SG11201510635PA - Treatment of papulopustular rosacea with ivermectin - Google Patents

Treatment of papulopustular rosacea with ivermectin

Info

Publication number
SG11201510635PA
SG11201510635PA SG11201510635PA SG11201510635PA SG11201510635PA SG 11201510635P A SG11201510635P A SG 11201510635PA SG 11201510635P A SG11201510635P A SG 11201510635PA SG 11201510635P A SG11201510635P A SG 11201510635PA SG 11201510635P A SG11201510635P A SG 11201510635PA
Authority
SG
Singapore
Prior art keywords
ivermectin
treatment
papulopustular rosacea
papulopustular
rosacea
Prior art date
Application number
SG11201510635PA
Inventor
Jean Jacovella
Jean-Paul Chappuis
Alexandre Kaoukhov
Michael Graeber
Laurence Salin
Michel Poncet
Philippe Briantais
Original Assignee
Galderma Sa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=52133217&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=SG11201510635P(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Galderma Sa filed Critical Galderma Sa
Publication of SG11201510635PA publication Critical patent/SG11201510635PA/en

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/41641,3-Diazoles
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61JCONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J9/00Feeding-bottles in general
    • A61J9/06Holders for bottles
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/41641,3-Diazoles
    • A61K31/4174Arylalkylimidazoles, e.g. oxymetazolin, naphazoline, miconazole
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/70Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7048Compounds having saccharide radicals and heterocyclic rings having oxygen as a ring hetero atom, e.g. leucoglucosan, hesperidin, erythromycin, nystatin, digitoxin or digoxin
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/02Inorganic compounds
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/10Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/12Carboxylic acids; Salts or anhydrides thereof
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/14Esters of carboxylic acids, e.g. fatty acid monoglycerides, medium-chain triglycerides, parabens or PEG fatty acid esters
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/16Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing nitrogen, e.g. nitro-, nitroso-, azo-compounds, nitriles, cyanates
    • A61K47/18Amines; Amides; Ureas; Quaternary ammonium compounds; Amino acids; Oligopeptides having up to five amino acids
    • A61K47/183Amino acids, e.g. glycine, EDTA or aspartame
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/26Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/32Macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. carbomers, poly(meth)acrylates, or polyvinyl pyrrolidone
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/0012Galenical forms characterised by the site of application
    • A61K9/0014Skin, i.e. galenical aspects of topical compositions
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/06Ointments; Bases therefor; Other semi-solid forms, e.g. creams, sticks, gels
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00Drugs for dermatological disorders
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00Antiparasitic agents
    • A61P33/14Ectoparasiticides, e.g. scabicides
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2300/00Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/24Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing atoms other than carbon, hydrogen, oxygen, halogen, nitrogen or sulfur, e.g. cyclomethicone or phospholipids

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Molecular Biology (AREA)
  • Dermatology (AREA)
  • Inorganic Chemistry (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
SG11201510635PA 2013-07-08 2014-07-08 Treatment of papulopustular rosacea with ivermectin SG11201510635PA (en)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201361843540P 2013-07-08 2013-07-08
US201361919208P 2013-12-20 2013-12-20
US201461927717P 2014-01-15 2014-01-15
US14/209,958 US9233118B2 (en) 2013-07-08 2014-03-13 Treatment of papulopustular rosacea with ivermectin
PCT/US2014/045739 WO2015006319A1 (en) 2013-07-08 2014-07-08 Treatment of papulopustular rosacea with ivermectin

Publications (1)

Publication Number Publication Date
SG11201510635PA true SG11201510635PA (en) 2016-01-28

Family

ID=52133217

Family Applications (2)

Application Number Title Priority Date Filing Date
SG11201510635PA SG11201510635PA (en) 2013-07-08 2014-07-08 Treatment of papulopustular rosacea with ivermectin
SG11201510420UA SG11201510420UA (en) 2013-07-08 2014-07-08 Treatment of inflammatory lesions of rosacea with ivermectin

Family Applications After (1)

Application Number Title Priority Date Filing Date
SG11201510420UA SG11201510420UA (en) 2013-07-08 2014-07-08 Treatment of inflammatory lesions of rosacea with ivermectin

Country Status (17)

Country Link
US (12) US9233118B2 (en)
EP (2) EP3019174A1 (en)
JP (7) JP6438466B2 (en)
KR (2) KR101864799B1 (en)
CN (4) CN111494399A (en)
AU (2) AU2014287422B2 (en)
BR (2) BR112016000350A8 (en)
CA (2) CA2916704C (en)
CL (2) CL2016000008A1 (en)
HK (2) HK1223842A1 (en)
IL (3) IL243315B (en)
MX (2) MX2016000122A (en)
NZ (2) NZ716033A (en)
RU (2) RU2633076C2 (en)
SG (2) SG11201510635PA (en)
WO (2) WO2015006305A1 (en)
ZA (1) ZA201600358B (en)

Families Citing this family (13)

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Publication number Priority date Publication date Assignee Title
RU2669942C1 (en) 2013-11-29 2018-10-17 Галдерма Са Compound of avermectin family or of milbemycin family for treatment and/or prevention of atopic dermatitis
FR3032616B1 (en) * 2015-02-12 2017-02-24 Galderma Sa COMPOSITION OF THE AVERMECTIN FAMILY FOR THE TREATMENT AND / OR PREVENTION OF FOLLICULITES
EP3377063B1 (en) 2015-11-17 2023-08-09 Galderma S.A. Use of ivermectin and brimonidine in the treatment and/or prevention of moderate to severe rosacea
JP2019523291A (en) * 2016-08-04 2019-08-22 ネスレ スキン ヘルス エス アー Composition and use thereof for treating or preventing rosacea
CN106397233A (en) * 2016-08-26 2017-02-15 南通奥凯生物技术开发有限公司 Preparation method of pharmaceutical grade disodium ethylene diamine tetraacetate
WO2018060870A1 (en) * 2016-09-30 2018-04-05 Aurobindo Pharma Limited Pharmaceutical composition of ivermectin and process for preparation thereof
PL3723739T3 (en) 2017-12-15 2024-09-16 Tarsus Pharmaceuticals, Inc. Isoxazoline parasiticide formulations and their use for treating blepharitis
JP7129005B2 (en) * 2018-09-28 2022-09-01 Toto株式会社 flush toilet
EP3927349A1 (en) 2019-02-18 2021-12-29 Mary Kay, Inc. Topical skin compositions for treating rosacea and skin redness
CN111728959B (en) * 2020-08-11 2023-02-03 黑龙江天龙药业有限公司 Nasal mask capable of inhibiting grease secretion and clearing mites and preparation method thereof
EP4062907A1 (en) 2021-03-23 2022-09-28 Substipharm Formulation for oral administration of ivermectin and uses thereof
WO2022269665A1 (en) * 2021-06-21 2022-12-29 マルホ株式会社 External preparation
KR102346125B1 (en) 2021-10-15 2022-01-03 (주)나비바이오텍 Rapid Kit for Ivermectin Quantitative Test

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NZ197796A (en) 1980-08-04 1984-11-09 Merck & Co Inc Stabilised aqueous formulations containing ivermectin
US5332577A (en) 1988-12-27 1994-07-26 Dermamed Transdermal administration to humans and animals
US5656280A (en) 1994-12-06 1997-08-12 Helene Curtis, Inc. Water-in-oil-in-water compositions
FR2754452B1 (en) 1996-10-11 2003-02-14 Oreal O / W EMULSION WITH HIGH ELECTROLYTE CONTENT AND THEIR USE IN DERMO-COSMETICS, PARTICULARLY FOR TREATING PHENOMENES OF IRRITATION AND / OR SENSITIVE SKIN
US5952372A (en) 1998-09-17 1999-09-14 Mcdaniel; William Robert Method for treating rosacea using oral or topical ivermectin
FR2787322B1 (en) 1998-12-18 2002-10-18 Galderma Res & Dev OIL-IN-WATER EMULSION COMPRISING A MICRONIZED ACTIVE AGENT AND AN APPROPRIATE EMULSION SYSTEM
US6133310A (en) 1999-08-26 2000-10-17 Parks; L. Dean Method of treatment of rosacea
US6720001B2 (en) 1999-10-18 2004-04-13 Lipocine, Inc. Emulsion compositions for polyfunctional active ingredients
US6399651B1 (en) 2000-06-29 2002-06-04 L. Dean Parks Method of treating dermatoses using avermectin compound
US6319945B1 (en) 2000-06-29 2001-11-20 L. Dean Parks Method of treatment of seborrheic dermatitis
US6399652B1 (en) 2000-06-29 2002-06-04 L. Dean Parks Method of treating acne vulgaris using avermectin compound
DE10063946A1 (en) 2000-12-20 2002-07-04 Basf Ag Use of light stabilizer combinations which contain 2,2'-p-phenylene-bis (3,1-benzoxazin-4-one) as an essential constituent as a photostable UV filter in cosmetic and pharmaceutical preparations
AU2003215011A1 (en) 2002-02-08 2003-09-02 Mcneil-Ppc, Inc. Topical ivermectin composition
CN1649578A (en) 2002-03-04 2005-08-03 戴弗根斯公司 Nematicidal fatty acid and fatty acid ester related compounds
FR2854074B1 (en) * 2003-04-24 2007-11-23 Galderma Res & Dev USE OF IVERMECTIN FOR THE TREATMENT OF DERMATOLOGICAL DISORDERS
MXPA05011208A (en) 2003-04-24 2005-12-14 Galderma Sa Topical formulation of ivermectin for the treatment of dermatological conditions.
EP1600158A1 (en) 2004-05-26 2005-11-30 Galderma Research & Development, S.N.C. Use of ondansetron for the treatment of inflammation, and pharmaceutical compositions thereof
FR2867684B1 (en) 2004-03-18 2006-05-05 Galderma Sa CREAM GEL CONTAINING IVERMECTIN
DE602005020912D1 (en) 2004-03-18 2010-06-10 Galderma Sa IVERMECTIN CONTAINING CREAM
FR2883181B1 (en) 2005-03-17 2007-05-18 Galderma Sa COMPOSITION BASED ON AVERMECTIN AND AZELAIC ACID, IN PARTICULAR FOR THE TREATMENT OF ROSACEA
FR2886851B1 (en) 2005-06-10 2007-10-05 Galderma Sa COMPOSITION BASED ON AVERMECTIN AND METRONIDAZOLE, IN PARTICULAR FOR THE TREATMENT OF ROSACEA
FR2886850B1 (en) 2005-06-10 2007-10-05 Galderma Sa COMPOSITION BASED ON AVERMECTIN AND BENZOYL PEROXIDE, IN PARTICULAR FOR THE TREATMENT OF ROSACEA
FR2886852B1 (en) 2005-06-10 2007-11-23 Galderma Sa COMPOSITION BASED ON AVERMECTIN AND HYDROCORTISONE, IN PARTICULAR FOR THE TREATMENT OF ROSACEA
FR2894823B1 (en) 2005-12-20 2008-02-29 Galderma Sa REVERSE EMULSION TYPE COMPOSITION COMPRISING IVERMECTIN AND ITS USES IN COSMETICS AND DERMATOLOGY
FR2900052B1 (en) 2006-04-19 2011-02-18 Galderma Sa COMPOSITION COMPRISING AT LEAST ONE AQUEOUS PHASE AND AT LEAST ONE FATTY PHASE COMPRISING IVERMECTIN
FR2906468B1 (en) 2006-09-28 2012-09-21 Galderma Sa USE OF COMPOUNDS OF THE AVERMECTIN FAMILY FOR THE TREATMENT OF DERMATOLOGICAL DISORDERS
FR2907013B1 (en) 2006-10-12 2012-09-21 Galderma Sa DOUBLE COMPRESSED SKIN CARE PRODUCTS COMPRISING IVERMECTIN, AND USES THEREOF
FR2907012B1 (en) 2006-10-12 2012-09-21 Galderma Sa DERMATOLOGICAL COMPOSITION COMPRISING AVERMECTIN NANOCAPSULES, PROCESS FOR PREPARING THE SAME AND USE THEREOF
JP2012513387A (en) 2008-12-23 2012-06-14 ガルデルマ・ソシエテ・アノニム Topical pharmaceutical composition comprising a water-sensitive active ingredient
WO2010086725A1 (en) 2009-01-30 2010-08-05 Yissum Research Development Company Of The Hebrew University Of Jerusalem Ltd Compositions for nail and skin treatment
FR2942138A1 (en) * 2009-02-16 2010-08-20 Galderma Res & Dev ASSOCIATION OF COMPOUNDS FOR THE TREATMENT OR PREVENTION OF DERMATOLOGICAL DISEASES
FR3000397A1 (en) 2012-12-31 2014-07-04 Galderma Res & Dev COMBINATION OF LAROPIPRANT AND IVERMECTIN FOR THE TREATMENT OF ROSACEA

Also Published As

Publication number Publication date
KR101863085B1 (en) 2018-06-01
US20150011491A1 (en) 2015-01-08
CN111494399A (en) 2020-08-07
WO2015006305A1 (en) 2015-01-15
MX2016000122A (en) 2016-06-15
US20160143935A1 (en) 2016-05-26
US20220347198A1 (en) 2022-11-03
AU2014287422B2 (en) 2017-04-13
BR112016000350A8 (en) 2020-01-07
IL243315B (en) 2022-02-01
IL243315A0 (en) 2016-02-29
JP2023052490A (en) 2023-04-11
CN111467301A (en) 2020-07-31
JP2021059590A (en) 2021-04-15
WO2015006319A1 (en) 2015-01-15
US20210177882A1 (en) 2021-06-17
RU2633076C2 (en) 2017-10-11
NZ716033A (en) 2017-01-27
JP6438466B2 (en) 2018-12-12
US20160175337A1 (en) 2016-06-23
BR112016000350A2 (en) 2017-07-25
KR20160061310A (en) 2016-05-31
IL243314B (en) 2022-02-01
CA2916704A1 (en) 2015-01-15
AU2014287408A1 (en) 2016-02-11
AU2014287408B2 (en) 2017-05-04
JP2016526572A (en) 2016-09-05
MX2016000121A (en) 2016-07-14
US20180207188A1 (en) 2018-07-26
US20180264021A1 (en) 2018-09-20
RU2016103715A (en) 2017-08-11
IL243314A0 (en) 2016-02-29
US9233117B2 (en) 2016-01-12
SG11201510420UA (en) 2016-01-28
US20200000835A1 (en) 2020-01-02
BR112016000335A2 (en) 2017-07-25
US20150011490A1 (en) 2015-01-08
JP2019073527A (en) 2019-05-16
KR20160061311A (en) 2016-05-31
CL2016000008A1 (en) 2016-08-05
NZ716034A (en) 2017-01-27
US9233118B2 (en) 2016-01-12
EP3019173A1 (en) 2016-05-18
CA2916668A1 (en) 2015-01-15
CL2016000009A1 (en) 2016-08-19
JP6653734B2 (en) 2020-02-26
EP3019174A1 (en) 2016-05-18
RU2016103753A (en) 2017-08-11
IL274058B (en) 2022-02-01
BR112016000335A8 (en) 2020-01-07
CN105828825A (en) 2016-08-03
HK1223842A1 (en) 2017-08-11
US10206939B2 (en) 2019-02-19
AU2014287422A1 (en) 2016-02-11
US9089587B2 (en) 2015-07-28
JP2016523968A (en) 2016-08-12
HK1223841A1 (en) 2017-08-11
CN105792829A (en) 2016-07-20
US20150011489A1 (en) 2015-01-08
US20180177813A1 (en) 2018-06-28
RU2633481C2 (en) 2017-10-12
US20160184342A1 (en) 2016-06-30
JP2017197562A (en) 2017-11-02
CA2916704C (en) 2018-11-20
JP2018184437A (en) 2018-11-22
KR101864799B1 (en) 2018-06-05
IL274058A (en) 2020-06-30
ZA201600358B (en) 2019-11-27

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