SG11201604763PA - Multilayered nanoparticle and methods of manufacturing and using the same - Google Patents

Multilayered nanoparticle and methods of manufacturing and using the same

Info

Publication number
SG11201604763PA
SG11201604763PA SG11201604763PA SG11201604763PA SG11201604763PA SG 11201604763P A SG11201604763P A SG 11201604763PA SG 11201604763P A SG11201604763P A SG 11201604763PA SG 11201604763P A SG11201604763P A SG 11201604763PA SG 11201604763P A SG11201604763P A SG 11201604763PA
Authority
SG
Singapore
Prior art keywords
manufacturing
methods
same
multilayered nanoparticle
multilayered
Prior art date
Application number
SG11201604763PA
Inventor
Subramanian Venkatraman
Tzee Ling Tina Wong
Bjorn Neu
Original Assignee
Univ Nanyang Tech
Singapore Health Serv Pte Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ Nanyang Tech, Singapore Health Serv Pte Ltd filed Critical Univ Nanyang Tech
Publication of SG11201604763PA publication Critical patent/SG11201604763PA/en

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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7088—Compounds having three or more nucleosides or nucleotides
    • A61K31/713—Double-stranded nucleic acids or oligonucleotides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
    • A61K48/0008—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy characterised by an aspect of the 'non-active' part of the composition delivered, e.g. wherein such 'non-active' part is not delivered simultaneously with the 'active' part of the composition
    • A61K48/0025—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy characterised by an aspect of the 'non-active' part of the composition delivered, e.g. wherein such 'non-active' part is not delivered simultaneously with the 'active' part of the composition wherein the non-active part clearly interacts with the delivered nucleic acid
    • A61K48/0041—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy characterised by an aspect of the 'non-active' part of the composition delivered, e.g. wherein such 'non-active' part is not delivered simultaneously with the 'active' part of the composition wherein the non-active part clearly interacts with the delivered nucleic acid the non-active part being polymeric
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/5005—Wall or coating material
    • A61K9/501—Inorganic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/5005—Wall or coating material
    • A61K9/5021—Organic macromolecular compounds
    • A61K9/5036—Polysaccharides, e.g. gums, alginate; Cyclodextrin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/5005—Wall or coating material
    • A61K9/5021—Organic macromolecular compounds
    • A61K9/5052—Proteins, e.g. albumin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/5073—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals having two or more different coatings optionally including drug-containing subcoatings
    • A61K9/5078—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals having two or more different coatings optionally including drug-containing subcoatings with drug-free core
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/5089—Processes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A61P27/06—Antiglaucoma agents or miotics
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/111—General methods applicable to biologically active non-coding nucleic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/51—Nanocapsules; Nanoparticles
    • A61K9/5107—Excipients; Inactive ingredients
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/10—Type of nucleic acid
    • C12N2310/14—Type of nucleic acid interfering N.A.
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2320/00—Applications; Uses
    • C12N2320/30—Special therapeutic applications
    • C12N2320/32—Special delivery means, e.g. tissue-specific
SG11201604763PA 2013-12-13 2014-12-09 Multilayered nanoparticle and methods of manufacturing and using the same SG11201604763PA (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201361915790P 2013-12-13 2013-12-13
PCT/SG2014/000587 WO2015088445A1 (en) 2013-12-13 2014-12-09 Multilayered nanoparticle and methods of manufacturing and using the same

Publications (1)

Publication Number Publication Date
SG11201604763PA true SG11201604763PA (en) 2016-07-28

Family

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Family Applications (2)

Application Number Title Priority Date Filing Date
SG11201604763PA SG11201604763PA (en) 2013-12-13 2014-12-09 Multilayered nanoparticle and methods of manufacturing and using the same
SG10201805073VA SG10201805073VA (en) 2013-12-13 2014-12-09 Multilayered nanoparticle and methods of manufacturing and using the same

Family Applications After (1)

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Country Status (6)

Country Link
US (1) US10465189B2 (en)
EP (1) EP3079705A4 (en)
JP (1) JP2017500312A (en)
CN (1) CN107073028A (en)
SG (2) SG11201604763PA (en)
WO (1) WO2015088445A1 (en)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US11672866B2 (en) 2016-01-08 2023-06-13 Paul N. DURFEE Osteotropic nanoparticles for prevention or treatment of bone metastases
CN110582302A (en) 2016-12-14 2019-12-17 利甘达尔股份有限公司 Compositions and methods for nucleic acid and/or protein payload delivery
WO2018141865A1 (en) 2017-02-01 2018-08-09 Centre National De La Recherche Scientifique Particles and compositions comprising the same for transfection
WO2018160865A1 (en) 2017-03-01 2018-09-07 Charles Jeffrey Brinker Active targeting of cells by monosized protocells
WO2019002942A1 (en) * 2017-06-30 2019-01-03 Avectas Limited Electrospray catheter
CA3074248A1 (en) * 2017-07-26 2019-01-31 Albert-Ludwigs-Universitat Freiburg Biodegradable multilayer nanocapsules for the delivery of biologically active agents in target cells
US11059016B2 (en) 2018-06-25 2021-07-13 Microsoft Technology Licensing, Llc Silica encapsulated DNA on magnetic nanoparticles
WO2021140509A1 (en) * 2020-01-06 2021-07-15 Yissum Research Development Company Of The Hebrew University Of Jerusalem Ltd. Stimuli-responsive microcapsule-in-microcapsule multiple load carriers, uses thereof and processes for their preparation
US20230226169A1 (en) * 2020-04-01 2023-07-20 University Of Florida Research Foundation Incorporated Multilamellar rna nanoparticle vaccine against sars-cov-2
WO2021236016A1 (en) * 2020-05-22 2021-11-25 Formulytica Pty Ltd. Compositions and methods for the delivery of agents to biological targets
EP4185275A1 (en) * 2020-07-24 2023-05-31 Nanyang Technological University Layer-by-layer coated nanolipsome for oral delivery of insulin
CN114376988B (en) * 2022-01-20 2024-02-20 国家纳米科学中心 Nucleic acid delivery nano-carrier acting on phagocytic cells and preparation method and application thereof

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2007264361B2 (en) * 2006-06-26 2013-07-18 The University Of British Columbia Secreted Protein Acidic and Rich in Cysteine (SPARC) as chemotherapeutic sensitizers
CA2704056A1 (en) * 2007-10-29 2009-05-07 University Of Massachusetts Encapsulated nanoparticles for nucleic acid delivery
WO2011041680A2 (en) * 2009-10-02 2011-04-07 The Brigham And Women's Hospital, Inc. Compositions and methods of prophylaxis for contact dermatitis
EP2485739B1 (en) * 2009-10-09 2014-12-10 Singapore Health Services PTE. Ltd. Methods and compositions for maintenance of a functional wound
US9265844B2 (en) * 2010-12-01 2016-02-23 The Methodist Hospital System Protease degradable polypeptides and uses thereof
US9074187B2 (en) * 2011-03-21 2015-07-07 Board Of Trustees Of The University Of Arkansas Nanostructural materials that increase mineralization in bone cells and affect gene expression through miRNA regulation and applications of same
KR101255149B1 (en) * 2011-10-14 2013-04-22 포항공과대학교 산학협력단 Composition for nucleic acid delivery using metal nanoparticles and preparing method thereof
EP2841056A4 (en) * 2012-04-23 2015-09-16 Massachusetts Inst Technology Stable layer-by-layer coated particles

Also Published As

Publication number Publication date
SG10201805073VA (en) 2018-07-30
CN107073028A (en) 2017-08-18
EP3079705A4 (en) 2017-07-19
EP3079705A1 (en) 2016-10-19
JP2017500312A (en) 2017-01-05
US20160319280A1 (en) 2016-11-03
US10465189B2 (en) 2019-11-05
WO2015088445A1 (en) 2015-06-18

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