SG10202102920QA - Egfr inhibitor compounds - Google Patents

Egfr inhibitor compounds

Info

Publication number
SG10202102920QA
SG10202102920QA SG10202102920QA SG10202102920QA SG10202102920QA SG 10202102920Q A SG10202102920Q A SG 10202102920QA SG 10202102920Q A SG10202102920Q A SG 10202102920QA SG 10202102920Q A SG10202102920Q A SG 10202102920QA SG 10202102920Q A SG10202102920Q A SG 10202102920QA
Authority
SG
Singapore
Prior art keywords
inhibitor compounds
egfr inhibitor
egfr
compounds
inhibitor
Prior art date
Application number
SG10202102920QA
Inventor
Kevin Bunker
Peter Huang
Sunny Abraham
Joseph Pinchman
Chad Hopkins
Deborah Slee
Original Assignee
Recurium Ip Holdings Llc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Recurium Ip Holdings Llc filed Critical Recurium Ip Holdings Llc
Publication of SG10202102920QA publication Critical patent/SG10202102920QA/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/08—Indoles; Hydrogenated indoles with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, directly attached to carbon atoms of the hetero ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
    • A61K31/404—Indoles, e.g. pindolol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C13/00—Cyclic hydrocarbons containing rings other than, or in addition to, six-membered aromatic rings
    • C07C13/28—Polycyclic hydrocarbons or acyclic hydrocarbon derivatives thereof
    • C07C13/32—Polycyclic hydrocarbons or acyclic hydrocarbon derivatives thereof with condensed rings
    • C07C13/36—Polycyclic hydrocarbons or acyclic hydrocarbon derivatives thereof with condensed rings with a bicyclo ring system containing five carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C211/00—Compounds containing amino groups bound to a carbon skeleton
    • C07C211/33—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to carbon atoms of rings other than six-membered aromatic rings
    • C07C211/34—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to carbon atoms of rings other than six-membered aromatic rings of a saturated carbon skeleton
    • C07C211/38—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to carbon atoms of rings other than six-membered aromatic rings of a saturated carbon skeleton containing condensed ring systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
    • C07D209/32—Oxygen atoms
    • C07D209/34—Oxygen atoms in position 2
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2602/00—Systems containing two condensed rings
    • C07C2602/36—Systems containing two condensed rings the rings having more than two atoms in common
    • C07C2602/38—Systems containing two condensed rings the rings having more than two atoms in common the bicyclo ring system containing five carbon atoms
SG10202102920QA 2016-05-26 2017-05-24 Egfr inhibitor compounds SG10202102920QA (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US201662342141P 2016-05-26 2016-05-26

Publications (1)

Publication Number Publication Date
SG10202102920QA true SG10202102920QA (en) 2021-05-28

Family

ID=60411884

Family Applications (2)

Application Number Title Priority Date Filing Date
SG10202102920QA SG10202102920QA (en) 2016-05-26 2017-05-24 Egfr inhibitor compounds
SG11201809751XA SG11201809751XA (en) 2016-05-26 2017-05-24 Egfr inhibitor compounds

Family Applications After (1)

Application Number Title Priority Date Filing Date
SG11201809751XA SG11201809751XA (en) 2016-05-26 2017-05-24 Egfr inhibitor compounds

Country Status (15)

Country Link
US (3) US10513509B2 (en)
EP (1) EP3464275A4 (en)
JP (1) JP7030066B2 (en)
KR (2) KR102444835B1 (en)
CN (2) CN112624954A (en)
AR (1) AR110038A1 (en)
AU (2) AU2017269335B2 (en)
BR (1) BR112018074232A2 (en)
CA (1) CA3023176A1 (en)
IL (2) IL263081B (en)
MX (2) MX2018013413A (en)
RU (1) RU2751341C2 (en)
SG (2) SG10202102920QA (en)
TW (1) TWI752033B (en)
WO (1) WO2017205459A1 (en)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2017205459A1 (en) 2016-05-26 2017-11-30 Kalyra Pharmaceuticals, Inc. Egfr inhibitor compounds
CN108864079B (en) * 2017-05-15 2021-04-09 深圳福沃药业有限公司 Triazine compound and pharmaceutically acceptable salt thereof
WO2019051038A1 (en) 2017-09-11 2019-03-14 Zeno Royalties & Milestones, LLC Continuous flow processes for making bicyclic compounds
CN110041302B (en) * 2019-03-01 2021-11-30 南方医科大学 2-amino-4-substituted pyridine derivative and synthesis method and application thereof
CN114364798A (en) 2019-03-21 2022-04-15 欧恩科斯欧公司 Combination of Dbait molecules with kinase inhibitors for the treatment of cancer
US20220340547A1 (en) * 2019-05-22 2022-10-27 Shanghi Hansoh Biosoh Biomedical Co., Ltd. Indole derivative-containing inhibitor, preparation method therefor and application thereof
US20220229072A1 (en) 2019-06-04 2022-07-21 INSERM (Institut National de la Santé et de la Recherche Médicale) Use of cd9 as a biomarker and as a biotarget in glomerulonephritis or glomerulosclerosis
CN114761006A (en) 2019-11-08 2022-07-15 Inserm(法国国家健康医学研究院) Methods of treating cancer resistant to kinase inhibitors
WO2021148581A1 (en) 2020-01-22 2021-07-29 Onxeo Novel dbait molecule and its use
KR20230026383A (en) * 2020-06-23 2023-02-24 선전 포워드 파머수티컬즈 코 엘티디 Salts of the compound and pharmaceutical compositions comprising the salts
EP4330256A1 (en) * 2021-04-30 2024-03-06 Suzhou Puhe Biopharma Co., Ltd. Pyrimidinylaminobenzenes for lung cancer treatment

Family Cites Families (144)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US1051350A (en) 1910-02-02 1913-01-21 Thomas Nogier Apparatus for the sterilization of liquids.
DE4124942A1 (en) 1991-07-27 1993-01-28 Thomae Gmbh Dr K 5-LOW HETEROCYCLES, METHOD FOR THE PRODUCTION THEREOF AND MEDICAMENTS CONTAINING SUCH COMPOUNDS
AU693475B2 (en) 1993-10-01 1998-07-02 Novartis Ag Pyrimidineamine derivatives and processes for the preparation thereof
TW440563B (en) 1996-05-23 2001-06-16 Hoffmann La Roche Aryl pyrimidine derivatives and a pharmaceutical composition thereof
US6689778B2 (en) * 2001-07-03 2004-02-10 Vertex Pharmaceuticals Incorporated Inhibitors of Src and Lck protein kinases
US7396940B2 (en) 2003-10-23 2008-07-08 Hoffmann-La Roche Inc. Combinatorial library of 3-aryl-1H-indole-2-carboxylic acid
US20080153869A1 (en) 2004-06-14 2008-06-26 Bressi Jerome C Kinase Inhibitors
JP2008512380A (en) 2004-09-03 2008-04-24 プレキシコン，インコーポレーテッド PDE4B inhibitor
US7855205B2 (en) 2004-10-29 2010-12-21 Janssen Pharmaceutica Nv Pyrimidinyl substituted fused-pyrrolyl compounds useful in treating kinase disorders
GB0500492D0 (en) 2005-01-11 2005-02-16 Cyclacel Ltd Compound
KR20070110324A (en) 2005-03-04 2007-11-16 머크 앤드 캄파니 인코포레이티드 Fused aromatic compounds having anti-diabetic activity
GB0520657D0 (en) 2005-10-11 2005-11-16 Ludwig Inst Cancer Res Pharmaceutical compounds
US20100267707A1 (en) 2006-06-22 2010-10-21 Merck Sharp & Dohme Corp. Tyrosine Kinase Inhibitors
WO2008024978A2 (en) 2006-08-24 2008-02-28 Serenex, Inc. Tetrahydroindolone and tetrahydroindazolone derivatives
EP2155187B1 (en) 2007-05-07 2016-05-25 Merck Sharp & Dohme Corp. Method of treatment using fused aromatic compounds having anti-diabetic activity
JP2010031249A (en) 2008-06-23 2010-02-12 Sumitomo Chemical Co Ltd Composition and light-emitting element using the composition
CA2986640C (en) * 2008-06-27 2019-03-26 Celgene Avilomics Research, Inc. Heteroaryl compounds and uses thereof
GB0815369D0 (en) 2008-08-22 2008-10-01 Summit Corp Plc Compounds for treatment of duchenne muscular dystrophy
CN101723936B (en) 2008-10-27 2014-01-15 上海睿星基因技术有限公司 Kinase suppressor and pharmaceutical application thereof
WO2011019780A1 (en) 2009-08-11 2011-02-17 Bristol-Myers Squibb Company Azaindazoles as btk kinase modulators and use thereof
TW201609747A (en) 2009-09-09 2016-03-16 阿維拉製藥公司 PI3 kinase inhibitors and uses thereof
KR101116234B1 (en) 2009-10-29 2014-03-06 (주)퓨쳐켐 Aryl derivatives substituted with (3-fluoro-2-hydroxy)propyl group or pharmaceutically acceptable salts thereof, preparation method thereof, and phrmaceutical composition for the diagnosis or treatment of degenerative brain disease containing the same as an active ingredient
UY33539A (en) 2010-08-02 2012-02-29 Astrazeneca Ab ALK CHEMICAL COMPOUNDS
JP5809279B2 (en) 2010-10-14 2015-11-10 ジェイダブリュ ファーマセウティカル コーポレーション Novel compounds of reverse turn analogues and their production and use
AR085908A1 (en) 2011-03-16 2013-11-06 Hoffmann La Roche DERIVATIVES OF 3-BUTIN-2-OL AND CARBONITRILE WITH INHIBITING ACTIVITY OF THE NF-kB INDUCTING KINASE (NIK)
CN103608014A (en) 2011-03-24 2014-02-26 罗楹 Use of kinase inhibitors in preventing and treating inflammatory disorder
SI3333161T1 (en) * 2011-07-27 2020-07-31 Astrazeneca Ab 2-(2,4,5-substituted-anilino)pyrimidine derivatives as egfr modulators useful for treating cancer
US9382239B2 (en) 2011-11-17 2016-07-05 Dana-Farber Cancer Institute, Inc. Inhibitors of c-Jun-N-terminal kinase (JNK)
JP6399660B2 (en) 2012-04-10 2018-10-03 ザ・リージエンツ・オブ・ザ・ユニバーシテイー・オブ・カリフオルニア Cancer treatment compositions and methods
CN103508961B (en) 2012-06-26 2015-07-22 中美冠科生物技术（太仓）有限公司 Antitumor drug
WO2014047662A2 (en) 2012-09-24 2014-03-27 Whitehead Institute For Biomedical Research Indazole derivatives and uses thereof
EP2909194A1 (en) 2012-10-18 2015-08-26 Dana-Farber Cancer Institute, Inc. Inhibitors of cyclin-dependent kinase 7 (cdk7)
KR20240005211A (en) 2012-11-21 2024-01-11 얀센 바이오테크 인코포레이티드 BISPECIFIC EGFR/c-Met ANTIBODIES
US9695228B2 (en) 2012-11-21 2017-07-04 Janssen Biotech, Inc. EGFR and c-Met fibronectin type III domain binding molecules
HUE041881T2 (en) 2013-04-29 2019-06-28 Chong Kun Dang Pharmaceutical Corp Novel compounds for selective histone deacetylase inhibitors, and pharmaceutical composition comprising the same
US20180057603A1 (en) 2013-08-09 2018-03-01 The Trustees Of The University Of Pennsylvania Combination of IFN-gamma with Anti-ERBB Antibody for the Treatment of Cancers
CN105683166B (en) 2013-08-30 2020-06-16 Ptc医疗公司 Substituted pyrimidine Bmi-1 inhibitors
CA2923667A1 (en) 2013-09-09 2015-03-12 Triact Therapeutics, Inc. Cancer therapy
US20160319032A1 (en) 2013-10-01 2016-11-03 Medlmmune Limited Methods of treating and diagnosing alpha-v-beta-6 overexpressing cancer
GB201400034D0 (en) 2014-01-02 2014-02-19 Astrazeneca Ab Pharmaceutical Compositions comprising AZD9291
CN104761544B (en) 2014-01-03 2019-03-15 北京轩义医药科技有限公司 The selective depressant of the important mutant of clinic of EGFR tyrosine kinase
WO2015112705A2 (en) 2014-01-24 2015-07-30 Clovis Oncology, Inc. Therapeutic combinations for treating cancer
WO2015127234A1 (en) 2014-02-20 2015-08-27 Board Of Regents, The University Of Texas System Use of ibrutinib to treat egfr mutant cancer
CN104860941B (en) * 2014-02-25 2017-03-22 上海海雁医药科技有限公司 2,4-disubstituted phenyl-1,5-diamine derivatives and use thereof, and pharmaceutical composition and medicinal composition prepared from 2,4-disubstituted phenyl-1,5-diamine derivative
CN104876914B (en) 2014-02-28 2017-04-19 山东轩竹医药科技有限公司 Pyrimidine derivative type anaplastic lymphoma kinase inhibitor
TW201622744A (en) 2014-03-04 2016-07-01 美國禮來大藥廠 Combination therapy for cancer
CN104892585B (en) 2014-03-06 2018-07-03 山东轩竹医药科技有限公司 Pyrimidine derivates species anaplastic lymphoma kinase inhibitor
JP6549147B2 (en) 2014-04-04 2019-07-24 アストラゼネカ・アクチエボラーグＡｓｔｒａｚｅｎｅｃａ Ａｋｔｉｅｂｏｌａｇ Combination of EGFR inhibitor and MEK inhibitor for use in the treatment of NRAS mutant cancer
KR20170003553A (en) * 2014-04-04 2017-01-09 사이로스 파마수티컬스, 인크. Inhibitors of cyclin-dependent kinase 7 (cdk7)
WO2015175965A1 (en) 2014-05-15 2015-11-19 The Research Foundation For Suny Compositions targeting the interaction domain between p27kip1 and brk and methods of use thereof
CN111892579B (en) 2014-06-12 2023-07-25 上海艾力斯医药科技股份有限公司 Kinase inhibitors
BR112016029662B1 (en) * 2014-06-19 2023-10-24 Takeda Pharmaceutical Company Limited COMPOUND OF FORMULA Bf OR A PHARMACEUTICALLY ACCEPTABLE FORM THEREOF, PHARMACEUTICAL COMPOSITION COMPRISING THE SAME AND ITS USE
CA2952758A1 (en) 2014-07-11 2016-01-14 Genmab A/S Antibodies binding axl
CN105254615B (en) 2014-07-11 2017-02-22 杭州华东医药集团新药研究院有限公司 Phenylaminopyrimidine derivatives and their use in preparation of drugs for resisting cancers
CN105315285B (en) 2014-07-25 2017-12-08 上海海雁医药科技有限公司 2,4 2 substitution 7H pyrrolo-es [2,3 d] pyrimidine derivatives, its preparation method and purposes pharmaceutically
JP6585158B2 (en) 2014-08-12 2019-10-02 ファイザー・インク Pyrrolo [2,3-d] pyrimidine derivatives useful for the inhibition of Janus kinase
JP2017523231A (en) 2014-08-15 2017-08-17 ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング Afatinib drug kit for cancer treatment
CN104140418B (en) 2014-08-15 2016-08-24 常州润诺生物科技有限公司 2-(2,4,5-substituted aniline) pyrimidine derivatives and application thereof
CN106458969A (en) 2014-08-25 2017-02-22 四川海思科制药有限公司 (substituted phenyl) (substituted pyrimidine) amino derivative, preparation method therefor, and medication use
WO2016032003A1 (en) 2014-08-30 2016-03-03 国立大学法人金沢大学 Treatment agent for lung cancer patient, and method for predicting and testing efficacy of treatment for lung cancer patient
CA2959775A1 (en) 2014-09-08 2016-03-17 Yeda Research And Development Co. Ltd. Compositions and methods for treating cancer resistant to a tyrosine kinase inhibitor (tki)
CA2959716A1 (en) 2014-09-08 2016-03-17 Yeda Research And Development Co. Ltd. Anti-her3 antibodies and uses of same
EP3191128A4 (en) 2014-09-11 2018-03-14 Celldex Therapeutics, Inc. Uses of anti-her3 antibodies for treating cancer
ES2843829T3 (en) 2014-09-26 2021-07-20 Hi Stem Ggmbh Im Deutschen Krebsforschungszentrum Dkfz New methods for subtyping and cancer treatment
CN105461695B (en) 2014-09-29 2018-03-27 齐鲁制药有限公司 Pyrimidine or pyrrolotriazine derivatives and its production and use
CN105237515B (en) 2014-10-10 2018-06-05 益方生物科技（上海）有限公司 Deuterated pyrimidines, its preparation method, pharmaceutical composition and purposes
CN106661000B (en) * 2014-10-11 2019-04-09 上海翰森生物医药科技有限公司 EGFR inhibitor and its preparation and application
JP6524221B2 (en) * 2014-10-13 2019-06-05 ユハン コーポレーションＹｕｈａｎ Ｃｏｒｐｏｒａｔｉｏｎ Compounds and compositions for modulating EGFR mutant kinase activity
WO2016058544A1 (en) 2014-10-16 2016-04-21 Syros Pharmaceuticals, Inc. Inhibitors of cyclin-dependent kinase 7 (cdk7)
CN111170998B (en) * 2014-11-05 2023-04-11 益方生物科技(上海)股份有限公司 Pyrimidine or pyridine compound, preparation method and medical application thereof
AU2015358384B2 (en) 2014-12-03 2021-03-04 Auckland Uniservices, Ltd. Kinase inhibitor prodrug for the treatment of cancer
SG11201704685TA (en) 2014-12-11 2017-07-28 Beta Pharma Inc Substituted 2-anilinopyrimidine derivatives as egfr modulators
MA41265B1 (en) 2014-12-24 2023-05-31 Principia Biopharma Inc Compositions for administration of ileo-jejunal drugs.
US20180271853A1 (en) 2015-01-09 2018-09-27 Metastat, Inc. Method of Use for Inhibitors of Epidermal Growth Factor Receptor Variant III
WO2016112302A1 (en) 2015-01-09 2016-07-14 Metastat, Inc. Method of predicting sensitivity of tumor cell growth to combination therapy of fgfr inhibitor
CN107250130B (en) 2015-02-04 2019-11-08 Beyondbio株式会社 Heterocyclic compound and pharmaceutical composition comprising it
CN104961731A (en) 2015-02-05 2015-10-07 苏州晶云药物科技有限公司 Phosphate of epidermal growth factor receptor inhibitor, and crystal form and preparation method thereof
CN112494653A (en) 2015-02-05 2021-03-16 特尔诺沃有限公司 Combination of IRS/STAT3 dual modulators and anticancer agents for the treatment of cancer
CN105985323A (en) 2015-02-15 2016-10-05 宁波文达医药科技有限公司 Novel epidermal growth factor receptor inhibitor and application thereof
EP3265562A4 (en) 2015-03-05 2018-12-19 TrovaGene, Inc. Early assessment of mechanism of action and efficacy of anti-cancer therapies using molecular markers in bodily fluids
CN106138061B (en) 2015-04-03 2019-06-04 中国人民解放军第三军医大学第三附属医院 The compound and its preparation and purposes of prevention or decrease pulmonary fibrosis
CN106138020A (en) 2015-04-03 2016-11-23 中国人民解放军第三军医大学第三附属医院 Biguanides prevents in preparation or weakens the application in the medicine of pulmonary fibrosis
WO2016164217A1 (en) 2015-04-09 2016-10-13 Clovis Oncology, Inc. Therapeutic combinations for treating cancer
CN104844580B (en) 2015-04-17 2017-10-20 中国药科大学 Pyrimidines, its preparation method and medical usage
JP2018513178A (en) 2015-04-23 2018-05-24 メディミューン リミテッド Combination therapy of non-small cell lung cancer positive for EGFR gene mutation
CN104817541B (en) 2015-05-11 2017-06-16 苏州东南药业股份有限公司 A kind of synthetic method of antineoplastic
JP6949726B2 (en) 2015-05-15 2021-10-13 ノバルティス アーゲー How to treat EGFR mutant cancer
WO2016187393A1 (en) 2015-05-21 2016-11-24 Chemocentryx, Inc. Ccr2 modulators
WO2016191471A1 (en) 2015-05-27 2016-12-01 Metastat, Inc. Method of use for inhibitors of epidermal growth factor receptor variants ii, iii and vi
AU2016270375B2 (en) 2015-06-03 2021-05-13 Chang Gung Medical Foundation Keelung Chang Gung Memorial Hospital Methods and compositions for treating non-small cell lung cancer
US20160355503A1 (en) 2015-06-04 2016-12-08 Cleave Biosciences, Inc. NITROGEN HEXACYCLE COMPOUNDS AS INHIBITORS OF p97 COMPLEX
EP3307728A4 (en) 2015-06-12 2019-07-17 Dana Farber Cancer Institute, Inc. Combination therapy of transcription inhibitors and kinase inhibitors
CN104910049B (en) 2015-06-16 2016-06-29 苏州明锐医药科技有限公司 AZD9291 intermediate and preparation method thereof
RS60141B1 (en) 2015-07-10 2020-05-29 Genmab As Axl-specific antibody-drug conjugates for cancer treatment
ES2964607T3 (en) 2015-07-17 2024-04-08 Pacylex Pharmaceuticals Inc Epigenetic silencing of NMT2
US10550112B2 (en) 2015-07-20 2020-02-04 Dana-Farber Cancer Institute, Inc. Pyrimidines as EGFR inhibitors and methods of treating disorders
TW201716439A (en) 2015-07-20 2017-05-16 美國禮來大藥廠 HER3 antibodies
EP3120851A1 (en) 2015-07-21 2017-01-25 Pangaea Biotech S.L. 4-amino-6-(2,6-dichlorophenyl)-8-methyl-2-(phenylamino)-pyrido[2,3-d]pyrimidin-7(8h)-one for treatment of solid cancers
CN107531678B (en) 2015-07-24 2020-12-22 上海海雁医药科技有限公司 EGFR inhibitor and pharmaceutically acceptable salts and polymorphs thereof and uses thereof
CN105001208A (en) 2015-08-06 2015-10-28 南京雷科星生物技术有限公司 EGFR inhibitor and preparing method and application thereof
WO2017031036A1 (en) 2015-08-14 2017-02-23 Gray Alana Lea Isothiocyanatostilbenes as a novel method and product for treating cancer
CN105153122B (en) 2015-08-27 2018-07-20 上海圣考医药科技有限公司 [(indol-3-yl) pyrimidine -2-base] aminophenyl propyl- 2- alkenylamide derivatives and salt, preparation method, application
CN106478605A (en) 2015-09-02 2017-03-08 上海页岩科技有限公司 Pyrimidines, its preparation method and medical usage
CN105126125A (en) 2015-09-12 2015-12-09 复旦大学 Zinc oxide-gadolinium-drug composite nanoparticle, and preparation method and application thereof
AU2016328764B2 (en) 2015-09-25 2020-07-09 Dizal (Jiangsu) Pharmaceutical Co., Limited Compounds and methods for inhibiting JAK
CN106588943B (en) 2015-10-19 2018-10-16 广东东阳光药业有限公司 A kind of salt of EGFR inhibitor, crystal form and application thereof
US20170115275A1 (en) 2015-10-23 2017-04-27 Arizona Board Of Regents On Behalf Of Arizona State University Engineered substrates for high-throughput generation of 3d models of tumor dormancy, relapse and micrometastases for phenotype specific drug discovery and development
WO2017075367A1 (en) 2015-10-28 2017-05-04 Northwestern University Substituted aromatic n-heterocyclic compounds as inhibitors of mitogen-activated protein kinase interacting kinase 1 (mnk1) and 2 (mnk2)
KR20180097530A (en) 2015-11-02 2018-08-31 예일 유니버시티 Proteolysis Targeting Chimera compounds and methods for their manufacture and use
CN106674202A (en) 2015-11-05 2017-05-17 惠州信立泰药业有限公司 Dimethyl sulfonate of compound A, crystal form of dimethyl sulfonate, and medicinal composition containing dimethyl sulfonate
CN106699736A (en) 2015-11-17 2017-05-24 惠州信立泰药业有限公司 Crystal form gamma of compound A mesylate and pharmaceutical composition containing the same
CN105461729B (en) 2015-11-18 2017-12-05 乳源瑶族自治县大众药品贸易有限公司 A kind of salt of EGFR inhibitor, crystal formation and application thereof
CN105294717B (en) 2015-11-18 2017-12-22 乳源瑶族自治县大众药品贸易有限公司 A kind of salt of EGFR inhibitor, crystal formation and application thereof
RU2606949C9 (en) 2015-11-19 2018-03-14 ЗАО "Р-Фарм" Substituted n-{3-[4-(1-methyl-1h-indol-3-yl)pyrimidin-2-ylamino]-4-methoxyphenyl}-amides as modulators of egfr, applicable for treating cancer
RU2603960C1 (en) 2015-11-19 2016-12-10 Закрытое акционерное общество "Р-Фарм" (ЗАО "Р-Фарм") Dichloroacetate of n1,n2-disubstituted n4-[4-(1-methyl-1h-indole-3-yl)-pyrimidine-2-yl]-5-methoxybenzene-1,2,4-triamine as egfr modulator for treating cancer
CN105348267A (en) 2015-12-01 2016-02-24 中山奕安泰医药科技有限公司 Method for synthesizing AZD9291 intermediate
US10829495B2 (en) 2015-12-03 2020-11-10 Zhejiang Jianfeng-Yien Biotechnology Co., Ltd. Thieno-pyrimidine derivatives and uses thereof
WO2017096100A1 (en) 2015-12-03 2017-06-08 Shanghai Aeon Biotech Co., Ltd. Heterocycle compounds and uses thereof
CA3007644A1 (en) 2015-12-11 2017-06-15 Regeneron Pharmaceuticals, Inc. Methods for reducing or preventing growth of tumors resistant to egfr and/or erbb3 blockade
TWI623316B (en) 2015-12-22 2018-05-11 Taiho Pharmaceutical Co Ltd Antitumor effect enhancer derived from pyrrolopyrimidine compound
CN105601620A (en) 2015-12-25 2016-05-25 北京康立生医药技术开发有限公司 Method for preparing mereletinib mesylate
JP6605751B2 (en) 2015-12-27 2019-11-13 ノイフォルム・ファーマシューティカルズ・インコーポレイテッド Deuterium compounds for treating cancerous conditions
CN106928150B (en) 2015-12-31 2020-07-31 恩瑞生物医药科技（上海）有限公司 Acrylamide aniline derivative and pharmaceutical application thereof
EP3399968B8 (en) 2016-01-07 2021-12-01 Xuanzhu Biopharmaceutical Co., Ltd. Selective inhibitors of clinically important mutants of the egfr tyrosine kinase
WO2017120537A1 (en) 2016-01-08 2017-07-13 The Regents Of The University Of California Mesoporous silica nanoparticles with lipid bilayer coating for cargo delivery
KR20180100652A (en) 2016-01-08 2018-09-11 유클리세스 파마슈티컬스 인코포레이티드 A combination of a chromene compound and a second activator
CN105646454B (en) 2016-01-19 2018-05-08 浙江大学 The 2- aryl amine pyridine derivatives of the fragment containing hydroxamic acid and preparation and application
TWI745345B (en) 2016-02-01 2021-11-11 瑞典商阿斯特捷利康公司 Improved process for the preparation of osimertinib (azd9291) or a salt thereof, and “azd9291 aniline” or a salt thereof
WO2017136342A1 (en) 2016-02-02 2017-08-10 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Fulvestrant for inducing immune-mediated cytotoxic lysis of cancer cells
CN117045793A (en) 2016-02-04 2023-11-14 Sct二代有限责任公司 Anticancer pharmaceutical composition with reduced cardiotoxicity and use thereof
DK3411036T3 (en) 2016-02-04 2022-01-17 Pharmaengine Inc 3,5-DISubstituted PYRAZOLES USEFULLY AS CHECKPOINT CHINASE 1 (CHK1) INHIBITORS, AND THEIR MANUFACTURE AND USE
CN105777716B (en) 2016-02-25 2018-04-10 清华大学 A kind of EGFR inhibitor for targeted therapy of cancer and preparation method and application
CN105585557B (en) 2016-02-25 2018-06-22 清华大学 EGFR inhibitor for targeted therapy of cancer and preparation method and application
WO2017205459A1 (en) 2016-05-26 2017-11-30 Kalyra Pharmaceuticals, Inc. Egfr inhibitor compounds
CN105886648A (en) 2016-06-06 2016-08-24 武汉海吉力生物科技有限公司 Kit used for detecting T790M mutation of EGFR gene
CN106366022B (en) 2016-08-19 2018-03-13 上海工程技术大学 It is a kind of to be used to prepare AZD9291 intermediate and its preparation method and application
CN106366072B (en) 2016-08-19 2018-12-07 上海工程技术大学 A kind of preparation method of AZD9291
CN106397407B (en) 2016-08-31 2018-09-04 浙江科聚化工有限公司 The preparation method of antitumor drug AZD9291 derivatives
CN106432231B (en) 2016-09-09 2018-06-12 无锡佰翱得生物科学有限公司 The pharmaceutical salts and its crystal form and preparation method of AZD9291
CN106565522A (en) 2016-09-29 2017-04-19 福格森（武汉）生物科技股份有限公司 Method for preparing alkyloxy aromatic compound from fluoroaromatic compound
CN106496196B (en) 2016-10-20 2019-07-02 南京雷科星生物技术有限公司 A kind of quinazoline, Pyridopyrimidine or double and pyrimidine derivatives egf inhibitor and preparation method thereof and purposes
CN106543060B (en) 2016-10-31 2018-11-06 湖南欧亚药业有限公司 A kind of difficult to understand this replaces the preparation method of Buddhist nun's mesylate
CN106668866A (en) 2017-02-13 2017-05-17 江苏省中医药研究院 Medicinal composition for resisting non-small cell lung cancer, and application thereof
CN106883216B (en) 2017-04-06 2020-03-13 张家港威胜生物医药有限公司 Preparation method of oxitinib

Also Published As

Publication number Publication date
IL263081A (en) 2018-12-31
RU2018138584A (en) 2020-06-26
BR112018074232A2 (en) 2019-03-06
AU2017269335B2 (en) 2021-07-01
AR110038A1 (en) 2019-02-20
US20210395230A1 (en) 2021-12-23
US20200181120A1 (en) 2020-06-11
IL281537A (en) 2021-05-31
CA3023176A1 (en) 2017-11-30
US20170342055A1 (en) 2017-11-30
CN109311858A (en) 2019-02-05
IL263081B (en) 2021-04-29
US11098030B2 (en) 2021-08-24
MX2021007773A (en) 2021-08-05
US10513509B2 (en) 2019-12-24
EP3464275A1 (en) 2019-04-10
JP7030066B2 (en) 2022-03-04
TWI752033B (en) 2022-01-11
KR102444835B1 (en) 2022-09-19
NZ747854A (en) 2020-09-25
MX2018013413A (en) 2019-06-06
JP2019516766A (en) 2019-06-20
WO2017205459A1 (en) 2017-11-30
AU2017269335A1 (en) 2018-12-13
SG11201809751XA (en) 2018-12-28
CN109311858B (en) 2021-12-03
RU2751341C2 (en) 2021-07-13
RU2018138584A3 (en) 2020-06-26
KR20190007434A (en) 2019-01-22
CN112624954A (en) 2021-04-09
KR20220130249A (en) 2022-09-26
AU2021240162A1 (en) 2021-10-28
EP3464275A4 (en) 2019-10-30
TW201800384A (en) 2018-01-01
WO2017205459A8 (en) 2018-12-13

Similar Documents

Publication Publication Date Title
ZA202000395B (en) Aryl-phosphorus-oxygen compound as egfr kinase inhibitor
IL281537A (en) Egfr inhibitor compounds
GB201705971D0 (en) Inhibitor compounds
IL289686A (en) Beta-lactamase inhibitor compounds
GB201602934D0 (en) Compounds
HK1247607A1 (en) P62-zz chemical inhibitor
GB201604027D0 (en) Compounds
GB201403536D0 (en) Inhibitor compounds
GB201610854D0 (en) Compounds
GB201604020D0 (en) Compounds
GB201513481D0 (en) Inhibitor compounds
GB201505658D0 (en) Inhibitor compounds
GB201608777D0 (en) Compounds
GB201604030D0 (en) Compounds
GB201604022D0 (en) Compounds
GB201613946D0 (en) Compounds
GB201604029D0 (en) Compounds
GB201604031D0 (en) Compounds
GB201720145D0 (en) Inhibitor compounds
GB201621619D0 (en) Inhibitor compounds
GB201708502D0 (en) Inhibitor compounds
GB201708507D0 (en) Inhibitor compounds
GB201708510D0 (en) Inhibitor compounds
GB201705968D0 (en) Inhibitor compounds
GB201522453D0 (en) Inhibitor compounds