SG11201403368WA - Bodipy structure fluorescence probes for diverse biological applications - Google Patents

Bodipy structure fluorescence probes for diverse biological applications

Info

Publication number
SG11201403368WA
SG11201403368WA SG11201403368WA SG11201403368WA SG11201403368WA SG 11201403368W A SG11201403368W A SG 11201403368WA SG 11201403368W A SG11201403368W A SG 11201403368WA SG 11201403368W A SG11201403368W A SG 11201403368WA SG 11201403368W A SG11201403368W A SG 11201403368WA
Authority
SG
Singapore
Prior art keywords
biological applications
diverse biological
fluorescence probes
structure fluorescence
bodipy structure
Prior art date
Application number
SG11201403368WA
Inventor
Young-Tae Chang
Sung Chan Lee
Nam-Young Kang
Seong Wook Yun
Cheryl Kit Mun Leong
Hyung Ho Ha
Original Assignee
Univ Singapore
Agency Science Tech & Res
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ Singapore, Agency Science Tech & Res filed Critical Univ Singapore
Publication of SG11201403368WA publication Critical patent/SG11201403368WA/en

Links

Classifications

    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/5306Improving reaction conditions, e.g. reduction of non-specific binding, promotion of specific binding
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07FACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F5/00Compounds containing elements of Groups 3 or 13 of the Periodic Table
    • C07F5/02Boron compounds
    • C07F5/022Boron compounds without C-boron linkages
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00Preparations for testing in vivo
    • A61K49/001Preparation for luminescence or biological staining
    • A61K49/0013Luminescence
    • A61K49/0017Fluorescence in vivo
    • A61K49/0019Fluorescence in vivo characterised by the fluorescent group, e.g. oligomeric, polymeric or dendritic molecules
    • A61K49/0021Fluorescence in vivo characterised by the fluorescent group, e.g. oligomeric, polymeric or dendritic molecules the fluorescent group being a small organic molecule
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00Preparations for testing in vivo
    • A61K49/001Preparation for luminescence or biological staining
    • A61K49/006Biological staining of tissues in vivo, e.g. methylene blue or toluidine blue O administered in the buccal area to detect epithelial cancer cells, dyes used for delineating tissues during surgery
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07FACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F5/00Compounds containing elements of Groups 3 or 13 of the Periodic Table
    • C07F5/02Boron compounds
    • CCHEMISTRY; METALLURGY
    • C09DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
    • C09BORGANIC DYES OR CLOSELY-RELATED COMPOUNDS FOR PRODUCING DYES, e.g. PIGMENTS; MORDANTS; LAKES
    • C09B23/00Methine or polymethine dyes, e.g. cyanine dyes
    • C09B23/0075Methine or polymethine dyes, e.g. cyanine dyes the polymethine chain being part of an heterocyclic ring
    • CCHEMISTRY; METALLURGY
    • C09DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
    • C09BORGANIC DYES OR CLOSELY-RELATED COMPOUNDS FOR PRODUCING DYES, e.g. PIGMENTS; MORDANTS; LAKES
    • C09B23/00Methine or polymethine dyes, e.g. cyanine dyes
    • C09B23/14Styryl dyes
    • C09B23/145Styryl dyes the ethylene chain carrying an heterocyclic residue, e.g. heterocycle-CH=CH-C6H5
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/569Immunoassay; Biospecific binding assay; Materials therefor for microorganisms, e.g. protozoa, bacteria, viruses
    • G01N33/56966Animal cells
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/58Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances
    • G01N33/582Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances with fluorescent label
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2458/00Labels used in chemical analysis of biological material

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Immunology (AREA)
  • Urology & Nephrology (AREA)
  • Hematology (AREA)
  • Molecular Biology (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Cell Biology (AREA)
  • Physics & Mathematics (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Analytical Chemistry (AREA)
  • General Physics & Mathematics (AREA)
  • Food Science & Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Pathology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Zoology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Virology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biodiversity & Conservation Biology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Oncology (AREA)
  • Optics & Photonics (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
SG11201403368WA 2011-12-22 2012-12-20 Bodipy structure fluorescence probes for diverse biological applications SG11201403368WA (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201161579461P 2011-12-22 2011-12-22
PCT/SG2012/000483 WO2013095305A1 (en) 2011-12-22 2012-12-20 Bodipy structure fluorescence probes for diverse biological applications

Publications (1)

Publication Number Publication Date
SG11201403368WA true SG11201403368WA (en) 2014-07-30

Family

ID=48668990

Family Applications (1)

Application Number Title Priority Date Filing Date
SG11201403368WA SG11201403368WA (en) 2011-12-22 2012-12-20 Bodipy structure fluorescence probes for diverse biological applications

Country Status (4)

Country Link
US (1) US9423396B2 (en)
EP (1) EP2794620B1 (en)
SG (1) SG11201403368WA (en)
WO (1) WO2013095305A1 (en)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2012173575A1 (en) 2011-06-15 2012-12-20 National University Of Singapore Alkylamino bodipy dyes as selective fluorescent probes for proteins and mouse embryonic stem cells
CN104651874B (en) * 2013-11-19 2017-04-12 中国科学院化学研究所 Method for preparing colorless dipyrrolborane-typed composition
CN105198910A (en) * 2014-05-29 2015-12-30 安徽师范大学 Turn-on-type BODIPY fluorescent sensor and its preparation method and use
CN104774482B (en) * 2015-04-23 2016-08-31 华东理工大学 Can the novel fluorescence dyestuff and its preparation method and application of multifunction
DK3286200T3 (en) 2015-04-24 2020-06-02 Univ Nanyang Tech Chemical fluorescent probes for biofilm detection
CN105001856B (en) * 2015-07-13 2017-06-27 大连理工大学 One class is used to monitor the fluorescence probe of lipid peroxidation process in different subcellular organelles
CN106008581B (en) * 2016-07-15 2017-10-20 福州大学 The azole derivatives of fluorine boron two and its preparation and application containing six trifluoromethyl groups
CN109234759B (en) * 2018-11-02 2019-10-25 陕西师范大学 A kind of synthetic method of BODIPY
WO2023172102A1 (en) * 2022-03-10 2023-09-14 기초과학연구원 Bodipy derivative compound and fluorescent probe for detecting changes in ph and viscosity of oil comprising same

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP4312353B2 (en) 2000-07-05 2009-08-12 独立行政法人科学技術振興機構 Optical energy / electric energy conversion element in which antenna compound and charge separation type compound are integrated on electrode as mixed self-assembled monolayer
CN101020787A (en) 2006-02-14 2007-08-22 南京大学 Synthesis of dye and its application in detecting aluminium ion
JP2008239615A (en) 2007-02-26 2008-10-09 Tokyo Univ Of Science Compound susceptible to oxidation-reduction and isoalloxazine derivative
US8772487B2 (en) 2008-01-24 2014-07-08 Life Technologies Corporation Fluorogenic hydrazine-substituted compounds
CN101565554B (en) 2009-05-24 2013-06-05 大连理工大学 Strong-fluorescence boron dipyrromethene dye containing carbazole structure
DE102009028982A1 (en) 2009-08-28 2011-03-03 BAM Bundesanstalt für Materialforschung und -prüfung Difluoroboradiazaindacen dyes
WO2012173575A1 (en) 2011-06-15 2012-12-20 National University Of Singapore Alkylamino bodipy dyes as selective fluorescent probes for proteins and mouse embryonic stem cells

Also Published As

Publication number Publication date
WO2013095305A1 (en) 2013-06-27
US9423396B2 (en) 2016-08-23
US20140359794A1 (en) 2014-12-04
EP2794620B1 (en) 2017-11-15
EP2794620A4 (en) 2015-09-02
EP2794620A1 (en) 2014-10-29

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