SG11201405530SA - Esketamine for the treatment of treatment-refractory or treatment-resistant depression - Google Patents
Esketamine for the treatment of treatment-refractory or treatment-resistant depressionInfo
- Publication number
- SG11201405530SA SG11201405530SA SG11201405530SA SG11201405530SA SG11201405530SA SG 11201405530S A SG11201405530S A SG 11201405530SA SG 11201405530S A SG11201405530S A SG 11201405530SA SG 11201405530S A SG11201405530S A SG 11201405530SA SG 11201405530S A SG11201405530S A SG 11201405530SA
- Authority
- SG
- Singapore
- Prior art keywords
- treatment
- esketamine
- refractory
- resistant depression
- depression
- Prior art date
Links
- YQEZLKZALYSWHR-ZDUSSCGKSA-N (S)-ketamine Chemical compound C=1C=CC=C(Cl)C=1[C@@]1(NC)CCCCC1=O YQEZLKZALYSWHR-ZDUSSCGKSA-N 0.000 title 1
- 208000028552 Treatment-Resistant Depressive disease Diseases 0.000 title 1
- 229960000450 esketamine Drugs 0.000 title 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/13—Amines
- A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/13—Amines
- A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
- A61K31/137—Arylalkylamines, e.g. amphetamine, epinephrine, salbutamol, ephedrine or methadone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
- A61K31/551—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole having two nitrogen atoms, e.g. dilazep
- A61K31/5513—1,4-Benzodiazepines, e.g. diazepam or clozapine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
- A61K31/554—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole having at least one nitrogen and one sulfur as ring hetero atoms, e.g. clothiapine, diltiazem
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
Landscapes
- Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Emergency Medicine (AREA)
- Neurology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Organic Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Engineering & Computer Science (AREA)
- Psychiatry (AREA)
- Pain & Pain Management (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201261609641P | 2012-03-12 | 2012-03-12 | |
| US201261610058P | 2012-03-13 | 2012-03-13 | |
| PCT/US2013/030476 WO2013138322A1 (en) | 2012-03-12 | 2013-03-12 | Esketamine for the treatment of treatment-refractory or treatment-resistant depression |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| SG11201405530SA true SG11201405530SA (en) | 2014-11-27 |
Family
ID=47913632
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SG11201405530SA SG11201405530SA (en) | 2012-03-12 | 2013-03-12 | Esketamine for the treatment of treatment-refractory or treatment-resistant depression |
Country Status (14)
| Country | Link |
|---|---|
| US (2) | US20130236573A1 (en) |
| KR (1) | KR20140136982A (en) |
| CN (1) | CN104519878A (en) |
| CL (1) | CL2014002406A1 (en) |
| CO (1) | CO7071129A2 (en) |
| CR (1) | CR20140410A (en) |
| GT (1) | GT201400191A (en) |
| HK (1) | HK1209323A1 (en) |
| MX (1) | MX2014010939A (en) |
| NI (1) | NI201400104A (en) |
| PE (1) | PE20141906A1 (en) |
| PH (1) | PH12014501997A1 (en) |
| SG (1) | SG11201405530SA (en) |
| WO (1) | WO2013138322A1 (en) |
Families Citing this family (39)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US9737531B2 (en) * | 2012-07-12 | 2017-08-22 | Glytech, Llc | Composition and method for treatment of depression and psychosis in humans |
| US10583138B2 (en) | 2012-07-12 | 2020-03-10 | Glytech, Llc | Composition and method for treatment of depression and psychosis in humans |
| PE20200404A1 (en) | 2013-03-15 | 2020-02-26 | Janssen Pharmaceutica Nv | PHARMACEUTICAL COMPOSITION OF S-KETAMINE HYDROCHLORIDE |
| CN105377371A (en) | 2013-04-12 | 2016-03-02 | 西奈山伊坎医学院 | Method for treating post-traumatic stress disorder |
| RS62516B1 (en) | 2013-09-13 | 2021-11-30 | Univ Chiba Nat Univ Corp | Application of r-ketamine and salt thereof as pharmaceuticals |
| US9610259B2 (en) * | 2014-01-14 | 2017-04-04 | Children's Hospital Medical Center | Compositions and methods for treating an autism spectrum disorder |
| MX2016014581A (en) * | 2014-05-06 | 2018-02-16 | Univ Northwestern | Combinations of nmdar modulating compounds. |
| MX2017001908A (en) * | 2014-08-13 | 2017-08-08 | Janssen Pharmaceutica Nv | Method for the treatment of depression. |
| EP3725307A1 (en) * | 2014-09-15 | 2020-10-21 | Janssen Pharmaceutica NV | Val66met (snp rs6265) genotype specific dosing regimens and methods for the treatment of depression |
| EP3229788A4 (en) | 2014-12-08 | 2018-06-13 | Cima Labs Inc. | Immediate release abuse-deterrent granulated dosage forms |
| WO2016109427A1 (en) * | 2014-12-31 | 2016-07-07 | Icahn School Of Medicine At Mount Sinai | Method of maintaining the anti-depressant effect of ketamine with lithium |
| US9844551B2 (en) | 2015-01-14 | 2017-12-19 | Children's Hospital Medical Center | Compositions and methods for treatment of fragile X syndrome |
| WO2016172672A1 (en) * | 2015-04-24 | 2016-10-27 | Icahn School Of Medicine At Mount Sinai | Method for treating suicidal ideation |
| US20160332962A1 (en) | 2015-05-13 | 2016-11-17 | Janssen Pharmaceutica Nv | (s)-csa salt of s-ketamine, (r)-csa salt of s-ketamine and processes for the preparation of s-ketamine |
| US20160338977A1 (en) * | 2015-05-20 | 2016-11-24 | Janssen Pharmaceutica Nv | Methods and kits for treating depression |
| WO2017003935A1 (en) | 2015-06-27 | 2017-01-05 | Shenox Pharmaceuticals, Llc | Ketamine transdermal delivery system |
| CN106562952B (en) * | 2015-10-09 | 2020-06-09 | 江阴安博生物医药有限公司 | Use of ketamine in the treatment of major depressive disorder |
| WO2017087691A1 (en) | 2015-11-17 | 2017-05-26 | The Trustees Of Columbia University In The City Of New York | Pharmacological prophylactics against stress-induced affective disorders and their associated symptoms |
| WO2018079693A1 (en) * | 2016-10-27 | 2018-05-03 | 国立大学法人 千葉大学 | Pharmaceutical applications for (s)-norketamine and salts thereof |
| WO2018234568A2 (en) * | 2017-06-23 | 2018-12-27 | Develco Pharma Schweiz Ag | Hydroxynorketamine for the use in the treatment of depression |
| US20200009081A1 (en) | 2017-09-13 | 2020-01-09 | Janssen Pharmaceutica N.V. | Delivery Of Esketamine For The Treatment Of Depression |
| WO2019094596A1 (en) | 2017-11-09 | 2019-05-16 | The Trustees Of Columbia University In The City Of New York | Biomarkers for efficacy of prophylactic treatments against stress-induced affective disorders |
| CN107823195A (en) * | 2017-11-24 | 2018-03-23 | 无锡市精神卫生中心 | Application of the R ketamines in depression acute stages treated |
| CN112423789A (en) | 2017-12-22 | 2021-02-26 | 詹森药业有限公司 | Esketamine for the treatment of depression |
| HUE058320T2 (en) | 2017-12-29 | 2022-07-28 | Celon Pharma Sa | Dry powder ketamine composition for pulmonary administration in treatment-resistant depression |
| BR112020016500A2 (en) | 2018-02-15 | 2020-12-15 | National University Corporation Chiba University | PREVENTIVE OR THERAPEUTIC AGENT AND PHARMACEUTICAL COMPOSITION FOR INFLAMMATORY DISEASE OR BONE DISEASE |
| WO2019213551A1 (en) | 2018-05-04 | 2019-11-07 | Perception Neuroscience, Inc. | Methods of treating substance abuse |
| JP2021529732A (en) * | 2018-06-27 | 2021-11-04 | クレキシオ バイオサイエンシーズ エルティーディー． | How to treat major depressive disorder |
| WO2020027344A1 (en) * | 2018-08-03 | 2020-02-06 | Takeda Pharmaceutical Company Limited | Ch24h inhibitors for mdd use |
| EP3628313A1 (en) | 2018-09-28 | 2020-04-01 | Celon Pharma S.A. | Ketamine composition for use in a method of treatment of depression by pulmonary administration |
| CA3113198A1 (en) | 2018-10-05 | 2020-04-09 | Clexio Biosciences Ltd. | Dosage regime of esketamine for treating major depressive disorder |
| WO2020168337A1 (en) * | 2019-02-17 | 2020-08-20 | Magid Abraham | Compositions and methods for treatment of depression and other disorders |
| EP3934632A4 (en) | 2019-03-05 | 2022-11-23 | Janssen Pharmaceuticals, Inc. | Esketamine for the treatment of depression |
| WO2020239243A1 (en) | 2019-05-31 | 2020-12-03 | Celon Pharma S.A. | Electronically supervised administration of a pharmaceutical composition |
| WO2020239244A1 (en) | 2019-05-31 | 2020-12-03 | Celon Pharma S.A. | An inhaler for electronically supervised parenteral administration of a pharmaceutical composition |
| WO2021038500A2 (en) * | 2019-08-28 | 2021-03-04 | Janssen Pharmaceuticals, Inc. | Esketamine for the treatment of patients with major depressive disorder, including suicidality |
| EP4028085A4 (en) * | 2019-09-13 | 2023-10-04 | Janssen Pharmaceuticals, Inc. | Intranasal administration of esketamine |
| JP2023527343A (en) * | 2020-05-28 | 2023-06-28 | ヤンセン ファーマシューティカ エヌ．ベー． | how to treat depression |
| WO2023162987A1 (en) * | 2022-02-22 | 2023-08-31 | 国立大学法人京都大学 | Medicine for treatment and/or prevention of depression and/or depressive state |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6176242B1 (en) * | 1999-04-30 | 2001-01-23 | Medtronic Inc | Method of treating manic depression by brain infusion |
| EP1103256A1 (en) * | 1999-11-26 | 2001-05-30 | Claudius Dr. med. Böck | Use of ketamine for the treatment of neuroendocrine immune dysfunction und algogenic psychosyndrome |
| EP1551393A4 (en) * | 2002-07-30 | 2010-06-16 | Peter Migaly | Combination therapy for depression, prevention of suicide, and varous medical and psychiatric conditions |
| US7273889B2 (en) * | 2002-09-25 | 2007-09-25 | Innovative Drug Delivery Systems, Inc. | NMDA receptor antagonist formulation with reduced neurotoxicity |
| CN101466364A (en) * | 2006-03-22 | 2009-06-24 | 纽约大学西奈山医学院 | Intranasal administration of ketamine to treat depression |
| JP2009538331A (en) * | 2006-05-22 | 2009-11-05 | ヴァンダ ファーマシューティカルズ インコーポレイテッド | Treatment for depression disorders |
| DE102007009888A1 (en) * | 2007-02-28 | 2008-09-04 | Hermann, Holger Lars, Dr. | Use of S-(+)-ketamine for treating depression, which is therapy-refractive depression, preferably depressive episode, relapsing disorder and bipolar affective disorder |
| US20110038807A1 (en) * | 2009-08-14 | 2011-02-17 | Demitri Papolos | Compositions and methods for treating bipolar disorder |
| AU2011267474B2 (en) * | 2010-06-15 | 2016-05-26 | Grünenthal GmbH | Pharmaceutical combination for the treatment of pain |
-
2013
- 2013-03-12 WO PCT/US2013/030476 patent/WO2013138322A1/en active Application Filing
- 2013-03-12 PE PE2014001406A patent/PE20141906A1/en not_active Application Discontinuation
- 2013-03-12 SG SG11201405530SA patent/SG11201405530SA/en unknown
- 2013-03-12 MX MX2014010939A patent/MX2014010939A/en unknown
- 2013-03-12 KR KR1020147028246A patent/KR20140136982A/en not_active Application Discontinuation
- 2013-03-12 US US13/795,454 patent/US20130236573A1/en not_active Abandoned
- 2013-03-12 CN CN201380013908.XA patent/CN104519878A/en active Pending
- 2013-12-05 US US14/098,498 patent/US20140093592A1/en not_active Abandoned
-
2014
- 2014-09-04 CR CR20140410A patent/CR20140410A/en unknown
- 2014-09-08 PH PH12014501997A patent/PH12014501997A1/en unknown
- 2014-09-10 CO CO14200330A patent/CO7071129A2/en unknown
- 2014-09-10 NI NI201400104A patent/NI201400104A/en unknown
- 2014-09-11 GT GT201400191A patent/GT201400191A/en unknown
- 2014-09-11 CL CL2014002406A patent/CL2014002406A1/en unknown
-
2015
- 2015-10-14 HK HK15110013.5A patent/HK1209323A1/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| CO7071129A2 (en) | 2014-09-30 |
| PE20141906A1 (en) | 2014-12-05 |
| CR20140410A (en) | 2014-11-17 |
| KR20140136982A (en) | 2014-12-01 |
| US20140093592A1 (en) | 2014-04-03 |
| GT201400191A (en) | 2017-07-03 |
| WO2013138322A1 (en) | 2013-09-19 |
| CL2014002406A1 (en) | 2015-01-09 |
| CN104519878A (en) | 2015-04-15 |
| MX2014010939A (en) | 2014-11-13 |
| PH12014501997A1 (en) | 2014-11-24 |
| HK1209323A1 (en) | 2016-04-01 |
| NI201400104A (en) | 2016-11-30 |
| US20130236573A1 (en) | 2013-09-12 |
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