SG11201510266SA - Dengue virus vaccine compositions and methods of use thereof - Google Patents

Dengue virus vaccine compositions and methods of use thereof

Info

Publication number
SG11201510266SA
SG11201510266SA SG11201510266SA SG11201510266SA SG11201510266SA SG 11201510266S A SG11201510266S A SG 11201510266SA SG 11201510266S A SG11201510266S A SG 11201510266SA SG 11201510266S A SG11201510266S A SG 11201510266SA SG 11201510266S A SG11201510266S A SG 11201510266SA
Authority
SG
Singapore
Prior art keywords
methods
dengue virus
vaccine compositions
virus vaccine
compositions
Prior art date
Application number
SG11201510266SA
Inventor
Andrew Bett
Beth-Ann Griswold Coller
Govindarajan Dhanasekaran
Ramesh V Chintala
Original Assignee
Merck Sharp & Dohme
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck Sharp & Dohme filed Critical Merck Sharp & Dohme
Publication of SG11201510266SA publication Critical patent/SG11201510266SA/en

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K39/12Viral antigens
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12Antivirals
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • A61P37/02Immunomodulators
    • A61P37/04Immunostimulants
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K2039/51Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
    • A61K2039/525Virus
    • A61K2039/5254Virus avirulent or attenuated
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K2039/545Medicinal preparations containing antigens or antibodies characterised by the dose, timing or administration schedule
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K2039/555Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
    • A61K2039/55511Organic adjuvants
    • A61K2039/55577Saponins; Quil A; QS21; ISCOMS
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K2039/70Multivalent vaccine
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/005Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09Recombinant DNA-technology
    • C12N15/63Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/85Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
    • C12N15/86Viral vectors
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N7/00Viruses; Bacteriophages; Compositions thereof; Preparation or purification thereof
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02ATECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
SG11201510266SA 2013-06-21 2014-06-17 Dengue virus vaccine compositions and methods of use thereof SG11201510266SA (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201361837721P 2013-06-21 2013-06-21
PCT/US2014/042625 WO2014204892A1 (en) 2013-06-21 2014-06-17 Dengue virus vaccine compositions and methods of use thereof

Publications (1)

Publication Number Publication Date
SG11201510266SA true SG11201510266SA (en) 2016-01-28

Family

ID=52105172

Family Applications (1)

Application Number Title Priority Date Filing Date
SG11201510266SA SG11201510266SA (en) 2013-06-21 2014-06-17 Dengue virus vaccine compositions and methods of use thereof

Country Status (12)

Country Link
US (1) US9861692B2 (en)
EP (1) EP3010536A4 (en)
JP (1) JP2016523251A (en)
KR (1) KR20160023683A (en)
CN (1) CN105246506A (en)
AU (1) AU2014281713A1 (en)
BR (1) BR112015031226A2 (en)
MX (1) MX366154B (en)
MY (1) MY187896A (en)
PH (1) PH12015502666A1 (en)
SG (1) SG11201510266SA (en)
WO (1) WO2014204892A1 (en)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP3236997A4 (en) 2014-12-22 2018-05-30 Merck Sharp & Dohme Corp. Dengue virus vaccine compositions and methods of use thereof
US10105434B2 (en) 2015-08-03 2018-10-23 The United States Of America As Represented By The Secretary Of The Navy Immune enhancing recombinant dengue protein
WO2017056101A1 (en) * 2015-09-30 2017-04-06 Panacea Biotec Limited Stable live attenuated recombinant dengue vaccine
WO2018217906A1 (en) * 2017-05-23 2018-11-29 The University Of North Carolina At Chapel Hill Methods and compositions for dengue virus serotype 4 epitopes
CN117752780A (en) 2017-12-07 2024-03-26 默沙东有限责任公司 Formulations of dengue virus vaccine compositions
CN111346079B (en) * 2020-02-24 2023-06-20 南方医科大学 Bacterial DNA gyrase inhibitor BRD7716 as medicament for treating and/or preventing dengue virus infection and pharmaceutical application thereof

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US6254873B1 (en) 1995-04-17 2001-07-03 The United States Of America As Represented By The Secretary Of The Army Inactivated dengue virus vaccine
US6190859B1 (en) 1995-04-17 2001-02-20 The United States Of America As Represented By The Secretary Of The Army Method and kit for detection of dengue virus
AU6093296A (en) 1995-06-07 1996-12-30 Government Of The United States Of America, As Represented By The Secretary Of The Department Of Health And Human Services, The Infectious dengue 2 virus pdk-53 as quadravalent vaccine
EP0836090A1 (en) 1996-10-12 1998-04-15 Evotec BioSystems GmbH Method of analysis of samples by determination of the distribution of specific brightnesses of particles
NZ337522A (en) 1997-02-28 2001-02-23 St Chimeric flavivirus incorporating yellow fever virus modified such that a prM-E protein of a second flavivirus is expressed, and vaccines for flavivruses
ATE321567T1 (en) 1997-07-31 2006-04-15 Hawaii Biotech Inc RECOMBINANT DIMERIC ENVELOPE PROTEINS AS A VACCINE AGAINST A FLAVIVIRAL INFECTION
DE69942525D1 (en) 1998-09-02 2010-08-05 Us Government DENGUE VIRUSES NOT REPLICATED IN MOSQUITOS FOR USE AS A VACCINE
EP1165127B1 (en) 1999-03-26 2008-12-31 Walter Reed Army Institute of Research Multivalent dengue virus vaccine
EP1165131A2 (en) 1999-03-26 2002-01-02 Walter Reed Army Institute of Research Attenuated dengue-1 virus vaccine
EP1165128A2 (en) 1999-03-26 2002-01-02 Walter Reed Army Institute of Research Attenuated dengue-2 virus vaccine
US6537557B1 (en) 1999-03-26 2003-03-25 The United States Of America As Represented By The Secretary Of The Army Attenuated dengue-4 virus vaccine
US6432411B1 (en) 1999-07-13 2002-08-13 Hawaii Biotechnology Group Recombinant envelope vaccine against flavivirus infection
DK2290108T3 (en) 2001-05-22 2014-10-20 Us Gov Health & Human Serv Development of mutations useful in attenuating dengue viruses as well as chimeric dengue viruses
ES2924640T3 (en) 2002-01-15 2022-10-10 Sanofi Pasteur Biologics Llc flavivirus vaccines
ES2677348T3 (en) 2002-05-03 2018-08-01 The Government Of The United States Of America, As Represented By The Secretary, Department Of Health And Human Services A recombinant chimeric dengue virus rDEN3 / 4delta 30 (ME), rDEN2 / 4delta30 (ME) or rDEN1 / 4delta30 (ME) that contains a deletion of 30 nucleotides (delta30) in a section of the 3 'non-translated region of the genome of type 4 dengue, wherein said 30 nucleotide deletion corresponds to the stem-loop structure of TL2
WO2003101397A2 (en) * 2002-05-31 2003-12-11 Acambis, Inc. Tetravalent dengue vaccines
US7189403B2 (en) 2003-06-30 2007-03-13 Institut Pasteur Attenuated flavivirus strains containing a mutated M-ectodomain and their applications
EA015907B1 (en) 2004-10-20 2011-12-30 Санофи Пастер Байолоджикс Ко. Recombinant flavivirus and use thereof
BRPI0613287A2 (en) 2005-06-17 2010-12-28 Sanofi Pasteur live attenuated dengue-2 virus strain, immunogenic composition, vaccine composition, isolated nucleic acid, isolated polyprotein encoded by sequence id. 1 or fragments thereof and polyprotein fragment
KR101536612B1 (en) 2005-06-17 2015-07-14 사노피 파스퇴르 Dengue serotype 1 attenuated strain
JP5193856B2 (en) 2005-06-24 2013-05-08 インターベツト・インターナシヨナル・ベー・ベー Inactivated chimeric vaccine and related methods of use
WO2007015783A2 (en) 2005-07-22 2007-02-08 Research Development Foundation Attenuated strains of flaviviruses , and uses thereof
AR061197A1 (en) 2006-06-07 2008-08-13 Sanofi Pasteur DENGUE VIRUS 3 CEPAS VIVAS ATENUADAS
DK2589602T3 (en) 2006-08-15 2016-07-25 The Government Of The U S A As Repr By The Secretary Dept Of Health & Human Services The Nat Inst Of Development of dengue virus vaccine components
FR2906724B1 (en) 2006-10-04 2009-03-20 Sanofi Pasteur Sa METHOD OF IMMUNIZATION AGAINST THE 4 SEROTYPES OF DENGUE.
WO2008127307A2 (en) 2006-11-09 2008-10-23 The United States Of America As Represented By The Secretary Of The Navy Induction of an immune response against dengue virus using prime-boost approach
FR2909286B1 (en) * 2006-12-01 2012-06-08 Sanofi Pasteur IMMUNIZATION METHOD AGAINST THE 4 SEROTYPES OF DENGUE
BRPI0904020B8 (en) 2009-10-01 2021-05-25 Fundacao Oswaldo Cruz vaccine composition against the dengue virus, and kit
BR112013009649A2 (en) * 2010-10-29 2016-07-12 Merck Sharp & Dohme immunogenic composition, methods for eliciting a protective immune response in a human patient and for providing human immune protection against disease, and use of a composition
PE20150356A1 (en) 2012-07-24 2015-03-20 Sanofi Pasteur VACCINE COMPOSITIONS FOR THE PREVENTION AGAINST INFECTION BY DENGUE VIRUS

Also Published As

Publication number Publication date
US20160151477A1 (en) 2016-06-02
PH12015502666B1 (en) 2016-03-07
BR112015031226A2 (en) 2017-08-29
EP3010536A1 (en) 2016-04-27
KR20160023683A (en) 2016-03-03
EP3010536A4 (en) 2016-11-30
MX366154B (en) 2019-06-28
AU2014281713A1 (en) 2015-11-12
MY187896A (en) 2021-10-27
JP2016523251A (en) 2016-08-08
US9861692B2 (en) 2018-01-09
CN105246506A (en) 2016-01-13
WO2014204892A1 (en) 2014-12-24
PH12015502666A1 (en) 2016-03-07
MX2015017384A (en) 2016-04-06

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