SG10201804146XA - Methods for collecting and using placenta cord blood stem cells - Google Patents

Methods for collecting and using placenta cord blood stem cells

Info

Publication number
SG10201804146XA
SG10201804146XA SG10201804146XA SG10201804146XA SG10201804146XA SG 10201804146X A SG10201804146X A SG 10201804146XA SG 10201804146X A SG10201804146X A SG 10201804146XA SG 10201804146X A SG10201804146X A SG 10201804146XA SG 10201804146X A SG10201804146X A SG 10201804146XA
Authority
SG
Singapore
Prior art keywords
isolated
stem cells
cord blood
blood stem
collecting
Prior art date
Application number
SG10201804146XA
Inventor
Naoko Takebe
Original Assignee
Hli Cellular Therapeutics Llc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hli Cellular Therapeutics Llc filed Critical Hli Cellular Therapeutics Llc
Publication of SG10201804146XA publication Critical patent/SG10201804146XA/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N1/00—Preservation of bodies of humans or animals, or parts thereof
    • A01N1/02—Preservation of living parts
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/48—Reproductive organs
    • A61K35/51—Umbilical cord; Umbilical cord blood; Umbilical stem cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/36—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix
    • A61L27/38—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix containing added animal cells
    • A61L27/3804—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix containing added animal cells characterised by specific cells or progenitors thereof, e.g. fibroblasts, connective tissue cells, kidney cells
    • A61L27/3834—Cells able to produce different cell types, e.g. hematopoietic stem cells, mesenchymal stem cells, marrow stromal cells, embryonic stem cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/04—Immunostimulants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/06—Antianaemics
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0603—Embryonic cells ; Embryoid bodies
    • C12N5/0605—Cells from extra-embryonic tissues, e.g. placenta, amnion, yolk sac, Wharton's jelly
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0634—Cells from the blood or the immune system
    • C12N5/0647—Haematopoietic stem cells; Uncommitted or multipotent progenitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K2035/124—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells the cells being hematopoietic, bone marrow derived or blood cells

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Zoology (AREA)
  • Cell Biology (AREA)
  • Biotechnology (AREA)
  • Wood Science & Technology (AREA)
  • Immunology (AREA)
  • Developmental Biology & Embryology (AREA)
  • Genetics & Genomics (AREA)
  • Hematology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Reproductive Health (AREA)
  • General Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Microbiology (AREA)
  • Gynecology & Obstetrics (AREA)
  • Epidemiology (AREA)
  • Transplantation (AREA)
  • Oral & Maxillofacial Surgery (AREA)
  • Pregnancy & Childbirth (AREA)
  • Dermatology (AREA)
  • Botany (AREA)
  • Urology & Nephrology (AREA)
  • Diabetes (AREA)
  • Virology (AREA)
  • Oncology (AREA)
  • Dentistry (AREA)

Abstract

METHODSFOR COLLECTING AND USING PI,ACENTA CORD BLOOD STEM CELLS An ínnovative method of cotlecting cord blood stem cells ftrcm an isolated mammalian non- exsanguinated or partially exsanguinated placeufa by placcntal perfusion is described. Placental perfr¡sion can include perfusing the isolated placenfa with a pulsatile flow of perfusion solution, for example, gsing a pulsatile orperistalfic pufnp or device. The stem cells can thcn be isolated fiom tlte perfusate. The perftrsion solution can include an ariticoagr¡lant. The isolated mammaliân placenfa necd not be treated with an anticoagulant prior to perfusitrg. The isolated plãcenta can be free from an anticoagulant prior to pcrfising. Figure I
SG10201804146XA 2006-05-11 2007-05-11 Methods for collecting and using placenta cord blood stem cells SG10201804146XA (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US79973406P 2006-05-11 2006-05-11

Publications (1)

Publication Number Publication Date
SG10201804146XA true SG10201804146XA (en) 2018-06-28

Family

ID=38694487

Family Applications (3)

Application Number Title Priority Date Filing Date
SG10201804146XA SG10201804146XA (en) 2006-05-11 2007-05-11 Methods for collecting and using placenta cord blood stem cells
SG201103291-9A SG171669A1 (en) 2006-05-11 2007-05-11 Methods for collecting and using placenta cord blood stem cells
SG2013040373A SG191608A1 (en) 2006-05-11 2007-05-11 Methods for collecting and using placenta cord blood stem cells

Family Applications After (2)

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SG201103291-9A SG171669A1 (en) 2006-05-11 2007-05-11 Methods for collecting and using placenta cord blood stem cells
SG2013040373A SG191608A1 (en) 2006-05-11 2007-05-11 Methods for collecting and using placenta cord blood stem cells

Country Status (14)

Country Link
US (4) US8329468B2 (en)
EP (4) EP2023717B1 (en)
JP (1) JP5260499B2 (en)
KR (1) KR101514078B1 (en)
CN (2) CN101483998A (en)
BR (1) BRPI0711599B8 (en)
CA (3) CA3103505C (en)
ES (1) ES2581738T3 (en)
IL (1) IL195241A (en)
MX (1) MX2008014426A (en)
MY (1) MY157763A (en)
SG (3) SG10201804146XA (en)
WO (1) WO2007133665A2 (en)
ZA (1) ZA200809770B (en)

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NZ595786A (en) 2005-12-29 2013-05-31 Anthrogenesis Corp Placental stem cell populations
US9944900B2 (en) * 2006-01-18 2018-04-17 Hemacell Perfusion Pulsatile perfusion extraction method for non-embryonic pluripotent stem cells
WO2008109816A1 (en) * 2007-03-08 2008-09-12 Hemacell Perfusion, Inc. Method for isolation of afterbirth derived cells
CA2734236C (en) 2008-08-20 2020-08-25 Anthrogenesis Corporation Improved cell composition and methods of making the same
NZ591293A (en) 2008-08-22 2012-10-26 Anthrogenesis Corp Methods and compositions for treatment of bone defects with osteogenic placental adherent cells (OPACs)
CN103540566A (en) * 2008-11-14 2014-01-29 路易斯维尔大学研究基金会有限公司 Methods and compositions for long term hematopoietic repopulation
NZ602455A (en) 2008-11-19 2014-03-28 Anthrogenesis Corp Amnion derived adherent cells
US20130323708A1 (en) 2009-07-01 2013-12-05 Massachusetts Institute Of Technology Isolated adult cells, artificial organs, rehabilitated organs, research tools, organ encasements, organ perfusion systems, and methods for preparing and utilizing the same
CN102933221A (en) 2010-04-08 2013-02-13 人类起源公司 Treatment of sarcoidosis using placental stem cells
US10575515B2 (en) 2010-05-04 2020-03-03 The General Hospital Corporation Methods and compositions for preserving tissues and organs
US8969315B2 (en) 2010-12-31 2015-03-03 Anthrogenesis Corporation Enhancement of placental stem cell potency using modulatory RNA molecules
CN102757935A (en) * 2011-04-29 2012-10-31 北京汉氏联合生物技术有限公司 Method for extracting hematopoietic stem cell from placental chorionic tissue and construction method of hematopoietic stem cell
ES2707579T3 (en) 2011-06-01 2019-04-04 Celularity Inc Pain treatment using placental cytoblast
US10190092B2 (en) 2011-08-11 2019-01-29 Robert A. Dracker Procurement of placental stem cells
WO2013049670A1 (en) * 2011-09-28 2013-04-04 Epic Sciences, Inc. Method for optimizing the collection of rare cells in blood
KR20210054046A (en) * 2013-10-03 2021-05-12 안트로제네시스 코포레이션 Therapy with cells from human placenta and hematopoietic cells
RU2016123361A (en) * 2013-11-15 2017-12-20 Антродженезис Корпорейшн COMPOSITIONS INCLUDING HUMAN PLACENTAL PERFUSATE CELLS
CN103756965B (en) * 2014-01-27 2016-04-06 山东省齐鲁干细胞工程有限公司 A kind of method of lavation hemopoietic stem cell from placenta
CN103789262A (en) * 2014-02-17 2014-05-14 宁波普莱森特生物科技有限公司 Preparation method and preservation method of clinical application-level placental hematopoietic stem cells
US10918102B2 (en) 2014-03-13 2021-02-16 The General Hospital Corporation Devices and methods to improve and assess viability of human livers
FR3035407B1 (en) 2015-04-23 2022-06-17 Francais Du Sang Ets METHOD FOR PRESERVING CELLS, TISSUES OR ORGANS IN HYPOTHERMIA
AU2017316682B2 (en) 2016-08-24 2020-10-15 Arthrex, Inc. Tissue use for repair of injury
CN108531454A (en) * 2018-04-09 2018-09-14 孔五 The purposes of Cord blood regenerated particle and composition in treating brain degenerative disease
JP2022513164A (en) * 2018-11-30 2022-02-07 セルラリティ インク． Placenta-derived allogeneic CAR-T cells and their use
US11511017B2 (en) 2019-03-12 2022-11-29 Arthrex, Inc. Ligament reconstruction

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Also Published As

Publication number Publication date
CA2652051A1 (en) 2007-11-22
KR101514078B1 (en) 2015-04-22
EP3603390A1 (en) 2020-02-05
IL195241A (en) 2014-02-27
JP2009536824A (en) 2009-10-22
US10548926B2 (en) 2020-02-04
MY157763A (en) 2016-07-15
BRPI0711599A2 (en) 2011-11-16
US20130108591A1 (en) 2013-05-02
KR20090026158A (en) 2009-03-11
SG171669A1 (en) 2011-06-29
ES2581738T3 (en) 2016-09-07
EP2023717A4 (en) 2009-12-16
US20090123437A1 (en) 2009-05-14
BRPI0711599B8 (en) 2021-07-27
MX2008014426A (en) 2009-02-18
CA2909053C (en) 2021-02-09
CN101483998A (en) 2009-07-15
EP2023717B1 (en) 2016-04-13
US8329468B2 (en) 2012-12-11
CA3103505C (en) 2023-07-04
US20160220618A1 (en) 2016-08-04
BRPI0711599B1 (en) 2021-03-02
CA2652051C (en) 2015-12-08
JP5260499B2 (en) 2013-08-14
CA2909053A1 (en) 2007-11-22
US20200138872A1 (en) 2020-05-07
WO2007133665A2 (en) 2007-11-22
IL195241A0 (en) 2009-08-03
EP4094578A1 (en) 2022-11-30
EP2023717A2 (en) 2009-02-18
EP3114931A1 (en) 2017-01-11
CA3103505A1 (en) 2007-11-22
EP3603390B1 (en) 2023-12-20
BRPI0711599A8 (en) 2017-04-04
CN105087490A (en) 2015-11-25
WO2007133665A3 (en) 2008-12-18
ZA200809770B (en) 2010-03-31
SG191608A1 (en) 2013-07-31
US9364585B2 (en) 2016-06-14

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