SG10201700204TA - Mixed disulfide conjugates of thienopyridine compounds and uses thereof - Google Patents
Mixed disulfide conjugates of thienopyridine compounds and uses thereofInfo
- Publication number
- SG10201700204TA SG10201700204TA SG10201700204TA SG10201700204TA SG10201700204TA SG 10201700204T A SG10201700204T A SG 10201700204TA SG 10201700204T A SG10201700204T A SG 10201700204TA SG 10201700204T A SG10201700204T A SG 10201700204TA SG 10201700204T A SG10201700204T A SG 10201700204TA
- Authority
- SG
- Singapore
- Prior art keywords
- mixed disulfide
- disulfide conjugates
- thienopyridine compounds
- thienopyridine
- compounds
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
- A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
- A61K31/4525—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a five-membered ring with oxygen as a ring hetero atom
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
- A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
- A61K31/4545—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring hetero atom, e.g. pipamperone, anabasine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/50—Pyridazines; Hydrogenated pyridazines
- A61K31/501—Pyridazines; Hydrogenated pyridazines not condensed and containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
- A61K38/06—Tripeptides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/54—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/54—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound
- A61K47/542—Carboxylic acids, e.g. a fatty acid or an amino acid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/54—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound
- A61K47/545—Heterocyclic compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/62—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being a protein, peptide or polyamino acid
- A61K47/64—Drug-peptide, drug-protein or drug-polyamino acid conjugates, i.e. the modifying agent being a peptide, protein or polyamino acid which is covalently bonded or complexed to a therapeutically active agent
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/68—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
- C07D211/72—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, directly attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/08—Tripeptides
- C07K5/0819—Tripeptides with the first amino acid being acidic
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201361750633P | 2013-01-09 | 2013-01-09 |
Publications (1)
Publication Number | Publication Date |
---|---|
SG10201700204TA true SG10201700204TA (en) | 2017-03-30 |
Family
ID=51167312
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
SG11201505283RA SG11201505283RA (en) | 2013-01-09 | 2014-01-06 | Mixed disulfide conjugates of thienopyridine compounds and uses thereof |
SG10201700204TA SG10201700204TA (en) | 2013-01-09 | 2014-01-06 | Mixed disulfide conjugates of thienopyridine compounds and uses thereof |
Family Applications Before (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
SG11201505283RA SG11201505283RA (en) | 2013-01-09 | 2014-01-06 | Mixed disulfide conjugates of thienopyridine compounds and uses thereof |
Country Status (14)
Country | Link |
---|---|
US (2) | US9718778B2 (en) |
EP (1) | EP2943482B1 (en) |
JP (2) | JP6072938B2 (en) |
KR (1) | KR101841332B1 (en) |
CN (1) | CN105051025B (en) |
AU (1) | AU2014205629B2 (en) |
CA (1) | CA2897407C (en) |
DK (1) | DK2943482T3 (en) |
HK (1) | HK1218748A1 (en) |
IL (1) | IL239823B (en) |
MX (1) | MX2015008877A (en) |
NZ (1) | NZ709744A (en) |
SG (2) | SG11201505283RA (en) |
WO (1) | WO2014109987A1 (en) |
Families Citing this family (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2016176644A1 (en) | 2015-04-30 | 2016-11-03 | The Regents Of The University Of Michigan | Mixed disulfide conjugates of thienopyridine compounds and uses thereof |
JP2021511800A (en) * | 2018-01-31 | 2021-05-13 | ザ リージェンツ オブ ザ ユニバーシティ オブ ミシガン | Method for synthesizing a mixed disulfide bond of a biocatalyst and a thienopyridine compound |
US11642335B2 (en) * | 2019-09-26 | 2023-05-09 | Board Of Regents, The University Of Texas System | Chemical synthesis of clopidogrel active metabolites and disulfide conjugate prodrugs |
WO2021070200A2 (en) * | 2019-10-08 | 2021-04-15 | Ipca Laboratories Limited | Stable compositions of (7as,2's)-2-oxoclopidogrel and its pharmaceutical salts |
CN111484446A (en) * | 2020-04-02 | 2020-08-04 | 北京翼方生物科技有限责任公司 | Clopidogrel metabolic active body disulfide derivative, preparation method and medical application thereof |
CN112851570A (en) * | 2021-01-13 | 2021-05-28 | 北京沃邦医药科技有限公司 | Preparation method and medical application of unsaturated cyclic amine cysteine disulfide derivative |
CN112812098A (en) * | 2021-01-13 | 2021-05-18 | 北京沃邦医药科技有限公司 | Preparation method and medical application of unsaturated cyclic amine pyridine disulfide derivative |
CN115260086A (en) * | 2022-09-28 | 2022-11-01 | 吉林大学 | Fluoro internal standard substance and application and preparation method thereof |
Family Cites Families (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3989816A (en) | 1975-06-19 | 1976-11-02 | Nelson Research & Development Company | Vehicle composition containing 1-substituted azacycloheptan-2-ones |
US4444762A (en) | 1980-04-04 | 1984-04-24 | Nelson Research & Development Company | Vehicle composition containing 1-substituted azacyclopentan-2-ones |
KR100567950B1 (en) * | 1998-02-27 | 2006-04-05 | 상꾜 가부시키가이샤 | Cyclic amino compounds |
US7205404B1 (en) | 1999-03-05 | 2007-04-17 | Metabasis Therapeutics, Inc. | Phosphorus-containing prodrugs |
JP2001131067A (en) | 1999-08-26 | 2001-05-15 | Sankyo Co Ltd | Platelet coagulation inhibitor and arteriosclerosis- evolving inhibitor |
US6710058B2 (en) * | 2000-11-06 | 2004-03-23 | Bristol-Myers Squibb Pharma Company | Monocyclic or bicyclic carbocycles and heterocycles as factor Xa inhibitors |
JP4749702B2 (en) * | 2003-11-28 | 2011-08-17 | 第一三共株式会社 | Cyclic amine derivatives having a heteroaryl ring |
AU2006250335B2 (en) * | 2005-05-27 | 2010-09-02 | Daiichi Sankyo Company, Limited | Cyclic amine derivative having substituted alkyl group |
JP2008156343A (en) * | 2006-11-27 | 2008-07-10 | Daiichi Sankyo Co Ltd | Pharmaceutical composition comprising cyclic amine derivative with substituted alkyl group |
-
2014
- 2014-01-06 US US14/758,736 patent/US9718778B2/en active Active
- 2014-01-06 KR KR1020157019404A patent/KR101841332B1/en active IP Right Grant
- 2014-01-06 CA CA2897407A patent/CA2897407C/en active Active
- 2014-01-06 SG SG11201505283RA patent/SG11201505283RA/en unknown
- 2014-01-06 SG SG10201700204TA patent/SG10201700204TA/en unknown
- 2014-01-06 CN CN201480004402.7A patent/CN105051025B/en active Active
- 2014-01-06 AU AU2014205629A patent/AU2014205629B2/en active Active
- 2014-01-06 MX MX2015008877A patent/MX2015008877A/en active IP Right Grant
- 2014-01-06 WO PCT/US2014/010348 patent/WO2014109987A1/en active Application Filing
- 2014-01-06 NZ NZ709744A patent/NZ709744A/en unknown
- 2014-01-06 JP JP2015552723A patent/JP6072938B2/en active Active
- 2014-01-06 EP EP14737819.4A patent/EP2943482B1/en active Active
- 2014-01-06 DK DK14737819.4T patent/DK2943482T3/en active
-
2015
- 2015-07-07 IL IL239823A patent/IL239823B/en active IP Right Grant
-
2016
- 2016-05-16 HK HK16105559.4A patent/HK1218748A1/en unknown
- 2016-12-28 JP JP2016255530A patent/JP2017081968A/en active Pending
-
2017
- 2017-06-23 US US15/631,822 patent/US10196356B2/en active Active
Also Published As
Publication number | Publication date |
---|---|
CA2897407C (en) | 2018-05-08 |
CN105051025A (en) | 2015-11-11 |
US20170334853A1 (en) | 2017-11-23 |
KR101841332B1 (en) | 2018-03-22 |
JP2017081968A (en) | 2017-05-18 |
MX2015008877A (en) | 2015-12-07 |
IL239823A0 (en) | 2015-08-31 |
IL239823B (en) | 2020-04-30 |
KR20150096770A (en) | 2015-08-25 |
CN105051025B (en) | 2018-06-01 |
NZ709744A (en) | 2016-10-28 |
AU2014205629B2 (en) | 2016-12-22 |
JP2016511229A (en) | 2016-04-14 |
EP2943482B1 (en) | 2019-03-13 |
EP2943482A4 (en) | 2016-07-06 |
US10196356B2 (en) | 2019-02-05 |
HK1218748A1 (en) | 2017-03-10 |
EP2943482A1 (en) | 2015-11-18 |
CA2897407A1 (en) | 2014-07-17 |
US9718778B2 (en) | 2017-08-01 |
WO2014109987A1 (en) | 2014-07-17 |
AU2014205629A1 (en) | 2015-07-23 |
US20150353492A1 (en) | 2015-12-10 |
JP6072938B2 (en) | 2017-02-01 |
DK2943482T3 (en) | 2019-04-15 |
SG11201505283RA (en) | 2015-08-28 |
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