SG10202109873XA - Microfluidic Analytical Device - Google Patents

Microfluidic Analytical Device

Info

Publication number
SG10202109873XA
SG10202109873XA SG10202109873XA SG10202109873XA SG 10202109873X A SG10202109873X A SG 10202109873XA SG 10202109873X A SG10202109873X A SG 10202109873XA SG 10202109873X A SG10202109873X A SG 10202109873XA
Authority
SG
Singapore
Prior art keywords
analytical device
microfluidic analytical
microfluidic
analytical
Prior art date
Application number
Inventor
Thomas Henry Isaac
Pedro Cunha
Eoin Sheridan
David Love
Rebecca Palmer
Douglas J Kelly
Gareth Podd
Original Assignee
Base4 Innovation Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Base4 Innovation Ltd filed Critical Base4 Innovation Ltd
Publication of SG10202109873XA publication Critical patent/SG10202109873XA/en

Links

Classifications

    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01LCHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5027Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
    • B01L3/502769Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by multiphase flow arrangements
    • B01L3/502784Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by multiphase flow arrangements specially adapted for droplet or plug flow, e.g. digital microfluidics
    • B01L3/502792Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by multiphase flow arrangements specially adapted for droplet or plug flow, e.g. digital microfluidics for moving individual droplets on a plate, e.g. by locally altering surface tension
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01LCHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5027Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6869Methods for sequencing
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01LCHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2200/00Solutions for specific problems relating to chemical or physical laboratory apparatus
    • B01L2200/06Fluid handling related problems
    • B01L2200/0673Handling of plugs of fluid surrounded by immiscible fluid
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01LCHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2200/00Solutions for specific problems relating to chemical or physical laboratory apparatus
    • B01L2200/10Integrating sample preparation and analysis in single entity, e.g. lab-on-a-chip concept
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01LCHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00Additional constructional details
    • B01L2300/08Geometry, shape and general structure
    • B01L2300/0861Configuration of multiple channels and/or chambers in a single devices
    • B01L2300/0864Configuration of multiple channels and/or chambers in a single devices comprising only one inlet and multiple receiving wells, e.g. for separation, splitting
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01LCHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00Additional constructional details
    • B01L2300/08Geometry, shape and general structure
    • B01L2300/0887Laminated structure
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01LCHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00Additional constructional details
    • B01L2300/08Geometry, shape and general structure
    • B01L2300/089Virtual walls for guiding liquids
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01LCHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00Additional constructional details
    • B01L2300/16Surface properties and coatings
    • B01L2300/161Control and use of surface tension forces, e.g. hydrophobic, hydrophilic
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01LCHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00Additional constructional details
    • B01L2300/16Surface properties and coatings
    • B01L2300/161Control and use of surface tension forces, e.g. hydrophobic, hydrophilic
    • B01L2300/165Specific details about hydrophobic, oleophobic surfaces
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01LCHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00Additional constructional details
    • B01L2300/16Surface properties and coatings
    • B01L2300/168Specific optical properties, e.g. reflective coatings
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01LCHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2400/00Moving or stopping fluids
    • B01L2400/04Moving fluids with specific forces or mechanical means
    • B01L2400/0403Moving fluids with specific forces or mechanical means specific forces
    • B01L2400/0415Moving fluids with specific forces or mechanical means specific forces electrical forces, e.g. electrokinetic
    • B01L2400/0427Electrowetting
SG10202109873X 2017-06-21 2018-06-21 Microfluidic Analytical Device SG10202109873XA (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP17177204 2017-06-21
EP17180391 2017-07-07

Publications (1)

Publication Number Publication Date
SG10202109873XA true SG10202109873XA (en) 2021-10-28

Family

ID=60661872

Family Applications (2)

Application Number Title Priority Date Filing Date
SG10202109873X SG10202109873XA (en) 2017-06-21 2018-06-21 Microfluidic Analytical Device
SG11201912290XA SG11201912290XA (en) 2017-06-21 2018-06-21 Microfluidic analytical device

Family Applications After (1)

Application Number Title Priority Date Filing Date
SG11201912290XA SG11201912290XA (en) 2017-06-21 2018-06-21 Microfluidic analytical device

Country Status (10)

Country Link
US (2) US11318472B2 (en)
EP (2) EP3943192A1 (en)
JP (1) JP7257341B2 (en)
CN (2) CN113967488B (en)
AU (2) AU2018288533B2 (en)
BR (1) BR112019027770A2 (en)
CA (1) CA3067105A1 (en)
IL (1) IL271545B2 (en)
SG (2) SG10202109873XA (en)
WO (1) WO2018234446A1 (en)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN110831697B (en) 2017-06-21 2022-03-15 光投发现有限公司 Droplet manipulation device and method of manipulating aqueous droplets using the same
SG10202109873XA (en) 2017-06-21 2021-10-28 Base4 Innovation Ltd Microfluidic Analytical Device
PL3693086T3 (en) 2019-02-08 2021-04-19 Lightcast Discovery Ltd Microdroplet manipulation method
EP3927466A1 (en) * 2019-02-19 2021-12-29 Lightcast Discovery Ltd Microdroplet manipulation device
GB202001051D0 (en) * 2020-01-24 2020-03-11 Lightcast Discovery Ltd Methods and apparatus for high throughput microdroplet manipulation
JP2023546815A (en) * 2020-10-05 2023-11-08 ライトキャスト ディスカバリー リミテッド Improvements in devices and methods to facilitate manipulation of microdroplets

Family Cites Families (50)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4962020A (en) 1988-07-12 1990-10-09 President And Fellows Of Harvard College DNA sequencing
US6565727B1 (en) 1999-01-25 2003-05-20 Nanolytics, Inc. Actuators for microfluidics without moving parts
US6958132B2 (en) * 2002-05-31 2005-10-25 The Regents Of The University Of California Systems and methods for optical actuation of microfluidics based on opto-electrowetting
US20060153745A1 (en) 2005-01-11 2006-07-13 Applera Corporation Fluid processing device for oligonucleotide synthesis and analysis
WO2006081558A2 (en) 2005-01-28 2006-08-03 Duke University Apparatuses and methods for manipulating droplets on a printed circuit board
JP2008539759A (en) * 2005-05-11 2008-11-20 ナノリティックス・インコーポレイテッド Method and apparatus for performing biochemical or chemical reactions at multiple temperatures
WO2007024798A2 (en) * 2005-08-22 2007-03-01 Applera Corporation Apparatus, system, and method using immiscible-fluid-discrete-volumes
ITBO20050646A1 (en) * 2005-10-26 2007-04-27 Silicon Biosystem S R L METHOD AND APPARATUS FOR CHARACTERIZATION AND COUNTING OF PARTICLES
TWI303312B (en) * 2005-12-21 2008-11-21 Ind Tech Res Inst Matrix electrodes controlling device and digital fluid detection platform thereof
US8613889B2 (en) 2006-04-13 2013-12-24 Advanced Liquid Logic, Inc. Droplet-based washing
US8716015B2 (en) 2006-04-18 2014-05-06 Advanced Liquid Logic, Inc. Manipulation of cells on a droplet actuator
EP2021103B1 (en) * 2006-05-09 2017-07-12 Advanced Liquid Logic, Inc. Electrowetting droplet microactuator controlled via graphical user interface
US7939021B2 (en) * 2007-05-09 2011-05-10 Advanced Liquid Logic, Inc. Droplet actuator analyzer with cartridge
WO2008055256A2 (en) 2006-11-02 2008-05-08 The Regents Of The University Of California Method and apparatus for real-time feedback control of electrical manipulation of droplets on chip
US20100120130A1 (en) 2007-08-08 2010-05-13 Advanced Liquid Logic, Inc. Droplet Actuator with Droplet Retention Structures
US8454905B2 (en) * 2007-10-17 2013-06-04 Advanced Liquid Logic Inc. Droplet actuator structures
CN103707643B (en) 2007-12-23 2016-06-01 先进液体逻辑公司 The method of droplet actuator configuration and guiding droplet manipulation
CA2639954C (en) 2008-02-11 2017-08-15 Aaron R. Wheeler Droplet-based cell culture and cell assays using digital microfluidics
WO2009137415A2 (en) 2008-05-03 2009-11-12 Advanced Liquid Logic, Inc. Reagent and sample preparation, loading, and storage
FR2933713B1 (en) 2008-07-11 2011-03-25 Commissariat Energie Atomique METHOD AND DEVICE FOR HANDLING AND OBSERVING LIQUID DROPS
US9598725B2 (en) 2010-03-02 2017-03-21 Bio-Rad Laboratories, Inc. Emulsion chemistry for encapsulated droplets
US8753498B2 (en) 2009-06-25 2014-06-17 Purdue Research Foundation Open optoelectrowetting droplet actuation device and method
WO2011020011A2 (en) 2009-08-13 2011-02-17 Advanced Liquid Logic, Inc. Droplet actuator and droplet-based techniques
US8926065B2 (en) 2009-08-14 2015-01-06 Advanced Liquid Logic, Inc. Droplet actuator devices and methods
WO2012037308A2 (en) * 2010-09-16 2012-03-22 Advanced Liquid Logic, Inc. Droplet actuator systems, devices and methods
WO2012068055A2 (en) 2010-11-17 2012-05-24 Advanced Liquid Logic, Inc. Capacitance detection in a droplet actuator
KR101327783B1 (en) * 2011-12-08 2013-11-11 한국과학기술원 Microdroplet spacing controller and microdroplet mixing device using the same, microdroplet speed control method and microdroplet mixing method using the same
GB201217772D0 (en) 2012-10-04 2012-11-14 Base4 Innovation Ltd Sequencing method
GB201217770D0 (en) 2012-10-04 2012-11-14 Base4 Innovation Ltd Biological probes and the use thereof
GB201300957D0 (en) 2013-01-18 2013-03-06 Base4 Innovation Ltd Sequencing method
GB201306445D0 (en) 2013-04-09 2013-05-22 Base4 Innovation Ltd Single nucleotide detection method
GB201306444D0 (en) 2013-04-09 2013-05-22 Base4 Innovation Ltd Single nucleotide detection method
US20150306598A1 (en) * 2014-04-25 2015-10-29 Berkeley Lights, Inc. DEP Force Control And Electrowetting Control In Different Sections Of The Same Microfluidic Apparatus
US11192107B2 (en) 2014-04-25 2021-12-07 Berkeley Lights, Inc. DEP force control and electrowetting control in different sections of the same microfluidic apparatus
GB201412977D0 (en) 2014-07-22 2014-09-03 Base4 Innovation Ltd Single nucleotide detection method
WO2016018726A1 (en) 2014-07-31 2016-02-04 Becton, Dickinson And Company Methods and systems for separating components of a biological sample with gravity sedimentation
CN104307582B (en) * 2014-09-30 2017-08-15 中国科学院深圳先进技术研究院 A kind of open micro-fluidic chip and preparation method thereof and control method
DE102015106870B3 (en) 2014-11-10 2016-02-25 Leibniz-Institut für Naturstoff-Forschung und Infektionsbiologie e. V. Hans-Knöll-Institut System for incubation of microfluidic drops and method for providing homogeneous incubation conditions in a drop incubation unit
TWI698282B (en) * 2014-12-05 2020-07-11 加州大學董事會 Substrate, microfluidic device , method of moving a droplet in a microfluidic device and process for manipulating a droplet in a microfluidic device
WO2016094522A1 (en) 2014-12-09 2016-06-16 Berkeley Lights, Inc. Automated detection of assay-positive areas in microfluidic devices
GB201501012D0 (en) * 2015-01-21 2015-03-04 Base4 Innovation Ltd Improved droplet sequencing apparatus and method
US10576471B2 (en) * 2015-03-20 2020-03-03 Illumina, Inc. Fluidics cartridge for use in the vertical or substantially vertical position
GB201509640D0 (en) 2015-06-03 2015-07-15 Sphere Fluidics Ltd Systems and methods
US10799865B2 (en) 2015-10-27 2020-10-13 Berkeley Lights, Inc. Microfluidic apparatus having an optimized electrowetting surface and related systems and methods
CN109790572A (en) 2016-09-02 2019-05-21 贝斯4创新公司 Mononucleotide detection method and unrelated probe
CN109790573A (en) 2016-09-06 2019-05-21 贝斯4创新公司 Mononucleotide detection method and relevant probe
CN109790566A (en) 2016-09-20 2019-05-21 贝斯4创新公司 Mononucleotide detection method and relevant probe
US20180313819A1 (en) 2017-04-26 2018-11-01 Mike Joseph Pugia High speed droplet sorter
SG10202109873XA (en) 2017-06-21 2021-10-28 Base4 Innovation Ltd Microfluidic Analytical Device
CN110831697B (en) 2017-06-21 2022-03-15 光投发现有限公司 Droplet manipulation device and method of manipulating aqueous droplets using the same

Also Published As

Publication number Publication date
US20200197941A1 (en) 2020-06-25
IL271545B1 (en) 2023-05-01
CN110769936B (en) 2022-07-08
EP3641935A1 (en) 2020-04-29
US20220219173A1 (en) 2022-07-14
EP3641935B1 (en) 2021-09-08
CN113967488A (en) 2022-01-25
EP3943192A1 (en) 2022-01-26
US11318472B2 (en) 2022-05-03
AU2018288533A1 (en) 2020-02-06
SG11201912290XA (en) 2020-01-30
CN110769936A (en) 2020-02-07
AU2018288533B2 (en) 2023-07-13
CA3067105A1 (en) 2018-12-27
IL271545B2 (en) 2023-09-01
IL271545A (en) 2020-02-27
AU2023204199A1 (en) 2023-07-20
KR20200019716A (en) 2020-02-24
CN113967488B (en) 2024-02-06
WO2018234446A1 (en) 2018-12-27
JP7257341B2 (en) 2023-04-13
JP2020525769A (en) 2020-08-27
BR112019027770A2 (en) 2020-07-07

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