SE9904502D0 - Production of peptides - Google Patents

Production of peptides

Info

Publication number
SE9904502D0
SE9904502D0 SE9904502A SE9904502A SE9904502D0 SE 9904502 D0 SE9904502 D0 SE 9904502D0 SE 9904502 A SE9904502 A SE 9904502A SE 9904502 A SE9904502 A SE 9904502A SE 9904502 D0 SE9904502 D0 SE 9904502D0
Authority
SE
Sweden
Prior art keywords
organic carbon
carbon source
production
cultivation
peptides
Prior art date
Application number
SE9904502A
Other languages
Swedish (sv)
Inventor
Andreas Castan
Original Assignee
Pharmacia & Upjohn Ab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pharmacia & Upjohn Ab filed Critical Pharmacia & Upjohn Ab
Priority to SE9904502A priority Critical patent/SE9904502D0/en
Publication of SE9904502D0 publication Critical patent/SE9904502D0/en
Priority to IL14962400A priority patent/IL149624A0/en
Priority to KR1020027007309A priority patent/KR20020060258A/en
Priority to EP00982029A priority patent/EP1244769A1/en
Priority to AU19105/01A priority patent/AU780122B2/en
Priority to JP2001544297A priority patent/JP2003516140A/en
Priority to NZ518919A priority patent/NZ518919A/en
Priority to CA002392268A priority patent/CA2392268A1/en
Priority to PCT/SE2000/002373 priority patent/WO2001042420A1/en
Priority to CNB008168865A priority patent/CN1267562C/en
Priority to ARP000106466A priority patent/AR026743A1/en
Priority to US09/732,638 priority patent/US6680181B2/en
Priority to TW089126391A priority patent/TWI222998B/en
Priority to HK03105539A priority patent/HK1053326A1/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P21/00—Preparation of peptides or proteins
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P21/00—Preparation of peptides or proteins
    • C12P21/02—Preparation of peptides or proteins having a known sequence of two or more amino acids, e.g. glutathione
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/61—Growth hormone [GH], i.e. somatotropin
    • C07K14/615—Extraction from natural sources

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Endocrinology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Microbiology (AREA)
  • Toxicology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biophysics (AREA)
  • Medicinal Chemistry (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)

Abstract

The invention relates to a method for the production of recombinant peptides by fedbatch cultivation of a microorganism in a bioreactor containing a medium comprising organic carbon source, nitrogen source and mineral salts. The cultivation is carried out by the addition of the organic carbon source by oscillation feed and/or by oscillation variation of stirring speed, e.g. in a square or sinus wave pattern. Preferably the organic carbon source is glucose and the recombinant peptide is growth hormone.
SE9904502A 1999-12-09 1999-12-09 Production of peptides SE9904502D0 (en)

Priority Applications (14)

Application Number Priority Date Filing Date Title
SE9904502A SE9904502D0 (en) 1999-12-09 1999-12-09 Production of peptides
CNB008168865A CN1267562C (en) 1999-12-09 2000-11-29 Production of peptides by fedbatch cultivation of microoganism
NZ518919A NZ518919A (en) 1999-12-09 2000-11-29 Production of peptides by fedbatch cultivation of a microorganism
KR1020027007309A KR20020060258A (en) 1999-12-09 2000-11-29 Production of peptides by fedbatch cultivation of a microorganism
EP00982029A EP1244769A1 (en) 1999-12-09 2000-11-29 Production of peptides by fedbatch cultivation of a microorganism
AU19105/01A AU780122B2 (en) 1999-12-09 2000-11-29 Production of peptides by fedbatch cultivation of a microorganism
JP2001544297A JP2003516140A (en) 1999-12-09 2000-11-29 Peptide production by fed-batch culture of microorganisms.
IL14962400A IL149624A0 (en) 1999-12-09 2000-11-29 Production of peptides by fedbatch cultivation of a microorganism
CA002392268A CA2392268A1 (en) 1999-12-09 2000-11-29 Production of peptides by fedbatch cultivation of a microorganism
PCT/SE2000/002373 WO2001042420A1 (en) 1999-12-09 2000-11-29 Production of peptides by fedbatch cultivation of a microorganism
ARP000106466A AR026743A1 (en) 1999-12-09 2000-12-06 PRODUCTION OF PEPTIDES
US09/732,638 US6680181B2 (en) 1999-12-09 2000-12-08 Production of peptides
TW089126391A TWI222998B (en) 1999-12-09 2000-12-11 Method for the production of recombinant peptides
HK03105539A HK1053326A1 (en) 1999-12-09 2003-08-01 Production of peptides by fedbatch cultivation of a microorganism

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
SE9904502A SE9904502D0 (en) 1999-12-09 1999-12-09 Production of peptides

Publications (1)

Publication Number Publication Date
SE9904502D0 true SE9904502D0 (en) 1999-12-09

Family

ID=20418057

Family Applications (1)

Application Number Title Priority Date Filing Date
SE9904502A SE9904502D0 (en) 1999-12-09 1999-12-09 Production of peptides

Country Status (11)

Country Link
EP (1) EP1244769A1 (en)
JP (1) JP2003516140A (en)
KR (1) KR20020060258A (en)
CN (1) CN1267562C (en)
AU (1) AU780122B2 (en)
CA (1) CA2392268A1 (en)
HK (1) HK1053326A1 (en)
IL (1) IL149624A0 (en)
NZ (1) NZ518919A (en)
SE (1) SE9904502D0 (en)
WO (1) WO2001042420A1 (en)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
MXPA05003121A (en) * 2002-09-20 2005-06-22 Pharmacia Corp Process for decreasing aggregate levels of pegylated protein.
TWI281864B (en) * 2002-11-20 2007-06-01 Pharmacia Corp N-terminally monopegylated human growth hormone conjugates and process for their preparation
CA2589716A1 (en) * 2004-12-21 2006-06-29 Usv Limited Low cell density fermentation process for the production of heterologous recombinant proteins in microorganisms
WO2008010005A1 (en) * 2006-07-14 2008-01-24 Abb Research Ltd A method for on-line optimization of a fed-batch fermentation unit to maximize the product yield.
CA2811709C (en) * 2010-09-21 2019-08-13 Ferring B.V. Improved process for production of recombinant human growth hormone
CN106222309A (en) * 2016-07-28 2016-12-14 山东金朗生物科技有限公司 A kind of fermentable produces the control of additive raw material method improving L alanine yield
CN108624516B (en) * 2017-03-20 2022-08-26 华东理工大学 Method for improving metabolite amount in fermentation cells and preparing IDMS standard substance
GB202010934D0 (en) * 2020-07-15 2020-08-26 Ipsen Biopharm Ltd Controlling operation of a bioreactor vessel

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DD271850A1 (en) * 1988-05-12 1989-09-20 Adw Ddr MIXING DEVICE FOR FLUID DISTRIBUTION AND / OR FOR GAS ADMISSION IN BIOLOGICAL CULTURAL SUSPENSIONS WITH PENDULUM ROTORS
IT1256566B (en) * 1990-11-30 1995-12-11 Ajinomoto Kk PROCEDURE AND EQUIPMENT TO CONTROL THE CONCENTRATION OF THE CARBON SOURCE IN AN AEROBIC CULTURE OF A MICROORGANISM

Also Published As

Publication number Publication date
CN1409755A (en) 2003-04-09
AU1910501A (en) 2001-06-18
HK1053326A1 (en) 2003-10-17
NZ518919A (en) 2003-10-31
JP2003516140A (en) 2003-05-13
IL149624A0 (en) 2002-11-10
EP1244769A1 (en) 2002-10-02
CA2392268A1 (en) 2001-06-14
KR20020060258A (en) 2002-07-16
WO2001042420A1 (en) 2001-06-14
CN1267562C (en) 2006-08-02
AU780122B2 (en) 2005-03-03

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