SG11201604528WA - Polycarbonates bearing aromatic n-heterocycles for drug delivery - Google Patents

Polycarbonates bearing aromatic n-heterocycles for drug delivery

Info

Publication number
SG11201604528WA
SG11201604528WA SG11201604528WA SG11201604528WA SG11201604528WA SG 11201604528W A SG11201604528W A SG 11201604528WA SG 11201604528W A SG11201604528W A SG 11201604528WA SG 11201604528W A SG11201604528W A SG 11201604528WA SG 11201604528W A SG11201604528W A SG 11201604528WA
Authority
SG
Singapore
Prior art keywords
heterocycles
drug delivery
bearing aromatic
polycarbonates
polycarbonates bearing
Prior art date
Application number
SG11201604528WA
Inventor
Julian M W Chan
Amanda C Engler
James L Hedrick
Xiyu Ke
Victor W L Ng
Hariz Sardon
Jeremy P K Tan
Yi Yan Yang
Original Assignee
Ibm
Agency Science Tech & Res
Univ Pais Vasco
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ibm, Agency Science Tech & Res, Univ Pais Vasco filed Critical Ibm
Publication of SG11201604528WA publication Critical patent/SG11201604528WA/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/34—Macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyesters, polyamino acids, polysiloxanes, polyphosphazines, copolymers of polyalkylene glycol or poloxamers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7028—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages
    • A61K31/7034—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a carbocyclic compound, e.g. phloridzin
    • A61K31/704—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a carbocyclic compound, e.g. phloridzin attached to a condensed carbocyclic ring system, e.g. sennosides, thiocolchicosides, escin, daunorubicin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7088—Compounds having three or more nucleosides or nucleotides
    • A61K31/713—Double-stranded nucleic acids or oligonucleotides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/51—Nanocapsules; Nanoparticles
    • A61K9/5107—Excipients; Inactive ingredients
    • A61K9/513—Organic macromolecular compounds; Dendrimers
    • A61K9/5146—Organic macromolecular compounds; Dendrimers obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, polyamines, polyanhydrides
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
    • C08G64/00—Macromolecular compounds obtained by reactions forming a carbonic ester link in the main chain of the macromolecule
    • C08G64/02—Aliphatic polycarbonates
    • C08G64/0208—Aliphatic polycarbonates saturated
    • C08G64/0225—Aliphatic polycarbonates saturated containing atoms other than carbon, hydrogen or oxygen
    • C08G64/0241—Aliphatic polycarbonates saturated containing atoms other than carbon, hydrogen or oxygen containing nitrogen
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
    • C08G64/00—Macromolecular compounds obtained by reactions forming a carbonic ester link in the main chain of the macromolecule
    • C08G64/18—Block or graft polymers
    • C08G64/183—Block or graft polymers containing polyether sequences
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08L—COMPOSITIONS OF MACROMOLECULAR COMPOUNDS
    • C08L69/00—Compositions of polycarbonates; Compositions of derivatives of polycarbonates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Polymers & Plastics (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Physics & Mathematics (AREA)
  • Biomedical Technology (AREA)
  • Nanotechnology (AREA)
  • Optics & Photonics (AREA)
  • Biochemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Inorganic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Polyesters Or Polycarbonates (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Immunology (AREA)
SG11201604528WA 2013-12-05 2014-12-03 Polycarbonates bearing aromatic n-heterocycles for drug delivery SG11201604528WA (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US14/097,488 US9717797B2 (en) 2013-12-05 2013-12-05 Polycarbonates bearing aromatic N-heterocycles for drug delivery
PCT/JP2014/006043 WO2015083377A1 (en) 2013-12-05 2014-12-03 Polycarbonates bearing aromatic n-heterocycles for drug delivery

Publications (1)

Publication Number Publication Date
SG11201604528WA true SG11201604528WA (en) 2016-07-28

Family

ID=53270065

Family Applications (1)

Application Number Title Priority Date Filing Date
SG11201604528WA SG11201604528WA (en) 2013-12-05 2014-12-03 Polycarbonates bearing aromatic n-heterocycles for drug delivery

Country Status (7)

Country Link
US (2) US9717797B2 (en)
EP (1) EP3076955A4 (en)
JP (1) JP6238263B2 (en)
CN (1) CN105792814B (en)
SG (1) SG11201604528WA (en)
TW (1) TWI607762B (en)
WO (1) WO2015083377A1 (en)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9469726B2 (en) * 2014-10-06 2016-10-18 International Business Machines Corporation Water soluble polycarbonates for medical applications
SG10201707897XA (en) * 2017-09-25 2019-04-29 Agency Science Tech & Res Nanoparticle
CN109054010B (en) * 2018-07-13 2022-08-16 沈阳信达泰康医药科技有限公司 Imidazole ring modified acid-sensitive polycarbonate material and preparation and application thereof
US11179475B2 (en) * 2018-11-28 2021-11-23 International Business Machines Corporation Biodegradable functional polycarbonate nanoparticle carries for delivering molecular cargo
CN112448027B (en) * 2019-09-03 2021-10-22 华南师范大学 Blended gel polymer electrolyte and preparation method and application thereof

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JPH02236817A (en) * 1989-03-09 1990-09-19 Konica Corp Magnetic recording medium
US5128351A (en) 1990-05-04 1992-07-07 American Cyanamid Company Bis-aryl amide and urea antagonists of platelet activating factor
US6323180B1 (en) 1998-08-10 2001-11-27 Boehringer Ingelheim (Canada) Ltd Hepatitis C inhibitor tri-peptides
GB0121214D0 (en) 2001-08-31 2001-10-24 Btg Int Ltd Synthetic method
CN1174019C (en) 2002-04-30 2004-11-03 武汉大学 Poly(2-substituent carbonyl-2-methyltrimethylene carbonate) and its prepn and use
AU2003247425B2 (en) 2002-05-22 2007-03-08 Amgen Inc. Amino-pyridine, -pyridine and pyridazine derivatives for use as vanilloid receptor ligands for the treatment of pain
US8124128B2 (en) 2005-11-08 2012-02-28 Industrial Technology Research Institute Amphiphilic block copolymers and nano particles comprising the same
US7531615B2 (en) * 2006-01-04 2009-05-12 Sabic Innovative Platics Ip B.V. Thermally stable polycarbonates, thermoplastic compositions thereof, and articles formed therefrom
JP2007293222A (en) 2006-03-31 2007-11-08 Fujifilm Corp Method for making lithographic printing plate and original plate of lithographic printing plate
JP2008088194A (en) 2006-09-29 2008-04-17 Yokohama Rubber Co Ltd:The Thermoplastic elastomeric composition
JP2009040709A (en) 2007-08-08 2009-02-26 Kyorin Pharmaceut Co Ltd 12-substituted mutilin derivative
CA2745302A1 (en) 2008-12-12 2010-06-17 University Of Massachusetts Zwitterionic polymers with therapeutic moieties
EP2389161A2 (en) * 2009-01-23 2011-11-30 Surmodics Pharmaceuticals, Inc. Controlled release systems from polymer blends
US8143369B2 (en) 2009-06-02 2012-03-27 International Business Machines Corporation Polymers bearing pendant pentafluorophenyl ester groups, and methods of synthesis and functionalization thereof
WO2010146029A2 (en) 2009-06-16 2010-12-23 Basf Se Fungicidal mixtures
WO2010146032A2 (en) 2009-06-16 2010-12-23 Basf Se Fungicidal mixtures
US8470891B2 (en) * 2009-12-23 2013-06-25 International Business Machines Corporation Biodegradable block polymers for drug delivery, and methods related thereto
US8207351B2 (en) * 2010-04-30 2012-06-26 International Business Machines Corporation Cyclic carbonyl compounds with pendant carbonate groups, preparations thereof, and polymers therefrom
KR101468306B1 (en) 2013-05-10 2014-12-22 경희대학교 산학협력단 An adhesive nanoparticle comprising catechol groups grafted onto the surface thereof and uses thereof

Also Published As

Publication number Publication date
EP3076955A1 (en) 2016-10-12
JP6238263B2 (en) 2017-11-29
TWI607762B (en) 2017-12-11
WO2015083377A1 (en) 2015-06-11
US9717797B2 (en) 2017-08-01
JP2016540054A (en) 2016-12-22
CN105792814A (en) 2016-07-20
EP3076955A4 (en) 2017-08-02
US20150157723A1 (en) 2015-06-11
US10610597B2 (en) 2020-04-07
US20170281662A1 (en) 2017-10-05
CN105792814B (en) 2019-07-12
TW201609147A (en) 2016-03-16

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