SG11201502014XA - Hydropyrrolopyrrole derivatives for use as fatty acid synthase inhibitors - Google Patents
Hydropyrrolopyrrole derivatives for use as fatty acid synthase inhibitorsInfo
- Publication number
- SG11201502014XA SG11201502014XA SG11201502014XA SG11201502014XA SG11201502014XA SG 11201502014X A SG11201502014X A SG 11201502014XA SG 11201502014X A SG11201502014X A SG 11201502014XA SG 11201502014X A SG11201502014X A SG 11201502014XA SG 11201502014X A SG11201502014X A SG 11201502014XA
- Authority
- SG
- Singapore
- Prior art keywords
- hydropyrrolopyrrole
- derivatives
- fatty acid
- acid synthase
- synthase inhibitors
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A61K31/407—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with other heterocyclic ring systems, e.g. ketorolac, physostigmine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/472—Non-condensed isoquinolines, e.g. papaverine
- A61K31/4725—Non-condensed isoquinolines, e.g. papaverine containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Epidemiology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pain & Pain Management (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Oncology (AREA)
- Rheumatology (AREA)
- Hematology (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP12006668 | 2012-09-24 | ||
| PCT/EP2013/002606 WO2014044356A1 (en) | 2012-09-24 | 2013-08-30 | Hydropyrrolopyrrole derivatives for use as fatty acid synthase inhibitors |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| SG11201502014XA true SG11201502014XA (en) | 2015-04-29 |
Family
ID=47088611
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SG11201502014XA SG11201502014XA (en) | 2012-09-24 | 2013-08-30 | Hydropyrrolopyrrole derivatives for use as fatty acid synthase inhibitors |
Country Status (16)
| Country | Link |
|---|---|
| US (1) | US9416133B2 (en) |
| EP (1) | EP2897958B1 (en) |
| JP (1) | JP6259460B2 (en) |
| KR (1) | KR20150061644A (en) |
| CN (1) | CN104640866B (en) |
| AR (1) | AR092211A1 (en) |
| AU (1) | AU2013320636A1 (en) |
| BR (1) | BR112015005862A2 (en) |
| CA (1) | CA2885673A1 (en) |
| ES (1) | ES2608040T3 (en) |
| HK (1) | HK1210470A1 (en) |
| IL (1) | IL237839A0 (en) |
| MX (1) | MX2015003542A (en) |
| RU (1) | RU2015115278A (en) |
| SG (1) | SG11201502014XA (en) |
| WO (1) | WO2014044356A1 (en) |
Families Citing this family (20)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR102104144B1 (en) | 2012-03-07 | 2020-04-23 | 디 인스티튜트 오브 캔서 리서치:로얄 캔서 하스피틀 | 3-aryl-5-substituted-isoquinolin-1-one compounds and their therapeutic use |
| AR095079A1 (en) | 2013-03-12 | 2015-09-16 | Hoffmann La Roche | DERIVATIVES OF OCTAHIDRO-PIRROLO [3,4-C] -PIRROL AND PIRIDINA-FENILO |
| PT2968316T (en) | 2013-03-13 | 2019-10-29 | Forma Therapeutics Inc | 2-hydroxy-1-{4-[(4-phenylphenyl)carbonyl]piperazin-1-yl}ethan-1-one derivatives and related compounds as fatty acid synthase (fasn) inhibitors for the treatment of cancer |
| DK3044221T3 (en) | 2013-09-11 | 2018-04-23 | Institute Of Cancer Res Royal Cancer Hospital The | 3-ARYL-5-SUBSTITUTED-ISOQUINOLIN-1-ON COMPOUNDS AND THERAPEUTIC APPLICATION THEREOF |
| UA118201C2 (en) | 2013-11-26 | 2018-12-10 | Ф. Хоффманн-Ля Рош Аг | NEW OCTAHYDRO-CYCLOBUTA [1,2-c;3,4-c']DIPYRROL-2-YL |
| CA2937616A1 (en) | 2014-03-26 | 2015-10-01 | F. Hoffmann-La Roche Ag | Bicyclic compounds as autotaxin (atx) and lysophosphatidic acid (lpa) production inhibitors |
| PE20180572A1 (en) | 2015-06-18 | 2018-04-04 | Cephalon Inc | 1,4-SUBSTITUTED PIPERIDINE DERIVATIVES |
| ES2849951T3 (en) | 2015-06-18 | 2021-08-24 | 89Bio Ltd | 4-benzyl and 4-benzoyl substituted piperidine derivatives |
| UA123362C2 (en) | 2015-09-04 | 2021-03-24 | Ф. Хоффманн-Ля Рош Аг | Phenoxymethyl derivatives |
| AU2016328535A1 (en) | 2015-09-24 | 2017-11-09 | F. Hoffmann-La Roche Ag | Bicyclic compounds as ATX inhibitors |
| JP6845230B2 (en) * | 2015-09-24 | 2021-03-17 | エフ．ホフマン−ラ ロシュ アーゲーＦ． Ｈｏｆｆｍａｎｎ−Ｌａ Ｒｏｃｈｅ Ａｋｔｉｅｎｇｅｓｅｌｌｓｃｈａｆｔ | A novel bicyclic compound as a dual ATX / CA inhibitor |
| KR20180054635A (en) | 2015-09-24 | 2018-05-24 | 에프. 호프만-라 로슈 아게 | As an autotaxin (ATX) inhibitor, |
| US10722484B2 (en) | 2016-03-09 | 2020-07-28 | K-Gen, Inc. | Methods of cancer treatment |
| BR112019019017A2 (en) | 2017-03-16 | 2020-04-14 | Hoffmann La Roche | heterocyclic compounds useful as dual atx / ca inhibitors |
| JP7090099B2 (en) | 2017-03-16 | 2022-06-23 | エフ．ホフマン－ラ ロシュ アーゲー | A novel bicyclic compound as an ATX inhibitor |
| TW202244048A (en) | 2017-03-20 | 2022-11-16 | 美商佛瑪治療公司 | Pyrrolopyrrole compositions as pyruvate kinase (pkr) activators |
| US20230055923A1 (en) | 2018-09-19 | 2023-02-23 | Forma Therapeutics, Inc. | Activating pyruvate kinase r |
| BR112021005188A2 (en) | 2018-09-19 | 2021-06-08 | Forma Therapeutics, Inc. | treating sickle cell anemia with a pyruvate kinase r activating compound |
| TWI767148B (en) | 2018-10-10 | 2022-06-11 | 美商弗瑪治療公司 | Inhibiting fatty acid synthase (fasn) |
| CN113382633A (en) | 2018-10-29 | 2021-09-10 | 福马治疗股份有限公司 | Solid forms of (4- (2-fluoro-4- (1-methyl-1H-benzo [ d ] imidazol-5-yl) benzoyl) piperazin-1-yl) (1-hydroxycyclopropyl) methanone |
Family Cites Families (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP1987036A1 (en) * | 2006-02-15 | 2008-11-05 | F.Hoffmann-La Roche Ag | Hetero-bycyclic antiviral compounds |
| WO2007117401A2 (en) * | 2006-04-07 | 2007-10-18 | Janssen Pharmaceutica N.V. | Indoles and benzoimidazoles as modulators of the histamine h4 receptor |
| WO2008059214A1 (en) * | 2006-11-13 | 2008-05-22 | Astrazeneca Ab | Bisamlde derivatives and use thereof as fatty acid synthase inhibitors |
| MX2009009415A (en) * | 2007-03-01 | 2009-09-11 | Janssen Pharmaceutica Nv | Tetrahydroisoquinoline compounds as modulators of the histamine h3 receptor. |
| EP2170064A4 (en) * | 2007-06-22 | 2010-08-04 | Merck Sharp & Dohme | 6.5-pyrrolopiperidine tachykinin receptor antagonists |
| EP2491009B1 (en) | 2009-10-19 | 2017-07-05 | Boehringer Ingelheim International GmbH | Cyclopentanecarboxamide derivatives, medicaments containing such compounds and their use |
| US20120208827A1 (en) | 2009-10-27 | 2012-08-16 | Glaxosmithkline Llc | Benzimidazoles as fatty acid synthase inhibitors |
| US8633183B2 (en) * | 2010-01-26 | 2014-01-21 | Boehringer Ingelheim International Gmbh | 5-alkynyl-pyrimidines |
| US20130237535A1 (en) | 2010-11-08 | 2013-09-12 | Nicholas D. Adams | Fatty acid synthase inhibitors |
| AU2012225390B2 (en) * | 2011-03-08 | 2015-11-12 | Sagimet Biosciences Inc. | Heterocyclic modulators of lipid synthesis |
| WO2013028445A1 (en) * | 2011-08-19 | 2013-02-28 | Glaxosmithkline Llc | Fatty acid synthase inhibitors |
-
2013
- 2013-08-23 AR ARP130102988A patent/AR092211A1/en unknown
- 2013-08-30 EP EP13758748.1A patent/EP2897958B1/en not_active Not-in-force
- 2013-08-30 RU RU2015115278A patent/RU2015115278A/en unknown
- 2013-08-30 ES ES13758748.1T patent/ES2608040T3/en active Active
- 2013-08-30 KR KR1020157010529A patent/KR20150061644A/en not_active Application Discontinuation
- 2013-08-30 WO PCT/EP2013/002606 patent/WO2014044356A1/en active Application Filing
- 2013-08-30 SG SG11201502014XA patent/SG11201502014XA/en unknown
- 2013-08-30 MX MX2015003542A patent/MX2015003542A/en unknown
- 2013-08-30 AU AU2013320636A patent/AU2013320636A1/en not_active Abandoned
- 2013-08-30 BR BR112015005862A patent/BR112015005862A2/en not_active IP Right Cessation
- 2013-08-30 CN CN201380049347.9A patent/CN104640866B/en not_active Expired - Fee Related
- 2013-08-30 JP JP2015532318A patent/JP6259460B2/en not_active Expired - Fee Related
- 2013-08-30 CA CA 2885673 patent/CA2885673A1/en not_active Abandoned
- 2013-08-30 US US14/430,630 patent/US9416133B2/en not_active Expired - Fee Related
-
2015
- 2015-03-19 IL IL237839A patent/IL237839A0/en unknown
- 2015-11-16 HK HK15111265.8A patent/HK1210470A1/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| JP6259460B2 (en) | 2018-01-10 |
| EP2897958A1 (en) | 2015-07-29 |
| WO2014044356A1 (en) | 2014-03-27 |
| US20150252046A1 (en) | 2015-09-10 |
| IL237839A0 (en) | 2015-05-31 |
| HK1210470A1 (en) | 2016-04-22 |
| JP2015529229A (en) | 2015-10-05 |
| AR092211A1 (en) | 2015-04-08 |
| KR20150061644A (en) | 2015-06-04 |
| BR112015005862A2 (en) | 2017-07-04 |
| AU2013320636A1 (en) | 2015-05-07 |
| EP2897958B1 (en) | 2016-09-21 |
| ES2608040T3 (en) | 2017-04-05 |
| MX2015003542A (en) | 2015-07-17 |
| CA2885673A1 (en) | 2014-03-27 |
| CN104640866A (en) | 2015-05-20 |
| US9416133B2 (en) | 2016-08-16 |
| CN104640866B (en) | 2017-06-06 |
| RU2015115278A (en) | 2016-11-20 |
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