SG10201805571PA - Hyaluronic acid compositions including mepivacaine - Google Patents

Hyaluronic acid compositions including mepivacaine

Info

Publication number
SG10201805571PA
SG10201805571PA SG10201805571PA SG10201805571PA SG10201805571PA SG 10201805571P A SG10201805571P A SG 10201805571PA SG 10201805571P A SG10201805571P A SG 10201805571PA SG 10201805571P A SG10201805571P A SG 10201805571PA SG 10201805571P A SG10201805571P A SG 10201805571PA
Authority
SG
Singapore
Prior art keywords
hyaluronic acid
mepivacaine
mepi
compositions including
acid compositions
Prior art date
Application number
SG10201805571PA
Inventor
Betemps Jérémie Bon
Guy Vitally
Original Assignee
Lab Vivacy
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Lab Vivacy filed Critical Lab Vivacy
Publication of SG10201805571PA publication Critical patent/SG10201805571PA/en

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61LMETHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/50Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
    • A61L27/54Biologically active materials, e.g. therapeutic substances
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445Non condensed piperidines, e.g. piperocaine
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445Non condensed piperidines, e.g. piperocaine
    • A61K31/4458Non condensed piperidines, e.g. piperocaine only substituted in position 2, e.g. methylphenidate
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/70Carbohydrates; Sugars; Derivatives thereof
    • A61K31/715Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
    • A61K31/726Glycosaminoglycans, i.e. mucopolysaccharides
    • A61K31/728Hyaluronic acid
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/10Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/36Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00Cosmetics or similar toiletry preparations
    • A61K8/02Cosmetics or similar toiletry preparations characterised by special physical form
    • A61K8/04Dispersions; Emulsions
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00Cosmetics or similar toiletry preparations
    • A61K8/18Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/49Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00Cosmetics or similar toiletry preparations
    • A61K8/18Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/49Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds
    • A61K8/4906Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with one nitrogen as the only hetero atom
    • A61K8/4926Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with one nitrogen as the only hetero atom having six membered rings
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00Cosmetics or similar toiletry preparations
    • A61K8/18Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/72Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
    • A61K8/73Polysaccharides
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00Cosmetics or similar toiletry preparations
    • A61K8/18Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/72Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
    • A61K8/73Polysaccharides
    • A61K8/735Mucopolysaccharides, e.g. hyaluronic acid; Derivatives thereof
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/0012Galenical forms characterised by the site of application
    • A61K9/0019Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/10Dispersions; Emulsions
    • A61K9/107Emulsions ; Emulsion preconcentrates; Micelles
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61LMETHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/14Macromolecular materials
    • A61L27/20Polysaccharides
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61LMETHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/50Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
    • A61L27/52Hydrogels or hydrocolloids
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00Drugs for dermatological disorders
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00Drugs for skeletal disorders
    • A61P19/02Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P23/00Anaesthetics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61QSPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00Preparations for care of the skin
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61QSPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00Preparations for care of the skin
    • A61Q19/08Anti-ageing preparations
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2300/00Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2800/00Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
    • A61K2800/80Process related aspects concerning the preparation of the cosmetic composition or the storage or application thereof
    • A61K2800/91Injection
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61LMETHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2300/00Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
    • A61L2300/40Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
    • A61L2300/402Anaestetics, analgesics, e.g. lidocaine
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61LMETHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2400/00Materials characterised by their function or physical properties
    • A61L2400/06Flowable or injectable implant compositions

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical & Material Sciences (AREA)
  • Epidemiology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Dermatology (AREA)
  • Birds (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Dispersion Chemistry (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Molecular Biology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Oral & Maxillofacial Surgery (AREA)
  • Transplantation (AREA)
  • Inorganic Chemistry (AREA)
  • Gerontology & Geriatric Medicine (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Rheumatology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Immunology (AREA)
  • Biomedical Technology (AREA)
  • Anesthesiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

BY ALURONIC ACID COMPOSITIONS INCLUDING MEPIV ACAINE The invention relates to a sterilised aqueous composition including at least one hyaluronic acid and at least mepivacaine, and optionally one or more additional compounds, the weight ratio between the concentration of hyaluronic acid [HA] and the concentration of mepivacaine [MEPI] - [HA]/[MEPI] - being no lower than 0.1; [HA]/[MEPI] ~ 0.1. The invention also relates to the use of mepivacaine as a substitute for lidocaine in an equivalent amount in order to obtain a hyaluronic acid composition including a local anaesthetic with rheological properties after heat sterilisation that are superior to the rheological properties of the same composition of hyaluronic acid including lidocaine. Figure for publication: None
SG10201805571PA 2013-12-23 2014-12-23 Hyaluronic acid compositions including mepivacaine SG10201805571PA (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR1363505A FR3015290B1 (en) 2013-12-23 2013-12-23 HYALURONIC ACID COMPOSITIONS COMPRISING MEPIVACAINE

Publications (1)

Publication Number Publication Date
SG10201805571PA true SG10201805571PA (en) 2018-08-30

Family

ID=50624705

Family Applications (2)

Application Number Title Priority Date Filing Date
SG10201805571PA SG10201805571PA (en) 2013-12-23 2014-12-23 Hyaluronic acid compositions including mepivacaine
SG11201604862XA SG11201604862XA (en) 2013-12-23 2014-12-23 Hyaluronic acid compositions including mepivacaine

Family Applications After (1)

Application Number Title Priority Date Filing Date
SG11201604862XA SG11201604862XA (en) 2013-12-23 2014-12-23 Hyaluronic acid compositions including mepivacaine

Country Status (17)

Country Link
US (2) US20160346433A1 (en)
EP (3) EP3049091B1 (en)
JP (1) JP6446462B2 (en)
KR (1) KR102343660B1 (en)
CN (2) CN110623954A (en)
AU (1) AU2014372513B2 (en)
BR (1) BR112016014247A2 (en)
CA (1) CA2932967C (en)
EA (3) EA202091755A1 (en)
ES (2) ES2796648T3 (en)
FR (2) FR3015290B1 (en)
IL (2) IL246062B (en)
MX (1) MX362530B (en)
PL (2) PL3173086T3 (en)
PT (1) PT3049091T (en)
SG (2) SG10201805571PA (en)
WO (1) WO2015097261A1 (en)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2837626T3 (en) 2013-07-10 2021-07-01 Matrix Biology Inst Hyaluronan compositions with high elasticity and uses thereof
US9421198B2 (en) 2013-07-30 2016-08-23 Teoxane Composition comprising hyaluronic acid and mepivacaine
US10004824B2 (en) 2015-05-11 2018-06-26 Laboratoires Vivacy Compositions comprising at least one polyol and at least one anesthetic
PT3352766T (en) 2015-09-24 2022-03-22 Matrix Biology Inst High elasticity hyaluronan compositions and methods of use thereof
FR3058064B1 (en) 2016-10-28 2020-08-07 Lab Vivacy COMPOSITION BASED ON HYALURONIC ACID INCLUDING MEPIVACAINE
KR102091452B1 (en) * 2017-12-19 2020-03-20 대화제약 주식회사 Method for preparing prefilled syringe comprising local anesthetics and hyaluronic acid hydrogel
CN114144200A (en) * 2019-05-17 2022-03-04 多伦多大学管理委员会 Sustained release local anesthetic hydrogel compositions
KR102566288B1 (en) * 2019-12-24 2023-08-11 주식회사 엘지화학 Injectable composition comprising anesthetics, buffer solution and hyaluronic acid hydrogel, and method for preparing the same
KR102493003B1 (en) * 2022-05-09 2023-01-27 구태훈 Composition for joint synovial fluid supplement having hyaluronic acid and lidocaine

Family Cites Families (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR1352971A (en) 1963-01-09 1964-02-21 Siemens Ag Assembly for measuring the distance of faults on lines
SE442820B (en) 1984-06-08 1986-02-03 Pharmacia Ab GEL OF THE CROSS-BOND HYALURONIC ACID FOR USE AS A GLASS BODY SUBSTITUTE
JPH02215707A (en) * 1989-02-15 1990-08-28 Chisso Corp Skin cosmetic
GB9902412D0 (en) 1999-02-03 1999-03-24 Fermentech Med Ltd Process
FR2861734B1 (en) 2003-04-10 2006-04-14 Corneal Ind CROSSLINKING OF LOW AND HIGH MOLECULAR MASS POLYSACCHARIDES; PREPARATION OF INJECTABLE SINGLE PHASE HYDROGELS; POLYSACCHARIDES AND HYDROGELS OBTAINED
US8124120B2 (en) 2003-12-22 2012-02-28 Anika Therapeutics, Inc. Crosslinked hyaluronic acid compositions for tissue augmentation
CA2567532C (en) 2004-05-20 2013-10-01 Mentor Corporation Methods for making injectable polymer hydrogels
FR2924615B1 (en) 2007-12-07 2010-01-22 Vivacy Lab HYDROGEL COHESIVE BIODEGRADABLE.
US8357795B2 (en) * 2008-08-04 2013-01-22 Allergan, Inc. Hyaluronic acid-based gels including lidocaine
FR2938187B1 (en) * 2008-11-07 2012-08-17 Anteis Sa INJECTABLE COMPOSITION BASED ON HYALURONIC ACID OR ONE OF ITS HEAT-STERILIZED SALTS, POLYOLS AND LIDOCAINE
EP2484387A1 (en) 2011-02-03 2012-08-08 Q-Med AB Hyaluronic acid composition
FR2979539B1 (en) * 2011-09-05 2013-09-27 Teoxane DERMO-INJECTABLE STERILE COMPOSITION
EP2581079B1 (en) 2011-10-11 2016-12-07 BioPolymer GmbH & Co. KG Combination of hyaluronic acid and prilocaine
FR2983483B1 (en) 2011-12-02 2014-11-14 Vivacy Lab PROCESS FOR SIMULTANEOUS SUBSTITUTION AND RETICULATION OF A POLYSACCHARIDE VIA ITS HYDROXYL FUNCTIONS
FR2991876B1 (en) * 2012-06-13 2014-11-21 Vivacy Lab COMPOSITION, IN AQUEOUS MEDIUM, COMPRISING AT LEAST ONE HYALURONIC ACID AND AT LEAST ONE WATER-SOLUBLE SALT OF SUCROSE OCTASULFATE
KR20140025117A (en) * 2012-08-21 2014-03-04 김종서 Composition of anesthetic comprising hyaluronic acid
CN102805882B (en) * 2012-08-28 2014-04-23 华熙福瑞达生物医药有限公司 Method for mixing soft tissue filling agent with anesthetic injecta before use
FR2994846B1 (en) * 2012-08-29 2014-12-26 Vivacy Lab COMPOSITION, STERILIZED, COMPRISING AT LEAST ONE HYALURONIC ACID AND MAGNESIUM ASCORBYL PHOSPHATE
US9421198B2 (en) * 2013-07-30 2016-08-23 Teoxane Composition comprising hyaluronic acid and mepivacaine

Also Published As

Publication number Publication date
MX362530B (en) 2019-01-23
BR112016014247A2 (en) 2020-05-26
EA202091755A1 (en) 2021-01-29
CN110623954A (en) 2019-12-31
JP2017500358A (en) 2017-01-05
ES2625841T3 (en) 2017-07-20
IL246062B (en) 2020-05-31
US20200000969A1 (en) 2020-01-02
AU2014372513A1 (en) 2016-07-28
WO2015097261A1 (en) 2015-07-02
KR20160096205A (en) 2016-08-12
SG11201604862XA (en) 2016-07-28
EP3049091B1 (en) 2017-01-04
US20160346433A1 (en) 2016-12-01
EA031349B1 (en) 2018-12-28
FR3015290A1 (en) 2015-06-26
EP3049091A1 (en) 2016-08-03
AU2014372513B2 (en) 2020-04-30
IL246062A0 (en) 2016-07-31
PL3049091T3 (en) 2017-07-31
CN105916512A (en) 2016-08-31
CN105916512B (en) 2019-09-24
MX2016007921A (en) 2016-10-07
EA036502B1 (en) 2020-11-17
IL274454A (en) 2020-06-30
PL3173086T3 (en) 2020-11-16
EA201691019A1 (en) 2016-10-31
JP6446462B2 (en) 2018-12-26
CA2932967C (en) 2022-08-23
EP3799875A1 (en) 2021-04-07
FR3015290B1 (en) 2017-01-13
EP3173086B1 (en) 2020-01-08
EP3173086A1 (en) 2017-05-31
EA201891754A1 (en) 2019-01-31
ES2796648T3 (en) 2020-11-27
KR102343660B1 (en) 2021-12-28
FR3044228A1 (en) 2017-06-02
PT3049091T (en) 2017-04-07
CA2932967A1 (en) 2015-07-02
FR3044228B1 (en) 2019-06-21

Similar Documents

Publication Publication Date Title
SG10201805571PA (en) Hyaluronic acid compositions including mepivacaine
PH12017501478A1 (en) 1-(het)arylsulfonyl-(pyrrolidine or piperidine)-2-carboxamide derivatives and their use as trpa1 antagonists
MX2010010135A (en) Fungicide hydroximoyl-tetrazole derivatives.
MY162146A (en) Pharmaceutical composition
MX354543B (en) Sterilised composition comprising at least one hyaluronic acid and magnesium ascorbyl phosphate.
BR112015024846A2 (en) compositions for use in stimulating bone growth
MX2013001234A (en) Deuterated tandospirone derivatives as 5-ht1a receptor agonists.
MX2010007677A (en) Fungicide hydroximoyl-tetrazole derivatives.
IN2015DN01489A (en)
MX342947B (en) Treatment of type 2 diabetes.
PH12016500054A1 (en) Substituted pyrazolo-pyridinamines
BR112014002940A2 (en) use and agrochemical composition of carboxylic acid dibutylamides
MX2016002296A (en) Aqueous liquid compositions.
MX2016008221A (en) Prebiotic oral care compositions containing an alkyl glycoside.
MX2012007541A (en) Fungicide hydroximoyl-heterocycles derivatives.
MX367949B (en) Fabric softener composition.
BR112014015841A2 (en) alkyd resin composition comprising silica
MX2013004878A (en) N-hetarylmethyl pyrazolylcarboxamides.
MY182591A (en) Compositions for use in treating eye disorders using dipyridamole
PH12015501643B1 (en) Methods of use of phenoxypropylamine compounds to treat depression
SA112330437B1 (en) Pharmaceutical compositions containing hypnotic or anesthetic agent and method for their preparation
PL404379A1 (en) Ointment
MX346713B (en) A stable iron oligosaccharide compound.
MX2023006909A (en) Use of phenoxypropylamine compounds to treat depression.
MX2012007158A (en) Dibenzoyl peroxide derivatives, preparation method thereof and cosmetic or dermatological compositions containing same.