SG10201504075YA - Method for improved bioactivation of medications - Google Patents

Method for improved bioactivation of medications

Info

Publication number
SG10201504075YA
SG10201504075YA SG10201504075YA SG10201504075YA SG10201504075YA SG 10201504075Y A SG10201504075Y A SG 10201504075YA SG 10201504075Y A SG10201504075Y A SG 10201504075YA SG 10201504075Y A SG10201504075Y A SG 10201504075YA SG 10201504075Y A SG10201504075Y A SG 10201504075YA
Authority
SG
Singapore
Prior art keywords
bioactivation
medications
improved
improved bioactivation
Prior art date
Application number
SG10201504075YA
Inventor
Bernd Clement
Dennis Schade
Original Assignee
Dritte Patentportfolio Beteiligungs Gmbh & Co Kg
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Dritte Patentportfolio Beteiligungs Gmbh & Co Kg filed Critical Dritte Patentportfolio Beteiligungs Gmbh & Co Kg
Publication of SG10201504075YA publication Critical patent/SG10201504075YA/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C279/00—Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups
    • C07C279/18—Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of guanidine groups bound to carbon atoms of six-membered aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C257/00—Compounds containing carboxyl groups, the doubly-bound oxygen atom of a carboxyl group being replaced by a doubly-bound nitrogen atom, this nitrogen atom not being further bound to an oxygen atom, e.g. imino-ethers, amidines
    • C07C257/10—Compounds containing carboxyl groups, the doubly-bound oxygen atom of a carboxyl group being replaced by a doubly-bound nitrogen atom, this nitrogen atom not being further bound to an oxygen atom, e.g. imino-ethers, amidines with replacement of the other oxygen atom of the carboxyl group by nitrogen atoms, e.g. amidines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/13—Amines
    • A61K31/155—Amidines (), e.g. guanidine (H2N—C(=NH)—NH2), isourea (N=C(OH)—NH2), isothiourea (—N=C(SH)—NH2)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/16—Antivirals for RNA viruses for influenza or rhinoviruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C217/00—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton
    • C07C217/02—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C257/00—Compounds containing carboxyl groups, the doubly-bound oxygen atom of a carboxyl group being replaced by a doubly-bound nitrogen atom, this nitrogen atom not being further bound to an oxygen atom, e.g. imino-ethers, amidines
    • C07C257/10—Compounds containing carboxyl groups, the doubly-bound oxygen atom of a carboxyl group being replaced by a doubly-bound nitrogen atom, this nitrogen atom not being further bound to an oxygen atom, e.g. imino-ethers, amidines with replacement of the other oxygen atom of the carboxyl group by nitrogen atoms, e.g. amidines
    • C07C257/18—Compounds containing carboxyl groups, the doubly-bound oxygen atom of a carboxyl group being replaced by a doubly-bound nitrogen atom, this nitrogen atom not being further bound to an oxygen atom, e.g. imino-ethers, amidines with replacement of the other oxygen atom of the carboxyl group by nitrogen atoms, e.g. amidines having carbon atoms of amidino groups bound to carbon atoms of six-membered aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C259/00—Compounds containing carboxyl groups, an oxygen atom of a carboxyl group being replaced by a nitrogen atom, this nitrogen atom being further bound to an oxygen atom and not being part of nitro or nitroso groups
    • C07C259/12—Compounds containing carboxyl groups, an oxygen atom of a carboxyl group being replaced by a nitrogen atom, this nitrogen atom being further bound to an oxygen atom and not being part of nitro or nitroso groups with replacement of the other oxygen atom of the carboxyl group by nitrogen atoms, e.g. N-hydroxyamidines
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D309/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings
    • C07D309/16—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D309/28—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
SG10201504075YA 2009-01-09 2010-01-08 Method for improved bioactivation of medications SG10201504075YA (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE102009004204A DE102009004204A1 (en) 2009-01-09 2009-01-09 Process for improved bioactivation of drugs

Publications (1)

Publication Number Publication Date
SG10201504075YA true SG10201504075YA (en) 2015-06-29

Family

ID=42049535

Family Applications (2)

Application Number Title Priority Date Filing Date
SG10201504075YA SG10201504075YA (en) 2009-01-09 2010-01-08 Method for improved bioactivation of medications
SG2011049897A SG172911A1 (en) 2009-01-09 2010-01-08 Method for improved bioactivation of medications

Family Applications After (1)

Application Number Title Priority Date Filing Date
SG2011049897A SG172911A1 (en) 2009-01-09 2010-01-08 Method for improved bioactivation of medications

Country Status (13)

Country Link
US (1) US20120077876A1 (en)
EP (1) EP2376074B1 (en)
JP (1) JP5918538B2 (en)
KR (3) KR20150015002A (en)
CN (1) CN102378628A (en)
AU (1) AU2010204395B2 (en)
BR (1) BRPI1004900A2 (en)
CA (1) CA2749009A1 (en)
DE (1) DE102009004204A1 (en)
IL (1) IL213955A (en)
RU (1) RU2550969C2 (en)
SG (2) SG10201504075YA (en)
WO (1) WO2010078867A1 (en)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PT2550966T (en) * 2011-07-25 2017-01-31 Dritte Patentportfolio Beteili Amidoxime carboxylic acid esters of dabigatran as prodrugs and their use as medicament

Family Cites Families (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1501529A (en) * 1975-09-11 1978-02-15 Philagro Sa Derivatives of amidoximes
DE3431916A1 (en) * 1984-08-30 1986-03-13 Bayer Ag, 5090 Leverkusen FLUORALKOXYPHENYLSULFONYLGUANIDINE
DE3516616A1 (en) * 1984-08-30 1986-03-13 Bayer Ag, 5090 Leverkusen BENZODISULTAME
JPH02295961A (en) * 1989-05-09 1990-12-06 Nippon Soda Co Ltd Guanidine derivative, production thereof and insecticide and acaricide
FR2678938B1 (en) * 1991-07-10 1993-10-08 Rhone Poulenc Rorer Sa PYRROLIDINE DERIVATIVES, THEIR PREPARATION AND THE MEDICINAL PRODUCTS CONTAINING THEM.
US5587372A (en) * 1991-12-12 1996-12-24 Roussel Uclaf Cephalosporins
US5225408A (en) * 1991-12-20 1993-07-06 E. R. Squibb & Sons, Inc. Biphenyl oxadiazinone angiotensin II inhibitors
DE4321444A1 (en) 1993-06-28 1995-01-05 Bernd Prof Dr Clement Pharmaceutical preparation
US5723495A (en) * 1995-11-16 1998-03-03 The University Of North Carolina At Chapel Hill Benzamidoxime prodrugs as antipneumocystic agents
TWI238827B (en) * 1995-12-21 2005-09-01 Astrazeneca Ab Prodrugs of thrombin inhibitors
US5840758A (en) * 1996-06-06 1998-11-24 Abbott Laboratories Oxime derivatives of fenamates as inhibitors of prostaglandin biosynthesis
ES2282127T3 (en) * 1999-07-08 2007-10-16 University Of North Carolina At Chapel Hill NEW PROPHARMS FOR ANTI -ROBIAL AMIDINS.
WO2003053917A1 (en) * 2001-12-21 2003-07-03 Nippon Soda Co.,Ltd. Guanidine compounds and pest controllers
US7956191B2 (en) * 2004-10-20 2011-06-07 Merck Serono Sa 3-arylamino pyridine derivatives
US7875602B2 (en) * 2005-10-21 2011-01-25 Sutter West Bay Hospitals Camptothecin derivatives as chemoradiosensitizing agents
CN101454299A (en) * 2006-03-27 2009-06-10 东丽株式会社 Ureide derivative and use thereof for medical purposes
DE102006034256A1 (en) * 2006-07-21 2008-01-31 Christian-Albrechts-Universität Zu Kiel Improve bioavailability of amidine-functional drugs in pharmaceuticals
DE102008005484A1 (en) * 2008-01-22 2009-07-23 Schaper, Wolfgang, Dr. Induction and promotion of arteriogenesis
DE102008007440A1 (en) * 2008-02-01 2009-08-13 Dritte Patentportfolio Beteiligungsgesellschaft Mbh & Co.Kg Amino acid derivatives as drugs
DE102008007381A1 (en) * 2008-02-01 2009-08-13 Dritte Patentportfolio Beteiligungsgesellschaft Mbh & Co.Kg Amidines and guanidines and their derivatives for the treatment of diseases

Also Published As

Publication number Publication date
KR20110102506A (en) 2011-09-16
KR20150015002A (en) 2015-02-09
JP5918538B2 (en) 2016-05-18
EP2376074B1 (en) 2019-03-13
WO2010078867A1 (en) 2010-07-15
CN102378628A (en) 2012-03-14
CA2749009A1 (en) 2010-07-15
IL213955A (en) 2016-12-29
AU2010204395A1 (en) 2011-09-01
SG172911A1 (en) 2011-08-29
US20120077876A1 (en) 2012-03-29
AU2010204395B2 (en) 2016-04-14
EP2376074A1 (en) 2011-10-19
BRPI1004900A2 (en) 2016-04-05
JP2012514608A (en) 2012-06-28
IL213955A0 (en) 2011-08-31
RU2011133233A (en) 2013-02-20
KR20160042140A (en) 2016-04-18
DE102009004204A1 (en) 2010-07-15
RU2550969C2 (en) 2015-05-20

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