SG10201408789WA - Therapeutic compounds and related methods of use - Google Patents
Therapeutic compounds and related methods of useInfo
- Publication number
- SG10201408789WA SG10201408789WA SG10201408789WA SG10201408789WA SG10201408789WA SG 10201408789W A SG10201408789W A SG 10201408789WA SG 10201408789W A SG10201408789W A SG 10201408789WA SG 10201408789W A SG10201408789W A SG 10201408789WA SG 10201408789W A SG10201408789W A SG 10201408789WA
- Authority
- SG
- Singapore
- Prior art keywords
- related methods
- therapeutic compounds
- therapeutic
- compounds
- methods
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/517—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with carbocyclic ring systems, e.g. quinazoline, perimidine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/08—Drugs for disorders of the alimentary tract or the digestive system for nausea, cinetosis or vertigo; Antiemetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/12—Antidiarrhoeals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/14—Prodigestives, e.g. acids, enzymes, appetite stimulants, antidyspeptics, tonics, antiflatulents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/10—Drugs for genital or sexual disorders; Contraceptives for impotence
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/06—Antimigraine agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/26—Psychostimulants, e.g. nicotine, cocaine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
- A61P25/32—Alcohol-abuse
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
- A61P25/36—Opioid-abuse
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P39/00—General protective or antinoxious agents
- A61P39/02—Antidotes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
- C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D495/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Psychiatry (AREA)
- Epidemiology (AREA)
- Addiction (AREA)
- Pain & Pain Management (AREA)
- Diabetes (AREA)
- Endocrinology (AREA)
- Obesity (AREA)
- Psychology (AREA)
- Hematology (AREA)
- Reproductive Health (AREA)
- Hospice & Palliative Care (AREA)
- Anesthesiology (AREA)
- Toxicology (AREA)
- Child & Adolescent Psychology (AREA)
- Gynecology & Obstetrics (AREA)
- Emergency Medicine (AREA)
- Nutrition Science (AREA)
- Otolaryngology (AREA)
- Rheumatology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US29154409P | 2009-12-31 | 2009-12-31 | |
US29155409P | 2009-12-31 | 2009-12-31 | |
US29155009P | 2009-12-31 | 2009-12-31 |
Publications (1)
Publication Number | Publication Date |
---|---|
SG10201408789WA true SG10201408789WA (en) | 2015-02-27 |
Family
ID=44226819
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
SG2012041323A SG181523A1 (en) | 2009-12-31 | 2010-12-30 | Therapeutic compounds and related methods of use |
SG10201408789WA SG10201408789WA (en) | 2009-12-31 | 2010-12-30 | Therapeutic compounds and related methods of use |
Family Applications Before (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
SG2012041323A SG181523A1 (en) | 2009-12-31 | 2010-12-30 | Therapeutic compounds and related methods of use |
Country Status (28)
Country | Link |
---|---|
US (3) | US9073890B2 (en) |
EP (2) | EP2521549B1 (en) |
JP (3) | JP5753194B2 (en) |
KR (1) | KR20120115350A (en) |
CN (2) | CN102883723B (en) |
AR (1) | AR079814A1 (en) |
AU (2) | AU2010339423C1 (en) |
BR (1) | BR112012016392A2 (en) |
CA (1) | CA2785923C (en) |
CO (1) | CO6571895A2 (en) |
CY (1) | CY1118249T1 (en) |
DK (1) | DK2521549T3 (en) |
EA (2) | EA028066B1 (en) |
ES (1) | ES2598577T3 (en) |
HK (1) | HK1173654A1 (en) |
HR (1) | HRP20161330T1 (en) |
HU (1) | HUE030752T2 (en) |
IL (1) | IL219974A0 (en) |
LT (1) | LT2521549T (en) |
MX (2) | MX2012007727A (en) |
MY (1) | MY161082A (en) |
PH (1) | PH12015502823A1 (en) |
PL (1) | PL2521549T3 (en) |
PT (1) | PT2521549T (en) |
SG (2) | SG181523A1 (en) |
SI (1) | SI2521549T1 (en) |
TW (2) | TWI591063B (en) |
WO (1) | WO2011082337A1 (en) |
Families Citing this family (35)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
LT3575288T (en) | 2009-09-03 | 2021-12-10 | Bristol-Myers Squibb Company | Quinazolines as potassium ion channel inhibitors |
US9238643B2 (en) | 2010-09-06 | 2016-01-19 | Guangzhou Institutes Of Biomedicine And Health, Chinese Academy Of Sciences | Amide compounds |
JP6121658B2 (en) * | 2011-06-29 | 2017-04-26 | 大塚製薬株式会社 | Therapeutic compounds and related methods of use |
AR086798A1 (en) * | 2011-06-29 | 2014-01-22 | Otsuka Pharma Co Ltd | USEFUL QUINAZOLINIC DERIVATIVES TO TREAT CENTRAL NERVOUS SYSTEM DISORDERS AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM |
CN103957711A (en) * | 2011-07-04 | 2014-07-30 | 拜耳知识产权有限责任公司 | Use of substituted isoquinolinones, isoquinolindiones, isoquinolintriones and dihydroisoquinolinones or in each case salts thereof as active agents against abiotic stress in plants |
WO2013013614A1 (en) * | 2011-07-28 | 2013-01-31 | 南京英派药业有限公司 | 4-(3-heteroarylarylamino)quinazoline and 1-(3-heteroarylarylamino)isoquinoline as hedgehog pathway inhibitor and use thereof |
CN104350056A (en) * | 2012-06-07 | 2015-02-11 | 霍夫曼-拉罗奇有限公司 | Pyrrolopyrimidone and pyrrolopyridone inhibitors of tankyrase |
LT2858987T (en) | 2012-06-11 | 2018-07-10 | Bristol-Myers Squibb Company | Phosphoramidic acid prodrugs of 5-[5-phenyl-4-(pyridin-2-ylmethylamino)quinazolin-2-yl]pyridine-3-sulfonamide |
CN102702116B (en) * | 2012-06-13 | 2014-12-31 | 华南理工大学 | 4-(3-chloro-4-methoxylanilino)-6-(3-amidophenyl)quinazoline compound or pharmaceutically-acceptable salt thereof and preparation methods and applications thereof |
WO2014143609A1 (en) | 2013-03-11 | 2014-09-18 | Bristol-Myers Squibb Company | Isoquinolines as potassium ion channel inhibitors |
EP2968360B1 (en) | 2013-03-14 | 2021-01-20 | ConverGene LLC | Quinolinone derivatives for the inhibition of bromodomain-containing proteins |
RU2663999C2 (en) * | 2013-10-16 | 2018-08-14 | Шанхай Инли Фармасьютикал Ко., Лтд | Fused heterocyclic compound, preparation method therefor, pharmaceutical composition and uses thereof |
ES2813875T3 (en) | 2014-01-01 | 2021-03-25 | Medivation Tech Llc | Compounds and procedures for use |
KR20170117023A (en) * | 2014-12-05 | 2017-10-20 | 서브라마니암 아난탄 | Heterocyclic compounds as biogenic amine transport modulators |
CA2969974C (en) | 2014-12-15 | 2020-08-04 | The Regents Of The University Of Michigan | Small molecule inhibitors of egfr and pi3k |
ES2918589T3 (en) * | 2015-11-25 | 2022-07-19 | Convergene Llc | Bicyclic BET bromodome inhibitors and uses thereof |
WO2017205536A2 (en) * | 2016-05-24 | 2017-11-30 | Genentech, Inc. | Therapeutic compounds and uses thereof |
CN107722012B (en) | 2016-08-11 | 2020-05-29 | 斯福瑞(南通)制药有限公司 | Process for preparing 4-chloro-7H-pyrrolo [2,3-d ] pyrimidines |
US11787783B2 (en) | 2016-12-13 | 2023-10-17 | Beta Therapeutics Pty Ltd | Heparanase inhibitors and use thereof |
AU2017376817B2 (en) | 2016-12-13 | 2022-03-31 | Beta Therapeutics Pty Ltd | Heparanase inhibitors and use thereof |
MX2019007391A (en) | 2016-12-20 | 2019-08-16 | Lts Lohmann Therapie Systeme Ag | Transdermal therapeutic system containing asenapine. |
SI3558997T1 (en) | 2016-12-20 | 2021-07-30 | Astrazeneca Ab | Amino-triazolopyridine compounds and their use in treating cancer |
EP3558276A1 (en) | 2016-12-20 | 2019-10-30 | LTS Lohmann Therapie-Systeme AG | Transdermal therapeutic system containing asenapine and polysiloxane or polyisobutylene |
AR112027A1 (en) * | 2017-06-15 | 2019-09-11 | Biocryst Pharm Inc | ALK 2 KINASE INHIBITORS CONTAINING IMIDAZOLE |
WO2019002204A1 (en) | 2017-06-26 | 2019-01-03 | Lts Lohmann Therapie-Systeme Ag | Transdermal therapeutic system containing asenapine and silicone acrylic hybrid polymer |
MX2020001261A (en) * | 2017-08-02 | 2020-08-17 | Univ Northwestern | Substituted fused pyrimidine compounds and uses there. |
WO2019113079A1 (en) | 2017-12-05 | 2019-06-13 | Sunovion Pharmaceuticals Inc. | Nonracemic mixtures and uses thereof |
AU2018378348A1 (en) | 2017-12-05 | 2020-06-18 | Sunovion Pharmaceuticals Inc. | Crystal forms and production methods thereof |
WO2019243452A1 (en) | 2018-06-20 | 2019-12-26 | Lts Lohmann Therapie-Systeme Ag | Transdermal therapeutic system containing asenapine |
EP3827001A1 (en) | 2018-07-26 | 2021-06-02 | Domain Therapeutics | Substituted quinazolinone derivatives and their use as positive allosteric modulators of mglur4 |
WO2020132409A1 (en) * | 2018-12-20 | 2020-06-25 | Trustees Of Boston University | Stk19 inhibitors for treatment of cancer |
CA3142355A1 (en) | 2019-06-04 | 2020-12-10 | Sunovion Pharmaceuticals Inc. | Modified release formulations and uses thereof |
CN116096714A (en) | 2020-06-10 | 2023-05-09 | 安力高医药股份有限公司 | Antiviral compounds for the treatment of coronavirus, picornavirus and norovirus infections |
EP4267554A1 (en) | 2020-12-22 | 2023-11-01 | Mekanistic Therapeutics LLC | Substituted aminobenzyl heteroaryl compounds as egfr and/or pi3k inhibitors |
IL309732A (en) | 2021-07-09 | 2024-02-01 | Aligos Therapeutics Inc | Anti-viral compounds |
Family Cites Families (38)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2657760B2 (en) | 1992-07-15 | 1997-09-24 | 小野薬品工業株式会社 | 4-aminoquinazoline derivatives and pharmaceuticals containing them |
US20020025968A1 (en) * | 1998-04-15 | 2002-02-28 | Rifat Pamukcu | Method for inhibiting neoplastic cells and related conditions by exposure to 4-aminoquinazoline derivatives |
AU5261001A (en) * | 2000-04-27 | 2001-11-12 | Imperial Cancer Research Technology Ltd | Condensed heteroaryl derivatives |
WO2002062767A1 (en) | 2001-02-07 | 2002-08-15 | Sumitomo Pharmaceuticals Company, Limited | Novel quinazoline derivatives |
JP4329003B2 (en) | 2001-03-23 | 2009-09-09 | バイエル コーポレイション | Rho kinase inhibitor |
AU2002350105A1 (en) | 2001-06-21 | 2003-01-08 | Ariad Pharmaceuticals, Inc. | Novel quinazolines and uses thereof |
WO2003059913A1 (en) | 2002-01-10 | 2003-07-24 | Bayer Healthcare Ag | Roh-kinase inhibitors |
EP1471910A2 (en) * | 2002-01-17 | 2004-11-03 | Neurogen Corporation | Substituted quinazolin-4-ylamine analogues as modulators of capsaicin receptors |
US20040142958A1 (en) * | 2002-12-13 | 2004-07-22 | Neurogen Corporation | Combination therapy for the treatment of pain |
US7432275B2 (en) * | 2002-12-13 | 2008-10-07 | Neurogen Corporation | Carboxylic acid, phosphate or phosphonate substituted quinazolin-4-ylamine analogues as capsaicin receptor modulators |
WO2004065392A1 (en) * | 2003-01-24 | 2004-08-05 | Smithkline Beecham Corporation | Condensed pyridines and pyrimidines and their use as alk-5 receptor ligands |
CL2004000409A1 (en) | 2003-03-03 | 2005-01-07 | Vertex Pharma | COMPOUNDS DERIVED FROM 2- (REPLACED CILO) -1- (AMINO OR REPLACED OXI) -CHINAZOLINE, INHIBITORS OF IONIC SODIUM AND CALCIUM VOLTAGE DEPENDENTS; PHARMACEUTICAL COMPOSITION; AND USE OF THE COMPOUND IN THE TREATMENT OF ACUTE PAIN, CHRONIC, NEU |
US7763627B2 (en) * | 2003-04-09 | 2010-07-27 | Exelixis, Inc. | Tie-2 modulators and methods of use |
US20090143399A1 (en) | 2003-10-14 | 2009-06-04 | Arizona Board Of Regents On Behalf Of The University Of Arizona | Protein Kinase Inhibitors |
CA2543710A1 (en) * | 2003-11-03 | 2005-05-12 | Warner-Lambert Company Llc | Novel norepinephrine reuptake inhibitors for the treatment of central nervous system disorders |
CA2548495A1 (en) * | 2003-12-08 | 2005-06-23 | Pfizer Inc. | Interaction of nmda receptor with the protein tyrosine phosphatase step in psychotic disorders |
WO2005099711A1 (en) | 2004-04-13 | 2005-10-27 | Icagen, Inc. | Polycyclic pyrimidines as potassium ion channel modulators |
US20060128702A1 (en) | 2004-11-23 | 2006-06-15 | Manojit Pal | Heterocyclic and bicyclic compounds, compositions and methods |
JP2007084494A (en) | 2005-09-22 | 2007-04-05 | Oncorex Inc | Pim-1 activity inhibitor |
GB0524436D0 (en) | 2005-11-30 | 2006-01-11 | Novartis Ag | Organic compounds |
JP2009519995A (en) * | 2005-12-20 | 2009-05-21 | ノイロサーチ アクティーゼルスカブ | 2-Pyridin-2-yl-quinazoline derivatives as potassium channel modulators for the treatment of respiratory diseases |
RU2457854C2 (en) | 2005-12-30 | 2012-08-10 | Цзэньсунь (Шанхай) Сайенс Энд Текнолоджи Лимитед | Prolonged release of neuregulin for improvement in cardiac function |
DE102006012251A1 (en) | 2006-03-15 | 2007-11-08 | Grünenthal GmbH | Substituted 4-aminoquinazoline derivatives and their use for the preparation of medicaments |
US20080033000A1 (en) | 2006-05-15 | 2008-02-07 | Senex Biotechnology, Inc. | Identification of CDKI pathway inhibitors |
GB0724349D0 (en) | 2007-12-13 | 2008-01-30 | Prolysis Ltd | Antibacterial agents |
US9259426B2 (en) | 2006-07-20 | 2016-02-16 | Gilead Sciences, Inc. | 4,6-di- and 2,4,6-trisubstituted quinazoline derivatives useful for treating viral infections |
WO2008092862A1 (en) | 2007-01-30 | 2008-08-07 | Janssen Pharmaceutica N.V. | Bicyclic derivatives as ep4 agonists |
UA98482C2 (en) | 2007-03-28 | 2012-05-25 | Ньюросерч А/С | Purinyl derivatives and their use as potassium channel modulators |
US20100152210A1 (en) | 2007-03-28 | 2010-06-17 | Neuro Search A/S/ | Purinyl derivatives and their use as potassium channel modulators |
US20090023773A1 (en) | 2007-06-27 | 2009-01-22 | Painceptor Pharma Corporation | Compositions and methods for modulating gated ion channels |
US7893059B2 (en) | 2007-09-24 | 2011-02-22 | Genentech, Inc. | Thiazolopyrimidine PI3K inhibitor compounds and methods of use |
ES2494365T3 (en) | 2008-01-30 | 2014-09-15 | Genentech, Inc. | Pyrazolopyrimidine compounds that inhibit PI3K and methods of use |
US20090192176A1 (en) | 2008-01-30 | 2009-07-30 | Wyeth | 1H-PYRAZOLO[3,4-D]PYRIMIDINE, PURINE, 7H-PURIN-8(9H)-ONE, 3H-[1,2,3]TRIAZOLO[4,5-D]PYRIMIDINE, AND THIENO[3,2-D]PYRIMIDINE COMPOUNDS, THEIR USE AS mTOR KINASE AND PI3 KINASE INHIBITORS, AND THEIR SYNTHESES |
EP2445346A4 (en) | 2009-06-24 | 2012-12-05 | Genentech Inc | Oxo-heterocycle fused pyrimidine compounds, compositions and methods of use |
WO2010151799A2 (en) | 2009-06-26 | 2010-12-29 | University Of Massachusetts | Compounds for modulating rna binding proteins and uses therefor |
EP2789615B1 (en) | 2009-08-11 | 2017-05-03 | Bristol-Myers Squibb Company | Azaindazoles as Btk kinase modulators and use thereof |
LT3575288T (en) * | 2009-09-03 | 2021-12-10 | Bristol-Myers Squibb Company | Quinazolines as potassium ion channel inhibitors |
EP2496081B1 (en) | 2009-11-02 | 2020-03-25 | Ariagen, Inc. | Ite for cancer intervention and eradication |
-
2010
- 2010-12-29 AR ARP100105018A patent/AR079814A1/en unknown
- 2010-12-30 EA EA201290593A patent/EA028066B1/en not_active IP Right Cessation
- 2010-12-30 CA CA2785923A patent/CA2785923C/en not_active Expired - Fee Related
- 2010-12-30 SG SG2012041323A patent/SG181523A1/en unknown
- 2010-12-30 PL PL10841742T patent/PL2521549T3/en unknown
- 2010-12-30 TW TW099146921A patent/TWI591063B/en not_active IP Right Cessation
- 2010-12-30 EP EP10841742.9A patent/EP2521549B1/en not_active Not-in-force
- 2010-12-30 HU HUE10841742A patent/HUE030752T2/en unknown
- 2010-12-30 WO PCT/US2010/062555 patent/WO2011082337A1/en active Application Filing
- 2010-12-30 MX MX2012007727A patent/MX2012007727A/en active IP Right Grant
- 2010-12-30 CN CN201080060265.0A patent/CN102883723B/en not_active Expired - Fee Related
- 2010-12-30 BR BR112012016392A patent/BR112012016392A2/en not_active IP Right Cessation
- 2010-12-30 MX MX2015012332A patent/MX349476B/en unknown
- 2010-12-30 KR KR1020127020038A patent/KR20120115350A/en active IP Right Grant
- 2010-12-30 TW TW105116505A patent/TWI601723B/en not_active IP Right Cessation
- 2010-12-30 ES ES10841742.9T patent/ES2598577T3/en active Active
- 2010-12-30 MY MYPI2012002782A patent/MY161082A/en unknown
- 2010-12-30 JP JP2012547310A patent/JP5753194B2/en not_active Expired - Fee Related
- 2010-12-30 EA EA201790962A patent/EA201790962A1/en unknown
- 2010-12-30 AU AU2010339423A patent/AU2010339423C1/en not_active Ceased
- 2010-12-30 DK DK10841742.9T patent/DK2521549T3/en active
- 2010-12-30 EP EP16159344.7A patent/EP3056207B1/en not_active Not-in-force
- 2010-12-30 US US13/520,018 patent/US9073890B2/en not_active Expired - Fee Related
- 2010-12-30 SG SG10201408789WA patent/SG10201408789WA/en unknown
- 2010-12-30 LT LTEP10841742.9T patent/LT2521549T/en unknown
- 2010-12-30 PT PT108417429T patent/PT2521549T/en unknown
- 2010-12-30 SI SI201031302A patent/SI2521549T1/en unknown
- 2010-12-30 CN CN201510562796.4A patent/CN105218516A/en active Pending
-
2012
- 2012-05-24 IL IL219974A patent/IL219974A0/en unknown
- 2012-07-31 CO CO12128701A patent/CO6571895A2/en active IP Right Grant
-
2013
- 2013-01-16 HK HK13100713.1A patent/HK1173654A1/en not_active IP Right Cessation
-
2015
- 2015-04-21 US US14/692,434 patent/US9630947B2/en active Active
- 2015-05-20 JP JP2015102620A patent/JP6062999B2/en not_active Expired - Fee Related
- 2015-12-18 PH PH12015502823A patent/PH12015502823A1/en unknown
-
2016
- 2016-10-12 HR HRP20161330TT patent/HRP20161330T1/en unknown
- 2016-10-19 CY CY20161101048T patent/CY1118249T1/en unknown
- 2016-12-14 JP JP2016242519A patent/JP2017071639A/en active Pending
-
2017
- 2017-02-22 AU AU2017201175A patent/AU2017201175A1/en not_active Abandoned
- 2017-03-13 US US15/456,927 patent/US20170217923A1/en not_active Abandoned
Also Published As
Similar Documents
Publication | Publication Date | Title |
---|---|---|
HK1173654A1 (en) | Therapeutic compounds and related methods of use | |
EP2448581A4 (en) | Therapeutic compositions and related methods of use | |
HK1211889A1 (en) | Therapeutic use of diaminophenothiazines | |
HK1172896A1 (en) | Compounds and methods of use | |
HK1161094A1 (en) | Compounds and methods of use | |
IL222227A0 (en) | Pyrazol - 4 - heterocyclyl-carboxamide compounds and methods of use | |
ZA201106730B (en) | Methods of treatment using combination therapy | |
EP2464227A4 (en) | Compounds and methods of use thereof | |
IL236830A0 (en) | Diazahomoadamantane derivatives and methods of use thereof | |
HK1149933A1 (en) | Diazacarbazoles and methods of use | |
IL209548A0 (en) | Diazacarbazoles and methods of use | |
ZA201201287B (en) | Therapeutic aryl-amido-aryl compounds and their use | |
ZA201205057B (en) | Fungicidal compounds and methods of their use | |
GB201011411D0 (en) | Therapeutic compounds and their use | |
EP2406244A4 (en) | Estrogenic compounds and their methods of use | |
EP2440238A4 (en) | Methods of treatment | |
GB0913300D0 (en) | Therapeutic compounds and their use | |
HK1174620A1 (en) | Indazolyl-substituted dihydroisoxa-zolopyridines and methods of use thereof | |
GB201009614D0 (en) | Therapeutic use of compounds | |
GB0819854D0 (en) | Therapeutic use of zolpidem | |
GB0809936D0 (en) | Therapeutic use of zolpidem | |
GB201019938D0 (en) | Determination of therapeutic agents | |
GB201004480D0 (en) | Therapeutic use of new compounds II |