SG10201610161UA - Facultatively attenuated bacterial species and methods of preparation and use thereof - Google Patents

Facultatively attenuated bacterial species and methods of preparation and use thereof

Info

Publication number
SG10201610161UA
SG10201610161UA SG10201610161UA SG10201610161UA SG10201610161UA SG 10201610161U A SG10201610161U A SG 10201610161UA SG 10201610161U A SG10201610161U A SG 10201610161UA SG 10201610161U A SG10201610161U A SG 10201610161UA SG 10201610161U A SG10201610161U A SG 10201610161UA
Authority
SG
Singapore
Prior art keywords
preparation
methods
bacterial species
attenuated bacterial
facultatively
Prior art date
Application number
SG10201610161UA
Inventor
William G Hanson
Justin Skoble
Peter M Lauer
Original Assignee
Aduro Biotech Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Aduro Biotech Inc filed Critical Aduro Biotech Inc
Publication of SG10201610161UA publication Critical patent/SG10201610161UA/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
    • C12N1/20—Bacteria; Culture media therefor
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/74—Vectors or expression systems specially adapted for prokaryotic hosts other than E. coli, e.g. Lactobacillus, Micromonospora
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/02—Bacterial antigens
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/02—Bacterial antigens
    • A61K39/0208—Specific bacteria not otherwise provided for
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/10—Transferases (2.)
    • C12N9/12—Transferases (2.) transferring phosphorus containing groups, e.g. kinases (2.7)
    • C12N9/1241—Nucleotidyltransferases (2.7.7)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y207/00—Transferases transferring phosphorus-containing groups (2.7)
    • C12Y207/07—Nucleotidyltransferases (2.7.7)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
    • A61K2039/52—Bacterial cells; Fungal cells; Protozoal cells
    • A61K2039/522—Bacterial cells; Fungal cells; Protozoal cells avirulent or attenuated
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2800/00—Nucleic acids vectors
    • C12N2800/30—Vector systems comprising sequences for excision in presence of a recombinase, e.g. loxP or FRT
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
SG10201610161UA 2012-11-06 2013-11-06 Facultatively attenuated bacterial species and methods of preparation and use thereof SG10201610161UA (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US201261723234P 2012-11-06 2012-11-06

Publications (1)

Publication Number Publication Date
SG10201610161UA true SG10201610161UA (en) 2017-01-27

Family

ID=50622722

Family Applications (2)

Application Number Title Priority Date Filing Date
SG11201502770PA SG11201502770PA (en) 2012-11-06 2013-11-06 Facultatively attenuated bacterial species and methods of preparation and use thereof
SG10201610161UA SG10201610161UA (en) 2012-11-06 2013-11-06 Facultatively attenuated bacterial species and methods of preparation and use thereof

Family Applications Before (1)

Application Number Title Priority Date Filing Date
SG11201502770PA SG11201502770PA (en) 2012-11-06 2013-11-06 Facultatively attenuated bacterial species and methods of preparation and use thereof

Country Status (10)

Country Link
US (2) US9511129B2 (en)
EP (1) EP2916854A4 (en)
JP (1) JP2015534822A (en)
KR (1) KR20150084033A (en)
CN (1) CN104838004A (en)
AU (1) AU2013341242B2 (en)
CA (1) CA2888678A1 (en)
HK (1) HK1213008A1 (en)
SG (2) SG11201502770PA (en)
WO (1) WO2014074635A1 (en)

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US9265819B2 (en) * 2011-09-21 2016-02-23 St. Jude Children's Research Hospital Live, attenuated Streptococcus pneumoniae strain and vaccine for protection against pneumococcal disease
WO2017040859A1 (en) * 2015-09-02 2017-03-09 The Regents Of The University Of California Methods and compositions for modulating prfa mediated virulence gene activation in listeria spp.
CN106540260A (en) * 2015-12-09 2017-03-29 聊城市奥润生物医药科技有限公司 Interferon gene stimulatory protein(SP)（STING）Application of the agonist in anti-alzheimer's disease
CN106119165A (en) * 2016-07-06 2016-11-16 上海理工大学 Dual-gene attenuation Listeria Monocytogenes knocked out and preparation method thereof
BR112019013863A2 (en) * 2017-01-06 2020-03-03 Synlogic Operating Company, Inc. MICRO-ORGANISMS PROGRAMMED TO PRODUCE IMMUNE AND ANTICANCER THERAPEUTIC MODULATORS IN TUMOR CELLS
CN107058202A (en) * 2017-03-23 2017-08-18 上海理工大学 A kind of gene knockout attenuation Listeria Monocytogenes and preparation method thereof
MX2019012667A (en) * 2017-04-28 2020-01-21 Univ Kansas State Targeted gene disruption methods and immunogenic compositions.
CA3069523A1 (en) 2017-07-11 2019-01-17 Actym Therapeutics, Inc. Engineered immunostimulatory bacterial strains and uses thereof
KR20210030973A (en) 2018-07-11 2021-03-18 액팀 테라퓨틱스, 인코퍼레이티드 Engineered immunostimulatory bacterial strains and uses thereof
WO2020047161A2 (en) 2018-08-28 2020-03-05 Actym Therapeutics, Inc. Engineered immunostimulatory bacterial strains and uses thereof
CN111440755B (en) * 2020-04-10 2023-03-10 西北农林科技大学 Brucella S2 vaccine strain DnaA gene conditional induction deletion strain, and construction method and application thereof
WO2022226319A1 (en) * 2021-04-23 2022-10-27 Wake Forest University Health Sciences Psoralen-inactivated neisseria gonorrhoeae vaccines and methods thereof
WO2024061748A1 (en) 2022-09-21 2024-03-28 Prokarium Limited Salmonella strain with chromosomally integrated landing pad

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US5830702A (en) 1990-10-31 1998-11-03 The Trustees Of The University Of Pennsylvania Live, recombinant listeria monocytogenes and production of cytotoxic T-cell response
US5856457A (en) 1991-03-29 1999-01-05 Genentech, Inc. Nucleic acids encoding a human IL-8 receptor
IT1262895B (en) 1992-03-02 1996-07-22 Protein extracted from cytotoxic strains of Helicobacter pylori, gene expressing it, use of the protein as a vaccine or for diagnostic purposes.
US6379943B1 (en) 1999-03-05 2002-04-30 Merck & Co., Inc. High-efficiency Cre/loxp based system for construction of adenovirus vectors
US6051237A (en) 1994-11-08 2000-04-18 The Trustees Of The University Of Pennsylvania Specific immunotherapy of cancer using a live recombinant bacterial vaccine vector
AU6501296A (en) 1995-07-21 1997-02-18 General Hospital Corporation, The Method and apparatus of enhancing the delivery of a pharmaceutical formulation
US6099848A (en) 1997-11-18 2000-08-08 The Trustees Of The University Of Pennsylvania Immunogenic compositions comprising DAL/DAT double-mutant, auxotrophic, attenuated strains of Listeria and their methods of use
EP1320602A2 (en) 2000-09-21 2003-06-25 The Regents Of The University Of California Spas-1 cancer antigen
US6989265B2 (en) * 2002-01-23 2006-01-24 Wisconsin Alumni Research Foundation Bacteria with reduced genome
US7425449B2 (en) * 2002-04-30 2008-09-16 The Regents Of The University Of California Site specific Listeria integration vectors and methods for using the same
EP1513924A4 (en) 2002-05-29 2008-05-21 Univ California Attenuated listeria spp. and methods for using the same
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US20120121643A1 (en) * 2006-03-01 2012-05-17 Dubensky Jr Thomas W Engineered listeria and methods of use thereof
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US7935804B2 (en) 2006-03-01 2011-05-03 Aduro Biotech Engineered Listeria and methods of use thereof
CN101139567A (en) * 2007-08-08 2008-03-12 扬州大学 Double genes knockout Listeria monocytogenes attenuation mutant and constructing method
CN102076843A (en) * 2008-05-19 2011-05-25 艾杜罗生物科技公司 Compositions comprising prfa*mutant listeria and methods of use thereof
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Also Published As

Publication number Publication date
CA2888678A1 (en) 2014-05-15
EP2916854A4 (en) 2016-06-22
CN104838004A (en) 2015-08-12
AU2013341242B2 (en) 2018-06-28
JP2015534822A (en) 2015-12-07
SG11201502770PA (en) 2015-06-29
KR20150084033A (en) 2015-07-21
US9511129B2 (en) 2016-12-06
US20170081673A1 (en) 2017-03-23
HK1213008A1 (en) 2016-06-24
EP2916854A1 (en) 2015-09-16
US20140127816A1 (en) 2014-05-08
WO2014074635A1 (en) 2014-05-15

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