SG11201603299PA - Personalized immunotherapy against several neuronal and brain tumors - Google Patents

Personalized immunotherapy against several neuronal and brain tumors

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Publication number
SG11201603299PA
SG11201603299PA SG11201603299PA SG11201603299PA SG11201603299PA SG 11201603299P A SG11201603299P A SG 11201603299PA SG 11201603299P A SG11201603299P A SG 11201603299PA SG 11201603299P A SG11201603299P A SG 11201603299PA SG 11201603299P A SG11201603299P A SG 11201603299PA
Authority
SG
Singapore
Prior art keywords
brain tumors
against several
immunotherapy against
personalized immunotherapy
several neuronal
Prior art date
Application number
SG11201603299PA
Inventor
Toni Weinschenk
Jens Fritsche
Steffen Walter
Norbert Hilf
Oliver Schorr
Harpreet Singh
Sabrina Kuttruff-Coqui
Colette Song
Original Assignee
Immatics Biotechnologies Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Immatics Biotechnologies Gmbh filed Critical Immatics Biotechnologies Gmbh
Publication of SG11201603299PA publication Critical patent/SG11201603299PA/en

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Families Citing this family (77)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US10704021B2 (en) 2012-03-15 2020-07-07 Flodesign Sonics, Inc. Acoustic perfusion devices
TWI777198B (en) * 2013-08-05 2022-09-11 德商伊瑪提克斯生物科技有限公司 Novel peptides, cells, and their use against several tumors, methods for production thereof and pharmaceutical composition comprising the same
MX2019013161A (en) * 2013-11-04 2020-02-03 Immatics Biotechnologies Gmbh Personalized immunotherapy against several neuronal and brain tumors.
US9725710B2 (en) 2014-01-08 2017-08-08 Flodesign Sonics, Inc. Acoustophoresis device with dual acoustophoretic chamber
US10000533B2 (en) * 2014-06-20 2018-06-19 Immatics Biotechnologies Gmbh Immunotherapy against several tumors of the blood, in particular chronic lymphoid leukemia (CLL)
WO2016174085A1 (en) * 2015-04-27 2016-11-03 Cancer Research Technology Limited Method for treating cancer
US11377651B2 (en) 2016-10-19 2022-07-05 Flodesign Sonics, Inc. Cell therapy processes utilizing acoustophoresis
US11708572B2 (en) 2015-04-29 2023-07-25 Flodesign Sonics, Inc. Acoustic cell separation techniques and processes
GB201507719D0 (en) 2015-05-06 2015-06-17 Immatics Biotechnologies Gmbh Novel peptides and combination of peptides and scaffolds thereof for use in immunotherapy against colorectal carcinoma (CRC) and other cancers
PE20180253A1 (en) * 2015-06-19 2018-02-02 Immatics Biotechnologies Gmbh NEW PEPTIDES AND NEW COMBINATIONS OF PEPTIDES FOR USE IN IMMUNOTHERAPY AND METHODS TO CREATE SUPPORTS FOR USE AGAINST PANCREAS CANCER AND OTHER TYPES OF CANCER
MY189596A (en) * 2015-07-15 2022-02-18 Immatics Biotechnologies Gmbh A novel peptides for use in immunotherapy against epithelial ovarian cancer and other cancers
CN105092859B (en) * 2015-08-04 2016-09-14 中国农业大学 NET49 albumen is as diabetes biomarker and the application of therapy target
GB201513921D0 (en) 2015-08-05 2015-09-23 Immatics Biotechnologies Gmbh Novel peptides and combination of peptides for use in immunotherapy against prostate cancer and other cancers
GB201516047D0 (en) 2015-09-10 2015-10-28 Cancer Rec Tech Ltd Method
GB201520567D0 (en) * 2015-11-23 2016-01-06 Immunocore Ltd & Adaptimmune Ltd Peptides
GB201520550D0 (en) 2015-11-23 2016-01-06 Immunocore Ltd & Adaptimmune Ltd Peptides
GB201520568D0 (en) 2015-11-23 2016-01-06 Immunocore Ltd Peptides
WO2017095632A1 (en) 2015-11-30 2017-06-08 Mayo Foundation For Medical Education And Research Heatr1 as a marker for chemoresistance
GB201521746D0 (en) 2015-12-10 2016-01-27 Immatics Biotechnologies Gmbh Novel peptides and combination of peptides for use in immunotherapy against CLL and other cancers
GB201521894D0 (en) 2015-12-11 2016-01-27 Immatics Biotechnologies Gmbh Novel peptides and combination of peptides for use in immunotherapy against various cancers
US10383896B2 (en) 2015-12-11 2019-08-20 Immatics Biotechnologies Gmbh Peptides and combination of peptides for use in immunotherapy against various cancers
MY196837A (en) 2015-12-11 2023-05-03 Immatics Biotechnologies Gmbh Novel peptides and combination of peptides for use in immunotherapy against various cancers
SG11201804957VA (en) 2015-12-16 2018-07-30 Gritstone Oncology Inc Neoantigen identification, manufacture, and use
GB201522667D0 (en) 2015-12-22 2016-02-03 Immatics Biotechnologies Gmbh Novel peptides and combination of peptides for use in immunotherapy against breast cancer and other cancers
SG10202111399YA (en) 2015-12-22 2021-11-29 Immatics Biotechnologies Gmbh Peptides and combination of peptides for use in immunotherapy against breast cancer and other cancers
GB201603568D0 (en) * 2016-03-01 2016-04-13 Immatics Biotechnologies Gmbh Efficient treatment options including peptides and combination of peptide and cell based medicaments for use in immunotherapy against urinary bladder cancer
GB201604494D0 (en) * 2016-03-16 2016-04-27 Immatics Biotechnologies Gmbh Transfected T-Cells and T-Cell receptors for use in immunotherapy against cancers
MY193474A (en) * 2016-03-16 2022-10-15 Immatics Biotechnologies Gmbh Transfected t-cells and t-cell receptors for use in immunotherapy against cancers
GB201604458D0 (en) * 2016-03-16 2016-04-27 Immatics Biotechnologies Gmbh Peptides and combination of peptides for use in immunotherapy against cancers
GB201604490D0 (en) 2016-03-16 2016-04-27 Immatics Biotechnologies Gmbh Peptides combination of peptides for use in immunotherapy against cancers
US11214789B2 (en) 2016-05-03 2022-01-04 Flodesign Sonics, Inc. Concentration and washing of particles with acoustics
GB201609193D0 (en) * 2016-05-25 2016-07-06 Immatics Biotechnologies Gmbh Novel peptides, combination of peptides as targets for use in immunotherapy against gallbladder cancer and cholangiocarcinoma and other cancers
JP7075125B2 (en) 2016-05-25 2022-05-25 イマティクス バイオテクノロジーズ ゲーエムベーハー A novel peptide, peptide combination as a target and for use in immunotherapy for gallbladder cancer and cholangiocarcinoma and other cancers
TWI796299B (en) * 2016-08-26 2023-03-21 德商英麥提克生物技術股份有限公司 Novel peptides and scaffolds for use in immunotherapy against head and neck squamous cell carcinoma and other cancers
AU2017363308B2 (en) * 2016-11-23 2024-08-08 Gritstone Bio, Inc. Viral delivery of neoantigens
KR102639592B1 (en) 2016-12-08 2024-02-21 이매틱스 바이오테크놀로지스 게엠베하 T cell receptors with improved pairing
DE102016123893A1 (en) 2016-12-08 2018-06-14 Immatics Biotechnologies Gmbh T cell receptors with improved binding
TWI796314B (en) * 2017-01-27 2023-03-21 德商英麥提克生物技術股份有限公司 Novel peptides and combination of peptides for use in immunotherapy against ovarian cancer and other cancers
NZ754139A (en) 2017-01-27 2022-07-01 Immatics Biotechnologies Gmbh Novel peptides and combination of peptides for use in immunotherapy against ovarian cancer and other cancers
EA201991444A1 (en) 2017-01-27 2019-12-30 Имматикс Байотекнолоджиз Гмбх NEW PEPTIDES AND PEPTID COMBINATIONS FOR APPLICATION IN THE IMMUNOTHERAPY OF OVARIAN CANCER AND OTHER TYPES OF CANCER
SG11201906969PA (en) 2017-02-01 2019-08-27 Modernatx Inc Immunomodulatory therapeutic mrna compositions encoding activating oncogene mutation peptides
BR112019021094A2 (en) 2017-04-10 2020-05-12 Immatics Biotechnologies Gmbh PEPTIDES AND COMBINATIONS OF THE SAME FOR USE IN IMMUNOTHERAPY AGAINST LEUKEMIA AND OTHER CANCERS
SG11201909153UA (en) * 2017-04-10 2019-10-30 Immatics Biotechnologies Gmbh Peptides and combination thereof for use in the immunotherapy against cancers
WO2018189148A1 (en) 2017-04-10 2018-10-18 Immatics Biotechnologies Gmbh Peptides and combination thereof for use in the immunotherapy against cancers
US10899819B2 (en) 2017-04-10 2021-01-26 Immatics Biotechnologies Gmbh Peptides and combination of peptides for use in immunotherapy against leukemias and other cancers
BR112019023477A2 (en) 2017-05-08 2020-06-30 Gritstone Oncology, Inc. alphavirus neoantigen vectors
WO2018212237A1 (en) * 2017-05-16 2018-11-22 学校法人 久留米大学 Method for determining eligibility of brain tumor patient for tailor-made type peptide vaccine agent
WO2019007974A1 (en) 2017-07-07 2019-01-10 Immatics Biotechnologies Gmbh Novel peptides and combination of peptides for use in immunotherapy against lung cancer, including nsclc, sclc and other cancers
BR112019028070A2 (en) 2017-07-07 2020-07-14 Immatics Biotechnologies Gmbh peptides and combinations of peptides for use in immunotherapy against lung cancer, including cpcnp, cppc and other cancers
JP7227237B2 (en) 2017-10-10 2023-02-21 グリットストーン バイオ インコーポレイテッド Identification of neoantigens using hotspots
CN111630602A (en) 2017-11-22 2020-09-04 磨石肿瘤生物技术公司 Reducing presentation of conjugated epitopes by neoantigens
KR102439221B1 (en) 2017-12-14 2022-09-01 프로디자인 소닉스, 인크. Acoustic transducer actuators and controllers
KR20200118029A (en) 2018-01-04 2020-10-14 아이코닉 테라퓨틱스, 인코포레이티드 Anti-tissue factor antibodies, antibody-drug conjugates, and related methods
DE102018107224A1 (en) 2018-02-21 2019-08-22 Immatics Biotechnologies Gmbh Peptides and combinations of peptides of non-canonical origin for use in immunotherapy against various cancers
CN108623661B (en) * 2018-05-14 2021-04-27 中国医学科学院肿瘤医院 Bispecific polypeptide molecular probe targeting pancreatic cancer tumor cells and application thereof
TW202016131A (en) 2018-05-16 2020-05-01 德商英麥提克生物技術股份有限公司 Peptides for use in immunotherapy against cancers
DE102018115865A1 (en) * 2018-06-29 2020-02-20 Immatics Biotechnologies Gmbh A * 03 restricted peptides for use in cancer immunotherapy and related methods
US10925947B2 (en) 2018-06-29 2021-02-23 Immatics Biotechnologies Gmbh A*03 restricted peptides for use in immunotherapy against cancers and related methods
US11945850B2 (en) 2018-09-17 2024-04-02 Immatics Biotechnologies Gmbh B*44 restricted peptides for use in immunotherapy against cancers and related methods
TW202024121A (en) 2018-09-18 2020-07-01 德商英麥提克生物技術股份有限公司 Immunotherapy with a*01 restricted peptides and combination of peptides against cancers and related methods
TW202039535A (en) 2018-12-18 2020-11-01 德商英麥提克生物技術股份有限公司 Immunotherapy with b*08 restricted peptides and combination of peptides against cancers and related methods
CN109706065A (en) * 2018-12-29 2019-05-03 深圳裕策生物科技有限公司 Tumor neogenetic antigen load detection device and storage medium
CN109750040B (en) * 2019-03-05 2023-05-12 上海市第七人民医院 Application of HEATR1 gene or protein inhibitor in preparation of antitumor drugs
MX2021014525A (en) 2019-05-30 2022-03-17 Gritstone Bio Inc Modified adenoviruses.
US12036204B2 (en) 2019-07-26 2024-07-16 Eisai R&D Management Co., Ltd. Pharmaceutical composition for treating tumor
WO2021138209A1 (en) * 2020-01-02 2021-07-08 The Regents Of The University Of California Methods for culturing cancer cells and for inhibiting invasion of cancer
GR1010022B (en) * 2020-03-17 2021-06-01 Πανεπιστημιο Πατρων Methods for determining prognosis of a subject with lung adenocarcinoma and responsiveness to treatment
KR20230046313A (en) 2020-08-06 2023-04-05 그릿스톤 바이오, 인코포레이티드 Multi-epitope vaccine cassette
CN112053785A (en) * 2020-09-02 2020-12-08 北京小白世纪网络科技有限公司 Coronary heart disease diagnosis method and system based on coronary heart disease diagnosis neural network model
US20230349920A1 (en) * 2020-09-04 2023-11-02 Meso Scale Technologies, Llc. Methods for isolating central nervous system surface marker displaying agents
CN112946279A (en) * 2021-03-17 2021-06-11 扬州大学 Method for detecting serum biomarkers of cervical cancer patient by using sandwich SERS (surface enhanced Raman scattering) immunosensor based on oil-water interface self-assembly
CN114022472B (en) * 2021-11-17 2022-05-20 深圳裕策生物科技有限公司 Tumor infiltrating lymphocyte analysis method, device and storage medium
CN114231494B (en) * 2021-11-29 2023-09-05 中国科学院动物研究所 Application and method of USP10 gene and/or Ascl1 gene in inducing fibroblast to transdifferentiate into neuron cell
CN114146180B (en) * 2021-12-22 2022-12-23 首都医科大学附属北京地坛医院 Application of substance inhibiting CHCHCHD 2 activity in preparation of product for treating NASH and hepatic fibrosis caused by liver injury
US20230377140A1 (en) * 2022-02-01 2023-11-23 4D Path Inc. Systems and Methods for Image-Based Disease Characterization
WO2023213904A1 (en) * 2022-05-04 2023-11-09 Deutsches Krebsforschungszentrum Stiftung des öffentlichen Rechts T cell receptor derived binding polypeptides
EP4382121A1 (en) 2022-12-07 2024-06-12 Altevax Vaccines against ptprz1-positive tumors

Family Cites Families (58)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2000E (en) 1901-04-20 1903-11-24 Albert Lagarde Folding iron frame for transporting fruit and early vegetables in wagons
US3119139A (en) 1961-02-06 1964-01-28 Taylor Mfg Bottle case inverter
DE2148469A1 (en) 1971-09-28 1973-04-05 Ullrich G Messwerkzeug Kg SPIRIT LEVEL WITH AN ANGLE ADJUSTABLE LEVEL
US4440859A (en) 1977-05-27 1984-04-03 The Regents Of The University Of California Method for producing recombinant bacterial plasmids containing the coding sequences of higher organisms
US4704362A (en) 1977-11-08 1987-11-03 Genentech, Inc. Recombinant cloning vehicle microbial polypeptide expression
DD147855A5 (en) 1978-12-22 1981-04-22 Biogen Nv METHOD OF GENERATING AT LEAST ONE HBV ANTIGEN IMPACT POLYPEPTIDE
US4530901A (en) 1980-01-08 1985-07-23 Biogen N.V. Recombinant DNA molecules and their use in producing human interferon-like polypeptides
US4342566A (en) 1980-02-22 1982-08-03 Scripps Clinic & Research Foundation Solid phase anti-C3 assay for detection of immune complexes
US4678751A (en) 1981-09-25 1987-07-07 Genentech, Inc. Hybrid human leukocyte interferons
US4766075A (en) 1982-07-14 1988-08-23 Genentech, Inc. Human tissue plasminogen activator
US4582800A (en) 1982-07-12 1986-04-15 Hoffmann-La Roche Inc. Novel vectors and method for controlling interferon expression
US4816567A (en) 1983-04-08 1989-03-28 Genentech, Inc. Recombinant immunoglobin preparations
US4757006A (en) 1983-10-28 1988-07-12 Genetics Institute, Inc. Human factor VIII:C gene and recombinant methods for production
US4677063A (en) 1985-05-02 1987-06-30 Cetus Corporation Human tumor necrosis factor
US4810648A (en) 1986-01-08 1989-03-07 Rhone Poulenc Agrochimie Haloarylnitrile degrading gene, its use, and cells containing the gene
US4897445A (en) 1986-06-27 1990-01-30 The Administrators Of The Tulane Educational Fund Method for synthesizing a peptide containing a non-peptide bond
US6193969B1 (en) 1993-06-03 2001-02-27 Protherics Inc. Antibody fragments in therapy
AUPM322393A0 (en) 1993-12-24 1994-01-27 Austin Research Institute, The Mucin carbohydrate compounds and their use in immunotherapy
WO1997026328A1 (en) 1996-01-17 1997-07-24 Imperial College Innovations Limited Immunotherapy using cytotoxic t lymphocytes (ctl)
US5849589A (en) 1996-03-11 1998-12-15 Duke University Culturing monocytes with IL-4, TNF-α and GM-CSF TO induce differentiation to dendric cells
US6406705B1 (en) 1997-03-10 2002-06-18 University Of Iowa Research Foundation Use of nucleic acids containing unmethylated CpG dinucleotide as an adjuvant
US6514935B1 (en) 1997-03-14 2003-02-04 President And Fellows Of Harvard Methods of treating hypertension
US7030235B1 (en) * 1998-09-29 2006-04-18 The Brigham & Women's Hospital, Inc. Compositions to detect lesions associated with hearing loss in the cochlear gene, COCH5B2
AU2001233114A1 (en) * 2000-02-04 2001-08-14 Aeomica, Inc. Methods and apparatus for predicting, confirming, and displaying functional information derived from genomic sequence
US20040191260A1 (en) 2003-03-26 2004-09-30 Technion Research & Development Foundation Ltd. Compositions capable of specifically binding particular human antigen presenting molecule/pathogen-derived antigen complexes and uses thereof
EP1294748B1 (en) 2000-03-27 2010-06-30 Technion Research and Development of Foundation, Ltd. Single chain class i major histo-compatibility complexes, constructs encoding same and methods of generating same
JP4439808B2 (en) 2000-06-05 2010-03-24 アルター・バイオサイエンス・コーポレーション T cell receptor fusions and conjugates and methods for their use
GB0017512D0 (en) 2000-07-17 2000-08-30 Smithkline Beecham Biolog Novel compounds
CA2439630A1 (en) * 2001-03-23 2002-10-03 Agy Therapeutics Use of biomolecular targets in the treatment and visualization of brain tumors
US7803915B2 (en) * 2001-06-20 2010-09-28 Genentech, Inc. Antibody compositions for the diagnosis and treatment of tumor
KR100628425B1 (en) * 2001-06-20 2006-09-28 제넨테크, 인크. Compositions and Methods for the Diagnosis and Treatment of Tumor
CA2457819A1 (en) * 2001-08-14 2003-02-27 The General Hospital Corporation Nucleic acid and amino acid sequences involved in pain
US6992176B2 (en) 2002-02-13 2006-01-31 Technion Research & Development Foundation Ltd. Antibody having a T-cell receptor-like specificity, yet higher affinity, and the use of same in the detection and treatment of cancer, viral infection and autoimmune disease
CA2476625A1 (en) 2002-02-20 2003-08-28 Dyax Corp. Mhc-peptide complex binding ligands
AU2003271904B2 (en) 2002-10-09 2009-03-05 Adaptimmune Limited Single chain recombinant T cell receptors
JP4975324B2 (en) 2002-11-09 2012-07-11 イムノコア リミテッド T cell receptor display
GB0304068D0 (en) 2003-02-22 2003-03-26 Avidex Ltd Substances
JP2005245430A (en) * 2003-08-25 2005-09-15 Medeinetto:Kk Method for inducing ctl
WO2006034334A2 (en) 2004-09-21 2006-03-30 University Of Pittsburgh Of The Commonwealth System Of Higher Education Peptide analogs capable of enhancing stimulation of a glioma-specific ctl response
WO2006091734A2 (en) * 2005-02-24 2006-08-31 Cemines, Inc. Compositions and methods for classifying biological samples
ES2341295T3 (en) 2005-09-05 2010-06-17 Immatics Biotechnologies Gmbh PEPTIDES ASSOCIATED WITH UNITED TUMORS PROMISCUALLY TO MOLECULES OF THE HUMAN LEUKOCYTE ANTIGEN (HLA) CLASS II.
DE602006015365D1 (en) 2006-05-09 2010-08-19 Comacchio Internat S A DRILLING MACHINE WITH CAROUSEL DRILLING AND MANTLE TUBE
ES2553270T3 (en) * 2007-07-27 2015-12-07 Immatics Biotechnologies Gmbh New immunogenic epitope for immunotherapy
CN103911358B (en) 2007-07-27 2017-03-01 伊玛提克斯生物技术有限公司 The novel immune therapy of neuron and the cerebral tumor
CN101648012A (en) * 2008-04-24 2010-02-17 伊玛提克斯生物技术有限公司 Novel formulations of tumour-associated peptides binding to human leukocyte antigen (hla) class i or ii molecules for vaccines
DE602008000891D1 (en) 2008-04-30 2010-05-12 Immatics Biotechnologies Gmbh Novel formulations of tumor-associated peptides which bind to human leukocyte antigens of class I or II for vaccination
RS53872B2 (en) 2008-05-14 2018-06-29 Immatics Biotechnologies Gmbh Novel and powerful mhc-class ii peptides derived from survivin and neurocan
DK2172211T3 (en) 2008-10-01 2015-02-16 Immatics Biotechnologies Gmbh Composition of tumor-associated peptides and related anti-cancer vaccine for the treatment of glioblastoma (GBM) and other cancers
EP2494351B1 (en) * 2009-10-26 2016-06-08 Externautics S.p.A. Colon and rectal tumor markers and methods of use thereof
EP2493916B1 (en) * 2009-10-26 2016-06-08 Externautics S.p.A. Lung tumor markers and methods of use thereof
GB201006360D0 (en) * 2010-04-16 2010-06-02 Immatics Biotechnologies Gmbh Method for differentially quantifying naturally processed HLA-restricted peptides for cancer, autoimmune and infectious diseases immunotherapy development
US20130310266A1 (en) * 2010-09-03 2013-11-21 Immport Therapeutics, Inc. Methods and Compositions For The Diagnosis And Treatment Of Cancer and Autoimmune Disorders
EP2632955A1 (en) 2010-10-26 2013-09-04 Technion Research & Development Foundation Ltd. Antibodies which bind soluble t-cell receptor ligands
US9103183B2 (en) 2011-08-03 2015-08-11 Vetco Gray Inc. Method and apparatus for launching multiple balls in a well
WO2013057586A1 (en) 2011-10-19 2013-04-25 Oslo Universitetssykehus Hf Compositions and methods for producing soluble t - cell receptors
US20140273091A1 (en) * 2011-11-10 2014-09-18 Rutgers, The State University Of New Jersey Transcript optimized expression enhancement for high-level production of proteins and protein domains
CN106661126B (en) * 2014-05-28 2021-12-10 诺诺公司 Chloride salt of TAT-NR2B9c
DE102016123893A1 (en) 2016-12-08 2018-06-14 Immatics Biotechnologies Gmbh T cell receptors with improved binding

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