SG10201911240PA - Compositions and methods for inhibiting arginase activity - Google Patents
Compositions and methods for inhibiting arginase activityInfo
- Publication number
- SG10201911240PA SG10201911240PA SG10201911240PA SG10201911240PA SG10201911240PA SG 10201911240P A SG10201911240P A SG 10201911240PA SG 10201911240P A SG10201911240P A SG 10201911240PA SG 10201911240P A SG10201911240P A SG 10201911240PA SG 10201911240P A SG10201911240P A SG 10201911240PA
- Authority
- SG
- Singapore
- Prior art keywords
- compositions
- methods
- arginase activity
- inhibiting arginase
- inhibiting
- Prior art date
Links
- 102000004452 Arginase Human genes 0.000 title 1
- 108700024123 Arginases Proteins 0.000 title 1
- 230000000694 effects Effects 0.000 title 1
- 230000002401 inhibitory effect Effects 0.000 title 1
- 239000000203 mixture Substances 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F5/00—Compounds containing elements of Groups 3 or 13 of the Periodic Table
- C07F5/02—Boron compounds
- C07F5/025—Boronic and borinic acid compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/4245—Oxadiazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/69—Boron compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
- A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
- A61K39/3955—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against proteinaceous materials, e.g. enzymes, hormones, lymphokines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
- A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
- A61K39/39558—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against tumor tissues, cells, antigens
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
- C07K16/2818—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against CD28 or CD152
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
- A61K2039/507—Comprising a combination of two or more separate antibodies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Organic Chemistry (AREA)
- Epidemiology (AREA)
- Immunology (AREA)
- Engineering & Computer Science (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Mycology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Microbiology (AREA)
- Oncology (AREA)
- Hematology (AREA)
- Endocrinology (AREA)
- Biomedical Technology (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Enzymes And Modification Thereof (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201662438092P | 2016-12-22 | 2016-12-22 | |
US201662439614P | 2016-12-28 | 2016-12-28 |
Publications (1)
Publication Number | Publication Date |
---|---|
SG10201911240PA true SG10201911240PA (en) | 2020-02-27 |
Family
ID=60972528
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
SG10201911240PA SG10201911240PA (en) | 2016-12-22 | 2017-12-22 | Compositions and methods for inhibiting arginase activity |
SG10201911243WA SG10201911243WA (en) | 2016-12-22 | 2017-12-22 | Compositions and methods for inhibiting arginase activity |
Family Applications After (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
SG10201911243WA SG10201911243WA (en) | 2016-12-22 | 2017-12-22 | Compositions and methods for inhibiting arginase activity |
Country Status (32)
Country | Link |
---|---|
US (4) | US10287303B2 (en) |
EP (2) | EP3842442B1 (en) |
JP (2) | JP7018949B2 (en) |
KR (1) | KR102579849B1 (en) |
CN (2) | CN114989205A (en) |
AU (2) | AU2017382405B2 (en) |
BR (1) | BR112019012589B1 (en) |
CA (1) | CA3046987A1 (en) |
CL (1) | CL2019001711A1 (en) |
CO (1) | CO2019007839A2 (en) |
CR (1) | CR20190339A (en) |
CY (1) | CY1124483T1 (en) |
DK (2) | DK3559009T3 (en) |
EC (1) | ECSP19045511A (en) |
ES (2) | ES2970715T3 (en) |
HR (1) | HRP20210848T1 (en) |
HU (1) | HUE054272T2 (en) |
IL (2) | IL292677A (en) |
LT (1) | LT3559009T (en) |
MD (1) | MD3559009T2 (en) |
MX (2) | MX2019007471A (en) |
MY (1) | MY197478A (en) |
NZ (1) | NZ754364A (en) |
PE (1) | PE20191541A1 (en) |
PH (1) | PH12019501396A1 (en) |
PL (1) | PL3559009T3 (en) |
PT (1) | PT3559009T (en) |
RS (1) | RS61996B1 (en) |
SG (2) | SG10201911240PA (en) |
SI (1) | SI3559009T1 (en) |
TW (1) | TWI818902B (en) |
WO (1) | WO2018119440A1 (en) |
Families Citing this family (42)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
PL2632927T3 (en) | 2010-10-26 | 2016-09-30 | Boronates as arginase inhibitors | |
TW201718581A (en) | 2015-10-19 | 2017-06-01 | 英塞特公司 | Heterocyclic compounds as immunomodulators |
LT3377488T (en) | 2015-11-19 | 2023-01-10 | Incyte Corporation | Heterocyclic compounds as immunomodulators |
SI3394033T1 (en) | 2015-12-22 | 2021-03-31 | Incyte Corporation | Heterocyclic compounds as immunomodulators |
MA44860A (en) | 2016-05-06 | 2019-03-13 | Incyte Holdings Corp | HETEROCYCLIC COMPOUNDS USED AS IMMUNOMODULATORS |
WO2017205464A1 (en) | 2016-05-26 | 2017-11-30 | Incyte Corporation | Heterocyclic compounds as immunomodulators |
EP4137489A1 (en) | 2016-06-20 | 2023-02-22 | Incyte Corporation | Heterocyclic compounds as immunomodulators |
WO2018013789A1 (en) | 2016-07-14 | 2018-01-18 | Incyte Corporation | Heterocyclic compounds as immunomodulators |
EP3504198B1 (en) | 2016-08-29 | 2023-01-25 | Incyte Corporation | Heterocyclic compounds as immunomodulators |
US20180179179A1 (en) | 2016-12-22 | 2018-06-28 | Incyte Corporation | Heterocyclic compounds as immunomodulators |
ES2874756T3 (en) | 2016-12-22 | 2021-11-05 | Incyte Corp | Triazolo [1,5-A] pyridine derivatives as immunomodulators |
TWI798192B (en) * | 2016-12-22 | 2023-04-11 | 美商英塞特公司 | Immunomodulator compounds and methods of use |
MX2019007416A (en) | 2016-12-22 | 2019-12-11 | Incyte Corp | Benzooxazole derivatives as immunomodulators. |
PT3559009T (en) * | 2016-12-22 | 2021-05-04 | Calithera Biosciences Inc | Compositions and methods for inhibiting arginase activity |
CN108322295B (en) | 2017-01-17 | 2021-12-24 | 维沃移动通信有限公司 | Sending method, receiving method, sending end and receiving end of sideband information |
WO2019159120A1 (en) | 2018-02-17 | 2019-08-22 | Astrazeneca Ab | Arginase inhibitors and methods of use thereof |
CA3094939A1 (en) | 2018-03-29 | 2019-10-03 | Oncoarendi Therapeutics S.A. | Dipeptide piperidine derivatives |
HRP20230306T1 (en) | 2018-05-11 | 2023-05-12 | Incyte Corporation | Tetrahydro-imidazo[4,5-c]pyridine derivatives as pd-l1 immunomodulators |
PT3840837T (en) * | 2018-08-22 | 2024-06-14 | Astrazeneca Ab | Arginase inhibitors and methods of use thereof |
US20220056051A1 (en) * | 2018-12-18 | 2022-02-24 | Merck Sharp & Dohme Corp. | Arginase inhibitors and methods of use |
MA56324B1 (en) * | 2019-02-08 | 2023-10-31 | Astrazeneca Ab 151 85 Soedertaelje | ARGINASE INHIBITORS AND METHODS OF USE |
CA3150434A1 (en) | 2019-08-09 | 2021-02-18 | Incyte Corporation | Salts of a pd-1/pd-l1 inhibitor |
CN110759843A (en) * | 2019-09-30 | 2020-02-07 | 东北师范大学 | Preparation and application of fluorine azide substituted quaternary heterocyclic compound |
CN110734456A (en) * | 2019-11-06 | 2020-01-31 | 南京谷睿生物科技有限公司 | compounds, preparation method and medical application thereof |
KR20220101664A (en) | 2019-11-11 | 2022-07-19 | 인사이트 코포레이션 | Salts and crystalline forms of PD-1/PD-L1 inhibitors |
US11753413B2 (en) | 2020-06-19 | 2023-09-12 | Incyte Corporation | Substituted pyrrolo[2,1-f][1,2,4]triazine compounds as JAK2 V617F inhibitors |
US11691971B2 (en) | 2020-06-19 | 2023-07-04 | Incyte Corporation | Naphthyridinone compounds as JAK2 V617F inhibitors |
JP2023533724A (en) | 2020-07-02 | 2023-08-04 | インサイト・コーポレイション | Tricyclic urea compounds as JAK2 V617F inhibitors |
US11767323B2 (en) | 2020-07-02 | 2023-09-26 | Incyte Corporation | Tricyclic pyridone compounds as JAK2 V617F inhibitors |
TW202216662A (en) | 2020-07-17 | 2022-05-01 | 美商英塞特公司 | Processes for the preparation of arginase inhibitors and their synthetic intermediates |
WO2022046989A1 (en) | 2020-08-27 | 2022-03-03 | Incyte Corporation | Tricyclic urea compounds as jak2 v617f inhibitors |
US11760756B2 (en) | 2020-11-06 | 2023-09-19 | Incyte Corporation | Crystalline form of a PD-1/PD-L1 inhibitor |
US11866434B2 (en) | 2020-11-06 | 2024-01-09 | Incyte Corporation | Process for making a PD-1/PD-L1 inhibitor and salts and crystalline forms thereof |
WO2022099018A1 (en) | 2020-11-06 | 2022-05-12 | Incyte Corporation | Process of preparing a pd-1/pd-l1 inhibitor |
CN112387262B (en) * | 2020-11-10 | 2021-12-07 | 泰州学院 | Preparation method of chiral stationary phase based on photocatalytic cross-linked protein, chiral stationary phase and application |
WO2022140231A1 (en) | 2020-12-21 | 2022-06-30 | Incyte Corporation | Deazaguaine compounds as jak2 v617f inhibitors |
TW202228720A (en) | 2020-12-22 | 2022-08-01 | 波蘭商昂科艾倫迪治療法股份公司 | Arginase inhibitors and methods of use thereof |
US11958861B2 (en) | 2021-02-25 | 2024-04-16 | Incyte Corporation | Spirocyclic lactams as JAK2 V617F inhibitors |
WO2023133505A2 (en) * | 2022-01-07 | 2023-07-13 | The Trustees Of Columbia University In The City Of New York | Inhibition of kynurenine synthesis and/or signaling to treat leukemia and myelodysplasia |
WO2023178285A1 (en) | 2022-03-17 | 2023-09-21 | Incyte Corporation | Tricyclic urea compounds as jak2 v617f inhibitors |
US20240190876A1 (en) | 2022-10-21 | 2024-06-13 | Incyte Corporation | Tricyclic Urea Compounds As JAK2 V617F Inhibitors |
US20240317744A1 (en) | 2023-03-13 | 2024-09-26 | Incyte Corporation | Bicyclic Ureas As Kinase Inhibitors |
Family Cites Families (101)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4172896A (en) | 1978-06-05 | 1979-10-30 | Dainippon Pharmaceutical Co., Ltd. | Methane-sulfonamide derivatives, the preparation thereof and composition comprising the same |
US4938949A (en) | 1988-09-12 | 1990-07-03 | University Of New York | Treatment of damaged bone marrow and dosage units therefor |
GB9217295D0 (en) | 1992-08-14 | 1992-09-30 | Wellcome Found | Controlled released tablets |
US5541231A (en) | 1993-07-30 | 1996-07-30 | Glaxo Wellcome Inc. | Stabilized Pharmaceutical |
GB9315856D0 (en) | 1993-07-30 | 1993-09-15 | Wellcome Found | Stabilized pharmaceutical |
US5358970A (en) | 1993-08-12 | 1994-10-25 | Burroughs Wellcome Co. | Pharmaceutical composition containing bupropion hydrochloride and a stabilizer |
ES2302881T3 (en) | 1997-07-29 | 2008-08-01 | Alcon Laboratories, Inc. | OPHTHALMIC COMPOSITIONS CONTAINING GALACTOMANANA AND BORATE POLYMERS. |
CA2305703A1 (en) | 1997-10-10 | 1999-04-22 | David W. Christianson | Compositions and methods for inhibiting arginase activity |
US6110973A (en) | 1998-01-29 | 2000-08-29 | Sepracor | Methods for treating obesity and weight gain using optically pure (-)-bupropion |
US20040063666A1 (en) | 1998-10-09 | 2004-04-01 | David Christianson | Compositions for inhibiting arginase activity |
US8889112B2 (en) | 1999-09-16 | 2014-11-18 | Ocularis Pharma, Llc | Ophthalmic formulations including selective alpha 1 antagonists |
EP2287191B1 (en) | 2000-05-10 | 2016-10-12 | Mayo Foundation For Medical Education And Research | Human igm antibodies with the capability of inducing remyelination, and diagnostic and therapeutic uses thereof particularly in the central nervous system |
AU2001275870A1 (en) | 2000-07-06 | 2002-01-21 | Fal Diagnostics | Methods and kits for the detection of arginine compounds |
CA2431080A1 (en) | 2003-06-02 | 2004-12-02 | Catherine Adele O'brien | Enhancement of anticancer immunity through inhibition of arginase |
US6933289B2 (en) | 2003-07-01 | 2005-08-23 | Allergan, Inc. | Inhibition of irritating side effects associated with use of a topical ophthalmic medication |
DK1654002T4 (en) | 2003-08-07 | 2014-02-17 | Allergan Inc | Compositions for applying therapeutic agents to the eyes |
US20050059744A1 (en) | 2003-09-12 | 2005-03-17 | Allergan, Inc. | Methods and compositions for the treatment of pain and other alpha 2 adrenergic-mediated conditions |
EP1915143A4 (en) | 2005-07-01 | 2009-11-11 | Univ Johns Hopkins | Arginase ii: a target treatment of aging heart and heart failure |
US20070203140A1 (en) | 2006-02-09 | 2007-08-30 | Combs Andrew P | N-hydroxyguanidines as modulators of indoleamine 2,3-dioxygenase |
JP5319532B2 (en) | 2006-09-19 | 2013-10-16 | インサイト・コーポレイション | N-hydroxyamidino heterocycle as a modulator of indoleamine 2,3-dioxygenase |
CL2007002650A1 (en) | 2006-09-19 | 2008-02-08 | Incyte Corp | COMPOUNDS DERIVED FROM HETEROCICLO N-HIDROXIAMINO; PHARMACEUTICAL COMPOSITION, USEFUL TO TREAT CANCER, VIRAL INFECTIONS AND NEURODEGENERATIVE DISORDERS BETWEEN OTHERS. |
US20080146624A1 (en) | 2006-09-19 | 2008-06-19 | Incyte Corporation | Amidines as modulators of indoleamine 2,3-dioxygenase |
US20080119491A1 (en) | 2006-09-19 | 2008-05-22 | Incyte Corporation | Amidinoheterocycles as modulators of indoleamine 2,3-dioxygenase |
WO2008058178A1 (en) | 2006-11-08 | 2008-05-15 | Incyte Corporation | N-hydroxyamidinoheterocycles as modulators of indoleamine 2,3-dioxygenase |
EP2083812B1 (en) | 2006-11-21 | 2017-04-05 | Rijksuniversiteit Groningen | Use of arginase inhibitors in the treatment of asthma and allergic rhinitis |
EA026126B1 (en) | 2006-11-22 | 2017-03-31 | Инсайт Холдингс Корпорейшн | Imidazotriazines and imidazopyrimidines as kinase inhibitors |
EP2172655B1 (en) | 2007-07-12 | 2018-10-24 | Sanyo Denki Co., Ltd. | Dual reversal-rotating type axial blower |
CN101888839B (en) | 2007-10-12 | 2013-03-20 | 雷索维克斯药品公司 | Omega-3 fatty acids, hydroxy polyunsaturated fatty acids, lipoxin compounds, or oxylipin compounds for the treatment of ophthalmic conditions |
JP5583592B2 (en) | 2007-11-30 | 2014-09-03 | ニューリンク ジェネティクス コーポレイション | IDO inhibitor |
WO2009132238A2 (en) | 2008-04-24 | 2009-10-29 | Newlink Genetics | Ido inhibitors |
JP2011519868A (en) | 2008-05-05 | 2011-07-14 | シェーリング コーポレイション | Continuous administration of chemotherapeutic agents to treat cancer |
LT2824100T (en) | 2008-07-08 | 2018-05-10 | Incyte Holdings Corporation | 1,2,5-Oxadiazoles as inhibitors of indoleamine 2,3-dioxygenase |
JP2012515799A (en) | 2009-01-26 | 2012-07-12 | ザ トラスティーズ オブ ザ ユニバーシティ オブ ペンシルバニア | Arginase inhibitors and methods of use |
AU2010339508B2 (en) | 2009-12-31 | 2016-02-04 | Innocrin Pharmaceuticals, Inc. | Metalloenzyme inhibitor compounds |
EP2547366A4 (en) | 2010-03-18 | 2013-08-07 | Univ Colorado State Res Found | Myeloid derived suppressor cell inhibiting agents |
CN103068830B (en) | 2010-04-22 | 2016-06-29 | 马尔斯公司 | Arginase inhibitor and treatment use thereof |
PT2563771E (en) | 2010-04-24 | 2016-03-31 | Viamet Pharmaceuticals Inc | Metalloenzyme inhibitor compounds |
DK2603514T3 (en) | 2010-08-10 | 2018-10-29 | Rempex Pharmaceuticals Inc | Cyclic boronic ester derivatives and their therapeutic uses |
CA2809331C (en) | 2010-08-27 | 2018-09-25 | Merck Patent Gmbh | Triazolopyrazine derivatives |
PL2632927T3 (en) | 2010-10-26 | 2016-09-30 | Boronates as arginase inhibitors | |
US9056855B2 (en) | 2010-10-28 | 2015-06-16 | Viamet Pharmaceuticals, Inc. | Metalloenzyme inhibitor compounds |
EP2638021B1 (en) | 2010-11-13 | 2018-09-26 | Innocrin Pharmaceuticals, Inc. | 1-(6,7-Bis(difluoromethoxy)naphthalen-2-yl)-2-methyl-1-(1H-1,2,3-triazol-4-yl)propan-1-ol as inhibitor of CYP17 for the treatment of androgen dependent diseases like prostate cancer |
EA201390876A1 (en) | 2010-12-13 | 2013-12-30 | Вайамет Фармасьютикалс, Инк. | METALLIC ENZYME INHIBITING COMPOUNDS |
RU2019121905A (en) * | 2010-12-31 | 2019-09-03 | Астразенека Юкей Лимитед | ARGINASE INHIBITORS AND WAYS OF THEIR APPLICATION |
NO2694640T3 (en) | 2011-04-15 | 2018-03-17 | ||
BR122020013521B1 (en) | 2011-06-19 | 2021-05-25 | Viamet Pharmaceuticals (NC), Inc | metalloenzyme inhibitor compounds |
BR102012015199A2 (en) | 2011-06-19 | 2014-05-13 | Viamet Pharmaceuticals Inc | METALOZYME INHIBITORS |
CN103857675A (en) | 2011-06-23 | 2014-06-11 | 威尔金制药有限公司 | Metalloenzyme inhibitor compounds |
AU2012300275A1 (en) | 2011-08-30 | 2014-03-06 | Innocrin Pharmaceuticals, Inc. | Metalloenzyme inhibitor compounds |
US9266908B2 (en) | 2011-10-19 | 2016-02-23 | Mars, Incorporated | Inhibitors of arginase and their therapeutic applications |
AU2012325909B2 (en) * | 2011-10-20 | 2016-06-09 | Glaxosmithkline Llc | Substituted bicyclic aza-heterocycles and analogues as sirtuin modulators |
US9309273B2 (en) | 2011-12-11 | 2016-04-12 | Viamet Pharmaceuticals, Inc. | Metalloenzyme inhibitor compounds |
PL2804858T3 (en) | 2012-01-20 | 2020-06-29 | Mycovia Pharmaceuticals, Inc. | Metalloenzyme inhibitor compounds |
CN104066734B (en) | 2012-01-28 | 2017-03-29 | 默克专利股份公司 | Triazol [4,5 d] pyrimidine derivatives |
CN104254531B (en) | 2012-02-21 | 2017-05-03 | 默克专利股份公司 | Cyclic diaminopyrimidine derivatives |
CA2863723C (en) | 2012-02-21 | 2020-09-22 | Carl Deutsch | 8-substituted 2-amino-[1,2,4]triazolo[1,5-a]pyrazines as syk tryrosine kinase inhibitors and gcn2 serin kinase inhibitors |
WO2013131609A1 (en) | 2012-03-07 | 2013-09-12 | Merck Patent Gmbh | Triazolopyrazine derivatives |
CN104540836B (en) | 2012-04-18 | 2016-11-09 | 马尔斯公司 | Ring as arginase inhibitor retrains analog |
ES2618004T3 (en) | 2012-08-07 | 2017-06-20 | Merck Patent Gmbh | Pyridopyrimidine derivatives as protein kinase inhibitors |
WO2014043376A1 (en) | 2012-09-12 | 2014-03-20 | Dow Agrosciences Llc | Metalloenzyme inhibitor compounds |
PE20151604A1 (en) | 2012-11-02 | 2015-11-04 | Pharmacyclics Llc | ADJUVANT THERAPY WITH KINASE INHIBITORS FROM THE TEC FAMILY |
EP2948450A4 (en) | 2013-01-28 | 2016-11-09 | Viamet Pharmaceuticals Inc | Metalloenzyme inhibitor compounds |
EP2964648B1 (en) | 2013-03-05 | 2016-11-16 | Merck Patent GmbH | 9-(aryl or heteroaryl)-2-(pyrazolyl, pyrrolidinyl or cyclopentyl)aminopurine derivatives as anticancer agents |
AU2014224975B2 (en) | 2013-03-05 | 2017-09-14 | Merck Patent Gmbh | Triazolo(4,5-d)pyrimidine derivatives for the treatment of diseases such as cancer |
EP3366678A1 (en) | 2013-03-14 | 2018-08-29 | Newlink Genetics Corporation | Tricyclic compounds as inhibitors of immunosuppression mediated by tryptophan metabolization |
WO2014141110A2 (en) | 2013-03-14 | 2014-09-18 | Curadev Pharma Pvt. Ltd. | Aminonitriles as kynurenine pathway inhibitors |
EP2970173B1 (en) | 2013-03-14 | 2018-05-09 | Curadev Pharma Private Ltd. | Inhibitors of the kynurenine pathway |
CN105324362B (en) | 2013-03-15 | 2017-05-24 | 百时美施贵宝公司 | Ido inhibitors |
TR201810399T4 (en) | 2013-03-15 | 2018-08-27 | Gilead Sciences Llc | Indolamine 2,3-dioxygenase (ido) inhibitors. |
WO2014180524A1 (en) | 2013-05-06 | 2014-11-13 | Merck Patent Gmbh | Macrocycles as kinase inhibitors |
US9447073B2 (en) | 2013-05-28 | 2016-09-20 | Viamet Pharmaceuticals, Inc. | Fungicidal compositions |
EP3016932B1 (en) | 2013-07-01 | 2019-02-27 | Bristol-Myers Squibb Company | Ido inhibitors |
ES2707961T3 (en) | 2013-07-11 | 2019-04-08 | Bristol Myers Squibb Co | IDO inhibitors |
WO2015017402A1 (en) | 2013-07-29 | 2015-02-05 | Board Of Regents Of The University Of Nebraska | Compositions and methods for the treatment of biofilm infections |
EP3039020B1 (en) | 2013-08-27 | 2017-07-19 | Bristol-Myers Squibb Company | Ido inhibitors |
AU2014339816B2 (en) | 2013-10-25 | 2020-05-28 | Pharmacyclics Llc | Treatment using Bruton's tyrosine kinase inhibitors and immunotherapy |
AR098343A1 (en) | 2013-11-08 | 2016-05-26 | Incyte Holdings Corp | PROCESS FOR THE SYNTHESIS OF AN INDOLAMINE 2,3-DIOXYGENASE INHIBITOR |
MX2016010080A (en) | 2014-02-04 | 2016-10-07 | Incyte Corp | Combination of a pd-1 antagonist and an ido1 inhibitor for treating cancer. |
JP2017513848A (en) | 2014-04-15 | 2017-06-01 | ダウ アグロサイエンシィズ エルエルシー | Metalloenzyme inhibitor compounds as fungicides |
KR20160145640A (en) | 2014-04-15 | 2016-12-20 | 다우 아그로사이언시즈 엘엘씨 | Metalloenzyme inhibitor compounds as fungicides |
CN106535884A (en) | 2014-06-06 | 2017-03-22 | 弗雷克萨斯生物科学公司 | Immunoregulatory agents |
TW201619133A (en) | 2014-08-21 | 2016-06-01 | 裘拉德製藥私人有限公司 | Novel IMINONITRILE derivatives |
WO2016037026A1 (en) | 2014-09-05 | 2016-03-10 | Merck Patent Gmbh | Cyclohexyl-ethyl substituted diaza- and triaza-tricyclic compounds as indole-amine-2,3-dioxygenase (ido) antagonists for the treatment of cancer |
CN105879030A (en) | 2014-09-30 | 2016-08-24 | 复旦大学 | Synergistic drug compound for treating tumor and preparation method thereof |
GB201417369D0 (en) | 2014-10-01 | 2014-11-12 | Redx Pharma Ltd | Compounds |
WO2016057986A1 (en) | 2014-10-10 | 2016-04-14 | The Trustees Of Columbia University In The City Of New York | Tandem epitope constructs for presentation of cd4 and cd8 epitopes and uses thereof |
GB201418300D0 (en) | 2014-10-15 | 2014-11-26 | Redx Pharma Ltd | Compounds |
UY36390A (en) | 2014-11-05 | 2016-06-01 | Flexus Biosciences Inc | MODULATING COMPOUNDS OF INDOLAMINE ENZYME 2,3-DIOXYGENASE (IDO), ITS SYNTHESIS METHODS AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM |
UY36391A (en) | 2014-11-05 | 2016-06-01 | Flexus Biosciences Inc | MODULATING COMPOUNDS OF INDOLAMINE ENZYME 2,3-DIOXYGENASE (IDO1), ITS SYNTHESIS METHODS AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM |
EP3215141A4 (en) | 2014-11-05 | 2018-06-06 | Flexus Biosciences, Inc. | Immunoregulatory agents |
US9586949B2 (en) | 2015-02-09 | 2017-03-07 | Incyte Corporation | Aza-heteroaryl compounds as PI3K-gamma inhibitors |
KR20170129896A (en) | 2015-03-20 | 2017-11-27 | 새미 오유 오피요 | Use of suramin and arginase inhibitors for malignant neoplasms |
EA201792205A1 (en) | 2015-04-03 | 2018-02-28 | Инсайт Корпорейшн | HETEROCYCLIC COMPOUNDS AS LSD1 INHIBITORS |
MX2017012738A (en) | 2015-04-03 | 2017-11-15 | Bristol Myers Squibb Co | Inhibitors of indoleamine 2,3-dioxygenase for the treatment of cancer. |
WO2016181349A1 (en) | 2015-05-14 | 2016-11-17 | Pfizer Inc. | Combinations comprising a pyrrolidine-2,5-dione ido1 inhibitor and an anti-body |
WO2016196890A1 (en) | 2015-06-04 | 2016-12-08 | Vtv Therapeutics Llc | Inhibitors of hexokinase and methods of use thereof |
WO2016210106A1 (en) | 2015-06-23 | 2016-12-29 | Calithera Biosciences, Inc. | Compositions and methods for inhibiting arginase activity |
SI3368541T1 (en) | 2015-10-30 | 2020-10-30 | Calithera Biosciences, Inc. | Compositions and methods for inhibiting arginase activity |
PL417066A1 (en) | 2016-05-04 | 2017-11-06 | Oncoarendi Therapeutics Spółka Z Ograniczoną Odpowiedzialnością | Arginase inhibitors and their therapeutical applications |
PT3559009T (en) | 2016-12-22 | 2021-05-04 | Calithera Biosciences Inc | Compositions and methods for inhibiting arginase activity |
EA201992695A1 (en) | 2017-05-12 | 2020-05-15 | Калитера Байосайнсиз, Инк. | METHOD FOR PRODUCING (3R, 4S) -3-ACETAMIDO-4-ALLYL-N- (TRET-BUTYL) PYRROLIDIN-3-CARBOXAMIDE |
-
2017
- 2017-12-22 PT PT178295747T patent/PT3559009T/en unknown
- 2017-12-22 SI SI201730835T patent/SI3559009T1/en unknown
- 2017-12-22 ES ES21158664T patent/ES2970715T3/en active Active
- 2017-12-22 SG SG10201911240PA patent/SG10201911240PA/en unknown
- 2017-12-22 RS RS20210763A patent/RS61996B1/en unknown
- 2017-12-22 SG SG10201911243WA patent/SG10201911243WA/en unknown
- 2017-12-22 DK DK17829574.7T patent/DK3559009T3/en active
- 2017-12-22 MY MYPI2019003368A patent/MY197478A/en unknown
- 2017-12-22 EP EP21158664.9A patent/EP3842442B1/en active Active
- 2017-12-22 US US15/853,310 patent/US10287303B2/en active Active
- 2017-12-22 MD MDE20191232T patent/MD3559009T2/en unknown
- 2017-12-22 LT LTEP17829574.7T patent/LT3559009T/en unknown
- 2017-12-22 PL PL17829574T patent/PL3559009T3/en unknown
- 2017-12-22 WO PCT/US2017/068307 patent/WO2018119440A1/en active Application Filing
- 2017-12-22 CN CN202210836886.8A patent/CN114989205A/en active Pending
- 2017-12-22 BR BR112019012589-2A patent/BR112019012589B1/en not_active IP Right Cessation
- 2017-12-22 EP EP17829574.7A patent/EP3559009B1/en active Active
- 2017-12-22 ES ES17829574T patent/ES2881395T3/en active Active
- 2017-12-22 CA CA3046987A patent/CA3046987A1/en active Pending
- 2017-12-22 IL IL292677A patent/IL292677A/en unknown
- 2017-12-22 JP JP2019534159A patent/JP7018949B2/en active Active
- 2017-12-22 KR KR1020197021468A patent/KR102579849B1/en active IP Right Grant
- 2017-12-22 HU HUE17829574A patent/HUE054272T2/en unknown
- 2017-12-22 DK DK21158664.9T patent/DK3842442T3/en active
- 2017-12-22 TW TW106145440A patent/TWI818902B/en active
- 2017-12-22 AU AU2017382405A patent/AU2017382405B2/en active Active
- 2017-12-22 PE PE2019001311A patent/PE20191541A1/en unknown
- 2017-12-22 NZ NZ754364A patent/NZ754364A/en unknown
- 2017-12-22 CN CN201780080358.1A patent/CN110382508B/en active Active
- 2017-12-22 MX MX2019007471A patent/MX2019007471A/en unknown
- 2017-12-22 CR CR20190339A patent/CR20190339A/en unknown
-
2019
- 2019-03-29 US US16/370,857 patent/US10597411B2/en not_active Expired - Fee Related
- 2019-06-18 PH PH12019501396A patent/PH12019501396A1/en unknown
- 2019-06-19 CL CL2019001711A patent/CL2019001711A1/en unknown
- 2019-06-20 IL IL267532A patent/IL267532B/en unknown
- 2019-06-20 MX MX2020013649A patent/MX2020013649A/en unknown
- 2019-06-26 EC ECSENADI201945511A patent/ECSP19045511A/en unknown
- 2019-07-22 CO CONC2019/0007839A patent/CO2019007839A2/en unknown
-
2020
- 2020-02-14 US US16/792,186 patent/US11021495B2/en active Active
-
2021
- 2021-01-20 US US17/153,804 patent/US12054501B2/en active Active
- 2021-05-27 HR HRP20210848TT patent/HRP20210848T1/en unknown
- 2021-07-05 CY CY20211100602T patent/CY1124483T1/en unknown
-
2022
- 2022-02-01 JP JP2022014021A patent/JP2022066199A/en not_active Abandoned
- 2022-02-17 AU AU2022201072A patent/AU2022201072A1/en not_active Abandoned
Also Published As
Similar Documents
Publication | Publication Date | Title |
---|---|---|
IL267532B (en) | Compositions and methods for inhibiting arginase activity | |
IL288225A (en) | Compositions and methods for inhibiting arginase activity | |
ZA201800328B (en) | Compositions and methods for inhibiting arginase activity | |
HK1257295A1 (en) | Compositions and methods for immunooncology | |
HK1251610A1 (en) | Compositions and methods for inhibiting factor d | |
HK1252911A1 (en) | Compositions and methods for inhibiting the biological activity of soluble biomolecules | |
HK1245158A1 (en) | Apilimod compositions and methods for using same | |
HK1254550A1 (en) | Compositions and methods for inhibiting beta-lactamase | |
IL252191A0 (en) | Compositions and methods for modulating at2r activity | |
GB201521083D0 (en) | Compositions for treatment and methods thereof |