SE9903021D0 - Reduction of the immunogenicity of non-human grafts - Google Patents

Reduction of the immunogenicity of non-human grafts

Info

Publication number
SE9903021D0
SE9903021D0 SE9903021A SE9903021A SE9903021D0 SE 9903021 D0 SE9903021 D0 SE 9903021D0 SE 9903021 A SE9903021 A SE 9903021A SE 9903021 A SE9903021 A SE 9903021A SE 9903021 D0 SE9903021 D0 SE 9903021D0
Authority
SE
Sweden
Prior art keywords
relates
tissue
removal
porcine
macrophages
Prior art date
Application number
SE9903021A
Other languages
Swedish (sv)
Inventor
Thomas Brevig
Tom Kristensen
Jan Holgersson
Rasmussen Jens Zimmer
Original Assignee
Absorber Ab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Absorber Ab filed Critical Absorber Ab
Priority to SE9903021A priority Critical patent/SE9903021D0/en
Publication of SE9903021D0 publication Critical patent/SE9903021D0/en
Priority to JP2001518083A priority patent/JP2003507131A/en
Priority to PCT/SE2000/001648 priority patent/WO2001013947A1/en
Priority to EP00959076A priority patent/EP1207903A1/en
Priority to AU70460/00A priority patent/AU774651B2/en

Links

Abstract

The present invention relates to a transplantion material produced by dissociation of porcine tissue and removal of macrophages and/or microglial cells therefrom. The tissue could be an embryonic or fetal neural tissue and the removal could be effected by exposing the preparation above to antibodies against the Gal alpha 1-3Gal beta 1-R epitope and a complement reagent. The invention also relates to the use of such a transplantation material for preparing a pharmaceutical preparation useful when transplanting neural tissue. The invention also relates to a kit comprising one or more enzymes for tissue dissociation, an antibody preparation and a complement reagent. The invention also relates to a process for removal of macrophages and/or microglial cells from porcine embryonic or fetal neural tissue. Finally, the invention relates to a process for treatment of neurological disorders with such pretreated porcine neural grafts.
SE9903021A 1999-08-26 1999-08-26 Reduction of the immunogenicity of non-human grafts SE9903021D0 (en)

Priority Applications (5)

Application Number Priority Date Filing Date Title
SE9903021A SE9903021D0 (en) 1999-08-26 1999-08-26 Reduction of the immunogenicity of non-human grafts
JP2001518083A JP2003507131A (en) 1999-08-26 2000-08-28 Reduced immunogenicity of non-human grafts
PCT/SE2000/001648 WO2001013947A1 (en) 1999-08-26 2000-08-28 Reduction of the immunogenicity of non-human grafts
EP00959076A EP1207903A1 (en) 1999-08-26 2000-08-28 Reduction of the immunogenicity of non-human grafts
AU70460/00A AU774651B2 (en) 1999-08-26 2000-08-28 Reduction of the immunogenicity of non-human grafts

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
SE9903021A SE9903021D0 (en) 1999-08-26 1999-08-26 Reduction of the immunogenicity of non-human grafts

Publications (1)

Publication Number Publication Date
SE9903021D0 true SE9903021D0 (en) 1999-08-26

Family

ID=20416763

Family Applications (1)

Application Number Title Priority Date Filing Date
SE9903021A SE9903021D0 (en) 1999-08-26 1999-08-26 Reduction of the immunogenicity of non-human grafts

Country Status (5)

Country Link
EP (1) EP1207903A1 (en)
JP (1) JP2003507131A (en)
AU (1) AU774651B2 (en)
SE (1) SE9903021D0 (en)
WO (1) WO2001013947A1 (en)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20060147429A1 (en) * 2004-12-30 2006-07-06 Paul Diamond Facilitated cellular reconstitution of organs and tissues
EP3401682A1 (en) * 2017-05-09 2018-11-14 Université de Nantes Diagnosis, prevention and treatment of demyelinating disorders of the central nervous system
CN109187958A (en) * 2018-09-12 2019-01-11 福建中医药大学附属人民医院（福建省人民医院） A kind of rat CD4 antibody coating magnetic bead and its preparation method and application and the kit containing the magnetic bead

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1996036358A1 (en) * 1995-05-15 1996-11-21 Cedars-Sinai Medical Center Compositions and methods for inhibiting xenograft rejection
US6610288B1 (en) * 1995-05-26 2003-08-26 Diacrin, Inc. Porcine hepatocytes for use in treatment of disorders characterized by insufficient liver function

Also Published As

Publication number Publication date
WO2001013947A1 (en) 2001-03-01
AU7046000A (en) 2001-03-19
EP1207903A1 (en) 2002-05-29
JP2003507131A (en) 2003-02-25
AU774651B2 (en) 2004-07-01

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