SG11201605316VA - Methods and compositions relating to p62/sqstm1 for the treatment and prevention of inflammation-associated diseases - Google Patents
Methods and compositions relating to p62/sqstm1 for the treatment and prevention of inflammation-associated diseasesInfo
- Publication number
- SG11201605316VA SG11201605316VA SG11201605316VA SG11201605316VA SG11201605316VA SG 11201605316V A SG11201605316V A SG 11201605316VA SG 11201605316V A SG11201605316V A SG 11201605316VA SG 11201605316V A SG11201605316V A SG 11201605316VA SG 11201605316V A SG11201605316V A SG 11201605316VA
- Authority
- SG
- Singapore
- Prior art keywords
- sqstm1
- inflammation
- prevention
- treatment
- methods
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/0005—Vertebrate antigens
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/52—Cytokines; Lymphokines; Interferons
- C07K14/54—Interleukins [IL]
- C07K14/545—IL-1
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
- A61K31/436—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a six-membered ring having oxygen as a ring hetero atom, e.g. rapamycin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
- A61K31/57—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone
- A61K31/573—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone substituted in position 21, e.g. cortisone, dexamethasone, prednisone or aldosterone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/1703—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
- A61K38/1709—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/0005—Vertebrate antigens
- A61K39/0008—Antigens related to auto-immune diseases; Preparations to induce self-tolerance
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
- C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/52—Cytokines; Lymphokines; Interferons
- C07K14/521—Chemokines
- C07K14/523—Beta-chemokines, e.g. RANTES, I-309/TCA-3, MIP-1alpha, MIP-1beta/ACT-2/LD78/SCIF, MCP-1/MCAF, MCP-2, MCP-3, LDCF-1, LDCF-2
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/52—Cytokines; Lymphokines; Interferons
- C07K14/525—Tumour necrosis factor [TNF]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/52—Cytokines; Lymphokines; Interferons
- C07K14/54—Interleukins [IL]
- C07K14/5412—IL-6
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/24—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against cytokines, lymphokines or interferons
- C07K16/244—Interleukins [IL]
- C07K16/245—IL-1
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/24—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against cytokines, lymphokines or interferons
- C07K16/244—Interleukins [IL]
- C07K16/248—IL-6
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/62—DNA sequences coding for fusion proteins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
- A61K2039/53—DNA (RNA) vaccination
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
- A61K2039/55511—Organic adjuvants
- A61K2039/55566—Emulsions, e.g. Freund's adjuvant, MF59
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Organic Chemistry (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Genetics & Genomics (AREA)
- Immunology (AREA)
- Epidemiology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Zoology (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Gastroenterology & Hepatology (AREA)
- Biomedical Technology (AREA)
- Toxicology (AREA)
- Microbiology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Mycology (AREA)
- Rheumatology (AREA)
- Wood Science & Technology (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Biotechnology (AREA)
- General Engineering & Computer Science (AREA)
- Marine Sciences & Fisheries (AREA)
- Plant Pathology (AREA)
- Hospice & Palliative Care (AREA)
- Psychiatry (AREA)
- Pain & Pain Management (AREA)
- Transplantation (AREA)
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201361921504P | 2013-12-29 | 2013-12-29 | |
US201461949597P | 2014-03-07 | 2014-03-07 | |
PCT/US2014/072484 WO2015100446A1 (en) | 2013-12-29 | 2014-12-29 | Methods and compositions relating to p62/sqstm1 for the treatment and prevention of inflammation-associated diseases |
Publications (1)
Publication Number | Publication Date |
---|---|
SG11201605316VA true SG11201605316VA (en) | 2016-07-28 |
Family
ID=53479722
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
SG11201605316VA SG11201605316VA (en) | 2013-12-29 | 2014-12-29 | Methods and compositions relating to p62/sqstm1 for the treatment and prevention of inflammation-associated diseases |
Country Status (10)
Country | Link |
---|---|
US (3) | US20160324944A1 (en) |
EP (1) | EP3089753B8 (en) |
JP (1) | JP6498210B2 (en) |
KR (1) | KR102422580B1 (en) |
CN (1) | CN106061501A (en) |
AU (1) | AU2014369861B2 (en) |
CA (1) | CA2935232A1 (en) |
RU (1) | RU2016128557A (en) |
SG (1) | SG11201605316VA (en) |
WO (1) | WO2015100446A1 (en) |
Families Citing this family (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
SG11201605316VA (en) | 2013-12-29 | 2016-07-28 | Curelab Oncology Inc | Methods and compositions relating to p62/sqstm1 for the treatment and prevention of inflammation-associated diseases |
WO2020028923A2 (en) * | 2018-08-02 | 2020-02-06 | Curelab Oncology, Inc. | Compositions and methods relating to p62 for the treatment and prophylaxis of age-related macular degeneration |
US20220065875A1 (en) * | 2019-02-08 | 2022-03-03 | Ajou University Industry-Academic Cooperation Foundation | Biomarker composition for diagnosis of degenerative brain disease |
WO2021231652A1 (en) * | 2020-05-14 | 2021-11-18 | Curelab Oncology, Inc. | Using the p62 plasmid to treat or reduce the severity of coronavirus infections |
WO2022129180A1 (en) * | 2020-12-15 | 2022-06-23 | Centre National De La Recherche Scientifique | Sqstm1 and its use in cancer therapy |
WO2023156807A2 (en) * | 2021-09-27 | 2023-08-24 | Curelab Oncology, Inc. | Prevention and treatment of diseases by modulating activity of mesenchymal stem cells with p62 (sqstm1)-encoding vector and pharmaceutical formulations containing p62 (sqstm1) proteins |
CN117603982B (en) * | 2024-01-22 | 2024-04-19 | 中国医学科学院北京协和医院 | P.P374TfsTer18 mutant pathogenic gene of SQSTM1 for amyotrophic lateral sclerosis and application thereof |
Family Cites Families (30)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5364773A (en) | 1991-03-07 | 1994-11-15 | Virogenetics Corporation | Genetically engineered vaccine strain |
EP0681026A1 (en) | 1987-03-02 | 1995-11-08 | Whitehead Institute For Biomedical Research | Recombinant mycobacterial vaccine |
US5504005A (en) | 1987-03-02 | 1996-04-02 | Albert Einstein College Of Medicine Of Yeshiva University | Recombinant mycobacterial vaccine |
AU648505B2 (en) | 1989-05-19 | 1994-04-28 | Amgen, Inc. | Metalloproteinase inhibitor |
EP0517751A4 (en) | 1990-02-26 | 1993-03-31 | Commonwealth Scientific & Industrial Research Organisation ( C.S.I.R.O. ) | Shuttle plasmid for escherichia coli and mycobacteria |
GB9015888D0 (en) | 1990-07-19 | 1990-09-05 | Smithkline Biolog | Vectors |
WO1992015672A1 (en) | 1991-03-07 | 1992-09-17 | Virogenetics Corporation | Genetically engineered vaccine strain |
AU2185592A (en) | 1991-06-06 | 1993-01-08 | Med Immune, Inc. | Induction of ctl responses to foreign antigens expressed in mycobacteria |
US5962224A (en) * | 1995-12-19 | 1999-10-05 | Dana-Farber Cancer Institute | Isolated DNA encoding p62 polypeptides and uses therefor |
US5990091A (en) | 1997-03-12 | 1999-11-23 | Virogenetics Corporation | Vectors having enhanced expression, and methods of making and uses thereof |
US5977311A (en) * | 1997-09-23 | 1999-11-02 | Curagen Corporation | 53BP2 complexes |
NZ509966A (en) | 1998-08-18 | 2003-07-25 | Res Dev Foundation | Recombinant vector comprising a cassette with TET-ON under the control of a heat shock promoter, a cassette with a cloning site for a therapeutic gene, a cassette comprising antisense TET-ON and cassette with a dominative negative TET-ON and its use for metastatic prostate, breast and ovarian cancer |
CN1322730A (en) * | 2000-05-09 | 2001-11-21 | 上海博德基因开发有限公司 | New polypeptide-p62cdc6 protein 24 and encoding polynucleotides of the same polypeptide |
AU2001280767A1 (en) | 2000-07-31 | 2002-02-13 | Active Motif | Peptide-mediated delivery of molecules into cells |
US20060035823A1 (en) * | 2000-08-17 | 2006-02-16 | Seth Lederman | Isolated fragments of p62 nucleoporin and uses thereof |
EP1372720A4 (en) * | 2001-03-02 | 2006-07-26 | Medimmune Inc | Methods of preventing or treating inflammatory or autoimmune disorders by administering integrin alphav beta3 antagonists |
ATE389015T1 (en) | 2001-07-30 | 2008-03-15 | G R M O Groupe De Rech En Mala | PAGET BONE DISEASE |
ATE421532T1 (en) | 2002-05-14 | 2009-02-15 | Jaekyoon Shin | THE ROLE OF P62 IN AGE-RELATED DISEASES |
EP1578367A4 (en) * | 2002-11-01 | 2012-05-02 | Genentech Inc | Compositions and methods for the treatment of immune related diseases |
GB2443819B (en) | 2003-11-17 | 2009-09-02 | Univ Auburn | Methods and compositions for inhibiting intracellular aggregate formation |
WO2005073164A1 (en) * | 2004-01-30 | 2005-08-11 | Peplin Biolipids Pty Ltd | Therapeutic and carrier molecules |
GB0412301D0 (en) * | 2004-06-02 | 2004-07-07 | Diagenic As | Product and method |
WO2007044522A1 (en) * | 2005-10-05 | 2007-04-19 | Auburn University | P62 as a risk determinant for metabolic syndrome |
WO2011039734A2 (en) * | 2009-10-02 | 2011-04-07 | Enzo Medico | Use of genes involved in anchorage independence for the optimization of diagnosis and treatment of human cancer |
US8945847B2 (en) | 2010-05-24 | 2015-02-03 | Yissum Research Development Company Of The Hebrew University Of Jerusalem Ltd. | Methods and kits for ascertaining biosafety of an agent |
JP6193231B2 (en) * | 2011-08-08 | 2017-09-06 | チュアラボ オンコロジー, インコーポレーテッドCurelab Oncology, Inc. | Methods and compositions relating to P62 for the treatment and prevention of cancer |
KR20150038915A (en) | 2013-10-01 | 2015-04-09 | 코닝정밀소재 주식회사 | Method of fabricating graphene flake for electrode material of electric double layer capacitor, graphene flake fabricated by the same and electric double layer capacitor including the same by electrode material |
KR101594168B1 (en) | 2013-10-02 | 2016-02-15 | 서울대학교산학협력단 | Method for modulating autophagy mediated by p62 through ZZ domain and its use |
SG11201605316VA (en) | 2013-12-29 | 2016-07-28 | Curelab Oncology Inc | Methods and compositions relating to p62/sqstm1 for the treatment and prevention of inflammation-associated diseases |
WO2020028923A2 (en) * | 2018-08-02 | 2020-02-06 | Curelab Oncology, Inc. | Compositions and methods relating to p62 for the treatment and prophylaxis of age-related macular degeneration |
-
2014
- 2014-12-29 SG SG11201605316VA patent/SG11201605316VA/en unknown
- 2014-12-29 WO PCT/US2014/072484 patent/WO2015100446A1/en active Application Filing
- 2014-12-29 JP JP2016544567A patent/JP6498210B2/en active Active
- 2014-12-29 EP EP14874099.6A patent/EP3089753B8/en active Active
- 2014-12-29 CA CA2935232A patent/CA2935232A1/en active Pending
- 2014-12-29 RU RU2016128557A patent/RU2016128557A/en not_active Application Discontinuation
- 2014-12-29 KR KR1020167020392A patent/KR102422580B1/en active IP Right Grant
- 2014-12-29 AU AU2014369861A patent/AU2014369861B2/en active Active
- 2014-12-29 CN CN201480076576.4A patent/CN106061501A/en active Pending
- 2014-12-29 US US15/108,653 patent/US20160324944A1/en not_active Abandoned
-
2018
- 2018-10-22 US US16/167,171 patent/US11098098B2/en active Active
-
2021
- 2021-06-25 US US17/358,035 patent/US20220009985A1/en not_active Abandoned
Also Published As
Publication number | Publication date |
---|---|
US20220009985A1 (en) | 2022-01-13 |
JP6498210B2 (en) | 2019-04-10 |
US20190153056A1 (en) | 2019-05-23 |
EP3089753B8 (en) | 2020-10-28 |
CA2935232A1 (en) | 2015-07-02 |
EP3089753A4 (en) | 2017-08-09 |
KR20170016314A (en) | 2017-02-13 |
JP2017502974A (en) | 2017-01-26 |
WO2015100446A1 (en) | 2015-07-02 |
AU2014369861A1 (en) | 2016-06-23 |
KR102422580B1 (en) | 2022-07-20 |
AU2014369861B2 (en) | 2018-09-13 |
US20160324944A1 (en) | 2016-11-10 |
EP3089753A1 (en) | 2016-11-09 |
CN106061501A (en) | 2016-10-26 |
US11098098B2 (en) | 2021-08-24 |
RU2016128557A (en) | 2018-02-01 |
EP3089753B1 (en) | 2020-08-26 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
PL3349783T3 (en) | Compositions and methods relating to the treatment of diseases | |
HK1220980A1 (en) | Methods and compositions for treatment of pompe disease | |
EP3049070A4 (en) | Compositions and methods for treatment and prophylaxis of gastrointestinal diseases | |
IL241264A0 (en) | Compounds and compositions for the treatment of parasitic diseases | |
EP2958936A4 (en) | Methods and compositions for treatment of forbes-cori disease | |
HK1220324A1 (en) | Methods, compounds, and compositions for the treatment of angiotensin-related diseases | |
IL239851B (en) | Methods and compositions for treatment of demyelinating diseases | |
EP2983791A4 (en) | Methods and compositions of treating autoimmune diseases | |
SG11201605316VA (en) | Methods and compositions relating to p62/sqstm1 for the treatment and prevention of inflammation-associated diseases | |
HK1198909A1 (en) | Compositions and methods for the treatment of hepatic diseases and disorders | |
HK1211290A1 (en) | Heterocycle-substitued tetracyclic compounds and methods of use thereof for treatment of viral diseases | |
EP2986113A4 (en) | Compositions and methods for the treatment of brain injury | |
GB201404403D0 (en) | Compositions and methods relating to the treatment of diseases | |
EP3086809A4 (en) | Compositions and methods of treating ocular diseases | |
PL2892556T3 (en) | Compositions and methods relating to the treatment of diseases | |
EP2945953A4 (en) | Thiophene-substituted tetracyclic compounds and methods of use thereof for treatment of viral diseases | |
HK1220374A1 (en) | Compositions and methods for the treatment of carboxyhemoglobinemia | |
PL3082845T3 (en) | Methods and compositions for treatment of peripheral neuropathies | |
EP3043817A4 (en) | Methods and compositions for treatment of chlamydial infection and related diseases and disorders | |
EP2958591A4 (en) | Methods and compositions relating to the treatment of cancer | |
ZA201508452B (en) | Oral formulation for the treatment of cardiovascular diseases | |
EP2964227A4 (en) | Treatment and prophylaxis of kidney diseases | |
PL3079684T3 (en) | Compositions and methods for the treatment of diseases related to the renin-angiotensin-system | |
EP3089984A4 (en) | Novel compounds for the treatment of cancer and inflammatory diseases | |
GB201516303D0 (en) | Compositions and methods relating to the treatment of diseases |