SG10202111207TA - Therapeutic anti-cd40 ligand antibodies - Google Patents

Therapeutic anti-cd40 ligand antibodies

Info

Publication number
SG10202111207TA
SG10202111207TA SG10202111207TA SG10202111207TA SG10202111207TA SG 10202111207T A SG10202111207T A SG 10202111207TA SG 10202111207T A SG10202111207T A SG 10202111207TA SG 10202111207T A SG10202111207T A SG 10202111207TA SG 10202111207T A SG10202111207T A SG 10202111207TA
Authority
SG
Singapore
Prior art keywords
therapeutic anti
ligand antibodies
ligand
antibodies
therapeutic
Prior art date
Application number
SG10202111207TA
Inventor
Alexey Lugovskoy
Original Assignee
Als Therapy Development Inst
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Als Therapy Development Inst filed Critical Als Therapy Development Inst
Publication of SG10202111207TA publication Critical patent/SG10202111207TA/en

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K16/00Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2875Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the NGF/TNF superfamily, e.g. CD70, CD95L, CD153, CD154
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K39/395Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • A61P37/02Immunomodulators
    • A61P37/06Immunosuppressants, e.g. drugs for graft rejection
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K2039/505Medicinal preparations containing antigens or antibodies comprising antibodies
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/20Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/24Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/40Immunoglobulins specific features characterized by post-translational modification
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/40Immunoglobulins specific features characterized by post-translational modification
    • C07K2317/41Glycosylation, sialylation, or fucosylation
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/50Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/52Constant or Fc region; Isotype
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/50Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/565Complementarity determining region [CDR]
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/70Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76Antagonist effect on antigen, e.g. neutralization or inhibition of binding

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biochemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Microbiology (AREA)
  • Mycology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Transplantation (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicinal Preparation (AREA)
SG10202111207TA 2017-05-24 2018-05-23 Therapeutic anti-cd40 ligand antibodies SG10202111207TA (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US201762510471P 2017-05-24 2017-05-24

Publications (1)

Publication Number Publication Date
SG10202111207TA true SG10202111207TA (en) 2021-11-29

Family

ID=63592816

Family Applications (1)

Application Number Title Priority Date Filing Date
SG10202111207TA SG10202111207TA (en) 2017-05-24 2018-05-23 Therapeutic anti-cd40 ligand antibodies

Country Status (14)

Country Link
US (2) US11384152B2 (en)
EP (1) EP3630843A2 (en)
JP (2) JP2020521745A (en)
KR (1) KR20200010294A (en)
CN (2) CN117843789A (en)
AU (1) AU2018271915A1 (en)
CA (1) CA3063730A1 (en)
GB (1) GB2578037A (en)
IL (2) IL309444A (en)
MA (1) MA50435A (en)
MX (1) MX2023004314A (en)
RU (2) RU2770209C2 (en)
SG (1) SG10202111207TA (en)
WO (1) WO2018217918A2 (en)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
MA41459A (en) 2015-02-03 2017-12-12 Als Therapy Development Inst ANTI-CD40L ANTIBODIES AND METHODS FOR TREATING CD40L ILLNESSES OR DISORDERS
CN114423785A (en) * 2019-07-01 2022-04-29 通尼克斯制药有限公司 anti-CD 154 antibodies and uses thereof
KR20210095781A (en) 2020-01-24 2021-08-03 주식회사 에이프릴바이오 A multi-specific antibody comprising a fusion construct consisting of a Fab and a bioactive effector moiety
WO2023230538A2 (en) * 2022-05-27 2023-11-30 Eledon Pharmaceuticals, Inc. Methods for the treatment of amyotrophic lateral sclerosis
WO2024211211A1 (en) 2023-04-03 2024-10-10 Regeneron Pharmaceuticals, Inc. Methods of improving transplant survival using il-2 receptor gamma chain antibodies

Family Cites Families (61)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5851795A (en) 1991-06-27 1998-12-22 Bristol-Myers Squibb Company Soluble CTLA4 molecules and uses thereof
US5637481A (en) 1993-02-01 1997-06-10 Bristol-Myers Squibb Company Expression vectors encoding bispecific fusion proteins and methods of producing biologically active bispecific fusion proteins in a mammalian cell
US5962406A (en) 1991-10-25 1999-10-05 Immunex Corporation Recombinant soluble CD40 ligand polypeptide and pharmaceutical composition containing the same
US5961974A (en) 1991-10-25 1999-10-05 Immunex Corporation Monoclonal antibodies to CD40 ligand, pharmaceutical composition comprising the same and hybridomas producing the same
US5474771A (en) 1991-11-15 1995-12-12 The Trustees Of Columbia University In The City Of New York Murine monoclonal antibody (5c8) recognizes a human glycoprotein on the surface of T-lymphocytes, compositions containing same
US7070777B1 (en) 1991-11-15 2006-07-04 The Trustees Of Columbia University In The City Of New York Method for inhibiting inflammation with an antibody that binds the 5C8 protein
IL104684A0 (en) 1992-02-14 1993-06-10 Bristol Myers Squibb Co The cd40cr receptor and ligands therefor
CN100341896C (en) 1993-09-02 2007-10-10 达特茅斯学院理事 Anti-GP39 antibodies and uses therefor
US5833987A (en) 1995-06-07 1998-11-10 Trustees Of Dartmouth College Treatment of T cell mediated autoimmune disorders
US6001358A (en) 1995-11-07 1999-12-14 Idec Pharmaceuticals Corporation Humanized antibodies to human gp39, compositions containing thereof
US6340459B1 (en) 1995-12-01 2002-01-22 The Trustees Of Columbia University In The City Of New York Therapeutic applications for the anti-T-BAM (CD40-L) monoclonal antibody 5C8 in the treatment of reperfusion injury in non-transplant recipients
TR200001249T2 (en) 1997-01-10 2000-11-21 Biogen, Inc. Treatment of lupus nephritis with anti-CD40L compounds
CN1202864C (en) 1997-05-17 2005-05-25 拜奥根有限公司 Use of a CD40 : CD154 binding interruptor to prevent counter adaptive immune responses, particularly graft rejection
KR20010072564A (en) 1998-04-03 2001-07-31 존 에프. 카바나프 USE OF ANTI-gp39 ANTIBODIES FOR TREATMENT AND/OR REVERSAL OF LUPUS AND ASSOCIATED KIDNEY DISEASE
US6946129B1 (en) 1999-06-08 2005-09-20 Seattle Genetics, Inc. Recombinant anti-CD40 antibody and uses thereof
CA2390412A1 (en) 1999-11-08 2001-05-17 Idec Pharmaceuticals Corporation Treatment of b cell malignancies using anti-cd40l antibodies in combination with anti-cd20 antibodies and/or chemotherapeutics and radiotherapy
BR0108001A (en) 2000-02-01 2004-01-06 Tanox Inc CD-40-linked apc activator molecules
GB0006398D0 (en) 2000-03-16 2000-05-03 Novartis Ag Organic compounds
WO2001083755A2 (en) 2000-04-28 2001-11-08 La Jolla Institute For Allergy And Immunology Human anti-cd40 antibodies and methods of making and using same
CN1441675A (en) 2000-05-12 2003-09-10 贝斯以色列护理医疗中心有限公司 Compositions and methods for achieving immune suppression
IL153764A0 (en) 2000-07-12 2003-07-06 Idec Pharma Corp Treatment of b cell malignancies using combination of b cell depleting antibody and immune modulating antibody related applications
WO2002018540A2 (en) 2000-09-01 2002-03-07 Biogen, Inc. Pyridine derivatives useful as cd40:cd154 binding interruptor compounds and use thereof to treat immunological complications
AU8867501A (en) 2000-09-01 2002-03-13 Biogen Inc Co-crystal structure of monoclonal antibody 5c8 and cd154, and use thereof in drug design
US20040110226A1 (en) * 2002-03-01 2004-06-10 Xencor Antibody optimization
US20040146949A1 (en) 2002-10-25 2004-07-29 Jun Tan Methods and compounds for disruption of CD40R/CD40L signaling in the treatment of alzheimer's disease
DE602004029252D1 (en) 2003-06-13 2010-11-04 Biogen Idec Inc AGLYCOSYL-ANTI-CD154 (CD40-LIGAND) ANTIBODIES AND THEIR USES
WO2005003174A1 (en) 2003-07-08 2005-01-13 Genesto A/S BINDING MEMBER TOWARDS PNEUMOCOCCUS SURFACE ADHESIN A PROTEIN (PsaA)
JP4944608B2 (en) 2003-07-26 2012-06-06 バイオジェン・アイデック・エムエイ・インコーポレイテッド Altered antibodies with improved antigen binding affinity
EP2502935B1 (en) 2003-08-22 2017-03-29 Biogen MA Inc. Improved antibodies having altered effector function and methods for making the same
US20170166655A1 (en) * 2004-03-26 2017-06-15 Xencor, Inc. Novel immunoglobulin variants
GEP20105059B (en) 2004-07-26 2010-08-10 Biogen Idec Inc Anti-cd154 antibodies
US7563443B2 (en) * 2004-09-17 2009-07-21 Domantis Limited Monovalent anti-CD40L antibody polypeptides and compositions thereof
TWI380996B (en) * 2004-09-17 2013-01-01 Hoffmann La Roche Anti-ox40l antibodies
WO2006138316A2 (en) 2005-06-14 2006-12-28 Biogen Idec Ma Inc. Methods for delivering molecules to the central nervous system
CA2629647C (en) 2005-11-17 2013-05-21 Biogen Idec Ma Inc. Platelet aggregation assays
ES2436616T5 (en) 2005-12-20 2022-05-27 Bristol Myers Squibb Co Stable protein formulations
US7647438B1 (en) 2006-05-09 2010-01-12 Integrated Device Technology, Inc. Binary base address sorting method and device with shift vector
WO2008140603A2 (en) 2006-12-08 2008-11-20 Macrogenics, Inc. METHODS FOR THE TREATMENT OF DISEASE USING IMMUNOGLOBULINS HAVING FC REGIONS WITH ALTERED AFFINITIES FOR FCγR ACTIVATING AND FCγR INHIBITING
JP5721951B2 (en) 2007-03-22 2015-05-20 バイオジェン アイデック マサチューセッツ インコーポレイテッド Binding proteins that specifically bind to CD154, including antibodies, antibody derivatives, and antibody fragments, and uses thereof
BRPI0811857A2 (en) 2007-05-14 2014-10-21 Biogen Idec Inc SIMPLE CHAIN FC (SCFC) REGIONS, AGLUTINATION POLYPEPTIDES UNDERSTANDING THEM AND RELATED METHODS.
MX2011000616A (en) * 2008-07-17 2011-02-24 Novartis Ag Compositions and methods of use for therapeutic antibodies.
GB0815788D0 (en) * 2008-08-29 2008-10-08 Isis Innovation Therapeutic antibodies
ES2650267T3 (en) 2008-12-05 2018-01-17 Als Therapy Development Institute Method for the treatment of neurodegenerative diseases
US9044459B2 (en) 2008-12-05 2015-06-02 Als Therapy Development Institute Method for the treatment of neurodegenerative diseases
JP2012515556A (en) * 2009-01-23 2012-07-12 バイオジェン・アイデック・エムエイ・インコーポレイテッド Stabilized Fc polypeptides with reduced effector function and methods of use
EP2625203A1 (en) * 2010-10-05 2013-08-14 Novartis AG Anti-il12rbeta1 antibodies and their use in treating autoimmune and inflammatory disorders
WO2012103218A1 (en) 2011-01-25 2012-08-02 University Of South Florida A transgenic model of alzheimer's disease
ES2692268T3 (en) 2011-03-29 2018-12-03 Roche Glycart Ag Antibody Fc variants
US9028826B2 (en) 2011-04-04 2015-05-12 The Trustees Of Dartmouth College Methods of immune therapy with anti-CD154 antibodies having impaired FcR binding and/or complement binding properties
CA2832281C (en) * 2011-04-04 2019-11-05 Trustees Of Dartmouth College Anti-cd154 antibodies having impaired fcr binding and/or complement binding properties and the use thereof in immune therapies
AU2012245309C1 (en) 2011-04-21 2016-07-21 Bristol-Myers Squibb Company Antibody polypeptides that antagonize CD40
CA2843158A1 (en) * 2011-08-26 2013-03-07 Merrimack Pharmaceuticals, Inc. Tandem fc bispecific antibodies
TW201817744A (en) * 2011-09-30 2018-05-16 日商中外製藥股份有限公司 Therapeutic antigen-binding molecule with a FcRn-binding domain that promotes antigen clearance
KR101637915B1 (en) 2011-10-13 2016-07-11 브리스톨-마이어스 스큅 컴퍼니 Antibody polypeptides that antagonize cd40l
MX355234B (en) 2012-05-11 2018-04-11 Medimmune Ltd Ctla-4 variants.
WO2014132101A2 (en) 2012-10-18 2014-09-04 Yongxin Zhang Bioreactor system and methods for alternative cell culture between static and dynamic
TWI636062B (en) 2013-04-02 2018-09-21 中外製藥股份有限公司 Fc region variant
WO2015143209A1 (en) * 2014-03-19 2015-09-24 Bristol-Myers Squibb Company Methods of treating transplant rejection using a domain antibody directed against cd40l
US20170042972A1 (en) 2014-04-25 2017-02-16 Chetan KARYEKAR Use of ctla4 compound for achieving drug-free remission in subjects with early ra
WO2016028810A1 (en) * 2014-08-18 2016-02-25 Biogen Ma Inc. Anti-cd40 antibodies and uses thereof
MA41459A (en) 2015-02-03 2017-12-12 Als Therapy Development Inst ANTI-CD40L ANTIBODIES AND METHODS FOR TREATING CD40L ILLNESSES OR DISORDERS

Also Published As

Publication number Publication date
RU2019143098A3 (en) 2021-09-20
EP3630843A2 (en) 2020-04-08
CN110662768A (en) 2020-01-07
KR20200010294A (en) 2020-01-30
US20230048260A1 (en) 2023-02-16
US11384152B2 (en) 2022-07-12
RU2019143098A (en) 2021-06-24
IL270729A (en) 2020-01-30
GB2578037A (en) 2020-04-15
CA3063730A1 (en) 2018-11-29
CN110662768B (en) 2024-01-30
RU2770209C2 (en) 2022-04-14
WO2018217918A2 (en) 2018-11-29
GB201918703D0 (en) 2020-01-29
JP2020521745A (en) 2020-07-27
CN117843789A (en) 2024-04-09
JP2023065390A (en) 2023-05-12
WO2018217918A3 (en) 2019-01-17
AU2018271915A1 (en) 2019-11-28
MA50435A (en) 2020-09-02
MX2023004314A (en) 2023-05-04
RU2022108410A (en) 2022-04-05
US20200223932A1 (en) 2020-07-16
IL309444A (en) 2024-02-01

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