SG11201504746PA - Antiviral compounds - Google Patents

Antiviral compounds

Info

Publication number
SG11201504746PA
SG11201504746PA SG11201504746PA SG11201504746PA SG11201504746PA SG 11201504746P A SG11201504746P A SG 11201504746PA SG 11201504746P A SG11201504746P A SG 11201504746PA SG 11201504746P A SG11201504746P A SG 11201504746PA SG 11201504746P A SG11201504746P A SG 11201504746PA
Authority
SG
Singapore
Prior art keywords
antiviral compounds
antiviral
compounds
Prior art date
Application number
SG11201504746PA
Inventor
Elizabeth M Bacon
Jeromy J Cottell
John O Link
Martin Teresa Alejandra Trejo
Original Assignee
Gilead Sciences Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
Priority to US201261745452P priority Critical
Priority to US13/830,346 priority patent/US9233974B2/en
Application filed by Gilead Sciences Inc filed Critical Gilead Sciences Inc
Priority to PCT/US2013/076734 priority patent/WO2014100500A1/en
Publication of SG11201504746PA publication Critical patent/SG11201504746PA/en
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=50974893&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=SG11201504746P(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D491/00Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/04Ortho-condensed systems
    • C07D491/044Ortho-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring
    • C07D491/052Ortho-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring the oxygen-containing ring being six-membered
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/335Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/35Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
    • A61K31/352Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom condensed with carbocyclic rings, e.g. cannabinols, methantheline
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins
    • A61K31/41Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/41641,3-Diazoles
    • A61K31/41881,3-Diazoles condensed with other heterocyclic ring systems, e.g. biotin, sorbinil
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/70Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7052Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
    • A61K31/7056Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing five-membered rings with nitrogen as a ring hetero atom
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/70Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7052Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
    • A61K31/706Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
    • A61K31/7064Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines
    • A61K31/7068Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines having oxo groups directly attached to the pyrimidine ring, e.g. cytidine, cytidylic acid
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/70Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7052Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
    • A61K31/706Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
    • A61K31/7064Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines
    • A61K31/7068Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines having oxo groups directly attached to the pyrimidine ring, e.g. cytidine, cytidylic acid
    • A61K31/7072Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines having oxo groups directly attached to the pyrimidine ring, e.g. cytidine, cytidylic acid having two oxo groups directly attached to the pyrimidine ring, e.g. uridine, uridylic acid, thymidine, zidovudine
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • A61K38/16Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/19Cytokines; Lymphokines; Interferons
    • A61K38/21Interferons [IFN]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K45/00Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D491/00Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/04Ortho-condensed systems
SG11201504746PA 2012-12-21 2013-12-19 Antiviral compounds SG11201504746PA (en)

Priority Applications (3)

Application Number Priority Date Filing Date Title
US201261745452P true 2012-12-21 2012-12-21
US13/830,346 US9233974B2 (en) 2012-12-21 2013-03-14 Antiviral compounds
PCT/US2013/076734 WO2014100500A1 (en) 2012-12-21 2013-12-19 Antiviral compounds

Publications (1)

Publication Number Publication Date
SG11201504746PA true SG11201504746PA (en) 2015-07-30

Family

ID=50974893

Family Applications (1)

Application Number Title Priority Date Filing Date
SG11201504746PA SG11201504746PA (en) 2012-12-21 2013-12-19 Antiviral compounds

Country Status (28)

Country Link
US (5) US9233974B2 (en)
EP (3) EP2935279B1 (en)
JP (1) JP6333849B2 (en)
KR (1) KR20150100728A (en)
CN (2) CN104918943B (en)
AP (1) AP201508511A0 (en)
AR (1) AR094262A1 (en)
AU (1) AU2013361195B2 (en)
BR (1) BR112015014333A8 (en)
CA (1) CA2893963A1 (en)
CL (1) CL2015001702A1 (en)
CR (1) CR20150370A (en)
EA (2) EA027828B1 (en)
ES (1) ES2626392T3 (en)
HK (2) HK1214594A1 (en)
IL (1) IL239496D0 (en)
MA (1) MA38261A1 (en)
MD (1) MD20150062A2 (en)
MX (1) MX2015007888A (en)
PE (1) PE20151423A1 (en)
PH (1) PH12015501354A1 (en)
PL (1) PL2935279T3 (en)
PT (1) PT2935279T (en)
SG (1) SG11201504746PA (en)
SI (1) SI2935279T1 (en)
TW (2) TWI613202B (en)
UY (1) UY35241A (en)
WO (1) WO2014100500A1 (en)

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2817840A1 (en) 2010-11-17 2012-05-24 Gilead Sciences, Inc. Antiviral compounds
ES2687291T3 (en) 2011-11-16 2018-10-24 Gilead Pharmasset Llc Condensed Imidazolylimidazoles as antiviral compounds
US20130309196A1 (en) * 2012-05-16 2013-11-21 Gilead Sciences, Inc. Antiviral compounds
US9398640B2 (en) 2012-12-21 2016-07-19 Halliburton Energy Services, Inc. Digital multi-use thermo-cup
CN104870435B (en) 2012-12-21 2016-12-07 辉瑞大药厂 Aryl and heteroaryl-condensed lactams
US9040534B2 (en) 2013-03-14 2015-05-26 Janssen Pharmaceutica Nv [1,2,4]triazolo[4,3-a]pyrazines as P2X7 modulators
TWI627174B (en) 2013-03-14 2018-06-21 比利時商健生藥品公司 P2x7 modulators
UY35391A (en) 2013-03-14 2014-09-30 Boehringer Ingelheim Int Acid 2-azabicyclo [2.2.1] heptane-3-carboxylic acid (benzyl-cyanomethyl) substituted amides inhibitors of cathepsin c
EP3321266A1 (en) 2013-03-14 2018-05-16 Janssen Pharmaceutica NV P2x7 modulators
TWI644671B (en) 2013-03-14 2018-12-21 比利時商健生藥品公司 P2x7 modulators
US9717712B2 (en) 2013-07-02 2017-08-01 Bristol-Myers Squibb Company Combinations comprising tricyclohexadecahexaene derivatives for use in the treatment of hepatitis C virus
US9775831B2 (en) 2013-07-17 2017-10-03 Bristol-Myers Squibb Company Combinations comprising biphenyl derivatives for use in the treatment of HCV
US10150766B2 (en) 2014-09-12 2018-12-11 Janssen Pharmaceutica Nv P2X7 modulators
MX2017003156A (en) 2014-09-12 2017-05-23 Boehringer Ingelheim Int Spirocyclic inhibitors of cathepsin c.
CN105801462A (en) * 2014-12-29 2016-07-27 重庆博腾制药科技股份有限公司 (4S)-N-Boc-4-methoxymethyl-L-proline synthesis method
CN105732765B (en) * 2016-02-01 2019-07-26 杭州科巢生物科技有限公司 The novel synthesis of hepatitis drug Wei Patawei
CN106916134A (en) * 2016-04-14 2017-07-04 苏州楚凯药业有限公司 A kind of preparation method of 10,11- dihydros -5H- benzos [d] naphtho- [2,3-b] pyrone derivative
AU2017271990A1 (en) 2016-05-27 2018-11-29 Gilead Sciences, Inc. Methods for treating Hepatitis B virus infections using NS5A, NS5B or NS3 inhibitors
CN106831737A (en) * 2017-02-27 2017-06-13 上海众强药业有限公司 The preparation of Wei Patawei and its derivative

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4968788A (en) 1986-04-04 1990-11-06 Board Of Regents, The University Of Texas System Biologically reversible phosphate and phosphonate protective gruops
US4816570A (en) 1982-11-30 1989-03-28 The Board Of Regents Of The University Of Texas System Biologically reversible phosphate and phosphonate protective groups
DK0481214T3 (en) 1990-09-14 1999-02-22 Acad Of Science Czech Republic Prodrugs of phosphonates
US5543523A (en) 1994-11-15 1996-08-06 Regents Of The University Of Minnesota Method and intermediates for the synthesis of korupensamines
AU2005274700B2 (en) 2004-07-16 2011-11-10 Gilead Sciences, Inc. Antiviral compounds
US7741347B2 (en) * 2007-05-17 2010-06-22 Bristol-Myers Squibb Company Hepatitis C virus inhibitors
WO2010096777A1 (en) * 2009-02-23 2010-08-26 Presidio Pharmaceuticals, Inc. Inhibitors of hcv ns5a
CA2817840A1 (en) 2010-11-17 2012-05-24 Gilead Sciences, Inc. Antiviral compounds
US8552047B2 (en) * 2011-02-07 2013-10-08 Bristol-Myers Squibb Company Hepatitis C virus inhibitors
US8466159B2 (en) 2011-10-21 2013-06-18 Abbvie Inc. Methods for treating HCV
US20130309196A1 (en) * 2012-05-16 2013-11-21 Gilead Sciences, Inc. Antiviral compounds
AR091279A1 (en) 2012-06-08 2015-01-21 Gilead Sciences Inc macrocyclic inhibitors Flaviviridae virus

Also Published As

Publication number Publication date
WO2014100500A1 (en) 2014-06-26
HK1216177A1 (en) 2016-10-21
EA201790781A3 (en) 2017-11-30
UY35241A (en) 2014-07-31
PL2935279T3 (en) 2017-08-31
EP3404030A1 (en) 2018-11-21
US20170369502A1 (en) 2017-12-28
AU2013361195A1 (en) 2015-06-11
CN104918943A (en) 2015-09-16
TW201835087A (en) 2018-10-01
PE20151423A1 (en) 2015-10-17
AR094262A1 (en) 2015-07-22
MA38261A1 (en) 2017-06-30
IL239496D0 (en) 2015-08-31
US20180244684A1 (en) 2018-08-30
MD20150062A2 (en) 2015-12-31
MX2015007888A (en) 2015-09-29
US20160362416A1 (en) 2016-12-15
EP2935279B1 (en) 2017-03-15
CN104918943B (en) 2017-04-05
EA201590868A1 (en) 2015-11-30
SI2935279T1 (en) 2017-06-30
CA2893963A1 (en) 2014-06-26
US9233974B2 (en) 2016-01-12
CN107011350A (en) 2017-08-04
PT2935279T (en) 2017-06-02
HK1214594A1 (en) 2016-07-29
TW201441229A (en) 2014-11-01
KR20150100728A (en) 2015-09-02
EP3239152A1 (en) 2017-11-01
EP2935279A1 (en) 2015-10-28
CL2015001702A1 (en) 2015-08-07
AP201508511A0 (en) 2015-06-30
US20160083395A1 (en) 2016-03-24
EA201790781A2 (en) 2017-08-31
AU2013361195B2 (en) 2018-05-17
EA027828B1 (en) 2017-09-29
CR20150370A (en) 2015-08-14
JP6333849B2 (en) 2018-05-30
JP2016503800A (en) 2016-02-08
PH12015501354A1 (en) 2015-09-07
ES2626392T3 (en) 2017-07-24
US20140178336A1 (en) 2014-06-26
TWI613202B (en) 2018-02-01
BR112015014333A2 (en) 2017-07-11
BR112015014333A8 (en) 2019-10-15

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