SG11201607118PA - System and method for cell levitation and monitoring - Google Patents

System and method for cell levitation and monitoring

Info

Publication number
SG11201607118PA
SG11201607118PA SG11201607118PA SG11201607118PA SG11201607118PA SG 11201607118P A SG11201607118P A SG 11201607118PA SG 11201607118P A SG11201607118P A SG 11201607118PA SG 11201607118P A SG11201607118P A SG 11201607118PA SG 11201607118P A SG11201607118P A SG 11201607118PA
Authority
SG
Singapore
Prior art keywords
monitoring
cell levitation
levitation
cell
Prior art date
Application number
SG11201607118PA
Inventor
Utkan Demirci
Ionita Ghiran
Savas Tasoglu
Ronald W Davis
Lars Steinmetz
Naside Gozde Durmus
Huseyin Cumhur Tekin
Original Assignee
Brigham & Womens Hospital
Univ Leland Stanford Junior
Beth Israel Hospital
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Brigham & Womens Hospital, Univ Leland Stanford Junior, Beth Israel Hospital filed Critical Brigham & Womens Hospital
Publication of SG11201607118PA publication Critical patent/SG11201607118PA/en

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/80—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving blood groups or blood types or red blood cells
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
    • B01L3/502715—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by interfacing components, e.g. fluidic, electrical, optical or mechanical interfaces
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
    • B01L3/502761—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip specially adapted for handling suspended solids or molecules independently from the bulk fluid flow, e.g. for trapping or sorting beads, for physically stretching molecules
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B03—SEPARATION OF SOLID MATERIALS USING LIQUIDS OR USING PNEUMATIC TABLES OR JIGS; MAGNETIC OR ELECTROSTATIC SEPARATION OF SOLID MATERIALS FROM SOLID MATERIALS OR FLUIDS; SEPARATION BY HIGH-VOLTAGE ELECTRIC FIELDS
    • B03C—MAGNETIC OR ELECTROSTATIC SEPARATION OF SOLID MATERIALS FROM SOLID MATERIALS OR FLUIDS; SEPARATION BY HIGH-VOLTAGE ELECTRIC FIELDS
    • B03C1/00—Magnetic separation
    • B03C1/32—Magnetic separation acting on the medium containing the substance being separated, e.g. magneto-gravimetric-, magnetohydrostatic-, or magnetohydrodynamic separation
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N13/00—Treatment of microorganisms or enzymes with electrical or wave energy, e.g. magnetism, sonic waves
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/02—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving viable microorganisms
    • C12Q1/18—Testing for antimicrobial activity of a material
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume, or surface-area of porous materials
    • G01N15/06—Investigating concentration of particle suspensions
    • G01N15/0656—Investigating concentration of particle suspensions using electric, e.g. electrostatic methods or magnetic methods
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume, or surface-area of porous materials
    • G01N15/10—Investigating individual particles
    • G01N15/1031—Investigating individual particles by measuring electrical or magnetic effects thereof, e.g. conductivity or capacity
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N27/00—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means
    • G01N27/72—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating magnetic variables
    • G01N27/74—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating magnetic variables of fluids
    • G01N27/76—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating magnetic variables of fluids by investigating susceptibility
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/483—Physical analysis of biological material
    • G01N33/487—Physical analysis of biological material of liquid biological material
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/483—Physical analysis of biological material
    • G01N33/487—Physical analysis of biological material of liquid biological material
    • G01N33/48707—Physical analysis of biological material of liquid biological material by electrical means
    • G01N33/48728—Investigating individual cells, e.g. by patch clamp, voltage clamp
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/483—Physical analysis of biological material
    • G01N33/487—Physical analysis of biological material of liquid biological material
    • G01N33/49—Blood
    • G01N33/491—Blood by separating the blood components
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/574—Immunoassay; Biospecific binding assay; Materials therefor for cancer
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
    • B01L2200/06—Fluid handling related problems
    • B01L2200/0647—Handling flowable solids, e.g. microscopic beads, cells, particles
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/06—Auxiliary integrated devices, integrated components
    • B01L2300/0627—Sensor or part of a sensor is integrated
    • B01L2300/0654—Lenses; Optical fibres
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/08—Geometry, shape and general structure
    • B01L2300/0832—Geometry, shape and general structure cylindrical, tube shaped
    • B01L2300/0838—Capillaries
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/16—Surface properties and coatings
    • B01L2300/168—Specific optical properties, e.g. reflective coatings
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B03—SEPARATION OF SOLID MATERIALS USING LIQUIDS OR USING PNEUMATIC TABLES OR JIGS; MAGNETIC OR ELECTROSTATIC SEPARATION OF SOLID MATERIALS FROM SOLID MATERIALS OR FLUIDS; SEPARATION BY HIGH-VOLTAGE ELECTRIC FIELDS
    • B03C—MAGNETIC OR ELECTROSTATIC SEPARATION OF SOLID MATERIALS FROM SOLID MATERIALS OR FLUIDS; SEPARATION BY HIGH-VOLTAGE ELECTRIC FIELDS
    • B03C2201/00—Details of magnetic or electrostatic separation
    • B03C2201/18—Magnetic separation whereby the particles are suspended in a liquid
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B03—SEPARATION OF SOLID MATERIALS USING LIQUIDS OR USING PNEUMATIC TABLES OR JIGS; MAGNETIC OR ELECTROSTATIC SEPARATION OF SOLID MATERIALS FROM SOLID MATERIALS OR FLUIDS; SEPARATION BY HIGH-VOLTAGE ELECTRIC FIELDS
    • B03C—MAGNETIC OR ELECTROSTATIC SEPARATION OF SOLID MATERIALS FROM SOLID MATERIALS OR FLUIDS; SEPARATION BY HIGH-VOLTAGE ELECTRIC FIELDS
    • B03C2201/00—Details of magnetic or electrostatic separation
    • B03C2201/26—Details of magnetic or electrostatic separation for use in medical applications
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume, or surface-area of porous materials
    • G01N2015/0042—Investigating dispersion of solids
    • G01N2015/0053—Investigating dispersion of solids in liquids, e.g. trouble
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume, or surface-area of porous materials
    • G01N15/10—Investigating individual particles
    • G01N2015/1006—Investigating individual particles for cytology
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2500/00—Screening for compounds of potential therapeutic value
    • G01N2500/10—Screening for compounds of potential therapeutic value involving cells
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00—Detection or diagnosis of diseases
    • G01N2800/04—Endocrine or metabolic disorders
    • G01N2800/042—Disorders of carbohydrate metabolism, e.g. diabetes, glucose metabolism
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00—Detection or diagnosis of diseases
    • G01N2800/26—Infectious diseases, e.g. generalised sepsis
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00—Detection or diagnosis of diseases
    • G01N2800/52—Predicting or monitoring the response to treatment, e.g. for selection of therapy based on assay results in personalised medicine; Prognosis
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00—Detection or diagnosis of diseases
    • G01N2800/70—Mechanisms involved in disease identification
    • G01N2800/7042—Aging, e.g. cellular aging

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Physics & Mathematics (AREA)
  • Biomedical Technology (AREA)
  • General Health & Medical Sciences (AREA)
  • Immunology (AREA)
  • Analytical Chemistry (AREA)
  • Hematology (AREA)
  • Biochemistry (AREA)
  • Pathology (AREA)
  • General Physics & Mathematics (AREA)
  • Molecular Biology (AREA)
  • Urology & Nephrology (AREA)
  • Dispersion Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Food Science & Technology (AREA)
  • Organic Chemistry (AREA)
  • Biophysics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Fluid Mechanics (AREA)
  • Genetics & Genomics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Clinical Laboratory Science (AREA)
  • General Engineering & Computer Science (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Cell Biology (AREA)
  • Ecology (AREA)
  • Electrochemistry (AREA)
  • Oncology (AREA)
  • Hospice & Palliative Care (AREA)
  • Toxicology (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
SG11201607118PA 2014-02-26 2015-02-26 System and method for cell levitation and monitoring SG11201607118PA (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201461944707P 2014-02-26 2014-02-26
US201462072040P 2014-10-29 2014-10-29
PCT/US2015/017705 WO2015130913A1 (en) 2014-02-26 2015-02-26 System and method for cell levitation and monitoring

Publications (1)

Publication Number Publication Date
SG11201607118PA true SG11201607118PA (en) 2016-09-29

Family

ID=54009611

Family Applications (1)

Application Number Title Priority Date Filing Date
SG11201607118PA SG11201607118PA (en) 2014-02-26 2015-02-26 System and method for cell levitation and monitoring

Country Status (12)

Country Link
US (2) US10928404B2 (en)
EP (2) EP3111213B1 (en)
JP (3) JP6649891B2 (en)
KR (3) KR102360036B1 (en)
CN (1) CN106471370B (en)
AU (2) AU2015222978B2 (en)
CA (1) CA2940650C (en)
EA (1) EA035272B1 (en)
IL (1) IL247445B (en)
MY (1) MY187629A (en)
SG (1) SG11201607118PA (en)
WO (1) WO2015130913A1 (en)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SG11201607118PA (en) 2014-02-26 2016-09-29 Brigham & Womens Hospital System and method for cell levitation and monitoring
AU2016331215B2 (en) * 2015-10-02 2022-08-11 The Board Of Trustees Of The Leland Stanford Junior University Sorting biological and non-biological moieties using magnetic levitation
CN108474780A (en) * 2016-01-05 2018-08-31 浜松光子学株式会社 Organism observation method and organism observe device
WO2018089760A1 (en) * 2016-11-11 2018-05-17 Beth Israel Deaconess Medical Center, Inc. Detection and identification of cell bound and soluble antigens using magnetic levitation
FR3066503B1 (en) * 2017-05-22 2021-05-07 Commissariat Energie Atomique MICROORGANISMS ANALYSIS PROCESS
WO2019036403A1 (en) * 2017-08-15 2019-02-21 Trustees Of Boston University Compositions and methods for isolating and enriching igm-producing cells and uses thereof
CN108018205A (en) * 2017-12-28 2018-05-11 北京师范大学 A kind of microorganism change gravity simulator
WO2019191137A1 (en) * 2018-03-26 2019-10-03 Levitas, Inc. Magnetic particle isolation device and methods of use
JP7020308B2 (en) * 2018-06-14 2022-02-16 株式会社島津製作所 Equipment for manipulating magnetic particles
US11548011B2 (en) * 2018-07-23 2023-01-10 The Brigham And Women's Hospital, Inc. Magnetic levitation techniques to separate and analyze molecular entities
WO2020069081A1 (en) 2018-09-28 2020-04-02 President And Fellows Of Harvard College Magnetic levitation
TR201910569A2 (en) * 2019-07-16 2021-02-22 Izmir Yueksek Teknoloji Enstituesue DESIGN AND PRODUCTION OF PARTIAL GRAVITY PLATFORM USING MAGNETIC FORCES FOR CELLULAR APPLICATIONS
TR201916902A2 (en) * 2019-11-01 2021-05-21 Izmir Yueksek Teknoloji Enstituesue PROTEIN DETECTION USING LENSLESS HOLOGRAPHIC MICROSCOPY IMAGING TECHNIQUE IN A MAGNETIC LEVITATION DEVICE
WO2022192122A1 (en) * 2021-03-09 2022-09-15 Ohio State Innovation Foundation Diagnosis of hemoglobinopathies via cell magnetic properties
CN113155703B (en) * 2021-04-28 2022-05-31 特拓(青岛)轮胎技术有限公司 Method for testing porosity of rubber
WO2023018398A1 (en) * 2021-08-11 2023-02-16 İzmi̇r Yüksek Teknoloji̇ Ensti̇tüsü Hybrid detection and separation of target cells through magnetic levitation and deep learning

Family Cites Families (81)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4226534A (en) * 1978-11-13 1980-10-07 Fairfield University Micropolarimeter
NZ199916A (en) 1981-03-11 1985-07-12 Unilever Plc Low density polymeric block material for use as carrier for included liquids
US4508625A (en) 1982-10-18 1985-04-02 Graham Marshall D Magnetic separation using chelated magnetic ions
US6120735A (en) 1992-02-26 2000-09-19 The Ohio States University Fractional cell sorter
GB9308271D0 (en) * 1993-04-21 1993-06-02 Univ Edinburgh Method of isolating and/or enriching and/or selectively propagating pluripotential animal cells and animals for use in said method
US5852298A (en) 1995-03-30 1998-12-22 Ebara Corporation Micro-processing apparatus and method therefor
US6190870B1 (en) 1995-08-28 2001-02-20 Amcell Corporation Efficient enrichment and detection of disseminated tumor cells
ATE358525T1 (en) 1996-01-31 2007-04-15 Univ Texas FRACTIONATION USING DIELECTROPHORESIS AND FRACTIONATION USING A FLOW FIELD
US5968820A (en) 1997-02-26 1999-10-19 The Cleveland Clinic Foundation Method for magnetically separating cells into fractionated flow streams
US6159378A (en) 1999-02-23 2000-12-12 Battelle Memorial Institute Apparatus and method for handling magnetic particles in a fluid
US6858439B1 (en) * 1999-03-15 2005-02-22 Aviva Biosciences Compositions and methods for separation of moieties on chips
CN1181337C (en) * 2000-08-08 2004-12-22 清华大学 Solid molecule operating method in microfluid system
CN1185492C (en) 1999-03-15 2005-01-19 清华大学 Single-point strobed micro electromagnetic units array chip or electromagnetic biologic chip and application thereof
TW496775B (en) 1999-03-15 2002-08-01 Aviva Bioscience Corp Individually addressable micro-electromagnetic unit array chips
EP1309863A1 (en) 2000-08-08 2003-05-14 Aviva Biosciences Corporation Methods for manipulating moieties in microfluidic systems
JP3401487B2 (en) 2000-08-23 2003-04-28 日本学術振興会 Separation method of plastic mixture by magnetic Archimedes effect
JP3513591B2 (en) * 2000-09-13 2004-03-31 大阪大学長 Method and apparatus for separating magnetic traps in a liquid under a magnetic gradient
AU2001296516A1 (en) 2000-10-09 2002-04-22 Aviva Biosciences Coropration Compositions and methods for separation of moieties on chips
AU2002211363A1 (en) 2000-10-10 2002-04-22 Aviva Biosciences Corporation Individually addressable micro-electromagnetic unit array chips in horizontal configurations
US6677752B1 (en) * 2000-11-20 2004-01-13 Stereotaxis, Inc. Close-in shielding system for magnetic medical treatment instruments
US20020187072A1 (en) 2001-06-07 2002-12-12 Nanostream, Inc. Multi-layer microfluidic splitter
US8980568B2 (en) 2001-10-11 2015-03-17 Aviva Biosciences Corporation Methods and compositions for detecting non-hematopoietic cells from a blood sample
US8986944B2 (en) 2001-10-11 2015-03-24 Aviva Biosciences Corporation Methods and compositions for separating rare cells from fluid samples
US20140008210A1 (en) 2012-07-06 2014-01-09 Aviva Biosciences Corporation Methods and compositions for separating or enriching cells
CA2462914A1 (en) 2001-10-11 2003-04-17 Aviva Biosciences Corporation Methods, compositions, and automated systems for separating rare cells from fluid samples
US7166443B2 (en) 2001-10-11 2007-01-23 Aviva Biosciences Corporation Methods, compositions, and automated systems for separating rare cells from fluid samples
US7312085B2 (en) 2002-04-01 2007-12-25 Fluidigm Corporation Microfluidic particle-analysis systems
DE10311716A1 (en) 2003-03-17 2004-10-14 Evotec Oai Ag Method and device for separating particles in a liquid flow
GB0313015D0 (en) 2003-06-06 2003-07-09 Hall Effect Technologies Ltd Method and device for analysing a liquid
US7713923B2 (en) 2003-06-25 2010-05-11 Massachusetts Institute Of Technology Self-assembling peptides incorporating modifications and methods of use thereof
US20060247862A1 (en) * 2003-09-08 2006-11-02 Arini Nicholas S Determining cell cycle phase data
GB0409987D0 (en) 2004-05-05 2004-06-09 Univ Nottingham A method for materials separation in an inhomogeneous magnetic field using vibration
US7541190B2 (en) * 2005-02-07 2009-06-02 Beckman Coulter, Inc. Method of measurement of cellular hemoglobin
US8357759B2 (en) 2005-08-26 2013-01-22 CID Centro de Investigación y Desarrollo Tecnológico S.A. de C.V. Reactive block copolymers
US7740424B2 (en) 2006-02-15 2010-06-22 Battelle Memorial Institute Article separation apparatus and method for unit operations
CN101583722A (en) 2006-07-14 2009-11-18 阿维瓦生物科学股份有限公司 Methods and compositions for detecting rare cells from a biological sample
US7892434B2 (en) 2006-08-02 2011-02-22 The Regents Of The University Of California Microfluidic production of monodispersed submicron emulsion through filtration and sorting of satellite drops
WO2008127295A2 (en) 2006-10-20 2008-10-23 Children's Medical Center Corporation Guided self-assembly of matrices with orderd nano-scale structure for tissue engineering
US8034245B1 (en) 2006-12-19 2011-10-11 The United States Of America As Represented By The United States Department Of Energy Method of driving liquid flow at or near the free surface using magnetic microparticles
US7993525B2 (en) 2006-12-29 2011-08-09 Intel Corporation Device and method for particle complex handling
WO2009006409A2 (en) 2007-06-29 2009-01-08 President And Fellows Of Harvard College Density-based methods for separation of materials, monitoring of solid supported reactions and measuring densities of small liquid volumes and solids
JP5057226B2 (en) * 2007-10-12 2012-10-24 ローム株式会社 Microchip for blood test and method of using the same
KR100907213B1 (en) 2007-12-07 2009-07-10 한국과학기술원 Apparatus and method for separating particles using isomagnetophoresis
GB0814039D0 (en) * 2008-07-31 2008-09-10 Imp Innovations Ltd Optical arrangement for oblique plane microscopy
JP5775455B2 (en) 2008-09-25 2015-09-09 ウイリアム、マーシュ、ライス、ユーニヴァーサティ Systems and methods for magnetic induction and patterning of cells and materials
JP5337912B2 (en) 2009-06-10 2013-11-06 シンベニオ・バイオシステムズ・インコーポレーテッド Sheath flow apparatus and method
JP5769717B2 (en) 2009-09-25 2015-08-26 エヌ３ディー バイオサイエンスィズ，インコーポレイテッド Materials for magnetizing cells and magnetic manipulation
EP2510351A4 (en) 2009-12-07 2018-01-10 Yale University Label-free cellular manipulation and sorting via biocompatible ferrofluids
US20120288852A1 (en) * 2010-01-15 2012-11-15 Richard Willson Force Mediated Assays
WO2011089603A1 (en) 2010-01-21 2011-07-28 Biocep Ltd. Magnetic separation of rare cells
US9500644B2 (en) 2010-02-23 2016-11-22 Luminex Corporation Particle populations and assays having varying amounts of magnetic material and particle concentrations among different subsets of particles and methods for processing assays having such particle populations
US20120040846A1 (en) * 2010-07-23 2012-02-16 President And Fellows Of Harvard College Methods of Detecting Diseases or Conditions Using Phagocytic Cells
US9999855B2 (en) 2010-10-28 2018-06-19 Yale University Microfluidic processing of target species in ferrofluids
WO2012075009A1 (en) 2010-11-29 2012-06-07 President And Fellows Of Harvard College Quality control of diamagnetic materials using magnetic levitation
US9409265B2 (en) 2010-12-20 2016-08-09 President And Fellows Of Harvard College Three dimensional assembly of diamagnetic materials using magnetic levitation
US9051549B2 (en) 2011-02-22 2015-06-09 Scripps Health In situ tissue engineering using magnetically guided three dimensional cell patterning
JP5403306B2 (en) 2011-02-23 2014-01-29 宇部興産株式会社 Method and apparatus for separating a mixture
JP5440994B2 (en) 2011-03-31 2014-03-12 宇部興産株式会社 Method and apparatus for separating mixture
US9816993B2 (en) * 2011-04-11 2017-11-14 The Regents Of The University Of Michigan Magnetically induced microspinning for super-detection and super-characterization of biomarkers and live cells
US8721936B2 (en) 2011-04-21 2014-05-13 University Of Georgia Research Foundation, Inc. Devices and methods for forming non-spherical particles
US20130133419A1 (en) 2011-08-25 2013-05-30 George M. Whitesides Magnetic levitation for forensics analysis
WO2013027818A1 (en) 2011-08-25 2013-02-28 宇部興産株式会社 Mixture separation method and separation device
CN103797361A (en) 2011-09-12 2014-05-14 西门子公司 A method and a system for determining counts of a target cellular entity in a suspension using magnetic levitation
DK2572787T3 (en) 2011-09-23 2020-08-03 Nano Temper Tech Gmbh Capillary for detecting properties of chemical and / or biological fluids
WO2013044089A1 (en) 2011-09-23 2013-03-28 President And Fellows Of Harvard College Density analysis of organisms by magnetic levitation
US9370782B2 (en) 2011-12-12 2016-06-21 Osaka University Method and apparatus for separation of mixture
US9150907B2 (en) 2012-04-27 2015-10-06 General Electric Company Microfluidic flow cell assemblies and method of use
US9517474B2 (en) 2012-05-18 2016-12-13 University Of Georgia Research Foundation, Inc. Devices and methods for separating particles
WO2013188725A1 (en) 2012-06-14 2013-12-19 President And Fellows Of Harvard College Levitation of materials in paramagnetic ionic liquids
CN104540594B (en) 2012-06-25 2019-07-02 通用医疗公司 Classified using high-gradient magnetic field to particle
CN104736718A (en) 2012-10-26 2015-06-24 贝克顿·迪金森公司 Devices and methods for manipulating components in a fluid sample
US20160296944A1 (en) 2013-03-15 2016-10-13 Ancera, Inc. Systems and methods for three-dimensional extraction of target particles ferrofluids
EP3058316B1 (en) 2013-10-18 2019-03-13 The General Hospital Corporation Microfluidic sorting using high gradient magnetic fields
SG11201607118PA (en) 2014-02-26 2016-09-29 Brigham & Womens Hospital System and method for cell levitation and monitoring
SG11201607101VA (en) 2014-02-26 2016-09-29 Brigham & Womens Hospital System and method for magnetic self-assembly
EP3110747A4 (en) 2014-02-28 2017-11-08 DH Technologies Development Pte. Ltd. Magnetic elements for processing fluids
WO2016077067A2 (en) 2014-10-27 2016-05-19 President And Fellows Of Harvard College Magnetic capture of a target from a fluid
EP3294372B1 (en) 2015-05-08 2021-08-25 Biomagnetic Solutions LLC Apparatus and method for immunomagnetic cell separation
US10676719B2 (en) 2015-07-31 2020-06-09 University Of Georgia Research Foundation, Inc. Devices and methods for separating particles
US20180231555A1 (en) 2015-08-11 2018-08-16 Apocell, Inc. Systems and methods for isolating target particles and their use in diagnostic, prognostic, and therapeutic methods
AU2016331215B2 (en) 2015-10-02 2022-08-11 The Board Of Trustees Of The Leland Stanford Junior University Sorting biological and non-biological moieties using magnetic levitation

Also Published As

Publication number Publication date
AU2015222978B2 (en) 2021-05-13
KR102527270B1 (en) 2023-04-27
JP2020089377A (en) 2020-06-11
AU2021215160A1 (en) 2021-09-02
JP7368447B2 (en) 2023-10-24
KR20220020419A (en) 2022-02-18
EA035272B1 (en) 2020-05-22
JP2022058419A (en) 2022-04-12
KR20160132413A (en) 2016-11-18
AU2021215160B2 (en) 2023-11-09
JP2017509334A (en) 2017-04-06
US10928404B2 (en) 2021-02-23
MY187629A (en) 2021-10-05
KR20230061565A (en) 2023-05-08
EP3111213A4 (en) 2017-11-01
US20210373037A1 (en) 2021-12-02
IL247445B (en) 2022-07-01
AU2015222978A1 (en) 2016-09-08
CA2940650A1 (en) 2015-09-03
KR102360036B1 (en) 2022-02-07
EA201691698A1 (en) 2017-04-28
JP6649891B2 (en) 2020-02-19
WO2015130913A1 (en) 2015-09-03
CN106471370B (en) 2019-11-19
EP4253937A3 (en) 2023-11-08
US20160370386A1 (en) 2016-12-22
CA2940650C (en) 2022-10-04
CN106471370A (en) 2017-03-01
EP4253937A2 (en) 2023-10-04
EP3111213B1 (en) 2023-07-26
IL247445A0 (en) 2016-11-30
EP3111213A1 (en) 2017-01-04

Similar Documents

Publication Publication Date Title
IL247445A0 (en) System and method for cell levitation and monitoring
PL3090416T3 (en) Method and system for monitoring
GB2528554B (en) Monitoring device, monitoring system, and monitoring method
GB201501864D0 (en) Monitoring system and method
EP3213274C0 (en) Method and system for progressive order picking
GB2535091B (en) Monitoring device, monitoring system, and monitoring method
EP3125542A4 (en) Monitoring system and monitoring method
PL3379690T3 (en) Quick-charging method and system
SG11201703529PA (en) System and method for detecting active resource units
HK1248879A1 (en) System and method for activity monitoring
PT3101760T (en) Charging method and system
GB201408778D0 (en) Monitoring system and method
SG10201402026RA (en) Activity monitoring method and system
GB201410270D0 (en) Cell delivery system and method
SG11201700642TA (en) Usage monitoring system and method
SG11201705251WA (en) Point management system and point management method
PL3103153T3 (en) Assembly method and arrangement for a cell system
EP3084876A4 (en) Method and system for controlling power battery
SG11201704477VA (en) Power system and method
SG11201602367WA (en) Redundant system and redundant system management method
SG11201607244YA (en) Atm-cash-loading management system, and atm-cash-loading management method
GB201420078D0 (en) Energy system and method
IL247047A0 (en) Method and system for non-contact levitation
GB2517590B (en) Method and system for condition monitoring
GB201501850D0 (en) Monitoring system and method