SG10202011033QA - Phthalocyanine dye conjugates and their storage - Google Patents
Phthalocyanine dye conjugates and their storageInfo
- Publication number
- SG10202011033QA SG10202011033QA SG10202011033QA SG10202011033QA SG10202011033QA SG 10202011033Q A SG10202011033Q A SG 10202011033QA SG 10202011033Q A SG10202011033Q A SG 10202011033QA SG 10202011033Q A SG10202011033Q A SG 10202011033QA SG 10202011033Q A SG10202011033Q A SG 10202011033QA
- Authority
- SG
- Singapore
- Prior art keywords
- storage
- phthalocyanine dye
- dye conjugates
- conjugates
- phthalocyanine
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K41/00—Medicinal preparations obtained by treating materials with wave energy or particle radiation ; Therapies using these preparations
- A61K41/0057—Photodynamic therapy with a photosensitizer, i.e. agent able to produce reactive oxygen species upon exposure to light or radiation, e.g. UV or visible light; photocleavage of nucleic acids with an agent
- A61K41/0076—PDT with expanded (metallo)porphyrins, i.e. having more than 20 ring atoms, e.g. texaphyrins, sapphyrins, hexaphyrins, pentaphyrins, porphocyanines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K41/00—Medicinal preparations obtained by treating materials with wave energy or particle radiation ; Therapies using these preparations
- A61K41/0057—Photodynamic therapy with a photosensitizer, i.e. agent able to produce reactive oxygen species upon exposure to light or radiation, e.g. UV or visible light; photocleavage of nucleic acids with an agent
- A61K41/0071—PDT with porphyrins having exactly 20 ring atoms, i.e. based on the non-expanded tetrapyrrolic ring system, e.g. bacteriochlorin, chlorin-e6, or phthalocyanines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
- A61J1/00—Containers specially adapted for medical or pharmaceutical purposes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/62—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being a protein, peptide or polyamino acid
- A61K47/64—Drug-peptide, drug-protein or drug-polyamino acid conjugates, i.e. the modifying agent being a peptide, protein or polyamino acid which is covalently bonded or complexed to a therapeutically active agent
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
- A61K47/6801—Drug-antibody or immunoglobulin conjugates defined by the pharmacologically or therapeutically active agent
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
- A61K47/6835—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment the modifying agent being an antibody or an immunoglobulin bearing at least one antigen-binding site
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
- A61K47/6835—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment the modifying agent being an antibody or an immunoglobulin bearing at least one antigen-binding site
- A61K47/6839—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment the modifying agent being an antibody or an immunoglobulin bearing at least one antigen-binding site the antibody targeting material from viruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
- A61K47/6835—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment the modifying agent being an antibody or an immunoglobulin bearing at least one antigen-binding site
- A61K47/6843—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment the modifying agent being an antibody or an immunoglobulin bearing at least one antigen-binding site the antibody targeting a material from animals or humans
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
- A61K47/6835—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment the modifying agent being an antibody or an immunoglobulin bearing at least one antigen-binding site
- A61K47/6851—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment the modifying agent being an antibody or an immunoglobulin bearing at least one antigen-binding site the antibody targeting a determinant of a tumour cell
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/10—Antimycotics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201562206774P | 2015-08-18 | 2015-08-18 |
Publications (1)
Publication Number | Publication Date |
---|---|
SG10202011033QA true SG10202011033QA (en) | 2020-12-30 |
Family
ID=56801860
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
SG10202011033QA SG10202011033QA (en) | 2015-08-18 | 2016-08-18 | Phthalocyanine dye conjugates and their storage |
Country Status (11)
Country | Link |
---|---|
US (2) | US11141483B2 (en) |
EP (2) | EP3337568B1 (en) |
JP (4) | JP7055742B6 (en) |
CN (4) | CN114699525A (en) |
AU (1) | AU2016308286B2 (en) |
CA (1) | CA2994871A1 (en) |
DK (1) | DK3337568T3 (en) |
ES (1) | ES2889904T3 (en) |
NZ (1) | NZ739788A (en) |
SG (1) | SG10202011033QA (en) |
WO (1) | WO2017031363A2 (en) |
Families Citing this family (24)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US8524239B2 (en) | 2010-07-09 | 2013-09-03 | The United States of America as represented by the Secrectary, Department of Health and Human Services | Photosensitizing antibody-fluorophore conjugates |
SG11201610052TA (en) | 2014-08-08 | 2017-02-27 | Us Health | Photo-controlled removal of targets in vitro and in vivo |
CN108137701A (en) | 2015-08-07 | 2018-06-08 | 美国政府(由卫生和人类服务部的部长所代表) | For treating cancer for the near infrared light immunotherapy (NIR-PIT) for inhibiting cell |
CN114699525A (en) * | 2015-08-18 | 2022-07-05 | 乐天医药生技股份有限公司 | Method for producing phthalocyanine dye conjugate and stable conjugate |
EP3827846A1 (en) | 2015-08-18 | 2021-06-02 | Rakuten Medical, Inc. | Compositions, combinations and related methods for photoimmunotherapy |
CA3049926A1 (en) | 2017-01-17 | 2018-07-26 | Heparegenix Gmbh | Protein kinase inhibitors for promoting liver regeneration or reducing or preventing hepatocyte death |
US10682602B2 (en) * | 2017-01-19 | 2020-06-16 | National University Of Singapore | Nanofibrous filter |
EP3585433A4 (en) * | 2017-02-23 | 2020-12-30 | Rakuten Medical, Inc. | Therapeutic compositions and related methods for photoimmunotherapy |
CN111526730B (en) | 2017-12-29 | 2024-02-23 | 卡夫食品集团品牌有限责任公司 | Improved oxidative stability of oil-in-water emulsions using natural stabilizers |
WO2019172110A1 (en) * | 2018-03-09 | 2019-09-12 | 学校法人慈恵大学 | Conjugate of antibody targeting blood vessels and photosensitizer |
AU2019276572A1 (en) | 2018-06-01 | 2020-12-24 | Rakuten Medical, Inc. | Phthalocyanine dye conjugate compositions |
US20220226402A1 (en) * | 2019-03-25 | 2022-07-21 | Northshore University Health System | Methods and compositions comprising enhanced targeted immune gene therapy for the treatment of cancer |
EP3946631A1 (en) * | 2019-03-26 | 2022-02-09 | Shimadzu Corporation | Photoimmunotherapy and pharmaceutical agent used therefor |
CN115943306A (en) | 2019-03-29 | 2023-04-07 | 乐天医药生技股份有限公司 | Methods and related biomarkers for photoimmunotherapy |
JPWO2020246350A1 (en) * | 2019-06-03 | 2020-12-10 | ||
CN114585391A (en) * | 2019-08-07 | 2022-06-03 | 乐天医药生技股份有限公司 | Cetuximab-IR 700 conjugate compositions |
JPWO2021112174A1 (en) * | 2019-12-03 | 2021-06-10 | ||
US20230028062A1 (en) * | 2019-12-06 | 2023-01-26 | Rakuten Medical, Inc. | Methods for enhancing immunity and tumor treatment |
CN114981298A (en) | 2019-12-12 | 2022-08-30 | 听治疗有限责任公司 | Compositions and methods for preventing and treating hearing loss |
CN111057063B (en) * | 2019-12-19 | 2022-06-14 | 福州大学 | Phthalocyanine derivative for targeted photodynamic therapy of acute lymphocytic leukemia and preparation method thereof |
JPWO2021201284A1 (en) * | 2020-04-02 | 2021-10-07 | ||
JP2023526033A (en) | 2020-05-14 | 2023-06-20 | ラクテン・メディカル,インコーポレイテッド | Methods and compositions for treating tumors |
CN113150774B (en) * | 2021-04-30 | 2022-05-31 | 滨州学院 | Near-infrared fluorescent molecular probe, preparation method thereof and application thereof in cell imaging |
CN114409663B (en) * | 2022-01-28 | 2023-05-30 | 福州大学 | Zinc phthalocyanine 3-chloro-6 methylbenzo [ b ] thiophene-2-carboxylic acid conjugates targeting Mcl-1 enzyme and methods of making the same |
Family Cites Families (92)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
BE547020A (en) | 1955-04-20 | |||
US5494793A (en) | 1986-12-15 | 1996-02-27 | British Technology Group Usa Inc. | Monomeric phthalocyanine reagents |
US5530101A (en) | 1988-12-28 | 1996-06-25 | Protein Design Labs, Inc. | Humanized immunoglobulins |
US5196005A (en) | 1991-11-26 | 1993-03-23 | Pdt Systems, Inc. | Continuous gradient cylindrical diffusion tip for optical fibers and method for making |
JP2805723B2 (en) * | 1994-06-09 | 1998-09-30 | アイセロ化学株式会社 | Shade container for high purity chemicals |
US6176842B1 (en) | 1995-03-08 | 2001-01-23 | Ekos Corporation | Ultrasound assembly for use with light activated drugs |
US7521531B2 (en) | 1996-08-28 | 2009-04-21 | Immunomedics, Inc. | Methods for the purification of stable radioiodine conjugates |
DE19717904A1 (en) | 1997-04-23 | 1998-10-29 | Diagnostikforschung Inst | Acid-labile and enzymatically cleavable dye constructs for diagnostics with near infrared light and for therapy |
US6344050B1 (en) | 1998-12-21 | 2002-02-05 | Light Sciences Corporation | Use of pegylated photosensitizer conjugated with an antibody for treating abnormal tissue |
WO2001051924A2 (en) | 2000-01-12 | 2001-07-19 | Ventana Medical Systems, Inc. | Method for determining the response to cancer therapy |
WO2001057495A2 (en) | 2000-02-01 | 2001-08-09 | The Government Of The United States Of America As Represented By The Secretary, Department Of Health & Human Services | Methods for predicting the biological, chemical, and physical properties of molecules from their spectral properties |
WO2002100326A2 (en) | 2001-05-01 | 2002-12-19 | The General Hospital Corporation | Photoimmunotherapies for cancer using photosensitizer immunoconjugates and combination therapies |
US20030031627A1 (en) | 2001-07-31 | 2003-02-13 | Mallinckrodt Inc. | Internal image antibodies for optical imaging and therapy |
JP2003284757A (en) | 2002-01-24 | 2003-10-07 | Seputo:Kk | Red-ray therapeutic device equipped with heater |
AUPS146502A0 (en) | 2002-03-28 | 2002-05-09 | Traynor, Neil | Methods and apparatus relating to improved visual recognition and safety |
JP4074136B2 (en) | 2002-05-29 | 2008-04-09 | 浜松ホトニクス株式会社 | Fluorescence lifetime distribution image measuring apparatus and measuring method thereof |
US7005518B2 (en) | 2002-10-25 | 2006-02-28 | Li-Cor, Inc. | Phthalocyanine dyes |
US20040120949A1 (en) | 2002-11-08 | 2004-06-24 | Boehringer Ingelheim International Gmbh | Compositions and methods for treating cancer using cytotoxic CD44 antibody immunoconjugates and radiotherapy |
US20040202666A1 (en) | 2003-01-24 | 2004-10-14 | Immunomedics, Inc. | Anti-cancer anthracycline drug-antibody conjugates |
DE602004023183D1 (en) | 2003-03-07 | 2009-10-29 | Univ Texas | PHOTODYNAMIC THERAPY PROVIDED AGAINST ANTIBODIES |
WO2004099375A2 (en) | 2003-04-30 | 2004-11-18 | The General Hospital Corporation | Indirectly linked photosensitizer immunoconjugates, processes for the production thereof and methods of use therof |
US20080253960A1 (en) | 2004-04-01 | 2008-10-16 | The Trustees Of The University Of Pennsylvania Center For Technology Transfer | Lipoprotein-Based Nanoplatforms |
US8211883B2 (en) | 2004-04-01 | 2012-07-03 | Case Western Reserve University | Topical delivery of phthalocyanines |
CN101023084A (en) | 2004-09-03 | 2007-08-22 | 亨斯迈先进材料(瑞士)有限公司 | Compositions containing phthalocyanine dyes |
US20080095950A1 (en) | 2004-09-03 | 2008-04-24 | Huntsman International Llc | Compositions Containing Phthalocyanine Dyes |
GB0504278D0 (en) | 2005-03-02 | 2005-04-06 | Khanzada Javed | Personal adornment |
US20130039861A1 (en) * | 2005-04-06 | 2013-02-14 | Immunomedics, Inc. | Dye Conjugated Peptides for Fluorescent Imaging |
US8227621B2 (en) * | 2005-06-30 | 2012-07-24 | Li-Cor, Inc. | Cyanine dyes and methods of use |
JP5627181B2 (en) | 2005-09-07 | 2014-11-19 | アルケミア オンコロジー ピーティーワイ リミテッド | Therapeutic compositions comprising hyaluronan and therapeutic antibodies and methods of treatment |
US20080095699A1 (en) | 2006-10-20 | 2008-04-24 | Shiying Zheng | Imaging contrast agents using nanoparticles |
DE102005059338A1 (en) | 2005-12-08 | 2007-06-14 | Carl Zeiss Jena Gmbh | Method and arrangement for the examination of samples |
US7993927B2 (en) | 2006-07-03 | 2011-08-09 | Beth Israel Deaconess Medical Center, Inc. | Histology methods |
JP2010522982A (en) | 2007-03-29 | 2010-07-08 | コーニンクレッカ フィリップス エレクトロニクス エヌ ヴィ | Light emitting device including an elastomer layer |
GB0711560D0 (en) | 2007-06-14 | 2007-07-25 | Innova Biosciences Ltd | Improvements in or relating to production of conjugates |
WO2009038776A1 (en) | 2007-09-18 | 2009-03-26 | Victor Manneh | Therapeutic nanoconjugates |
JP2011500601A (en) | 2007-10-12 | 2011-01-06 | トランスモレキュラー, インコーポレイテッド | Systemic administration of chlorotoxin drugs for tumor diagnosis and treatment |
EP2244741B1 (en) | 2008-01-18 | 2015-03-25 | VisEn Medical, Inc. | Fluorescent imaging agents |
US8580520B2 (en) | 2008-09-15 | 2013-11-12 | Herlev Hospital | YKL-40 as a marker for gastrointestinal cancers |
GB0819594D0 (en) | 2008-10-24 | 2008-12-03 | Univ Coimbrra | Process |
US8771741B2 (en) | 2009-01-23 | 2014-07-08 | The Penn State Research Foundation | In vivo photodynamic therapy of cancer via a near infrared agent encapsulated in calcium phosphate nanoparticles |
US8246565B2 (en) | 2009-02-25 | 2012-08-21 | The Invention Science Fund I, Llc | Device for passively removing a target component from blood or lymph of a vertebrate subject |
US8317737B2 (en) | 2009-02-25 | 2012-11-27 | The Invention Science Fund I, Llc | Device for actively removing a target component from blood or lymph of a vertebrate subject |
GB0904825D0 (en) | 2009-03-20 | 2009-05-06 | Photobiotics Ltd | Biological materials and uses thereof |
CN107252489A (en) | 2009-04-13 | 2017-10-17 | 法国健康和医学研究院 | HPV particles and application thereof |
JP2012524153A (en) | 2009-04-17 | 2012-10-11 | ライコア インコーポレイテッド | Fluorescence imaging using substituted cyanine dyes |
EP2470887B1 (en) | 2009-08-28 | 2020-03-11 | VisEn Medical, Inc. | Systems for tomographic imaging in diffuse media using a hybrid inversion technique |
CN102781307B (en) | 2009-09-22 | 2016-01-20 | 文森医学公司 | For the system and method for the virtual refractive index match of diffusive medium |
GB0917054D0 (en) * | 2009-09-29 | 2009-11-11 | Cytoguide As | Agents, uses and methods |
GB0917044D0 (en) * | 2009-09-29 | 2009-11-18 | Cytoguide As | Agents, uses and methods |
WO2011123742A1 (en) | 2010-04-01 | 2011-10-06 | Baylor College Of Medicine | Non-radioactive agents for neuroblastoma imaging |
US8524239B2 (en) | 2010-07-09 | 2013-09-03 | The United States of America as represented by the Secrectary, Department of Health and Human Services | Photosensitizing antibody-fluorophore conjugates |
US20130287688A1 (en) | 2010-11-18 | 2013-10-31 | Xtuit Pharmaceuticals, Inc. | Novel compositions and uses of anti-hypertension agents for cancer therapy |
WO2012076631A1 (en) | 2010-12-07 | 2012-06-14 | Spectracure Ab | System and method for interstitial photodynamic light therapy in combination with photosensitizers |
US20140076404A1 (en) | 2010-12-15 | 2014-03-20 | Mei-Chee Tan | Ir-activated photoelectric systems |
US9018367B2 (en) | 2011-04-12 | 2015-04-28 | Board Of Regents, The University Of Texas System | Single stranded DNA aptamers binding NF-κB/RelA |
CN107929733A (en) * | 2011-07-11 | 2018-04-20 | 美国政府(由卫生和人类服务部的部长所代表) | Photosensitive antibody fluorescence rolls into a ball conjugate |
EP2771333A4 (en) | 2011-09-23 | 2015-05-20 | Li Cor Inc | Application of reduced dyes in imaging |
RU2642287C2 (en) | 2011-12-01 | 2018-01-24 | Юниверсити Оф Кейп Таун | Hpv chimeric particle |
CN102585003B (en) | 2012-02-06 | 2017-10-31 | 中国科学院福建物质结构研究所 | The preparation method and applications of tumor-targeted photosensitive immunoconjugate |
CA2866933C (en) | 2012-03-21 | 2020-08-18 | Rheinisch-Westfalische Technische Hochschule Aachen | Novel photoimmunoconjugates for use in photodynamic therapy |
US20160250337A9 (en) | 2012-04-17 | 2016-09-01 | Bahman Anvari | Biomedical imaging and therapy using red blood cells |
US9371362B2 (en) | 2012-08-15 | 2016-06-21 | Visen Medical, Inc. | Prostate specific antigen agents and methods of using same for prostate cancer imaging |
JP2016026471A (en) | 2012-11-27 | 2016-02-18 | パナソニックヘルスケア株式会社 | Cell discrimination/separation method and cell discrimination/separation device |
WO2014089247A2 (en) | 2012-12-04 | 2014-06-12 | Sloan-Kettering Institute For Cancer Research | Modular polymer hydrogel nanoparticles and methods of their manufacture |
CN105102484B (en) | 2013-01-30 | 2020-03-10 | 艾维拉斯生物科学公司 | Selective delivery molecules and methods of use |
US9889199B2 (en) | 2013-02-15 | 2018-02-13 | Case Western Reserve University | PSMA ligands and uses thereof |
AR095398A1 (en) * | 2013-03-13 | 2015-10-14 | Genentech Inc | FORMULATIONS WITH REDUCED OXIDATION |
CN105209058A (en) | 2013-03-13 | 2015-12-30 | 豪夫迈·罗氏有限公司 | Formulations with reduced oxidation |
JP2016516774A (en) | 2013-04-08 | 2016-06-09 | ユニバーシティー オブ ノースキャロライナ アット チャペル ヒルUniversity Of North Carolina At Chapel Hill | Photoresponsive compound |
WO2014176284A1 (en) | 2013-04-22 | 2014-10-30 | Avelas Biosciences, Inc. | Selective drug delivery compositions and methods of use |
PT3046583T (en) | 2013-09-18 | 2019-05-30 | Aura Biosciences Inc | Virus-like particle conjugates for treatment of tumors |
US10232058B2 (en) | 2013-10-14 | 2019-03-19 | The Johns Hopkins University | Prostate-specific membrane antigen-targeted photosensitizers for photodynamic therapy |
JP6487430B2 (en) | 2013-10-21 | 2019-03-20 | メルク パテント ゲゼルシャフト ミット ベシュレンクテル ハフツングMerck Patent Gesellschaft mit beschraenkter Haftung | Heteroaryl compounds as BTK inhibitors and their use |
EP3099325A4 (en) | 2014-01-31 | 2017-10-04 | The General Hospital Corporation Dba Massachusetts General Hospital | Methods of treating and imaging tumor micrometastases using photoactivatable immunoconjugates |
JP2017507931A (en) | 2014-02-05 | 2017-03-23 | シーダーズ−サイナイ メディカル センター | Method for treating cancer and infectious diseases and therapeutic composition |
US10011587B2 (en) | 2014-05-15 | 2018-07-03 | The Methodist Hospital System | Multivalent ligands targeting VEGFR |
US9209062B1 (en) | 2014-05-28 | 2015-12-08 | Spintrac Systems, Inc. | Removable spin chamber with vacuum attachment |
AU2015271830B2 (en) | 2014-06-02 | 2020-03-05 | Rakuten Medical, Inc. | Phthalocyanine probes and uses thereof |
SG11201610052TA (en) | 2014-08-08 | 2017-02-27 | Us Health | Photo-controlled removal of targets in vitro and in vivo |
CN108137701A (en) | 2015-08-07 | 2018-06-08 | 美国政府(由卫生和人类服务部的部长所代表) | For treating cancer for the near infrared light immunotherapy (NIR-PIT) for inhibiting cell |
EP3827846A1 (en) | 2015-08-18 | 2021-06-02 | Rakuten Medical, Inc. | Compositions, combinations and related methods for photoimmunotherapy |
CN114699525A (en) * | 2015-08-18 | 2022-07-05 | 乐天医药生技股份有限公司 | Method for producing phthalocyanine dye conjugate and stable conjugate |
US10416366B2 (en) | 2016-10-25 | 2019-09-17 | Rakuten Medical, Inc. | Light diffusing devices for use in photoimmunotherapy |
US10527771B2 (en) | 2016-10-25 | 2020-01-07 | Rakuten Medical, Inc. | Frontal light diffusing device for use in photoimmunotherapy |
EP3585433A4 (en) | 2017-02-23 | 2020-12-30 | Rakuten Medical, Inc. | Therapeutic compositions and related methods for photoimmunotherapy |
BR112020000184B8 (en) | 2017-07-07 | 2022-09-27 | Rakuten Medical Inc | LIGHT DIFFUSION DEVICES FOR USE IN PHOTOIMMUNOTHERAPY |
EP3668518A1 (en) | 2017-08-18 | 2020-06-24 | Li-Cor, Inc. | Sonodynamic therapy |
AU2019276572A1 (en) | 2018-06-01 | 2020-12-24 | Rakuten Medical, Inc. | Phthalocyanine dye conjugate compositions |
CN115943306A (en) | 2019-03-29 | 2023-04-07 | 乐天医药生技股份有限公司 | Methods and related biomarkers for photoimmunotherapy |
US20220313822A1 (en) | 2019-07-30 | 2022-10-06 | Rakuten Medical, Inc. | Near-infrared (nir) photoimmunotherapy (pit) for the treatment of cancers using anti-cd25 antibody-phthalocyanine dye conjugate and anti-pd1 antibody |
CN114585391A (en) | 2019-08-07 | 2022-06-03 | 乐天医药生技股份有限公司 | Cetuximab-IR 700 conjugate compositions |
WO2021046100A1 (en) | 2019-09-03 | 2021-03-11 | Rakuten Medical, Inc. | Methods for treatment using phthalocyanine dye-targeting molecule conjugates |
-
2016
- 2016-08-18 CN CN202210376649.8A patent/CN114699525A/en active Pending
- 2016-08-18 US US15/753,151 patent/US11141483B2/en active Active
- 2016-08-18 CA CA2994871A patent/CA2994871A1/en active Pending
- 2016-08-18 CN CN202011414729.5A patent/CN112494659B/en active Active
- 2016-08-18 JP JP2018528208A patent/JP7055742B6/en active Active
- 2016-08-18 ES ES16757476T patent/ES2889904T3/en active Active
- 2016-08-18 WO PCT/US2016/047636 patent/WO2017031363A2/en active Application Filing
- 2016-08-18 CN CN202210376570.5A patent/CN114681623A/en active Pending
- 2016-08-18 SG SG10202011033QA patent/SG10202011033QA/en unknown
- 2016-08-18 NZ NZ739788A patent/NZ739788A/en unknown
- 2016-08-18 AU AU2016308286A patent/AU2016308286B2/en active Active
- 2016-08-18 DK DK16757476.3T patent/DK3337568T3/en active
- 2016-08-18 EP EP16757476.3A patent/EP3337568B1/en active Active
- 2016-08-18 CN CN201680060819.4A patent/CN108136215B/en active Active
- 2016-08-18 EP EP20172729.4A patent/EP3777978A1/en active Pending
-
2019
- 2019-08-16 JP JP2019149235A patent/JP6689439B2/en active Active
-
2021
- 2021-09-08 US US17/469,799 patent/US20210401986A1/en active Pending
- 2021-09-08 JP JP2021145917A patent/JP7425026B2/en active Active
-
2023
- 2023-10-18 JP JP2023179281A patent/JP2023182791A/en active Pending
Also Published As
Publication number | Publication date |
---|---|
JP2019218374A (en) | 2019-12-26 |
AU2016308286B2 (en) | 2022-04-07 |
WO2017031363A2 (en) | 2017-02-23 |
JP2021193111A (en) | 2021-12-23 |
CN112494659A (en) | 2021-03-16 |
US20190015510A1 (en) | 2019-01-17 |
ES2889904T3 (en) | 2022-01-14 |
CN114699525A (en) | 2022-07-05 |
CN114681623A (en) | 2022-07-01 |
CN112494659B (en) | 2023-08-08 |
JP7425026B2 (en) | 2024-01-30 |
AU2016308286A1 (en) | 2018-03-08 |
JP2018528267A (en) | 2018-09-27 |
WO2017031363A3 (en) | 2017-04-20 |
CA2994871A1 (en) | 2017-02-23 |
JP7055742B2 (en) | 2022-04-18 |
JP2023182791A (en) | 2023-12-26 |
CN108136215A (en) | 2018-06-08 |
US11141483B2 (en) | 2021-10-12 |
EP3337568B1 (en) | 2021-08-04 |
DK3337568T3 (en) | 2021-09-27 |
US20210401986A1 (en) | 2021-12-30 |
JP6689439B2 (en) | 2020-04-28 |
CN108136215B (en) | 2022-04-29 |
JP7055742B6 (en) | 2022-06-07 |
EP3777978A1 (en) | 2021-02-17 |
NZ739788A (en) | 2023-07-28 |
EP3337568A2 (en) | 2018-06-27 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
SG10202011033QA (en) | Phthalocyanine dye conjugates and their storage | |
IL257669B (en) | Psma-targeted nir dyes and their uses | |
IL258248A (en) | Affinity-oligonucleotide conjugates and uses thereof | |
IL265919A (en) | Pyrrolobenzodiazepine conjugates | |
IL248221B (en) | Antibody-drug conjugates with high drug loading | |
GB201416112D0 (en) | Pyrrolobenzodiazepines and conjugates thereof | |
GB201607478D0 (en) | Pyrrolobenzodiazepine Conjugates | |
ZA201805526B (en) | Pyrrolobenzodiazepine conjugates | |
IL261470A (en) | Ca ix-target nir dyes and their uses | |
PL3303778T3 (en) | Improvements in energy storage | |
GB201716426D0 (en) | Energy storage | |
IL258759A (en) | Anti-cd3-folate conjugates and their uses | |
GB201602363D0 (en) | Pyrrolobenzodiazepine conjugates | |
GB201602359D0 (en) | Pyrrolobenzodiazepine Conjugates | |
PT3470471T (en) | Methine dyes | |
EP3160746A4 (en) | Dye microenvironment | |
GB201619490D0 (en) | Pyrrolobenzodiazepine conjugates | |
GB201615038D0 (en) | Improvements in searching technology | |
ZA201804329B (en) | Dye | |
GB201611481D0 (en) | Energy storage | |
GB201607488D0 (en) | Pyrrolobenzodiazepine Conjugates | |
GB201607485D0 (en) | Pyrrolobenzodiazepine Conjugates | |
GB201602360D0 (en) | Pyrrolobenzodiazepine conjugates | |
GB201514474D0 (en) | Improvements in damper assemblies |