SG11201500397XA - Methods for inhibition of bnip3 and prevention and treatment of ischemia reperfusion injury by tetra-o-methyl nordihydroguaiaretic acid - Google Patents

Methods for inhibition of bnip3 and prevention and treatment of ischemia reperfusion injury by tetra-o-methyl nordihydroguaiaretic acid

Info

Publication number
SG11201500397XA
SG11201500397XA SG11201500397XA SG11201500397XA SG11201500397XA SG 11201500397X A SG11201500397X A SG 11201500397XA SG 11201500397X A SG11201500397X A SG 11201500397XA SG 11201500397X A SG11201500397X A SG 11201500397XA SG 11201500397X A SG11201500397X A SG 11201500397XA
Authority
SG
Singapore
Prior art keywords
bnip3
tetra
inhibition
prevention
treatment
Prior art date
Application number
SG11201500397XA
Inventor
Ru Chih Huang
Kotohiko Kimura
Original Assignee
Univ Johns Hopkins
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ Johns Hopkins filed Critical Univ Johns Hopkins
Publication of SG11201500397XA publication Critical patent/SG11201500397XA/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/075—Ethers or acetals
    • A61K31/085—Ethers or acetals having an ether linkage to aromatic ring nuclear carbon
    • A61K31/09—Ethers or acetals having an ether linkage to aromatic ring nuclear carbon having two or more such linkages
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/075—Ethers or acetals
    • A61K31/085—Ethers or acetals having an ether linkage to aromatic ring nuclear carbon
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
SG11201500397XA 2012-07-18 2013-07-18 Methods for inhibition of bnip3 and prevention and treatment of ischemia reperfusion injury by tetra-o-methyl nordihydroguaiaretic acid SG11201500397XA (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201261672884P 2012-07-18 2012-07-18
PCT/US2013/051074 WO2014015136A2 (en) 2012-07-18 2013-07-18 Methods for inhibition of bnip3 and prevention and treatment of ischemia reperfusion injury by tetra-o-methyl nordihydroguaiaretic acid

Publications (1)

Publication Number Publication Date
SG11201500397XA true SG11201500397XA (en) 2015-03-30

Family

ID=49949373

Family Applications (1)

Application Number Title Priority Date Filing Date
SG11201500397XA SG11201500397XA (en) 2012-07-18 2013-07-18 Methods for inhibition of bnip3 and prevention and treatment of ischemia reperfusion injury by tetra-o-methyl nordihydroguaiaretic acid

Country Status (7)

Country Link
US (1) US9456995B2 (en)
EP (1) EP2874986A4 (en)
JP (1) JP2015528804A (en)
CN (1) CN104603094A (en)
AU (1) AU2013292576A1 (en)
SG (1) SG11201500397XA (en)
WO (1) WO2014015136A2 (en)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2857532A (en) * 1956-08-29 1958-10-21 Bell Telephone Labor Inc Ferroelectric crystal unit
US10531655B2 (en) 2011-12-02 2020-01-14 The Regents Of The University Of California Reperfusion protection solution and uses thereof
MX2017002227A (en) 2017-02-17 2018-08-16 Promotora Tecnica Ind S A De C V Composition based on nordihydroguaiaretic acid.

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3906004A (en) * 1968-12-09 1975-09-16 Hoffmann La Roche Stereoselective synthesis of intermediate for preparation of meso-nordihydroguaiaretic acid
US6365787B1 (en) * 1994-09-30 2002-04-02 The Johns Hopkins University Compounds for the suppression of HIV TAT transactivation
US6214874B1 (en) * 1999-10-15 2001-04-10 John Hopkins University Treatment of HPV induced cancer using in situ application of two nordihydroguiaretic acid derivatives, tetramethyl NDGA M4N and tetraglycinal NDGA G4N
WO2004009780A2 (en) * 2002-07-22 2004-01-29 University Of Miami Preventing ischemia-induced cell damage
CN102481283A (en) * 2009-08-31 2012-05-30 埃里克·B·施耐德 Treatment and prevention of secondary injury after trauma or damage to the central nervous system

Also Published As

Publication number Publication date
WO2014015136A2 (en) 2014-01-23
EP2874986A2 (en) 2015-05-27
US20150209304A1 (en) 2015-07-30
EP2874986A4 (en) 2016-02-10
JP2015528804A (en) 2015-10-01
WO2014015136A3 (en) 2014-03-13
AU2013292576A1 (en) 2015-02-05
CN104603094A (en) 2015-05-06
US9456995B2 (en) 2016-10-04

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