SG11201508752WA - 2,2-difluoropropionamide derivatives of bardoxolone methyl, polymorphic forms and methods of use thereof - Google Patents
2,2-difluoropropionamide derivatives of bardoxolone methyl, polymorphic forms and methods of use thereofInfo
- Publication number
- SG11201508752WA SG11201508752WA SG11201508752WA SG11201508752WA SG11201508752WA SG 11201508752W A SG11201508752W A SG 11201508752WA SG 11201508752W A SG11201508752W A SG 11201508752WA SG 11201508752W A SG11201508752W A SG 11201508752WA SG 11201508752W A SG11201508752W A SG 11201508752WA
- Authority
- SG
- Singapore
- Prior art keywords
- methods
- polymorphic forms
- bardoxolone methyl
- difluoropropionamide
- derivatives
- Prior art date
Links
- XJGBNZRVGOENRN-UHFFFAOYSA-N 2,2-difluoropropanamide Chemical class CC(F)(F)C(N)=O XJGBNZRVGOENRN-UHFFFAOYSA-N 0.000 title 1
- 229950002483 bardoxolone Drugs 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J63/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton has been modified by expansion of only one ring by one or two atoms
- C07J63/008—Expansion of ring D by one atom, e.g. D homo steroids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
- A61K31/565—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P39/00—General protective or antinoxious agents
- A61P39/06—Free radical scavengers or antioxidants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B2200/00—Indexing scheme relating to specific properties of organic compounds
- C07B2200/13—Crystalline forms, e.g. polymorphs
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Immunology (AREA)
- Rheumatology (AREA)
- Diabetes (AREA)
- Pain & Pain Management (AREA)
- Epidemiology (AREA)
- Toxicology (AREA)
- Cardiology (AREA)
- Biochemistry (AREA)
- Transplantation (AREA)
- Heart & Thoracic Surgery (AREA)
- Emergency Medicine (AREA)
- Endocrinology (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Pulmonology (AREA)
- Dermatology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Physical Education & Sports Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicinal Preparation (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201361815502P | 2013-04-24 | 2013-04-24 | |
| PCT/US2014/035279 WO2014176415A1 (en) | 2013-04-24 | 2014-04-24 | 2,2-difluoropropionamide derivatives of bardoxolone methyl, polymorphic forms and methods of use thereof |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| SG11201508752WA true SG11201508752WA (en) | 2015-11-27 |
Family
ID=50842351
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SG10201805231WA SG10201805231WA (en) | 2013-04-24 | 2014-04-24 | 2,2-difluoropropionamide derivatives of bardoxolone methyl, polymorphic forms and methods of use thereof |
| SG11201508752WA SG11201508752WA (en) | 2013-04-24 | 2014-04-24 | 2,2-difluoropropionamide derivatives of bardoxolone methyl, polymorphic forms and methods of use thereof |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SG10201805231WA SG10201805231WA (en) | 2013-04-24 | 2014-04-24 | 2,2-difluoropropionamide derivatives of bardoxolone methyl, polymorphic forms and methods of use thereof |
Country Status (36)
| Country | Link |
|---|---|
| US (4) | US9856286B2 (en) |
| EP (2) | EP3453715A1 (en) |
| JP (2) | JP6409050B2 (en) |
| KR (2) | KR20150144807A (en) |
| CN (1) | CN105324389B (en) |
| AR (1) | AR096046A1 (en) |
| AU (2) | AU2014257072C1 (en) |
| BR (1) | BR112015027012B1 (en) |
| CA (1) | CA2909066C (en) |
| CL (1) | CL2015003135A1 (en) |
| CR (1) | CR20150620A (en) |
| CY (1) | CY1120570T1 (en) |
| DK (1) | DK2989114T3 (en) |
| DO (1) | DOP2015000263A (en) |
| EC (1) | ECSP23088864A (en) |
| ES (1) | ES2683626T3 (en) |
| HK (2) | HK1221470A1 (en) |
| HR (1) | HRP20181321T1 (en) |
| HU (1) | HUE039899T2 (en) |
| IL (1) | IL242183B (en) |
| LT (1) | LT2989114T (en) |
| MX (1) | MX2015014792A (en) |
| MY (1) | MY182677A (en) |
| PE (1) | PE20160006A1 (en) |
| PH (1) | PH12015502459B1 (en) |
| PL (1) | PL2989114T3 (en) |
| PT (1) | PT2989114T (en) |
| RS (1) | RS57571B1 (en) |
| RU (2) | RU2019120236A (en) |
| SG (2) | SG10201805231WA (en) |
| SI (1) | SI2989114T1 (en) |
| TW (2) | TWI649330B (en) |
| UA (1) | UA118348C2 (en) |
| UY (2) | UY39092A (en) |
| WO (1) | WO2014176415A1 (en) |
| ZA (1) | ZA201507481B (en) |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA3062806C (en) | 2008-01-11 | 2022-09-13 | Reata Pharmaceuticals, Inc. | Synthetic triterpenoids and methods of use in the treatment of disease |
| ES2703274T3 (en) | 2008-04-18 | 2019-03-07 | Reata Pharmaceuticals Inc | Antioxidant modulators of inflammation: oleanolic acid derivatives with amino and other modifications in C-17 |
| CA2721665C (en) | 2008-04-18 | 2017-01-24 | Reata Pharmaceuticals, Inc. | Compounds including an anti-inflammatory pharmacore and methods of use |
| RS61544B1 (en) | 2012-04-27 | 2021-04-29 | Reata Pharmaceuticals Inc | 2,2-difluoropropionamide derivative of bardoxolone methyl, pharmaceutical compositions and polymorphs thereof for use in treating certain conditions |
| WO2013188818A1 (en) | 2012-06-15 | 2013-12-19 | Reata Pharmaceuticals, Inc. | A-ring epoxidized triterpenoid-based anti-inflammation modulators and methods of use thereof |
| WO2014040073A1 (en) | 2012-09-10 | 2014-03-13 | Reata Pharmaceuticals, Inc. | C13-hydroxy derivatives of oleanolic acid and methods of use thereof |
| US9512094B2 (en) | 2012-09-10 | 2016-12-06 | Reata Pharmaceuticals, Inc. | C17-heteroaryl derivatives of oleanolic acid and methods of use thereof |
| LT2892912T (en) | 2012-09-10 | 2019-07-10 | Reata Pharmaceuticals, Inc. | C17-alkanediyl and alkenediyl derivatives of oleanolic acid and methods of use thereof |
| UY39092A (en) | 2013-04-24 | 2021-03-26 | Abbvie Inc | DERIVATIVES OF 2,2-DIFLUOROPROPANAMIDE AND METHYL BARDOXOLONE, POLYMORPHIC FORMS AND METHODS OF USE |
| CN106279344A (en) * | 2016-08-14 | 2017-01-04 | 吴芊葭 | A kind of native compound separated from Radix Saposhnikoviae and preparation method thereof, medical applications |
| CN106309451A (en) * | 2016-08-14 | 2017-01-11 | 吴芊葭 | Pharmaceutical composition of cefuroxime axetil and medical application of pharmaceutical composition |
| CA3042123A1 (en) | 2016-11-08 | 2018-05-17 | Reata Pharmaceuticals, Inc. | Methods of treating alport syndrome using bardoxolone methyl or analogs thereof |
| CN108558985B (en) * | 2018-05-19 | 2019-06-07 | 河南省科学院高新技术研究中心 | Betulic acid derivative and its synthetic method and application |
| CN112839652A (en) * | 2018-08-15 | 2021-05-25 | 艾葳生物科技有限公司 | Multi-kinase inhibitors of VEGF and TGF beta and uses thereof |
| AU2019326368B2 (en) | 2018-08-20 | 2021-11-11 | Janssen Pharmaceutica Nv | Inhibitors of KEAP1-Nrf2 protein-protein interaction |
| CN113966237A (en) * | 2019-03-15 | 2022-01-21 | 罗德岛大学理事会 | pHLIP-mediated corticosteroid-targeted diseased tissue |
| WO2020226201A1 (en) * | 2019-05-08 | 2020-11-12 | 경상대학교병원 | Pharmaceutical composition for preventing or treating skin hypochromatism, health functional food, and cosmetic composition |
| KR20220116209A (en) * | 2019-12-19 | 2022-08-22 | 리아타 파마슈티컬즈, 아이엔씨. | Synthetic triterpenoids having a nitrogen-based substituent at C-17 and methods of using the same |
| MX2023008454A (en) * | 2021-01-18 | 2023-08-07 | Reata Pharmaceuticals Inc | Synthetic ursolic acid derivatives and methods of use thereof. |
| CN113197905B (en) * | 2021-04-23 | 2022-04-19 | 浙江大学 | Application of triterpenoid in preparation of medicine for treating neuroblastoma |
| CN114344308A (en) * | 2021-12-22 | 2022-04-15 | 山西医科大学第二医院 | Application of bardoxolone methyl in preparation of medicine for preventing and treating osteoarthritis |
| EP4349847A1 (en) * | 2022-09-21 | 2024-04-10 | Sicor Società Italiana Corticosteroidi S.r.l. | Process and intermediates for preparation of omaveloxolone and salts thereof |
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-
2014
- 2014-04-21 UY UY0001039092A patent/UY39092A/en not_active Application Discontinuation
- 2014-04-21 TW TW103114431A patent/TWI649330B/en active
- 2014-04-21 AR ARP140101652A patent/AR096046A1/en unknown
- 2014-04-21 UY UY0001035534A patent/UY35534A/en active IP Right Grant
- 2014-04-21 TW TW107147785A patent/TW201936625A/en unknown
- 2014-04-24 BR BR112015027012-3A patent/BR112015027012B1/en active IP Right Grant
- 2014-04-24 MX MX2015014792A patent/MX2015014792A/en active IP Right Grant
- 2014-04-24 PT PT14727306T patent/PT2989114T/en unknown
- 2014-04-24 DK DK14727306.4T patent/DK2989114T3/en active
- 2014-04-24 EP EP18170879.3A patent/EP3453715A1/en not_active Withdrawn
- 2014-04-24 SG SG10201805231WA patent/SG10201805231WA/en unknown
- 2014-04-24 HU HUE14727306A patent/HUE039899T2/en unknown
- 2014-04-24 US US14/260,532 patent/US9856286B2/en active Active
- 2014-04-24 KR KR1020157033427A patent/KR20150144807A/en not_active IP Right Cessation
- 2014-04-24 LT LTEP14727306.4T patent/LT2989114T/en unknown
- 2014-04-24 RS RS20180945A patent/RS57571B1/en unknown
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