SG11201401405PA - Cd44 monoclonal antibody for the treatment of b-cell chronic lymphocytic leukemia and other hematological malignancies - Google Patents
Cd44 monoclonal antibody for the treatment of b-cell chronic lymphocytic leukemia and other hematological malignanciesInfo
- Publication number
- SG11201401405PA SG11201401405PA SG11201401405PA SG11201401405PA SG11201401405PA SG 11201401405P A SG11201401405P A SG 11201401405PA SG 11201401405P A SG11201401405P A SG 11201401405PA SG 11201401405P A SG11201401405P A SG 11201401405PA SG 11201401405P A SG11201401405P A SG 11201401405PA
- Authority
- SG
- Singapore
- Prior art keywords
- treatment
- monoclonal antibody
- lymphocytic leukemia
- chronic lymphocytic
- hematological malignancies
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2884—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against CD44
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/574—Immunoassay; Biospecific binding assay; Materials therefor for cancer
- G01N33/57407—Specifically defined cancers
- G01N33/57426—Specifically defined cancers leukemia
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/574—Immunoassay; Biospecific binding assay; Materials therefor for cancer
- G01N33/57484—Immunoassay; Biospecific binding assay; Materials therefor for cancer involving compounds serving as markers for tumor, cancer, neoplasia, e.g. cellular determinants, receptors, heat shock/stress proteins, A-protein, oligosaccharides, metabolites
- G01N33/57492—Immunoassay; Biospecific binding assay; Materials therefor for cancer involving compounds serving as markers for tumor, cancer, neoplasia, e.g. cellular determinants, receptors, heat shock/stress proteins, A-protein, oligosaccharides, metabolites involving compounds localized on the membrane of tumor or cancer cells
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/77—Internalization into the cell
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Immunology (AREA)
- Engineering & Computer Science (AREA)
- Molecular Biology (AREA)
- Hematology (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Biomedical Technology (AREA)
- Cell Biology (AREA)
- Urology & Nephrology (AREA)
- Biochemistry (AREA)
- Oncology (AREA)
- Analytical Chemistry (AREA)
- Food Science & Technology (AREA)
- Physics & Mathematics (AREA)
- Hospice & Palliative Care (AREA)
- Pathology (AREA)
- Biotechnology (AREA)
- Microbiology (AREA)
- General Physics & Mathematics (AREA)
- Genetics & Genomics (AREA)
- Biophysics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Public Health (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Peptides Or Proteins (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201161551852P | 2011-10-26 | 2011-10-26 | |
| PCT/US2012/062266 WO2013063498A1 (en) | 2011-10-26 | 2012-10-26 | Cd44 monoclonal antibody for the treatment of b-cell chronic lymphocytic leukemia and other hematological malignancies |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| SG11201401405PA true SG11201401405PA (en) | 2014-05-29 |
Family
ID=47143316
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SG11201401405PA SG11201401405PA (en) | 2011-10-26 | 2012-10-26 | Cd44 monoclonal antibody for the treatment of b-cell chronic lymphocytic leukemia and other hematological malignancies |
Country Status (13)
| Country | Link |
|---|---|
| US (1) | US20140308301A1 (en) |
| EP (1) | EP2771363A1 (en) |
| JP (1) | JP2014534221A (en) |
| KR (1) | KR20140090997A (en) |
| CN (1) | CN103946239A (en) |
| AU (1) | AU2012328512A1 (en) |
| BR (1) | BR112014010009A2 (en) |
| CA (1) | CA2851545A1 (en) |
| IL (1) | IL231902A0 (en) |
| MX (1) | MX2014004969A (en) |
| RU (1) | RU2014120577A (en) |
| SG (1) | SG11201401405PA (en) |
| WO (1) | WO2013063498A1 (en) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| TWI535452B (en) | 2015-01-23 | 2016-06-01 | 長庚醫療財團法人 | Treatment and/or prevention of atrial fibrillation with anti-cd44 neutralizing antibody |
| EP3277823B1 (en) * | 2015-04-03 | 2023-09-13 | Dana-Farber Cancer Institute, Inc. | Composition and methods of genome editing of b-cells |
| US20230192879A1 (en) | 2020-05-19 | 2023-06-22 | Institut Curie | Methods for the diagnosis and treatment of cytokine release syndrome |
| KR20240008345A (en) | 2021-05-18 | 2024-01-18 | 얀센 바이오테크 인코포레이티드 | Composition comprising a T cell re-induction therapeutic agent and an anti-CD44 therapeutic agent |
| WO2024040195A1 (en) | 2022-08-17 | 2024-02-22 | Capstan Therapeutics, Inc. | Conditioning for in vivo immune cell engineering |
Family Cites Families (21)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4631190A (en) | 1981-06-26 | 1986-12-23 | Shen Wei C | Acidity-sensitive spacer molecule to control the release of pharmaceuticals from molecular carriers |
| US4816567A (en) | 1983-04-08 | 1989-03-28 | Genentech, Inc. | Recombinant immunoglobin preparations |
| US5225539A (en) | 1986-03-27 | 1993-07-06 | Medical Research Council | Recombinant altered antibodies and methods of making altered antibodies |
| DE3920358A1 (en) | 1989-06-22 | 1991-01-17 | Behringwerke Ag | BISPECIFIC AND OLIGO-SPECIFIC, MONO- AND OLIGOVALENT ANTI-BODY CONSTRUCTS, THEIR PRODUCTION AND USE |
| US5959177A (en) | 1989-10-27 | 1999-09-28 | The Scripps Research Institute | Transgenic plants expressing assembled secretory antibodies |
| GB9114948D0 (en) | 1991-07-11 | 1991-08-28 | Pfizer Ltd | Process for preparing sertraline intermediates |
| CA2116774C (en) | 1991-09-19 | 2003-11-11 | Paul J. Carter | Expression in e. coli antibody fragments having at least a cysteine present as a free thiol. use for the production of bifunctional f(ab') 2 antibodies |
| US5789199A (en) | 1994-11-03 | 1998-08-04 | Genentech, Inc. | Process for bacterial production of polypeptides |
| US5840523A (en) | 1995-03-01 | 1998-11-24 | Genetech, Inc. | Methods and compositions for secretion of heterologous polypeptides |
| US6287569B1 (en) | 1997-04-10 | 2001-09-11 | The Regents Of The University Of California | Vaccines with enhanced intracellular processing |
| US6040498A (en) | 1998-08-11 | 2000-03-21 | North Caroline State University | Genetically engineered duckweed |
| US7125978B1 (en) | 1999-10-04 | 2006-10-24 | Medicago Inc. | Promoter for regulating expression of foreign genes |
| DE60022369T2 (en) | 1999-10-04 | 2006-05-18 | Medicago Inc., Sainte Foy | PROCESS FOR REGULATING THE TRANSCRIPTION OF FOREIGN GENES IN THE PRESENCE OF NITROGEN |
| US8071072B2 (en) * | 1999-10-08 | 2011-12-06 | Hoffmann-La Roche Inc. | Cytotoxicity mediation of cells evidencing surface expression of CD44 |
| US20050100542A1 (en) * | 1999-10-08 | 2005-05-12 | Young David S. | Cytotoxicity mediation of cells evidencing surface expression of CD44 |
| US8048416B2 (en) * | 1999-10-08 | 2011-11-01 | Hoffmann-La Roche Inc. | Cytotoxicity mediation of cells evidencing surface expression of CD44 |
| US20050031610A1 (en) * | 2002-07-19 | 2005-02-10 | Tae-Wan Kim | CD44-related fragments, compositions and methods |
| US20050214283A1 (en) * | 2003-11-07 | 2005-09-29 | Robert Sackstein | Antibodies to CD44 glycoforms and uses thereof |
| EP1532984A1 (en) * | 2003-11-19 | 2005-05-25 | Institut National De La Sante Et De La Recherche Medicale (Inserm) | Use of anti CD44 antibodies for eradicating stem cells in acute myeloid leukemia |
| WO2010058396A1 (en) * | 2008-11-19 | 2010-05-27 | Yissum Research Development Company Of The Hebrew University Of Jerusalem Ltd. | A cd44vra antibody and diagnostic and therapeutic methods using same |
| RU2599447C2 (en) * | 2010-02-04 | 2016-10-10 | Юниверсити Оф Майами | Monoclonal antibodies to cd44, intended for use in treating squamous cell carcinoma of the head and the neck |
-
2012
- 2012-10-26 KR KR1020147012535A patent/KR20140090997A/en not_active Application Discontinuation
- 2012-10-26 RU RU2014120577/10A patent/RU2014120577A/en not_active Application Discontinuation
- 2012-10-26 CA CA2851545A patent/CA2851545A1/en not_active Abandoned
- 2012-10-26 CN CN201280052997.4A patent/CN103946239A/en active Pending
- 2012-10-26 EP EP12781555.3A patent/EP2771363A1/en not_active Withdrawn
- 2012-10-26 US US14/354,472 patent/US20140308301A1/en not_active Abandoned
- 2012-10-26 WO PCT/US2012/062266 patent/WO2013063498A1/en active Application Filing
- 2012-10-26 MX MX2014004969A patent/MX2014004969A/en unknown
- 2012-10-26 SG SG11201401405PA patent/SG11201401405PA/en unknown
- 2012-10-26 AU AU2012328512A patent/AU2012328512A1/en not_active Abandoned
- 2012-10-26 BR BR112014010009A patent/BR112014010009A2/en not_active Application Discontinuation
- 2012-10-26 JP JP2014539084A patent/JP2014534221A/en not_active Ceased
-
2014
- 2014-04-03 IL IL231902A patent/IL231902A0/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| KR20140090997A (en) | 2014-07-18 |
| AU2012328512A1 (en) | 2014-05-08 |
| MX2014004969A (en) | 2014-05-30 |
| WO2013063498A1 (en) | 2013-05-02 |
| BR112014010009A2 (en) | 2017-04-25 |
| CA2851545A1 (en) | 2013-05-02 |
| IL231902A0 (en) | 2014-05-28 |
| CN103946239A (en) | 2014-07-23 |
| RU2014120577A (en) | 2015-12-10 |
| EP2771363A1 (en) | 2014-09-03 |
| US20140308301A1 (en) | 2014-10-16 |
| JP2014534221A (en) | 2014-12-18 |
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