SG11201407498RA - Veliparib in combination with whole brain radiation therapy for the treatment of brain metastases - Google Patents
Veliparib in combination with whole brain radiation therapy for the treatment of brain metastasesInfo
- Publication number
- SG11201407498RA SG11201407498RA SG11201407498RA SG11201407498RA SG11201407498RA SG 11201407498R A SG11201407498R A SG 11201407498RA SG 11201407498R A SG11201407498R A SG 11201407498RA SG 11201407498R A SG11201407498R A SG 11201407498RA SG 11201407498R A SG11201407498R A SG 11201407498RA
- Authority
- SG
- Singapore
- Prior art keywords
- international
- treatment
- combination
- illinois
- brain
- Prior art date
Links
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K41/00—Medicinal preparations obtained by treating materials with wave energy or particle radiation ; Therapies using these preparations
- A61K41/0038—Radiosensitizing, i.e. administration of pharmaceutical agents that enhance the effect of radiotherapy
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N5/00—Radiation therapy
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/4164—1,3-Diazoles
- A61K31/4184—1,3-Diazoles condensed with carbocyclic rings, e.g. benzimidazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/04—Antineoplastic agents specific for metastasis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N5/00—Radiation therapy
- A61N5/10—X-ray therapy; Gamma-ray therapy; Particle-irradiation therapy
- A61N2005/1092—Details
- A61N2005/1098—Enhancing the effect of the particle by an injected agent or implanted device
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical & Material Sciences (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Biomedical Technology (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Organic Chemistry (AREA)
- Pathology (AREA)
- Radiology & Medical Imaging (AREA)
- Oncology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
(12) INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) (19) World Intellectual Property Organization International Bureau (43) International Publication Date 21 November 2013 (21.11.2013) WIPOIPCT (10) International Publication Number WO 2013/173428 A1 (51) International Patent Classification: A61K31/4184 (2006.01) A61P 35/04 (2006.01) A61K 41/00 (2006.01) (21) International Application Number: (22) International Filing Date: (25) Filing Language: (26) Publication Language: PCT/US2013/041095 15 May 2013 (15.05.2013) English English (30) Priority Data: 61/647,329 15 May 2012 (15.05.2012) US (71) Applicant: ABBVIE INC. [US/US]; 1 North Waukegan Road, North Chicago, Illinois 60064 (US). (72) Inventor: GIRANDA, Vincent L.; 272 S. Fork Dr., Gurnee, Illinois 60031 (US). (74) Agents: STEELE, Susan et al.; 100 Abbott Park Road, Bid AP06A-1/V377, Abbott Park, Illinois 60064 (US). (81) Designated States (unless otherwise indicated, for every kind of national protection available)'. AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW. (84) Designated States (unless otherwise indicated, for every kind of regional protection available)'. ARIPO (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, SZ, TZ, UG, ZM, ZW), Eurasian (AM, AZ, BY, KG, KZ, RU, TJ, TM), European (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR), OAPI (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG). Published: — with international search report (Art. 21(3)) (54) Title: VELIPARIB IN COMBINATION WITH WHOLE BRAIN RADIATION THERAPY FOR THE TREATMENT OF BRAIN METASTASES Observed vs. Expected Survival - NSCLC oo CJ m i> Predicted Overall Survival (Case I Controlled) Censored Observation Pts at Risk Predicted Observed 0 1 60 ' 120 ! 180 ! 240 1 300 360 ! 1 420 480 1 1 540 1 600 * 660 * 720 ! 780 1 840 1 900 30 90 150 210 270 330 390 450 510 570 830 690 750 810 870 Survival Boys 32 32 32 29 10 4 32 30 30 25 21 20 17 15 12 12 10 7 7 6 3 2 1 1 1111111111 T-H © (57) Abstract: The invention relates to a method for the treatment of brain metastases from non-small cell lung cancer in subject, a ^ comprising administering subject to the an effective amount of 2-[(2R)-2-methylpyrrolidin-2-yl]-lH-benzimidazole-4-carboxamide, Q or a pharmaceutical^ acceptable salt thereof, in combination with an effective amount of whole brain radiation.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201261647329P | 2012-05-15 | 2012-05-15 | |
| PCT/US2013/041095 WO2013173428A1 (en) | 2012-05-15 | 2013-05-15 | Veliparib in combination with whole brain radiation therapy for the treatment of brain metastases |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| SG11201407498RA true SG11201407498RA (en) | 2014-12-30 |
Family
ID=48576528
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SG11201407498RA SG11201407498RA (en) | 2012-05-15 | 2013-05-15 | Veliparib in combination with whole brain radiation therapy for the treatment of brain metastases |
Country Status (18)
| Country | Link |
|---|---|
| US (1) | US20130310625A1 (en) |
| EP (1) | EP2849750A1 (en) |
| JP (1) | JP2015521188A (en) |
| KR (1) | KR20150017355A (en) |
| CN (1) | CN104602688A (en) |
| AU (1) | AU2013262906A1 (en) |
| BR (1) | BR112014028618A2 (en) |
| CA (1) | CA2873119A1 (en) |
| CL (1) | CL2014003072A1 (en) |
| DO (1) | DOP2014000258A (en) |
| HK (1) | HK1207984A1 (en) |
| IL (1) | IL235389A0 (en) |
| MX (1) | MX2014013903A (en) |
| PH (1) | PH12014502464A1 (en) |
| RU (1) | RU2014150506A (en) |
| SG (1) | SG11201407498RA (en) |
| TW (1) | TW201400113A (en) |
| WO (1) | WO2013173428A1 (en) |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR20170055536A (en) * | 2014-09-16 | 2017-05-19 | 애브비 인코포레이티드 | Veliparib in combination with carboplatin and paclitaxel for the treatment of non-small cell lung cancer in smokers |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| TWI375673B (en) | 2005-04-11 | 2012-11-01 | Abbott Lab | 1h-benzimidazole-4-carboxamides substituted with a quaternary carbon at the 2-position are potent parp inhibitors |
| WO2007084532A2 (en) | 2006-01-17 | 2007-07-26 | Abbott Laboratories | Combination therapy with parp inhibitors |
| WO2011130689A1 (en) * | 2010-04-15 | 2011-10-20 | Tracon Pharmaceuticals, Inc. | Potentiation of anti-cancer activity through combination therapy with ber pathway inhibitors |
-
2013
- 2013-05-15 JP JP2015512782A patent/JP2015521188A/en active Pending
- 2013-05-15 US US13/894,555 patent/US20130310625A1/en not_active Abandoned
- 2013-05-15 TW TW102117250A patent/TW201400113A/en unknown
- 2013-05-15 CN CN201380025598.3A patent/CN104602688A/en active Pending
- 2013-05-15 BR BR112014028618A patent/BR112014028618A2/en not_active Application Discontinuation
- 2013-05-15 EP EP13726934.6A patent/EP2849750A1/en not_active Withdrawn
- 2013-05-15 KR KR1020147035036A patent/KR20150017355A/en not_active Application Discontinuation
- 2013-05-15 WO PCT/US2013/041095 patent/WO2013173428A1/en active Application Filing
- 2013-05-15 CA CA2873119A patent/CA2873119A1/en not_active Abandoned
- 2013-05-15 SG SG11201407498RA patent/SG11201407498RA/en unknown
- 2013-05-15 MX MX2014013903A patent/MX2014013903A/en unknown
- 2013-05-15 RU RU2014150506A patent/RU2014150506A/en unknown
- 2013-05-15 AU AU2013262906A patent/AU2013262906A1/en not_active Abandoned
-
2014
- 2014-10-29 IL IL235389A patent/IL235389A0/en unknown
- 2014-11-05 PH PH12014502464A patent/PH12014502464A1/en unknown
- 2014-11-12 CL CL2014003072A patent/CL2014003072A1/en unknown
- 2014-11-14 DO DO2014000258A patent/DOP2014000258A/en unknown
-
2015
- 2015-09-07 HK HK15108693.6A patent/HK1207984A1/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| AU2013262906A1 (en) | 2014-11-20 |
| PH12014502464A1 (en) | 2014-12-22 |
| DOP2014000258A (en) | 2015-01-15 |
| KR20150017355A (en) | 2015-02-16 |
| CA2873119A1 (en) | 2013-11-21 |
| TW201400113A (en) | 2014-01-01 |
| IL235389A0 (en) | 2014-12-31 |
| BR112014028618A2 (en) | 2017-06-27 |
| CL2014003072A1 (en) | 2015-02-27 |
| JP2015521188A (en) | 2015-07-27 |
| EP2849750A1 (en) | 2015-03-25 |
| WO2013173428A1 (en) | 2013-11-21 |
| RU2014150506A (en) | 2016-07-10 |
| HK1207984A1 (en) | 2016-02-19 |
| CN104602688A (en) | 2015-05-06 |
| MX2014013903A (en) | 2015-01-16 |
| US20130310625A1 (en) | 2013-11-21 |
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