SG11201505552XA - Multi-component crystalline particles for inhalation therapy - Google Patents

Multi-component crystalline particles for inhalation therapy

Info

Publication number
SG11201505552XA
SG11201505552XA SG11201505552XA SG11201505552XA SG11201505552XA SG 11201505552X A SG11201505552X A SG 11201505552XA SG 11201505552X A SG11201505552X A SG 11201505552XA SG 11201505552X A SG11201505552X A SG 11201505552XA SG 11201505552X A SG11201505552X A SG 11201505552XA
Authority
SG
Singapore
Prior art keywords
crystalline particles
inhalation therapy
component crystalline
component
inhalation
Prior art date
Application number
SG11201505552XA
Inventor
John Burns
Dipesh Parikh
Shyam Karki
Original Assignee
Prosonix Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Prosonix Ltd filed Critical Prosonix Ltd
Publication of SG11201505552XA publication Critical patent/SG11201505552XA/en

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/13Amines
    • A61K31/135Amines having aromatic rings, e.g. ketamine, nortriptyline
    • A61K31/137Arylalkylamines, e.g. amphetamine, epinephrine, salbutamol, ephedrine or methadone
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/13Amines
    • A61K31/135Amines having aromatic rings, e.g. ketamine, nortriptyline
    • A61K31/138Aryloxyalkylamines, e.g. propranolol, tamoxifen, phenoxybenzamine
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/16Amides, e.g. hydroxamic acids
    • A61K31/165Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
    • A61K31/167Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide having the nitrogen of a carboxamide group directly attached to the aromatic ring, e.g. lidocaine, paracetamol
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/4015Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil having oxo groups directly attached to the heterocyclic ring, e.g. piracetam, ethosuximide
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/41961,2,4-Triazoles
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/0012Galenical forms characterised by the site of application
    • A61K9/007Pulmonary tract; Aromatherapy
    • A61K9/0073Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy
    • A61K9/0075Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy for inhalation via a dry powder inhaler [DPI], e.g. comprising micronized drug mixed with lactose carrier particles
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/0012Galenical forms characterised by the site of application
    • A61K9/007Pulmonary tract; Aromatherapy
    • A61K9/0073Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy
    • A61K9/0078Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy for inhalation via a nebulizer such as a jet nebulizer, ultrasonic nebulizer, e.g. in the form of aqueous drug solutions or dispersions
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/0012Galenical forms characterised by the site of application
    • A61K9/007Pulmonary tract; Aromatherapy
    • A61K9/0073Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy
    • A61K9/008Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy comprising drug dissolved or suspended in liquid propellant for inhalation via a pressurized metered dose inhaler [MDI]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M15/00Inhalators
    • A61M15/009Inhalators using medicine packages with incorporated spraying means, e.g. aerosol cans
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M15/00Inhalators
    • A61M15/08Inhaling devices inserted into the nose
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00Drugs for disorders of the respiratory system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00Drugs for disorders of the respiratory system
    • A61P11/06Antiasthmatics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2202/00Special media to be introduced, removed or treated
    • A61M2202/06Solids
    • A61M2202/064Powder

Landscapes

  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pulmonology (AREA)
  • Otolaryngology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biomedical Technology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Hematology (AREA)
  • Anesthesiology (AREA)
  • Pain & Pain Management (AREA)
  • Emergency Medicine (AREA)
  • Dispersion Chemistry (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pyrrole Compounds (AREA)
SG11201505552XA 2013-01-31 2014-01-29 Multi-component crystalline particles for inhalation therapy SG11201505552XA (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GBGB1301721.5A GB201301721D0 (en) 2013-01-31 2013-01-31 Pharmaceutical Preparations
PCT/GB2014/050231 WO2014118530A1 (en) 2013-01-31 2014-01-29 Multi-component crystalline particles for inhalation therapy

Publications (1)

Publication Number Publication Date
SG11201505552XA true SG11201505552XA (en) 2015-08-28

Family

ID=47988481

Family Applications (1)

Application Number Title Priority Date Filing Date
SG11201505552XA SG11201505552XA (en) 2013-01-31 2014-01-29 Multi-component crystalline particles for inhalation therapy

Country Status (15)

Country Link
US (1) US20150352077A1 (en)
EP (1) EP2950791A1 (en)
JP (1) JP2016506946A (en)
CN (1) CN104955449A (en)
AU (1) AU2014210940A1 (en)
BR (1) BR112015018120A2 (en)
CA (1) CA2898678A1 (en)
EA (1) EA201591418A1 (en)
GB (1) GB201301721D0 (en)
HK (1) HK1215543A1 (en)
IL (1) IL239974A0 (en)
MX (1) MX2015009746A (en)
SG (1) SG11201505552XA (en)
WO (1) WO2014118530A1 (en)
ZA (1) ZA201505257B (en)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PT109445B (en) * 2016-06-08 2018-11-06 Hovione Farm Sa CRYSTALINE PHARMACEUTICAL CO-CRYSTALS OF LACTOSE GLYCOPYRONIUM BROMETTE
CN107915666A (en) * 2016-10-09 2018-04-17 四川海思科制药有限公司 A kind of glycopyrronium bromide compound
CN112137957B (en) * 2019-06-26 2022-07-29 长风药业股份有限公司 Medicinal inhalation aerosol and preparation method thereof
CN112972384B (en) * 2019-12-02 2022-03-18 长风药业股份有限公司 Preparation method of glycopyrronium bromide and indacaterol bulk drug micro-powder mixture
CN112051346A (en) * 2020-09-24 2020-12-08 珠海瑞思普利生物制药有限公司 HPLC method for simultaneously determining content of indacaterol and glycopyrronium bromide

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1782797A1 (en) * 2005-11-02 2007-05-09 Pharmatex Italia Srl Process for the preparation of sterile powdered pharmaceutical compounds.
GB0705159D0 (en) * 2007-03-19 2007-04-25 Prosonix Ltd Process for making crystals
CN102149437B (en) * 2008-07-18 2017-02-15 普罗索尼克斯有限公司 Process for improving crystallinity of fluticasone particles
US8815258B2 (en) * 2009-05-29 2014-08-26 Pearl Therapeutics, Inc. Compositions, methods and systems for respiratory delivery of two or more active agents
PL3111926T3 (en) * 2009-05-29 2020-06-29 Pearl Therapeutics, Inc. Compositions, methods & systems for respiratory delivery of two or more active agents
GB0918431D0 (en) * 2009-10-21 2009-12-09 Prosonix Ltd Process for improving crystallinity
JOP20120023B1 (en) * 2011-02-04 2022-03-14 Novartis Ag Dry powder formulations of particles that contain two or more active ingredients for treating obstructive or inflammatory airways diseases
GB201113662D0 (en) * 2011-08-08 2011-09-21 Prosonix Ltd Pharmaceutical compositions
WO2014118532A1 (en) * 2013-01-31 2014-08-07 Prosonix Limited Pharmaceutical compositions comprising multi-component crystalline particles suitable for use in inhalation therapy

Also Published As

Publication number Publication date
CN104955449A (en) 2015-09-30
EP2950791A1 (en) 2015-12-09
US20150352077A1 (en) 2015-12-10
MX2015009746A (en) 2016-03-31
BR112015018120A2 (en) 2017-07-18
WO2014118530A1 (en) 2014-08-07
HK1215543A1 (en) 2016-09-02
AU2014210940A1 (en) 2015-08-20
IL239974A0 (en) 2015-08-31
JP2016506946A (en) 2016-03-07
GB201301721D0 (en) 2013-03-20
ZA201505257B (en) 2016-12-21
EA201591418A1 (en) 2016-02-29
CA2898678A1 (en) 2014-08-07

Similar Documents

Publication Publication Date Title
ZA201602826B (en) Modular particles for immunotherapy
AU351520S (en) Inhaler
EP2950864A4 (en) Respiratory apparatus
AU352076S (en) Inhaler
TWD174566S (en) Respiratory apparatus
TWD174570S (en) Respiratory apparatus
PT3019225T (en) Inhaler
TWD174569S (en) Respiratory apparatus
EP2959944A4 (en) Particle therapy apparatus
TWD174568S (en) Respiratory apparatus
PL2978481T3 (en) Inhaler
TWD174572S (en) Respiratory apparatus
TWD174573S (en) Respiratory apparatus
SI3035885T1 (en) Inhaler
TWD174571S (en) Respiratory apparatus
HUE060180T2 (en) Inhalable medicaments
SI3035886T1 (en) Inhaler
HK1215543A1 (en) Multi-component crystalline particles for inhalation therapy
HK1215545A1 (en) Pharmaceutical compositions comprising multi-component crystalline particles suitable for use in inhalation therapy
TWD174574S (en) Respiratory apparatus
TWD174567S (en) Respiratory apparatus
ZA201508680B (en) Inhaler
IL239975A0 (en) Pharmaceutical compositions comprising multi-component crystalline particles suitable for use in inhalation therapy
HU4880U (en) Inhalator