SG10202108814VA - Conditionally active biological proteins - Google Patents

Conditionally active biological proteins

Info

Publication number
SG10202108814VA
SG10202108814VA SG10202108814VA SG10202108814VA SG10202108814VA SG 10202108814V A SG10202108814V A SG 10202108814VA SG 10202108814V A SG10202108814V A SG 10202108814VA SG 10202108814V A SG10202108814V A SG 10202108814VA SG 10202108814V A SG10202108814V A SG 10202108814VA
Authority
SG
Singapore
Prior art keywords
conditionally active
active biological
biological proteins
proteins
conditionally
Prior art date
Application number
SG10202108814VA
Inventor
Jay M Short
Hwai Wen Chang
Gerhard Frey
Original Assignee
Bioatla Llc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bioatla Llc filed Critical Bioatla Llc
Publication of SG10202108814VA publication Critical patent/SG10202108814VA/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/005—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies constructed by phage libraries
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • C07K16/2809—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against the T-cell receptor (TcR)-CD3 complex
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/30—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/10—Processes for the isolation, preparation or purification of DNA or RNA
    • C12N15/1034—Isolating an individual clone by screening libraries
    • C12N15/1058—Directional evolution of libraries, e.g. evolution of libraries is achieved by mutagenesis and screening or selection of mixed population of organisms
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/10—Processes for the isolation, preparation or purification of DNA or RNA
    • C12N15/1034—Isolating an individual clone by screening libraries
    • C12N15/1093—General methods of preparing gene libraries, not provided for in other subgroups
    • C—CHEMISTRY; METALLURGY
    • C40—COMBINATORIAL TECHNOLOGY
    • C40B—COMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
    • C40B30/00—Methods of screening libraries
    • C40B30/04—Methods of screening libraries by measuring the ability to specifically bind a target molecule, e.g. antibody-antigen binding, receptor-ligand binding
    • C—CHEMISTRY; METALLURGY
    • C40—COMBINATORIAL TECHNOLOGY
    • C40B—COMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
    • C40B40/00—Libraries per se, e.g. arrays, mixtures
    • C40B40/04—Libraries containing only organic compounds
    • C40B40/06—Libraries containing nucleotides or polynucleotides, or derivatives thereof
    • C40B40/08—Libraries containing RNA or DNA which encodes proteins, e.g. gene libraries
    • C—CHEMISTRY; METALLURGY
    • C40—COMBINATORIAL TECHNOLOGY
    • C40B—COMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
    • C40B40/00—Libraries per se, e.g. arrays, mixtures
    • C40B40/04—Libraries containing only organic compounds
    • C40B40/10—Libraries containing peptides or polypeptides, or derivatives thereof
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/10—Immunoglobulins specific features characterized by their source of isolation or production
    • C07K2317/14—Specific host cells or culture conditions, e.g. components, pH or temperature
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/31—Immunoglobulins specific features characterized by aspects of specificity or valency multispecific
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/94—Stability, e.g. half-life, pH, temperature or enzyme-resistance

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Immunology (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Biophysics (AREA)
  • Engineering & Computer Science (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • General Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Biotechnology (AREA)
  • Zoology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Wood Science & Technology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Computational Biology (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Plant Pathology (AREA)
  • Microbiology (AREA)
  • Virology (AREA)
  • Cell Biology (AREA)
  • Ecology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
SG10202108814VA 2015-02-24 2016-02-24 Conditionally active biological proteins SG10202108814VA (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201562120312P 2015-02-24 2015-02-24
US201562249907P 2015-11-02 2015-11-02

Publications (1)

Publication Number Publication Date
SG10202108814VA true SG10202108814VA (en) 2021-09-29

Family

ID=56789902

Family Applications (2)

Application Number Title Priority Date Filing Date
SG10202108814VA SG10202108814VA (en) 2015-02-24 2016-02-24 Conditionally active biological proteins
SG11201705988UA SG11201705988UA (en) 2015-02-24 2016-02-24 Conditionally active biological proteins

Family Applications After (1)

Application Number Title Priority Date Filing Date
SG11201705988UA SG11201705988UA (en) 2015-02-24 2016-02-24 Conditionally active biological proteins

Country Status (11)

Country Link
US (3) US10563194B2 (en)
EP (1) EP3262217A4 (en)
JP (3) JP7025214B2 (en)
KR (3) KR20210096326A (en)
CN (1) CN107580603A (en)
AU (2) AU2016222830B2 (en)
CA (2) CA2977687C (en)
MX (2) MX2017010795A (en)
RU (1) RU2733658C2 (en)
SG (2) SG10202108814VA (en)
WO (1) WO2016138071A1 (en)

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DK3083689T3 (en) 2013-12-17 2020-08-03 Genentech Inc Anti-CD3 antibodies and methods of use
US20170260261A1 (en) 2014-08-28 2017-09-14 Bioatla, Llc Conditionally Active Chimeric Antigen Receptors for Modified T-Cells
LT3455261T (en) * 2016-05-13 2022-11-10 Bioatla, Inc. Anti-ror2 antibodies, antibody fragments, their immunoconjugates and uses thereof
KR102585956B1 (en) * 2016-08-31 2023-10-05 바이오아트라, 인코퍼레이티드 Conditionally active polypeptides and methods of making them
CN109923128A (en) 2016-11-15 2019-06-21 基因泰克公司 Administration for being treated with anti-CD20/ AntiCD3 McAb bispecific antibody
AU2018205629A1 (en) 2017-01-03 2019-07-11 Bioatla Llc Protein therapeutics for treatment of senescent cells
US20230192839A1 (en) * 2017-04-12 2023-06-22 Pfizer Inc. Antibodies having conditional affinity and methods of use thereof
JP7473977B2 (en) * 2018-06-05 2024-04-24 バイオアトラ インコーポレイテッド Anti-IL22 antibodies, antibody fragments and immunoconjugates thereof and uses thereof
US20210253702A1 (en) * 2018-06-14 2021-08-19 Bioatla, Inc. Multi-specific antibody constructs
CN111505288B (en) * 2020-05-15 2022-03-01 重庆医科大学 Novel depression biomarker and application thereof
CN114259460B (en) * 2020-09-16 2024-03-15 苏州大学 Hydrogel composition based on immunoadjuvant and application thereof
CN118076632A (en) * 2021-10-19 2024-05-24 生物蛋白有限公司 Conditionally active proteins for neurodegenerative diseases

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Also Published As

Publication number Publication date
MX2020011052A (en) 2020-11-06
US20200199578A1 (en) 2020-06-25
JP7025214B2 (en) 2022-02-24
SG11201705988UA (en) 2017-08-30
KR102286801B1 (en) 2021-08-09
JP2018513206A (en) 2018-05-24
US10563194B2 (en) 2020-02-18
EP3262217A1 (en) 2018-01-03
KR20210096326A (en) 2021-08-04
RU2017127972A (en) 2019-03-25
CA2977687C (en) 2024-02-13
WO2016138071A1 (en) 2016-09-01
US20190024078A1 (en) 2019-01-24
KR20170117089A (en) 2017-10-20
JP2023182651A (en) 2023-12-26
AU2016222830A1 (en) 2017-08-10
CA3225013A1 (en) 2016-09-01
CN107580603A (en) 2018-01-12
CA2977687A1 (en) 2016-09-01
AU2016222830B2 (en) 2021-02-25
RU2733658C2 (en) 2020-10-06
US20220127595A1 (en) 2022-04-28
EP3262217A4 (en) 2018-07-18
JP2022031720A (en) 2022-02-22
AU2021203506A1 (en) 2021-06-17
KR20230109773A (en) 2023-07-20
MX2017010795A (en) 2018-04-11
RU2017127972A3 (en) 2019-08-09
US11254932B2 (en) 2022-02-22

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