SE9902918D0 - Methods for identification of compounds stimulating insulin secretion - Google Patents

Methods for identification of compounds stimulating insulin secretion

Info

Publication number
SE9902918D0
SE9902918D0 SE9902918A SE9902918A SE9902918D0 SE 9902918 D0 SE9902918 D0 SE 9902918D0 SE 9902918 A SE9902918 A SE 9902918A SE 9902918 A SE9902918 A SE 9902918A SE 9902918 D0 SE9902918 D0 SE 9902918D0
Authority
SE
Sweden
Prior art keywords
identification
compounds
methods
insulin secretion
tubulin
Prior art date
Application number
SE9902918A
Other languages
Swedish (sv)
Inventor
Per-Olof Berggren
Thomas Lundbaeck
Original Assignee
Pharmacia & Upjohn Ab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pharmacia & Upjohn Ab filed Critical Pharmacia & Upjohn Ab
Priority to SE9902918A priority Critical patent/SE9902918D0/en
Publication of SE9902918D0 publication Critical patent/SE9902918D0/en
Priority to NZ516788A priority patent/NZ516788A/en
Priority to CA002380983A priority patent/CA2380983A1/en
Priority to EP00953612A priority patent/EP1200835A1/en
Priority to AU66032/00A priority patent/AU6603200A/en
Priority to JP2001517172A priority patent/JP2003507365A/en
Priority to PCT/SE2000/001563 priority patent/WO2001013121A1/en
Priority to US09/637,134 priority patent/US6586188B1/en
Priority to NO20020576A priority patent/NO20020576L/en

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/74—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving hormones or other non-cytokine intercellular protein regulatory factors such as growth factors, including receptors to hormones and growth factors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/62—Insulins
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
    • G01N2333/575—Hormones
    • G01N2333/62—Insulins
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2500/00—Screening for compounds of potential therapeutic value

Abstract

According to the invention beta -tubulin, as well as a 65 kDa polypeptide present in pancreatic beta -cells, have been identified as molecular targets for sulfonylurea compounds. These findings enable for the identification of new insulin secretagogues. The invention thus relates to the use of sulfonylurea compounds, such as e.g. glibenclamide, in methods for identification of compounds binding the 65 kDa polypeptide or tubulin, or stimulating tubulin polymerization and/or turnover, said compounds thereby stimulating insulin secretion.
SE9902918A 1999-08-13 1999-08-13 Methods for identification of compounds stimulating insulin secretion SE9902918D0 (en)

Priority Applications (9)

Application Number Priority Date Filing Date Title
SE9902918A SE9902918D0 (en) 1999-08-13 1999-08-13 Methods for identification of compounds stimulating insulin secretion
NZ516788A NZ516788A (en) 1999-08-13 2000-08-10 Methods for identification of compounds stimulating insulin secretion
CA002380983A CA2380983A1 (en) 1999-08-13 2000-08-10 Methods for identification of compounds stimulating insulin secretion
EP00953612A EP1200835A1 (en) 1999-08-13 2000-08-10 Methods for identification of compounds stimulating insulin secretion
AU66032/00A AU6603200A (en) 1999-08-13 2000-08-10 Methods for identification of compounds stimulating insulin secretion
JP2001517172A JP2003507365A (en) 1999-08-13 2000-08-10 Methods for identifying compounds that promote insulin secretion
PCT/SE2000/001563 WO2001013121A1 (en) 1999-08-13 2000-08-10 Methods for identification of compounds stimulating insulin secretion
US09/637,134 US6586188B1 (en) 1999-08-13 2000-08-11 Method for identification of compounds that bind to β-tubulin and stimulate insulin secretion
NO20020576A NO20020576L (en) 1999-08-13 2002-02-05 Methods for identifying compounds that stimulate insulin secretion

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
SE9902918A SE9902918D0 (en) 1999-08-13 1999-08-13 Methods for identification of compounds stimulating insulin secretion

Publications (1)

Publication Number Publication Date
SE9902918D0 true SE9902918D0 (en) 1999-08-13

Family

ID=20416679

Family Applications (1)

Application Number Title Priority Date Filing Date
SE9902918A SE9902918D0 (en) 1999-08-13 1999-08-13 Methods for identification of compounds stimulating insulin secretion

Country Status (8)

Country Link
EP (1) EP1200835A1 (en)
JP (1) JP2003507365A (en)
AU (1) AU6603200A (en)
CA (1) CA2380983A1 (en)
NO (1) NO20020576L (en)
NZ (1) NZ516788A (en)
SE (1) SE9902918D0 (en)
WO (1) WO2001013121A1 (en)

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5260275A (en) * 1990-08-14 1993-11-09 Amylin Pharmaceuticals, Inc. Hypoglycemics
WO1996011398A1 (en) * 1994-10-07 1996-04-18 Merck & Co., Inc. Process for assessing tubulin protein polymerization
GB9715295D0 (en) * 1997-07-18 1997-09-24 Smithkline Beecham Plc Novel method of treatment

Also Published As

Publication number Publication date
JP2003507365A (en) 2003-02-25
NO20020576D0 (en) 2002-02-05
CA2380983A1 (en) 2001-02-22
AU6603200A (en) 2001-03-13
WO2001013121A1 (en) 2001-02-22
NO20020576L (en) 2002-02-05
EP1200835A1 (en) 2002-05-02
NZ516788A (en) 2003-07-25

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