SG11201502628SA - Combination of a 6-oxo-1,6-dihydro-pyridazine derivative having anti-cancer activity with a mek inhibitor - Google Patents
Combination of a 6-oxo-1,6-dihydro-pyridazine derivative having anti-cancer activity with a mek inhibitorInfo
- Publication number
- SG11201502628SA SG11201502628SA SG11201502628SA SG11201502628SA SG11201502628SA SG 11201502628S A SG11201502628S A SG 11201502628SA SG 11201502628S A SG11201502628S A SG 11201502628SA SG 11201502628S A SG11201502628S A SG 11201502628SA SG 11201502628S A SG11201502628S A SG 11201502628SA
- Authority
- SG
- Singapore
- Prior art keywords
- dihydro
- oxo
- combination
- mek inhibitor
- cancer activity
- Prior art date
Links
- AAILEWXSEQLMNI-UHFFFAOYSA-N 1h-pyridazin-6-one Chemical class OC1=CC=CN=N1 AAILEWXSEQLMNI-UHFFFAOYSA-N 0.000 title 1
- 229940124647 MEK inhibitor Drugs 0.000 title 1
- 230000001093 anti-cancer Effects 0.000 title 1
- 239000002829 mitogen activated protein kinase inhibitor Substances 0.000 title 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Hematology (AREA)
- Oncology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Physiology (AREA)
- Nutrition Science (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP12007039 | 2012-10-11 | ||
| PCT/EP2013/002747 WO2014056566A1 (en) | 2012-10-11 | 2013-09-13 | Combination of a 6-oxo-1,6-dihydro-pyridazine derivative having anti-cancer activity with a mek inhibitor |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| SG11201502628SA true SG11201502628SA (en) | 2015-05-28 |
Family
ID=47048932
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SG11201502628SA SG11201502628SA (en) | 2012-10-11 | 2013-09-13 | Combination of a 6-oxo-1,6-dihydro-pyridazine derivative having anti-cancer activity with a mek inhibitor |
Country Status (17)
| Country | Link |
|---|---|
| US (1) | US20150297594A1 (en) |
| EP (1) | EP2906294B1 (en) |
| JP (1) | JP2015536910A (en) |
| KR (1) | KR102157501B1 (en) |
| CN (1) | CN104703655A (en) |
| AR (1) | AR092991A1 (en) |
| AU (1) | AU2013329865B2 (en) |
| BR (1) | BR112015007870B1 (en) |
| CA (1) | CA2887628C (en) |
| ES (1) | ES2679372T3 (en) |
| HK (1) | HK1211255A1 (en) |
| IL (1) | IL238061B (en) |
| MX (1) | MX359110B (en) |
| RU (1) | RU2684407C2 (en) |
| SG (1) | SG11201502628SA (en) |
| WO (1) | WO2014056566A1 (en) |
| ZA (1) | ZA201503186B (en) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP3229796B1 (en) * | 2014-12-11 | 2023-03-01 | Merck Patent GmbH | Combination of a 6-oxo-1,6-dihydro-pyridazine derivative having anti-cancer activity with a quinazoline derivative |
| US10532052B2 (en) * | 2014-12-12 | 2020-01-14 | Merck Patent Gmbh | Combination of a 6-oxo-1,6-dihydro-pyridazine derivative having anti-cancer activity with an EGFR inhibitor |
| JP6719679B2 (en) * | 2016-10-27 | 2020-07-08 | フーチェン コサンテール ファーマスーティカル カンパニー リミテッド | Pyridone compounds as c-MET inhibitors |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE102007032507A1 (en) * | 2007-07-12 | 2009-04-02 | Merck Patent Gmbh | pyridazinone derivatives |
| CN101653607B (en) * | 2008-08-19 | 2013-02-13 | 鼎泓国际投资（香港）有限公司 | Pharmaceutical composition containing hepatocyte growth factor receptor inhibitor and mitogen extracellular kinase inhibitor and application thereof |
| AR084216A1 (en) * | 2010-12-09 | 2013-05-02 | Sanofi Sa | COMPOSITIONS AND METHODS TO TREAT CANCER USING A PI3K INHIBITOR AND MEK INHIBITOR, KIT |
-
2013
- 2013-09-13 BR BR112015007870-2A patent/BR112015007870B1/en active IP Right Grant
- 2013-09-13 WO PCT/EP2013/002747 patent/WO2014056566A1/en active Application Filing
- 2013-09-13 EP EP13762992.9A patent/EP2906294B1/en active Active
- 2013-09-13 SG SG11201502628SA patent/SG11201502628SA/en unknown
- 2013-09-13 ES ES13762992.9T patent/ES2679372T3/en active Active
- 2013-09-13 AU AU2013329865A patent/AU2013329865B2/en active Active
- 2013-09-13 CA CA2887628A patent/CA2887628C/en active Active
- 2013-09-13 RU RU2015117550A patent/RU2684407C2/en active
- 2013-09-13 MX MX2015004428A patent/MX359110B/en active IP Right Grant
- 2013-09-13 US US14/434,926 patent/US20150297594A1/en not_active Abandoned
- 2013-09-13 KR KR1020157012085A patent/KR102157501B1/en active IP Right Grant
- 2013-09-13 CN CN201380053015.8A patent/CN104703655A/en active Pending
- 2013-09-13 JP JP2015536004A patent/JP2015536910A/en active Pending
- 2013-10-11 AR ARP130103703A patent/AR092991A1/en unknown
-
2015
- 2015-03-31 IL IL23806115A patent/IL238061B/en active IP Right Grant
- 2015-05-08 ZA ZA2015/03186A patent/ZA201503186B/en unknown
- 2015-12-07 HK HK15112009.7A patent/HK1211255A1/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| IL238061A0 (en) | 2015-05-31 |
| HK1211255A1 (en) | 2016-05-20 |
| CN104703655A (en) | 2015-06-10 |
| ES2679372T3 (en) | 2018-08-24 |
| BR112015007870B1 (en) | 2021-12-07 |
| RU2015117550A (en) | 2016-12-10 |
| JP2015536910A (en) | 2015-12-24 |
| AU2013329865A1 (en) | 2015-05-21 |
| WO2014056566A1 (en) | 2014-04-17 |
| ZA201503186B (en) | 2021-09-29 |
| RU2684407C2 (en) | 2019-04-09 |
| KR102157501B1 (en) | 2020-09-18 |
| IL238061B (en) | 2019-10-31 |
| CA2887628C (en) | 2020-09-08 |
| BR112015007870A2 (en) | 2017-07-04 |
| MX359110B (en) | 2018-09-14 |
| US20150297594A1 (en) | 2015-10-22 |
| EP2906294B1 (en) | 2018-04-18 |
| AU2013329865B2 (en) | 2018-04-26 |
| EP2906294A1 (en) | 2015-08-19 |
| MX2015004428A (en) | 2015-06-24 |
| CA2887628A1 (en) | 2014-04-17 |
| AR092991A1 (en) | 2015-05-13 |
| KR20150067343A (en) | 2015-06-17 |
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