SG11201603383VA - Prostamide-containing intraocular implants and methods of use thereof - Google Patents

Prostamide-containing intraocular implants and methods of use thereof

Info

Publication number
SG11201603383VA
SG11201603383VA SG11201603383VA SG11201603383VA SG11201603383VA SG 11201603383V A SG11201603383V A SG 11201603383VA SG 11201603383V A SG11201603383V A SG 11201603383VA SG 11201603383V A SG11201603383V A SG 11201603383VA SG 11201603383V A SG11201603383V A SG 11201603383VA
Authority
SG
Singapore
Prior art keywords
prostamide
methods
intraocular implants
containing intraocular
implants
Prior art date
Application number
SG11201603383VA
Inventor
Alazar N Ghebremeskel
Michael R Robinson
Original Assignee
Allergan Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Allergan Inc filed Critical Allergan Inc
Publication of SG11201603383VA publication Critical patent/SG11201603383VA/en

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/14Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/557Eicosanoids, e.g. leukotrienes or prostaglandins
    • A61K31/5575Eicosanoids, e.g. leukotrienes or prostaglandins having a cyclopentane, e.g. prostaglandin E2, prostaglandin F2-alpha
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61FFILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02Prostheses implantable into the body
    • A61F2/14Eye parts, e.g. lenses, corneal implants; Implanting instruments specially adapted therefor; Artificial eyes
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61FFILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F9/00Methods or devices for treatment of the eyes; Devices for putting-in contact lenses; Devices to correct squinting; Apparatus to guide the blind; Protective devices for the eyes, carried on the body or in the hand
    • A61F9/0008Introducing ophthalmic products into the ocular cavity or retaining products therein
    • A61F9/0017Introducing ophthalmic products into the ocular cavity or retaining products therein implantable in, or in contact with, the eye, e.g. ocular inserts
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/16Amides, e.g. hydroxamic acids
    • A61K31/165Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/10Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/34Macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyesters, polyamino acids, polysiloxanes, polyphosphazines, copolymers of polyalkylene glycol or poloxamers
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/0012Galenical forms characterised by the site of application
    • A61K9/0048Eye, e.g. artificial tears
    • A61K9/0051Ocular inserts, ocular implants
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/14Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605Excipients; Inactive ingredients
    • A61K9/1629Organic macromolecular compounds
    • A61K9/1641Organic macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, poloxamers
    • A61K9/1647Polyesters, e.g. poly(lactide-co-glycolide)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00Drugs for disorders of the senses
    • A61P27/02Ophthalmic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00Drugs for disorders of the senses
    • A61P27/02Ophthalmic agents
    • A61P27/06Antiglaucoma agents or miotics
SG11201603383VA 2013-10-31 2014-10-31 Prostamide-containing intraocular implants and methods of use thereof SG11201603383VA (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201361898241P 2013-10-31 2013-10-31
PCT/US2014/063569 WO2015066548A1 (en) 2013-10-31 2014-10-31 Prostamide-containing intraocular implants and methods of use thereof

Publications (1)

Publication Number Publication Date
SG11201603383VA true SG11201603383VA (en) 2016-05-30

Family

ID=51982758

Family Applications (2)

Application Number Title Priority Date Filing Date
SG11201603383VA SG11201603383VA (en) 2013-10-31 2014-10-31 Prostamide-containing intraocular implants and methods of use thereof
SG10201800978UA SG10201800978UA (en) 2013-10-31 2014-10-31 Prostamide-containing intraocular implants and methods of use thereof

Family Applications After (1)

Application Number Title Priority Date Filing Date
SG10201800978UA SG10201800978UA (en) 2013-10-31 2014-10-31 Prostamide-containing intraocular implants and methods of use thereof

Country Status (29)

Country Link
US (6) US9492316B2 (en)
EP (4) EP3062775B1 (en)
JP (2) JP6482547B2 (en)
KR (1) KR102307281B1 (en)
CN (2) CN105682645B (en)
AU (3) AU2014342017B2 (en)
BR (1) BR112016009575B1 (en)
CA (1) CA2926515C (en)
CL (1) CL2016001041A1 (en)
CY (2) CY1119961T1 (en)
DK (2) DK3062775T3 (en)
ES (2) ES2805880T3 (en)
HK (1) HK1258014A1 (en)
HU (2) HUE050902T2 (en)
IL (2) IL244859B (en)
MX (2) MX2016005508A (en)
MY (1) MY177958A (en)
NO (1) NO3102476T3 (en)
PH (1) PH12016500767A1 (en)
PL (2) PL3351239T3 (en)
PT (2) PT3062775T (en)
RU (1) RU2650614C2 (en)
SA (1) SA516371022B1 (en)
SG (2) SG11201603383VA (en)
SI (2) SI3062775T1 (en)
TR (1) TR201802759T4 (en)
UA (1) UA119853C2 (en)
WO (1) WO2015066548A1 (en)
ZA (1) ZA201602556B (en)

Families Citing this family (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7431710B2 (en) 2002-04-08 2008-10-07 Glaukos Corporation Ocular implants with anchors and methods thereof
US8846073B2 (en) * 2006-12-19 2014-09-30 Allergan, Inc. Low temperature processes for making cyclic lipid implants for intraocular use
US10206813B2 (en) 2009-05-18 2019-02-19 Dose Medical Corporation Implants with controlled drug delivery features and methods of using same
US10245178B1 (en) 2011-06-07 2019-04-02 Glaukos Corporation Anterior chamber drug-eluting ocular implant
DK3062775T3 (en) * 2013-10-31 2018-03-12 Allergan Inc PROSTAMID-CONTAINING INTRAOCULAR IMPLANTS AND PROCEDURES FOR USE THEREOF
CN106132397A (en) * 2013-12-06 2016-11-16 恩维希亚治疗股份有限公司 For treating anterior chamber's implant of ocular disease
AU2015266850B2 (en) 2014-05-29 2019-12-05 Glaukos Corporation Implants with controlled drug delivery features and methods of using same
JP6827617B2 (en) 2015-03-06 2021-02-10 アエリー ファーマシューティカルズ インコーポレイテッド Medical graft delivery device
EP3324944A4 (en) 2015-07-23 2019-04-03 Aerie Pharmaceuticals, Inc. Intravitreal drug delivery systems for the treatment of ocular conditions
WO2017015675A1 (en) * 2015-07-23 2017-01-26 Envisia Therapeutics, Inc. Glaucoma treatment via intracameral ocular implants
US11925578B2 (en) 2015-09-02 2024-03-12 Glaukos Corporation Drug delivery implants with bi-directional delivery capacity
KR20180058758A (en) 2015-09-22 2018-06-01 그레이버그 비젼, 인크. Compounds and compositions for the treatment of ocular disorders
WO2017053885A1 (en) 2015-09-25 2017-03-30 Glaukos Corporation Punctal implants with controlled drug delivery features and methods of using same
AU2017252294B2 (en) 2016-04-20 2021-12-02 Dose Medical Corporation Bioresorbable ocular drug delivery device
WO2017210316A1 (en) 2016-05-31 2017-12-07 Qura, Inc. Implantable intraocular pressure sensors and methods of use
EP3506863A4 (en) * 2016-09-02 2020-04-29 Envisia Therapeutics Inc. Implant applicators
US20190192341A1 (en) * 2017-11-09 2019-06-27 Allergan, Inc. Sustained-Release Implants for Lowering Intraocular Pressure with Extended Duration of Effect
US20200069577A1 (en) * 2018-08-30 2020-03-05 Yunxiang Liu Ophthalmic formulations, process for preparing the same and method for administering the same
CN113301886A (en) * 2018-12-21 2021-08-24 瑞瓦纳治疗有限公司 Coated ocular implant
AU2020302924A1 (en) 2019-06-27 2022-02-17 Layerbio, Inc. Ocular device delivery methods and systems
FI3861985T3 (en) 2020-02-06 2023-08-07 Ocular Therapeutix Inc Compositions and methods for treating ocular diseases
CA3184833A1 (en) 2020-07-10 2022-01-13 Michael Robinson Posterior chamber delivery device for sustained release implant
MX2023000999A (en) * 2020-07-21 2023-03-01 Allergan Inc Intraocular implant with high loading of a prostamide.
CA3218251A1 (en) 2021-04-30 2022-11-03 Perfuse Therapeutics, Inc. Pharmaceutical compositions and intravitreal drug delivery systems for the treatment of ocular diseases

Family Cites Families (97)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3749776A (en) 1970-08-28 1973-07-31 Allergan Pharma Method for blocking prostaglandin activity
US6309669B1 (en) 1984-03-16 2001-10-30 The United States Of America As Represented By The Secretary Of The Army Therapeutic treatment and prevention of infections with a bioactive materials encapsulated within a biodegradable-biocompatible polymeric matrix
CA1311686C (en) 1986-06-25 1992-12-22 John Weldon Shell Controlled release bioerodible drug delivery system
US4997652A (en) 1987-12-22 1991-03-05 Visionex Biodegradable ocular implants
US4853224A (en) 1987-12-22 1989-08-01 Visionex Biodegradable ocular implants
CA2021316C (en) 1989-07-27 2000-10-24 Ming Fai Chan Intraocular pressure reducing 11-acyl prostaglandins
US5034413A (en) 1989-07-27 1991-07-23 Allergan, Inc. Intraocular pressure reducing 9,11-diacyl prostaglandins
US5028624A (en) 1989-07-27 1991-07-02 Allergan, Inc. Intraocular pressure reducing 9,15-diacyl prostaglandins
US4994274A (en) 1989-07-27 1991-02-19 Allergan, Inc. Intraocular pressure reducing 11,15-diacyl prostaglandins and method of using
US5164188A (en) 1989-11-22 1992-11-17 Visionex, Inc. Biodegradable ocular implants
US6602900B2 (en) 1992-09-21 2003-08-05 Allergan, Inc. Cyclopentane heptan(ENE)oic acid, 2-heteroarylalkenyl derivatives as therapeutic agents
US5834498A (en) 1992-09-21 1998-11-10 Allergan Cyclopentane heptan(ene)oic acid, 2-heteroarylalkenyl derivatives as therapeutic agents
US5972991A (en) 1992-09-21 1999-10-26 Allergan Cyclopentane heptan(ene) oic acid, 2-heteroarylalkenyl derivatives as therapeutic agents
US5688819A (en) 1992-09-21 1997-11-18 Allergan Cyclopentane heptanoic acid, 2-cycloalkyl or arylalkyl derivatives as therapeutic agents
MY113268A (en) 1992-12-29 2002-01-31 Insite Vision Incorporated Plasticized bioerodible controlled delivery system
US5994341A (en) 1993-07-19 1999-11-30 Angiogenesis Technologies, Inc. Anti-angiogenic Compositions and methods for the treatment of arthritis
US5443505A (en) 1993-11-15 1995-08-22 Oculex Pharmaceuticals, Inc. Biocompatible ocular implants
US6124344A (en) 1993-12-28 2000-09-26 Allergan Sales, Inc. Cyclopentane heptan(ene)oic acid, 2-heteroarylalkenyl derivatives as therapeutic agents
US5545665A (en) 1993-12-28 1996-08-13 Allergan Cyclopentane(ene) heptenoic or heptanoic acids and derivatives thereof useful as therapeutic agents
US5516522A (en) 1994-03-14 1996-05-14 Board Of Supervisors Of Louisiana State University Biodegradable porous device for long-term drug delivery with constant rate release and method of making the same
US6294563B1 (en) 1994-10-27 2001-09-25 Allergan Sales, Inc. Combinations of prostaglandins and brimonidine or derivatives thereof
US5585401A (en) 1994-12-09 1996-12-17 The Reents Of The University Of California Method for enhancing outflow of aqueous humor in treatment of glaucoma
US6369116B1 (en) 1995-06-02 2002-04-09 Oculex Pharmaceuticals, Inc. Composition and method for treating glaucoma
US5741810A (en) 1996-02-29 1998-04-21 Allergan Cyclopentane heptan(ene)oic acid, 2- heteroarylalkenyl derivatives as therapeutic agents
US6395787B1 (en) 2000-02-08 2002-05-28 Allergan Sales, Inc. Ocular hypotensive lipids
US7708711B2 (en) 2000-04-14 2010-05-04 Glaukos Corporation Ocular implant with therapeutic agents and methods thereof
US20040175410A1 (en) 2000-04-26 2004-09-09 Control Delivery Systems, Inc. Sustained release device and method for ocular delivery of carbonic anhydrase inhibitors
US6726918B1 (en) 2000-07-05 2004-04-27 Oculex Pharmaceuticals, Inc. Methods for treating inflammation-mediated conditions of the eye
PE20020146A1 (en) 2000-07-13 2002-03-31 Upjohn Co OPHTHALMIC FORMULATION INCLUDING A CYCLOOXYGENASE-2 (COX-2) INHIBITOR
EP1365811A2 (en) 2000-07-14 2003-12-03 Allergan, Inc. Compositions containing alpha-2-adrenergic agonist components
ES2250504T3 (en) 2000-11-29 2006-04-16 Allergan Inc. PREVENTION OF REJECTION OF GRAFT IN THE EYE.
JP2004536631A (en) 2001-05-03 2004-12-09 マサチューセッツ・アイ・アンド・イア・インファーマリー Implantable drug delivery device and use thereof
US20030220376A1 (en) 2001-08-10 2003-11-27 Pharmacia Corporation Methods for treating carbonic anhydrase mediated disorders
GB0122318D0 (en) 2001-09-14 2001-11-07 Novartis Ag Organic compounds
ATE546143T1 (en) 2002-08-29 2012-03-15 Santen Pharmaceutical Co Ltd AGENT FOR TREATING GLAUCOMA WITH A RHO-KINASE INHIBITOR AND PROSTAGLANDINS
US6899717B2 (en) 2002-09-18 2005-05-31 Allergan, Inc. Methods and apparatus for delivery of ocular implants
BR0315304A (en) 2002-11-06 2005-08-16 Alza Corp Depot formulations for controlled release
US20040137059A1 (en) * 2003-01-09 2004-07-15 Thierry Nivaggioli Biodegradable ocular implant
US20090148527A1 (en) 2007-12-07 2009-06-11 Robinson Michael R Intraocular formulation
US7169807B2 (en) 2004-04-09 2007-01-30 Allergan, Inc. 10-Hydroxy-11-dihydroprostaglandin analogs as selective EP4 agonists
US7589057B2 (en) 2004-04-30 2009-09-15 Allergan, Inc. Oil-in-water method for making alpha-2 agonist polymeric drug delivery systems
US20050244463A1 (en) 2004-04-30 2005-11-03 Allergan, Inc. Sustained release intraocular implants and methods for treating ocular vasculopathies
US8722097B2 (en) 2004-04-30 2014-05-13 Allergan, Inc. Oil-in-water method for making polymeric implants containing a hypotensive lipid
US20050244469A1 (en) 2004-04-30 2005-11-03 Allergan, Inc. Extended therapeutic effect ocular implant treatments
US20050244458A1 (en) 2004-04-30 2005-11-03 Allergan, Inc. Sustained release intraocular implants and methods for treating ocular neuropathies
US8147865B2 (en) 2004-04-30 2012-04-03 Allergan, Inc. Steroid-containing sustained release intraocular implants and related methods
US20070212395A1 (en) 2006-03-08 2007-09-13 Allergan, Inc. Ocular therapy using sirtuin-activating agents
US7993634B2 (en) 2004-04-30 2011-08-09 Allergan, Inc. Oil-in-oil emulsified polymeric implants containing a hypotensive lipid and related methods
US7799336B2 (en) 2004-04-30 2010-09-21 Allergan, Inc. Hypotensive lipid-containing biodegradable intraocular implants and related methods
US20230026451A1 (en) * 2004-04-30 2023-01-26 Allergan, Inc. Intraocular pressure reduction with intracameral bimatoprost implants
US8119154B2 (en) 2004-04-30 2012-02-21 Allergan, Inc. Sustained release intraocular implants and related methods
US20060182781A1 (en) 2004-04-30 2006-08-17 Allergan, Inc. Methods for treating ocular conditions with cyclic lipid contraining microparticles
US9498457B2 (en) * 2004-04-30 2016-11-22 Allergan, Inc. Hypotensive prostamide-containing biodegradable intraocular implants and related implants
US8685435B2 (en) 2004-04-30 2014-04-01 Allergan, Inc. Extended release biodegradable ocular implants
US8673341B2 (en) 2004-04-30 2014-03-18 Allergan, Inc. Intraocular pressure reduction with intracameral bimatoprost implants
US20050282902A1 (en) 2004-06-22 2005-12-22 Allergan, Inc. Abnormal cannabidiols as agents for lowering intraocular pressure
US7101904B2 (en) 2004-08-10 2006-09-05 Allergan, Inc. Cyclopentane heptan(ENE)OIC acid, 2-heteroarylalkenyl derivatives as therapeutic agents
US7473738B2 (en) * 2004-09-30 2009-01-06 Johnson & Johnson Vision Care, Inc. Lactam polymer derivatives
CA2582374A1 (en) 2004-10-04 2006-04-20 Qlt Usa, Inc. Ocular delivery of polymeric delivery formulations
CN101437478A (en) * 2004-10-04 2009-05-20 Qlt美国有限公司 Ocular delivery of polymeric delivery formulations
US7101906B2 (en) 2004-11-16 2006-09-05 Allergan, Inc. 2,3,4-substituted cyclopentanones as therapeutic agents
US7183324B2 (en) 2004-11-23 2007-02-27 Allergan, Inc. 2,3,4-substituted cyclopentanones as therapeutic agents
ATE465986T1 (en) 2005-01-14 2010-05-15 Allergan Inc SUBSTITUTED CYCLOPENTANES OR CYCLOPENTANONES FOR THE TREATMENT OF EYE HYPERTENSION
WO2006098918A2 (en) 2005-03-10 2006-09-21 Allergan, Inc. Substituted gamma lactams as therapeutic agents
EP1877050B1 (en) 2005-05-06 2011-07-06 Allergan, Inc. Substituted beta-lactams and their use in medicine
WO2007005176A1 (en) 2005-06-29 2007-01-11 Allergan, Inc. Pyrrolidinones for the treatment of glaucoma and ocular hypertension
DE102005033101A1 (en) * 2005-07-15 2007-01-25 Boehringer Ingelheim Pharma Gmbh & Co. Kg Resorbable polyether esters and their use for the manufacture of medical implants
JP5122460B2 (en) 2005-09-16 2013-01-16 アラーガン、インコーポレイテッド Compositions and methods for intraocular delivery of therapeutic agents
US20090082321A1 (en) 2007-09-21 2009-03-26 Allergan, Inc. Steroid containing drug delivery systems
EP1960353B1 (en) 2005-11-03 2014-03-12 Allergan, Inc. Prostaglandins and analogues as agents for lowering intraocular pressure
PE20080142A1 (en) 2006-03-15 2008-04-14 Boehringer Ingelheim Int ENANTHOMERICALLY PURE BETA-AGONISTS AND THEIR PREPARATION PROCEDURES
EP1996546B1 (en) 2006-03-20 2014-11-26 Allergan, Inc. Substituted gamma lactams as prostaglandin ep2 agonists
US7439372B2 (en) 2006-05-03 2008-10-21 Allergan, Inc. Therapeutic compounds
US7491844B2 (en) 2006-05-04 2009-02-17 Allergan, Inc. Therapeutic cyclopentane derivatives
US20070293873A1 (en) 2006-06-19 2007-12-20 Allergan, Inc. Apparatus and methods for implanting particulate ocular implants
US20070298073A1 (en) 2006-06-23 2007-12-27 Allergan, Inc. Steroid-containing sustained release intraocular implants and related methods
US8802128B2 (en) 2006-06-23 2014-08-12 Allergan, Inc. Steroid-containing sustained release intraocular implants and related methods
US20080097335A1 (en) 2006-08-04 2008-04-24 Allergan, Inc. Ocular implant delivery assemblies
US8969415B2 (en) 2006-12-01 2015-03-03 Allergan, Inc. Intraocular drug delivery systems
US8846073B2 (en) 2006-12-19 2014-09-30 Allergan, Inc. Low temperature processes for making cyclic lipid implants for intraocular use
US8231892B2 (en) 2007-05-24 2012-07-31 Allergan, Inc. Biodegradable drug delivery system
US20090081277A1 (en) 2007-09-21 2009-03-26 Allergan, Inc. Pharmaceutical formulations and methods for treating ocular conditions
US7740604B2 (en) 2007-09-24 2010-06-22 Ivantis, Inc. Ocular implants for placement in schlemm's canal
EP2296621A1 (en) 2008-05-20 2011-03-23 Yale University Biodegradable sustained-release polymeric microparticulates comprising a hydrophobic drug and determined for ophthalmic use
US20100098772A1 (en) 2008-10-21 2010-04-22 Allergan, Inc. Drug delivery systems and methods for treating neovascularization
US20100104654A1 (en) 2008-10-27 2010-04-29 Allergan, Inc. Prostaglandin and prostamide drug delivery systems and intraocular therapeutic uses thereof
US9095506B2 (en) 2008-11-17 2015-08-04 Allergan, Inc. Biodegradable alpha-2 agonist polymeric implants and therapeutic uses thereof
KR20110129869A (en) * 2009-01-23 2011-12-02 큐엘티 인코포레이티드 Sustained released delivery of one or more agents
US20100247606A1 (en) 2009-03-25 2010-09-30 Allergan, Inc. Intraocular sustained release drug delivery systems and methods for treating ocular conditions
WO2011075481A1 (en) 2009-12-16 2011-06-23 Allergan, Inc. Intracameral devices for sustained delivery
KR102126007B1 (en) * 2010-01-22 2020-06-24 알러간, 인코포레이티드 Intracameral sustained release therapeutic agent implants
US20130071349A1 (en) 2010-03-02 2013-03-21 Allergan, Inc. Biodegradable polymers for lowering intraocular pressure
MX2013012330A (en) 2011-04-22 2014-01-31 Allergan Inc Fatty acid amide hydrolase inhibitors for treating.
WO2012149278A1 (en) 2011-04-29 2012-11-01 Allergan, Inc. Sustained release latanoprost implant
DK3062775T3 (en) * 2013-10-31 2018-03-12 Allergan Inc PROSTAMID-CONTAINING INTRAOCULAR IMPLANTS AND PROCEDURES FOR USE THEREOF
US20190192341A1 (en) * 2017-11-09 2019-06-27 Allergan, Inc. Sustained-Release Implants for Lowering Intraocular Pressure with Extended Duration of Effect
MX2023000999A (en) * 2020-07-21 2023-03-01 Allergan Inc Intraocular implant with high loading of a prostamide.

Also Published As

Publication number Publication date
EP3351239A1 (en) 2018-07-25
CN110302138A (en) 2019-10-08
BR112016009575B1 (en) 2022-12-13
JP2019088881A (en) 2019-06-13
EP3062775A1 (en) 2016-09-07
TR201802759T4 (en) 2018-03-21
SI3351239T1 (en) 2020-09-30
EP3669865A1 (en) 2020-06-24
HUE050902T2 (en) 2021-01-28
KR20160077121A (en) 2016-07-01
US20210030766A1 (en) 2021-02-04
IL244859B (en) 2019-08-29
CA2926515A1 (en) 2015-05-07
SG10201800978UA (en) 2018-03-28
ES2661666T3 (en) 2018-04-03
CY1123077T1 (en) 2021-10-29
EP4046628A1 (en) 2022-08-24
IL268976B (en) 2021-04-29
CY1119961T1 (en) 2018-12-12
AU2020201778A1 (en) 2020-03-26
CA2926515C (en) 2020-11-24
PH12016500767B1 (en) 2016-06-20
PL3062775T3 (en) 2018-05-30
ES2805880T3 (en) 2021-02-15
RU2650614C2 (en) 2018-04-16
JP6482547B2 (en) 2019-03-13
AU2020201778B2 (en) 2021-11-04
JP6814829B2 (en) 2021-01-20
MX2016005508A (en) 2016-08-03
WO2015066548A1 (en) 2015-05-07
DK3062775T3 (en) 2018-03-12
US20220218721A1 (en) 2022-07-14
ZA201602556B (en) 2017-06-28
BR112016009575A2 (en) 2017-08-01
EP3062775B1 (en) 2017-12-06
US20150118279A1 (en) 2015-04-30
US20170056412A1 (en) 2017-03-02
US9492316B2 (en) 2016-11-15
DK3351239T3 (en) 2020-06-29
US20180271878A1 (en) 2018-09-27
UA119853C2 (en) 2019-08-27
AU2014342017A1 (en) 2016-06-02
SI3062775T1 (en) 2018-05-31
HUE036554T2 (en) 2018-07-30
HK1258014A1 (en) 2019-11-01
PT3351239T (en) 2020-07-03
CL2016001041A1 (en) 2016-10-28
MX2020002381A (en) 2020-07-22
CN110302138B (en) 2022-09-30
US9980974B2 (en) 2018-05-29
KR102307281B1 (en) 2021-09-29
SA516371022B1 (en) 2018-03-04
PL3351239T3 (en) 2020-12-28
CN105682645B (en) 2019-09-06
IL244859A0 (en) 2016-05-31
PT3062775T (en) 2018-03-06
JP2017500282A (en) 2017-01-05
AU2014342017B2 (en) 2020-01-23
PH12016500767A1 (en) 2016-06-20
IL268976A (en) 2019-10-31
MY177958A (en) 2020-09-28
NZ718992A (en) 2021-11-26
US20240108635A1 (en) 2024-04-04
EP3351239B1 (en) 2020-04-01
RU2016116378A (en) 2017-12-01
NO3102476T3 (en) 2018-05-26
AU2022200742A1 (en) 2022-02-24
CN105682645A (en) 2016-06-15

Similar Documents

Publication Publication Date Title
IL268976B (en) Prostamide-containing intraocular implants and methods of use thereof
EP2967683A4 (en) Adaptable interbody implant and methods of use
IL290547A (en) Antibodies and methods of use
GB2535360B (en) Methods of preparing polyhemiaminals and polyhexahydrotriazines
HK1217428A1 (en) Substituted benzoxazoles and methods of use thereof
IL244495B (en) Anti-alpha-synuclein antibodies and methods of use
EP2964115A4 (en) Bone fastener and methods of use
EP2895123A4 (en) Expanding ocular implant devices and methods
EP2964651A4 (en) Bmp inhibitors and methods of use thereof
GB201320723D0 (en) Composition and methods of treatment
EP2970311A4 (en) Bmp inhibitors and methods of use thereof
HK1217452A1 (en) Prostamide-containing intraocular implant
EP2999474A4 (en) Therapeutic and method of use
HK1225612A1 (en) Anti-ly6e antibodies and methods of use
HK1216833A1 (en) Tissue expanders, implants, and methods of use
EP3027147A4 (en) Artificial disc devices and related methods of use
IL273459B (en) Injectable alloplastic implants and methods of use thereof
GB201421052D0 (en) Artificial tissue
GB201306975D0 (en) Stents and methods of manufacture