SG11201604351RA - Irreversibly inhibited cyp450 microsomes, and uses thereof in enzymatic phenotyping of metabolic pathways - Google Patents

Irreversibly inhibited cyp450 microsomes, and uses thereof in enzymatic phenotyping of metabolic pathways

Info

Publication number
SG11201604351RA
SG11201604351RA SG11201604351RA SG11201604351RA SG11201604351RA SG 11201604351R A SG11201604351R A SG 11201604351RA SG 11201604351R A SG11201604351R A SG 11201604351RA SG 11201604351R A SG11201604351R A SG 11201604351RA SG 11201604351R A SG11201604351R A SG 11201604351RA
Authority
SG
Singapore
Prior art keywords
phenotyping
enzymatic
metabolic pathways
irreversibly inhibited
cyp450
Prior art date
Application number
SG11201604351RA
Other languages
English (en)
Inventor
Fabrice Caradec
Yannick Parmentier
Corinne Pothier
Original Assignee
Servier Lab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Servier Lab filed Critical Servier Lab
Publication of SG11201604351RA publication Critical patent/SG11201604351RA/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/0004—Oxidoreductases (1.)
    • C12N9/0071—Oxidoreductases (1.) acting on paired donors with incorporation of molecular oxygen (1.14)
    • C12N9/0077—Oxidoreductases (1.) acting on paired donors with incorporation of molecular oxygen (1.14) with a reduced iron-sulfur protein as one donor (1.14.15)
    • C12N9/0081—Cholesterol monooxygenase (cytochrome P 450scc)(1.14.15.6)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/0004—Oxidoreductases (1.)
    • C12N9/0071—Oxidoreductases (1.) acting on paired donors with incorporation of molecular oxygen (1.14)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/0004—Oxidoreductases (1.)
    • C12N9/0071—Oxidoreductases (1.) acting on paired donors with incorporation of molecular oxygen (1.14)
    • C12N9/0073—Oxidoreductases (1.) acting on paired donors with incorporation of molecular oxygen (1.14) with NADH or NADPH as one donor, and incorporation of one atom of oxygen 1.14.13
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/26—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving oxidoreductase
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y114/00—Oxidoreductases acting on paired donors, with incorporation or reduction of molecular oxygen (1.14)
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/573—Immunoassay; Biospecific binding assay; Materials therefor for enzymes or isoenzymes
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/90—Enzymes; Proenzymes
    • G01N2333/902—Oxidoreductases (1.)
    • G01N2333/90209—Oxidoreductases (1.) acting on NADH or NADPH (1.6), e.g. those with a heme protein as acceptor (1.6.2) (general), Cytochrome-b5 reductase (1.6.2.2) or NADPH-cytochrome P450 reductase (1.6.2.4)
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/90—Enzymes; Proenzymes
    • G01N2333/902—Oxidoreductases (1.)
    • G01N2333/90245—Oxidoreductases (1.) acting on paired donors with incorporation of molecular oxygen (1.14)

Landscapes

  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Genetics & Genomics (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Biomedical Technology (AREA)
  • Immunology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Medicinal Chemistry (AREA)
  • Analytical Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Biophysics (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • Cell Biology (AREA)
  • Food Science & Technology (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
SG11201604351RA 2013-12-05 2014-12-05 Irreversibly inhibited cyp450 microsomes, and uses thereof in enzymatic phenotyping of metabolic pathways SG11201604351RA (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201361912186P 2013-12-05 2013-12-05
EP13306674.6A EP2881470A1 (fr) 2013-12-05 2013-12-05 Microsomes irreversiblement inhibés pour des CYP450 leurs utilisations dans le phénotypage enzymatique des voies métaboliques
PCT/EP2014/076748 WO2015082694A1 (fr) 2013-12-05 2014-12-05 Microsomes irreversiblement inhibes pour des cyp450 leurs utilisations dans le phenotypage enzymatique des voies metaboliques

Publications (1)

Publication Number Publication Date
SG11201604351RA true SG11201604351RA (en) 2016-07-28

Family

ID=49885102

Family Applications (2)

Application Number Title Priority Date Filing Date
SG11201604351RA SG11201604351RA (en) 2013-12-05 2014-12-05 Irreversibly inhibited cyp450 microsomes, and uses thereof in enzymatic phenotyping of metabolic pathways
SG10201804727VA SG10201804727VA (en) 2013-12-05 2014-12-05 Irreversibly inhibited cyp450 microsomes, and uses thereof in enzymatic phenotyping of metabolic pathways

Family Applications After (1)

Application Number Title Priority Date Filing Date
SG10201804727VA SG10201804727VA (en) 2013-12-05 2014-12-05 Irreversibly inhibited cyp450 microsomes, and uses thereof in enzymatic phenotyping of metabolic pathways

Country Status (12)

Country Link
US (3) US20150247179A1 (pl)
EP (2) EP2881470A1 (pl)
JP (1) JP6869721B2 (pl)
KR (1) KR102291645B1 (pl)
CN (1) CN105960465A (pl)
DK (1) DK3077527T3 (pl)
ES (1) ES2743949T3 (pl)
HU (1) HUE045974T2 (pl)
PL (1) PL3077527T3 (pl)
PT (1) PT3077527T (pl)
SG (2) SG11201604351RA (pl)
WO (1) WO2015082694A1 (pl)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN108562732B (zh) * 2018-04-25 2019-06-18 中国人民解放军军事科学院军事医学研究院 减压低氧环境下肝外药物代谢酶动态变化评价体系

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2408746C (en) * 2000-05-17 2010-09-21 Patrick L. Iversen Antisense phosporodiamidate morpholino oligonucleotide inhibition of cytochrome p450 to modulate drug pharmacokinetics
WO2006114275A1 (en) * 2005-04-26 2006-11-02 Istituto Di Ricerche Di Biologia Molecolare P Angeletti Spa Assay for cytochrome p450 1a2
JP6105594B2 (ja) * 2011-09-30 2017-03-29 エンドゥ ファーマシューティカルズ，インコーポレイティド 癌処置用ｃｙｐ１７阻害剤としてのイミダゾール誘導体

Also Published As

Publication number Publication date
JP6869721B2 (ja) 2021-05-12
ES2743949T3 (es) 2020-02-21
US20200239861A1 (en) 2020-07-30
WO2015082694A1 (fr) 2015-06-11
JP2017501693A (ja) 2017-01-19
US20150247179A1 (en) 2015-09-03
PT3077527T (pt) 2019-08-05
CN105960465A (zh) 2016-09-21
EP3077527A1 (fr) 2016-10-12
EP3077527B1 (fr) 2019-05-29
PL3077527T3 (pl) 2019-12-31
US20170067035A1 (en) 2017-03-09
KR20160090391A (ko) 2016-07-29
SG10201804727VA (en) 2018-07-30
HUE045974T2 (hu) 2020-02-28
DK3077527T3 (da) 2019-09-02
EP2881470A1 (fr) 2015-06-10
KR102291645B1 (ko) 2021-08-18

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