SG10201912199XA - Anti-tim-3 antibodies and use thereof - Google Patents
Anti-tim-3 antibodies and use thereofInfo
- Publication number
- SG10201912199XA SG10201912199XA SG10201912199XA SG10201912199XA SG10201912199XA SG 10201912199X A SG10201912199X A SG 10201912199XA SG 10201912199X A SG10201912199X A SG 10201912199XA SG 10201912199X A SG10201912199X A SG 10201912199XA SG 10201912199X A SG10201912199X A SG 10201912199XA
- Authority
- SG
- Singapore
- Prior art keywords
- tim
- antibodies
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
- C07K16/2818—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against CD28 or CD152
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
- A61K2039/507—Comprising a combination of two or more separate antibodies
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/21—Immunoglobulins specific features characterized by taxonomic origin from primates, e.g. man
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/52—Constant or Fc region; Isotype
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
- C07K2317/565—Complementarity determining region [CDR]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/71—Decreased effector function due to an Fc-modification
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/77—Internalization into the cell
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
- C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2016096924 | 2016-08-26 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| SG10201912199XA true SG10201912199XA (en) | 2020-02-27 |
Family
ID=61246369
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SG10201912199XA SG10201912199XA (en) | 2016-08-26 | 2017-08-25 | Anti-tim-3 antibodies and use thereof |
| SG11201901548SA SG11201901548SA (en) | 2016-08-26 | 2017-08-25 | Anti-tim-3 antibodies and use thereof |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SG11201901548SA SG11201901548SA (en) | 2016-08-26 | 2017-08-25 | Anti-tim-3 antibodies and use thereof |
Country Status (15)
| Country | Link |
|---|---|
| US (3) | US11203637B2 (en) |
| EP (2) | EP3504243A4 (en) |
| JP (2) | JP6968872B2 (en) |
| KR (1) | KR102460525B1 (en) |
| CN (3) | CN109790218B (en) |
| AU (1) | AU2017317227A1 (en) |
| BR (1) | BR112019003976A2 (en) |
| CA (1) | CA3034962A1 (en) |
| EA (1) | EA201990594A1 (en) |
| MX (1) | MX2019002242A (en) |
| NZ (1) | NZ751246A (en) |
| SG (2) | SG10201912199XA (en) |
| TW (2) | TWI769174B (en) |
| WO (1) | WO2018036561A1 (en) |
| ZA (1) | ZA201901113B (en) |
Families Citing this family (35)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP6623353B2 (en) * | 2013-09-13 | 2019-12-25 | ベイジーン スウィッツァーランド ゲーエムベーハー | Anti-PD-1 antibodies and their use for therapy and diagnosis |
| JP6526189B2 (en) | 2014-07-03 | 2019-06-05 | ベイジーン リミテッド | Anti-PD-L1 antibodies and their use for therapy and diagnosis |
| CN109475536B (en) | 2016-07-05 | 2022-05-27 | 百济神州有限公司 | Combination of a PD-l antagonist and a RAF inhibitor for the treatment of cancer |
| JP7027401B2 (en) | 2016-07-14 | 2022-03-01 | ブリストル－マイヤーズ スクイブ カンパニー | Antibodies to TIM3 and its use |
| AU2017313085A1 (en) | 2016-08-19 | 2019-03-14 | Beigene Switzerland Gmbh | Use of a combination comprising a Btk inhibitor for treating cancers |
| JP6968872B2 (en) | 2016-08-26 | 2021-11-17 | ベイジーン リミテッド | Anti-Tim-3 antibody |
| MA50677A (en) | 2016-11-01 | 2021-07-14 | Anaptysbio Inc | ANTIBODIES DIRECTED AGAINST T-LYMPHOCYTE IMMUNOGLOBULIN PROTEIN AND MUCIN 3 (TIM-3) |
| MA47206A (en) | 2017-01-09 | 2019-11-13 | Tesaro Inc | CANCER TREATMENT METHODS USING ANTI-TIM-3 ANTIBODIES |
| CA3066518A1 (en) | 2017-06-26 | 2019-01-03 | Beigene, Ltd. | Immunotherapy for hepatocellular carcinoma |
| KR20200037353A (en) | 2017-08-07 | 2020-04-08 | 더 리전트 오브 더 유니버시티 오브 캘리포니아 | Platform for creating safe cell therapy products |
| WO2019108795A1 (en) | 2017-11-29 | 2019-06-06 | Beigene Switzerland Gmbh | Treatment of indolent or aggressive b-cell lymphomas using a combination comprising btk inhibitors |
| WO2019179420A1 (en) * | 2018-03-20 | 2019-09-26 | Wuxi Biologics (Shanghai) Co., Ltd. | Novel anti-tim-3 antibodies |
| TW202003565A (en) | 2018-03-23 | 2020-01-16 | 美商必治妥美雅史谷比公司 | Antibodies against MICA and/or MICB and uses thereof |
| WO2019196911A1 (en) * | 2018-04-12 | 2019-10-17 | Nanjing Leads Biolabs Co., Ltd. | Antibody binding tim-3 and use thereor |
| KR20210046701A (en) * | 2018-08-20 | 2021-04-28 | 지앙수 헨그루이 메디슨 컴퍼니 리미티드 | Use of TIM-3 antibodies in the manufacture of drugs for the treatment of tumors |
| CN112566936A (en) * | 2018-08-21 | 2021-03-26 | 阿尔伯特爱因斯坦医学院 | Monoclonal antibodies to human TIM-3 |
| US20220363760A1 (en) | 2019-05-30 | 2022-11-17 | Bristol-Myers Squibb Company | Multi-tumor gene signature for suitability to immuno-oncology therapy |
| KR20220016157A (en) | 2019-05-30 | 2022-02-08 | 브리스톨-마이어스 스큅 컴퍼니 | Cell localization signatures and combination therapies |
| WO2020243568A1 (en) | 2019-05-30 | 2020-12-03 | Bristol-Myers Squibb Company | Methods of identifying a subject suitable for an immuno-oncology (i-o) therapy |
| JP2022537411A (en) * | 2019-06-21 | 2022-08-25 | シングル セル テクノロジー， インコーポレイテッド | Anti-TIM-3 antibody |
| CN110498855A (en) * | 2019-07-25 | 2019-11-26 | 钟小泉 | A kind of TIM-3 antibody and application thereof |
| BR112022008184A2 (en) * | 2019-11-21 | 2022-07-12 | Beigene Ltd | METHODS OF TREATMENT OF CANCER AND TO INCREASE, POTENTIAL, OR STIMULATE AN IMMUNE RESPONSE OR FUNCTION |
| CN114507284B (en) * | 2020-05-09 | 2023-05-26 | 华博生物医药技术（上海）有限公司 | Antibodies against TIGIT, methods of preparation and uses thereof |
| AU2021334361A1 (en) | 2020-08-31 | 2023-05-11 | Bristol-Myers Squibb Company | Cell localization signature and immunotherapy |
| WO2022120179A1 (en) | 2020-12-03 | 2022-06-09 | Bristol-Myers Squibb Company | Multi-tumor gene signatures and uses thereof |
| JP2024501029A (en) | 2020-12-28 | 2024-01-10 | ブリストル－マイヤーズ スクイブ カンパニー | Subcutaneous administration of PD1/PD-L1 antibodies |
| AU2021411486A1 (en) | 2020-12-28 | 2023-06-29 | Bristol-Myers Squibb Company | Antibody compositions and methods of use thereof |
| CN112679613B (en) * | 2021-03-12 | 2021-10-01 | 广东新征程生命科学有限公司 | Application of bone marrow mesenchymal stem cells in combination with monoclonal antibody in treatment of cancer |
| EP4314068A1 (en) | 2021-04-02 | 2024-02-07 | The Regents Of The University Of California | Antibodies against cleaved cdcp1 and uses thereof |
| WO2022223048A1 (en) * | 2021-04-23 | 2022-10-27 | Suzhou Neologics Bioscience Co. , Ltd. | Tim-3-targetting antibodies and uses thereof |
| WO2023178329A1 (en) | 2022-03-18 | 2023-09-21 | Bristol-Myers Squibb Company | Methods of isolating polypeptides |
| WO2023235847A1 (en) | 2022-06-02 | 2023-12-07 | Bristol-Myers Squibb Company | Antibody compositions and methods of use thereof |
| WO2024041651A1 (en) * | 2022-08-25 | 2024-02-29 | Beigene, Ltd. | Methods of cancer treatment using anti-pd1 antibodies in combination with anti-tim3 antibodies and anti-lag3 antibodies |
| WO2024044675A1 (en) | 2022-08-25 | 2024-02-29 | Beigene, Ltd. | Methods of cancer treatment using anti-pd1 antibodies in combination with anti-tim3 antibodies |
| WO2024041652A1 (en) * | 2022-08-25 | 2024-02-29 | Beigene, Ltd. | Methods of cancer treatment |
Family Cites Families (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4376110A (en) | 1980-08-04 | 1983-03-08 | Hybritech, Incorporated | Immunometric assays using monoclonal antibodies |
| US7563874B2 (en) | 1998-08-31 | 2009-07-21 | The Regents Of The University Of California | Therapeutic monoclonal antibodies that neutralize botulinum neurotoxins |
| WO2003002722A2 (en) * | 2001-06-29 | 2003-01-09 | The Board Of Trustees Of The Leland Stanford Junior University | T cell regulatory genes and methods of use thereof |
| AU2003303082B2 (en) | 2002-01-30 | 2009-07-02 | Dana-Farber Cancer Institute, Inc. | Compositions and methods related to TIM-3, a Th1-specific cell surface molecule |
| WO2009052623A1 (en) * | 2007-10-26 | 2009-04-30 | Governing Council Of The University Of Toronto | Therapeutic and diagnostic methods using tim-3 |
| WO2009155609A1 (en) | 2008-06-20 | 2009-12-23 | Oklahoma Medical Research Foundation | IMMUNOGENIC MEMAPSIN 2 β-SECRETASE PEPTIDES AND METHODS OF USE |
| TR201807750T4 (en) | 2010-06-11 | 2018-06-21 | Kyowa Hakko Kirin Co Ltd | Anti-TIM-3 antibody. |
| WO2013006490A2 (en) | 2011-07-01 | 2013-01-10 | Cellerant Therapeutics, Inc. | Antibodies that specifically bind to tim3 |
| CN102492038B (en) * | 2011-12-09 | 2014-05-28 | 中国人民解放军军事医学科学院基础医学研究所 | Anti-human Tim-3 neutralized monoclonal antibody L3D and application thereof |
| EP3338793A1 (en) * | 2013-08-28 | 2018-06-27 | AbbVie Stemcentrx LLC | Novel sez6 modulators and methods of use |
| JP6623353B2 (en) | 2013-09-13 | 2019-12-25 | ベイジーン スウィッツァーランド ゲーエムベーハー | Anti-PD-1 antibodies and their use for therapy and diagnosis |
| CN103721255A (en) * | 2014-01-07 | 2014-04-16 | 苏州大学 | Application of co-blocking of PD-1 and TIM-3 signal paths to anti-stomach-cancer treatment |
| JOP20200096A1 (en) | 2014-01-31 | 2017-06-16 | Children’S Medical Center Corp | Antibody molecules to tim-3 and uses thereof |
| JP6526189B2 (en) | 2014-07-03 | 2019-06-05 | ベイジーン リミテッド | Anti-PD-L1 antibodies and their use for therapy and diagnosis |
| KR20170075778A (en) | 2014-10-27 | 2017-07-03 | 에이전시 포 사이언스, 테크놀로지 앤드 리서치 | Anti-tim-3 antibodies |
| RS59664B1 (en) * | 2014-11-06 | 2020-01-31 | Hoffmann La Roche | Anti-tim3 antibodies and methods of use |
| JP6968872B2 (en) | 2016-08-26 | 2021-11-17 | ベイジーン リミテッド | Anti-Tim-3 antibody |
-
2017
- 2017-08-25 JP JP2019511565A patent/JP6968872B2/en active Active
- 2017-08-25 SG SG10201912199XA patent/SG10201912199XA/en unknown
- 2017-08-25 CN CN201780052246.5A patent/CN109790218B/en active Active
- 2017-08-25 CA CA3034962A patent/CA3034962A1/en active Pending
- 2017-08-25 US US16/328,047 patent/US11203637B2/en active Active
- 2017-08-25 MX MX2019002242A patent/MX2019002242A/en unknown
- 2017-08-25 SG SG11201901548SA patent/SG11201901548SA/en unknown
- 2017-08-25 AU AU2017317227A patent/AU2017317227A1/en active Pending
- 2017-08-25 KR KR1020197007868A patent/KR102460525B1/en active IP Right Grant
- 2017-08-25 NZ NZ751246A patent/NZ751246A/en unknown
- 2017-08-25 BR BR112019003976A patent/BR112019003976A2/en unknown
- 2017-08-25 EP EP17842983.3A patent/EP3504243A4/en active Pending
- 2017-08-25 EA EA201990594A patent/EA201990594A1/en unknown
- 2017-08-25 TW TW106129066A patent/TWI769174B/en active
- 2017-08-25 EP EP21190971.8A patent/EP3970749A1/en active Pending
- 2017-08-25 TW TW111125696A patent/TW202246347A/en unknown
- 2017-08-25 CN CN202310121525.XA patent/CN116478290A/en active Pending
- 2017-08-25 CN CN202310121523.0A patent/CN116655790A/en active Pending
- 2017-08-25 WO PCT/CN2017/099098 patent/WO2018036561A1/en unknown
-
2019
- 2019-02-21 ZA ZA2019/01113A patent/ZA201901113B/en unknown
-
2021
- 2021-10-27 JP JP2021175867A patent/JP7158552B2/en active Active
- 2021-11-15 US US17/526,817 patent/US20220135675A1/en not_active Abandoned
-
2023
- 2023-09-27 US US18/475,552 patent/US20240076375A1/en active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| CA3034962A1 (en) | 2018-03-01 |
| US20220135675A1 (en) | 2022-05-05 |
| CN109790218B (en) | 2023-03-03 |
| EA201990594A1 (en) | 2019-08-30 |
| MX2019002242A (en) | 2019-08-16 |
| US20190276533A1 (en) | 2019-09-12 |
| SG11201901548SA (en) | 2019-03-28 |
| WO2018036561A1 (en) | 2018-03-01 |
| KR102460525B1 (en) | 2022-11-01 |
| JP6968872B2 (en) | 2021-11-17 |
| AU2017317227A1 (en) | 2019-04-11 |
| CN116478290A (en) | 2023-07-25 |
| NZ751246A (en) | 2023-04-28 |
| US11203637B2 (en) | 2021-12-21 |
| TW202246347A (en) | 2022-12-01 |
| ZA201901113B (en) | 2020-10-28 |
| EP3504243A4 (en) | 2020-03-11 |
| BR112019003976A2 (en) | 2019-05-28 |
| CN116655790A (en) | 2023-08-29 |
| JP2022027659A (en) | 2022-02-10 |
| CN109790218A (en) | 2019-05-21 |
| JP2019529373A (en) | 2019-10-17 |
| US20240076375A1 (en) | 2024-03-07 |
| EP3970749A1 (en) | 2022-03-23 |
| KR20190042037A (en) | 2019-04-23 |
| TWI769174B (en) | 2022-07-01 |
| EP3504243A1 (en) | 2019-07-03 |
| TW201819414A (en) | 2018-06-01 |
| JP7158552B2 (en) | 2022-10-21 |
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