西医院 Amide compound, preparation method and application thereof
JP2023500682A (en) * 2019-10-30 2023-01-10 ザ チルドレンズ メディカル センター コーポレーション Local anesthetic with selective sensory nerve blockade
WO2021142577A1 (en) * 2020-01-13 2021-07-22 易天奇 Arylamide compound based on benzene ring supramolecular interaction, self-assembly morphology, and use
CN113214107B (en) * 2020-05-11 2022-03-18 四川道珍科技有限公司 Aromatic compound, preparation method and application in medicine
CN115960013B (en) * 2020-05-25 2024-07-05 唐磊 Quaternary ammonium formate compound, supermolecule self-assembly and application
US20240226034A1 (en) * 2021-04-29 2024-07-11 The Regents Of The University Of California Use of Terpenoids and Salicylates as Anesthetics and Analgesics

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3998815A (en) * 1974-06-24 1976-12-21 Interx Research Corporation 1-hydrocarbonoyloxymethyl-3-carbamoyl or 3-carboethoxy-pyridinium salts
JPH09255565A (en) * 1996-03-26 1997-09-30 Daikyo Yakuhin Kogyo Kk Hydrogel patch for dermal local anesthesia
AU3162001A (en) * 1999-12-21 2001-07-03 Id-Pharma Gmbh Medicament, a method for its production and the use thereof
BRPI0404222A (en) * 2004-06-07 2006-02-07 Fundacao Oswaldo Cruz Lidocaine derivatives, pharmaceutical compositions containing them, use of the respective pharmaceutical compositions in the treatment, prevention or inhibition of diseases as well as the method of treating, preventing or inhibiting diseases with said pharmaceutical compositions
KR100912307B1 (en) * 2004-10-21 2009-08-14 유니버시티 오브 아이오와 리써치 파운데이션 In situ controlled release drug delivery system
US8603999B2 (en) * 2008-12-05 2013-12-10 Commonwealth Scientific And Industrial Research Organisation Amphiphile prodrugs
CN103601650B (en) * 2013-01-16 2014-08-06 四川大学华西医院 N-diethylaminoacetyl-2, 6-dimethylaniline derivative, preparation method and application

Also Published As

Publication number Publication date
US20170204053A1 (en) 2017-07-20
WO2016015581A1 (en) 2016-02-04
PH12017500136A1 (en) 2017-05-29
KR20170039258A (en) 2017-04-10
CN105315170B (en) 2017-08-25
EP3187485A4 (en) 2018-03-07
US10011562B2 (en) 2018-07-03
CN105315170A (en) 2016-02-10
AU2015296380A1 (en) 2017-03-16
RU2017103962A3 (en) 2018-09-03
EP3187485A1 (en) 2017-07-05
CA2955719A1 (en) 2016-02-04
RU2017103962A (en) 2018-09-03
JP2017523175A (en) 2017-08-17

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