SG10201607346XA - Angiopoietin-like 4 and its use in modulating cell leakiness - Google Patents
Angiopoietin-like 4 and its use in modulating cell leakinessInfo
- Publication number
- SG10201607346XA SG10201607346XA SG10201607346XA SG10201607346XA SG10201607346XA SG 10201607346X A SG10201607346X A SG 10201607346XA SG 10201607346X A SG10201607346X A SG 10201607346XA SG 10201607346X A SG10201607346X A SG 10201607346XA SG 10201607346X A SG10201607346X A SG 10201607346XA
- Authority
- SG
- Singapore
- Prior art keywords
- angiopoietin
- modulating cell
- leakiness
- cell leakiness
- modulating
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/22—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against growth factors ; against growth regulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
- A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
- A61K39/3955—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against proteinaceous materials, e.g. enzymes, hormones, lymphokines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/04—Antineoplastic agents specific for metastasis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/10—Antioedematous agents; Diuretics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2839—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the integrin superfamily
- C07K16/2842—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the integrin superfamily against integrin beta1-subunit-containing molecules, e.g. CD29, CD49
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/10—Type of nucleic acid
- C12N2310/14—Type of nucleic acid interfering N.A.
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2320/00—Applications; Uses
- C12N2320/30—Special therapeutic applications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2800/00—Detection or diagnosis of diseases
- G01N2800/52—Predicting or monitoring the response to treatment, e.g. for selection of therapy based on assay results in personalised medicine; Prognosis
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2800/00—Detection or diagnosis of diseases
- G01N2800/70—Mechanisms involved in disease identification
- G01N2800/7023—(Hyper)proliferation
- G01N2800/7028—Cancer
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201161521031P | 2011-08-08 | 2011-08-08 |
Publications (1)
Publication Number | Publication Date |
---|---|
SG10201607346XA true SG10201607346XA (en) | 2016-10-28 |
Family
ID=47668720
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
SG10201607346XA SG10201607346XA (en) | 2011-08-08 | 2012-08-08 | Angiopoietin-like 4 and its use in modulating cell leakiness |
SG10202101995WA SG10202101995WA (en) | 2011-08-08 | 2012-08-08 | Angiopoietin-like 4 and its use in modulating cell leakiness |
Family Applications After (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
SG10202101995WA SG10202101995WA (en) | 2011-08-08 | 2012-08-08 | Angiopoietin-like 4 and its use in modulating cell leakiness |
Country Status (5)
Country | Link |
---|---|
US (2) | US20140242084A1 (en) |
EP (2) | EP2742361A4 (en) |
CN (2) | CN103782177B (en) |
SG (2) | SG10201607346XA (en) |
WO (1) | WO2013022406A1 (en) |
Families Citing this family (10)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
SG10201406420XA (en) * | 2009-10-14 | 2014-11-27 | Univ Nanyang Tech | Antiproliferative agent |
SG11201408340SA (en) * | 2012-08-14 | 2015-01-29 | Univ Nanyang Tech | Angiopoietin-like 4 antibody and a method of its use in cancer treatment |
GB201301313D0 (en) | 2013-01-25 | 2013-03-06 | Univ Singapore | Respiratory Tract Infections |
WO2015157655A2 (en) * | 2014-04-10 | 2015-10-15 | University Of Tennessee Research Foundation | Method for predicting response to vegf targeted therapeutics |
DK3177642T3 (en) * | 2014-08-07 | 2022-02-21 | Novartis Ag | ANGIOPOIETIN-LIKE 4 ANTIBODIES AND METHODS OF USING IT |
AU2014407088B2 (en) | 2014-09-26 | 2021-09-23 | Somalogic Operating Co., Inc. | Cardiovascular risk event prediction and uses thereof |
CN106955349A (en) * | 2016-01-11 | 2017-07-18 | 石家庄以岭药业股份有限公司 | Application of the PP1158 4 in protection endothelial barrier function |
CN106822873B (en) * | 2017-02-24 | 2020-07-03 | 山东大学 | Application of mature form IL-37 in preparing medicine for inhibiting tumor metastasis |
EP4072562A4 (en) * | 2019-12-09 | 2023-12-20 | Empirico Inc. | Oligonucleotides for treatment of angiopoietin like 4 (angptl4) related diseases |
CN111549000B (en) * | 2020-06-18 | 2022-07-29 | 中国医学科学院整形外科医院 | Recombinant adipose-derived stem cell for over-expression of Hpgds, preparation method and application thereof |
Family Cites Families (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
ES2339789T3 (en) * | 2004-07-20 | 2010-05-25 | Genentech, Inc. | PROTEIN 4 INHIBITORS OF ANGIOPOYETINE TYPE, COMBINATIONS AND ITS USE. |
LT1781698T (en) * | 2004-07-20 | 2016-09-26 | Genentech, Inc. | Compositions and methods of using angiopoietin-like 4 protein |
US7655762B2 (en) * | 2005-01-07 | 2010-02-02 | Lexicon Pharmaceuticals, Inc. | Monoclonal antibodies against ANGPTL4 |
SG10201406420XA (en) * | 2009-10-14 | 2014-11-27 | Univ Nanyang Tech | Antiproliferative agent |
-
2012
- 2012-08-08 EP EP12821676.9A patent/EP2742361A4/en not_active Ceased
- 2012-08-08 SG SG10201607346XA patent/SG10201607346XA/en unknown
- 2012-08-08 EP EP18171445.2A patent/EP3399316A1/en not_active Ceased
- 2012-08-08 CN CN201280043626.XA patent/CN103782177B/en active Active
- 2012-08-08 US US14/237,861 patent/US20140242084A1/en not_active Abandoned
- 2012-08-08 SG SG10202101995WA patent/SG10202101995WA/en unknown
- 2012-08-08 WO PCT/SG2012/000282 patent/WO2013022406A1/en active Application Filing
- 2012-08-08 CN CN201710793159.7A patent/CN107536847A/en active Pending
-
2018
- 2018-07-16 US US16/036,848 patent/US20180319878A1/en not_active Abandoned
Also Published As
Publication number | Publication date |
---|---|
EP3399316A1 (en) | 2018-11-07 |
CN107536847A (en) | 2018-01-05 |
EP2742361A1 (en) | 2014-06-18 |
CN103782177A (en) | 2014-05-07 |
US20140242084A1 (en) | 2014-08-28 |
EP2742361A4 (en) | 2015-03-04 |
WO2013022406A1 (en) | 2013-02-14 |
US20180319878A1 (en) | 2018-11-08 |
CN103782177B (en) | 2017-10-03 |
SG10202101995WA (en) | 2021-04-29 |
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